4013-0813

2-[3-(4-bromophenoxy)-2-hydroxypropyl]-1,1-dioxo-1,2-benzothiazol-3-one

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1488
Screen concentration 75.9 μM
Source ChemDiv (Drug-like library)
PubChem CID 2910057
SMILES C1=CC=C2C(=C1)C(=O)N(S2(=O)=O)CC(COC3=CC=C(C=C3)Br)O
Standardized SMILES OC(COc1ccc(Br)cc1)CN2C(=O)c3ccccc3S2(=O)=O
Molecular weight 412.2551
ALogP 2.44
H-bond donor count 1
H-bond acceptor count 5
Response signature RPP1 & pyrimidine depletion

Pool Growth Kinetics
% growth inhibition (Het. pool) 10.14
% growth inhibition (Hom. pool) 6.31


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2910057
Download HIP data (tab-delimited text)  (excel)
Gene:BRR6(YGL247W)|FD-Score:3.47|P-value:2.62E-4|Clearance:0.43||SGD DESC:Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism Gene:RPP1(YHR062C)|FD-Score:5.19|P-value:1.07E-7|Clearance:1.72||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:BRR6(YGL247W)|FD-Score:3.47|P-value:2.62E-4|Clearance:0.43||SGD DESC:Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism Gene:RPP1(YHR062C)|FD-Score:5.19|P-value:1.07E-7|Clearance:1.72||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2910057
Download HOP data (tab-delimited text)  (excel)
Gene:ADD37(YMR184W)|FD-Score:-3.12|P-value:9.09E-4||SGD DESC:Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress Gene:BNI1(YNL271C)|FD-Score:4.78|P-value:8.79E-7||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 Gene:BUD6(YLR319C)|FD-Score:-3.54|P-value:1.96E-4||SGD DESC:Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate Gene:CLG1(YGL215W)|FD-Score:7.45|P-value:4.84E-14||SGD DESC:Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2 Gene:DST1(YGL043W)|FD-Score:-3.29|P-value:4.99E-4||SGD DESC:General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress Gene:LOT5(YKL183W)|FD-Score:-3.13|P-value:8.67E-4||SGD DESC:Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress Gene:MET12(YPL023C)|FD-Score:3.49|P-value:2.42E-4||SGD DESC:Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR Gene:PHO88(YBR106W)|FD-Score:3.81|P-value:7.02E-5||SGD DESC:Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations Gene:RRT8(YOL048C_p)|FD-Score:-3.31|P-value:4.70E-4||SGD DESC:Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress Gene:SKM1(YOL113W)|FD-Score:3.26|P-value:5.52E-4||SGD DESC:Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth Gene:SNX4(YJL036W)|FD-Score:4.4|P-value:5.45E-6||SGD DESC:Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p Gene:SRO77(YBL106C)|FD-Score:3.43|P-value:3.01E-4||SGD DESC:Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication Gene:SUR1(YPL057C)|FD-Score:-3.37|P-value:3.72E-4||SGD DESC:Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication Gene:TDA5(YLR426W_p)|FD-Score:4.45|P-value:4.25E-6||SGD DESC:Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele Gene:VPS71(YML041C)|FD-Score:3.1|P-value:9.71E-4||SGD DESC:Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting Gene:YBP2(YGL060W)|FD-Score:3.11|P-value:9.40E-4||SGD DESC:Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication Gene:YFL015C(YFL015C_d)|FD-Score:3.11|P-value:9.31E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene Gene:YIP4(YGL198W)|FD-Score:4.08|P-value:2.29E-5||SGD DESC:Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport Gene:YKL077W(YKL077W_p)|FD-Score:-3.42|P-value:3.09E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YKL118W(YKL118W_d)|FD-Score:4.66|P-value:1.61E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Gene:YMR247W-A(YMR247W-A_p)|FD-Score:4.52|P-value:3.05E-6||SGD DESC:Putative protein of unknown function Gene:YPR059C(YPR059C_d)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W Gene:YTA7(YGR270W)|FD-Score:-4.17|P-value:1.49E-5||SGD DESC:Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p Gene:ADD37(YMR184W)|FD-Score:-3.12|P-value:9.09E-4||SGD DESC:Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress Gene:BNI1(YNL271C)|FD-Score:4.78|P-value:8.79E-7||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 Gene:BUD6(YLR319C)|FD-Score:-3.54|P-value:1.96E-4||SGD DESC:Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate Gene:CLG1(YGL215W)|FD-Score:7.45|P-value:4.84E-14||SGD DESC:Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2 Gene:DST1(YGL043W)|FD-Score:-3.29|P-value:4.99E-4||SGD DESC:General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress Gene:LOT5(YKL183W)|FD-Score:-3.13|P-value:8.67E-4||SGD DESC:Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress Gene:MET12(YPL023C)|FD-Score:3.49|P-value:2.42E-4||SGD DESC:Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR Gene:PHO88(YBR106W)|FD-Score:3.81|P-value:7.02E-5||SGD DESC:Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations Gene:RRT8(YOL048C_p)|FD-Score:-3.31|P-value:4.70E-4||SGD DESC:Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress Gene:SKM1(YOL113W)|FD-Score:3.26|P-value:5.52E-4||SGD DESC:Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth Gene:SNX4(YJL036W)|FD-Score:4.4|P-value:5.45E-6||SGD DESC:Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p Gene:SRO77(YBL106C)|FD-Score:3.43|P-value:3.01E-4||SGD DESC:Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication Gene:SUR1(YPL057C)|FD-Score:-3.37|P-value:3.72E-4||SGD DESC:Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication Gene:TDA5(YLR426W_p)|FD-Score:4.45|P-value:4.25E-6||SGD DESC:Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele Gene:VPS71(YML041C)|FD-Score:3.1|P-value:9.71E-4||SGD DESC:Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting Gene:YBP2(YGL060W)|FD-Score:3.11|P-value:9.40E-4||SGD DESC:Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication Gene:YFL015C(YFL015C_d)|FD-Score:3.11|P-value:9.31E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene Gene:YIP4(YGL198W)|FD-Score:4.08|P-value:2.29E-5||SGD DESC:Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport Gene:YKL077W(YKL077W_p)|FD-Score:-3.42|P-value:3.09E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YKL118W(YKL118W_d)|FD-Score:4.66|P-value:1.61E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Gene:YMR247W-A(YMR247W-A_p)|FD-Score:4.52|P-value:3.05E-6||SGD DESC:Putative protein of unknown function Gene:YPR059C(YPR059C_d)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W Gene:YTA7(YGR270W)|FD-Score:-4.17|P-value:1.49E-5||SGD DESC:Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR062C5.191.07E-71.72RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YGL247W3.472.62E-40.43BRR6Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism
YGL075C3.040.001190.15MPS2Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
YMR013C2.890.001940.05SEC59Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YFL017C2.830.002300.05GNA1Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
YLR005W2.790.002650.03SSL1Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p
YGL055W2.760.002880.02OLE1Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YJL076W2.740.003080.12NET1Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication
YER094C2.620.004340.01PUP3Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
YAL033W2.610.004480.00POP5Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YEL035C_p2.610.004550.01UTR5_pProtein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions
YDR460W2.600.004720.02TFB3Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit
YHR070W2.570.005060.02TRM5tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya
YBR143C2.550.005370.12SUP45Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
YPL235W2.430.007500.05RVB2ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGL215W7.454.84E-14CLG1Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
YNL271C4.788.79E-7BNI1Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
YKL118W_d4.661.61E-6YKL118W_dDubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2
YMR247W-A_p4.523.05E-6YMR247W-A_pPutative protein of unknown function
YLR426W_p4.454.25E-6TDA5_pPutative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele
YJL036W4.405.45E-6SNX4Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p
YGL198W4.082.29E-5YIP4Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
YBR106W3.817.02E-5PHO88Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YPL023C3.492.42E-4MET12Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR
YPR059C_d3.432.98E-4YPR059C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
YBL106C3.433.01E-4SRO77Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication
YOL113W3.265.52E-4SKM1Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth
YFL015C_d3.119.31E-4YFL015C_dDubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YGL060W3.119.40E-4YBP2Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication
YML041C3.109.71E-4VPS71Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting

GO enrichment analysis for SGTC_1488
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1373.01E-26SGTC_265mycophenolic acid 32.9 μMMiscellaneous4465410.0705882RPP1 & pyrimidine depletion
0.1374.51E-26SGTC_1470k295-0292 231.0 μMChemDiv (Drug-like library)50456120.153846
0.1301.32E-23SGTC_26602',4'-dihydroxychalcone 17.1 μMTimTec (Pure natural product library)53572180.107692
0.1262.90E-22SGTC_32619137475 49.5 μMChembridge (Drug-like library)170276900.0731707RPP1 & pyrimidine depletion
0.1134.09E-18SGTC_15852',4'-dihydroxychalcone 10.4 μMTimTec (Pure natural product library)53572180.107692
0.1063.42E-16SGTC_1661st013063 9.7 μMTimTec (Natural product derivative library)7213950.0789474
0.1057.52E-16SGTC_1965Pectolinarigenin 58.4 μMTimTec (Natural product derivative library)53204380.121622RPP1 & pyrimidine depletion
0.1015.73E-15SGTC_2685mycophenolic acid 18.9 μMMiscellaneous4465410.0705882RNA pol III & RNase P/MRP
0.0992.50E-14SGTC_30749116018 49.5 μMChembridge (Drug-like library)170273030.0722892RNA processing & uracil transport
0.0979.24E-14SGTC_24984'-Methoxychalcone 54.6 μMMicrosource (Natural product library)6418180.140625RPP1 & pyrimidine depletion
0.0921.08E-12SGTC_28479005661 71.4 μMChembridge (Drug-like library)29914490.08
0.0912.22E-12SGTC_21745790901 200.0 μMChembridge (Fragment library)7860200.0684932tubulin folding & SWR complex
0.0863.46E-11SGTC_14873970-0795 2.8 μMChemDiv (Drug-like library)37651030.153846DNA intercalators
0.0863.92E-11SGTC_2051486-1330 71.9 μMChemDiv (Drug-like library)41188340.047619
0.0864.10E-11SGTC_32249130643 49.5 μMChembridge (Drug-like library)176443950.111111RPP1 & pyrimidine depletion

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_23945221648200 μM0.303571788586Miscellaneous346.132322.90504
SGTC_24045161160200 μM0.2985072831543Miscellaneous437.285984.61714
SGTC_544k015-002052.4 μM0.2982463008304ChemDiv (Drug-like library)316.14943.20802
SGTC_2422chlorphenesin carbamate384.24 μM0.2931032724Miscellaneous245.659581.59724
SGTC_11534055-0057267 μM0.28125882706ChemDiv (Drug-like library)299.299721.67306
SGTC_23975161689200 μM0.2769232259942Miscellaneous423.25944.6114
SGTC_2225665415215.4 μM0.2745197582Chembridge (Fragment library)245.09311.49702
SGTC_14823346-20498.48 μM0.2739733826804ChemDiv (Drug-like library)390.516363.84115
SGTC_7243910-0327137 μM0.2686572885483ChemDiv (Drug-like library)316.782083.59813ERG2
SGTC_2903592346463.88 μM0.2686572876576Chembridge (Drug-like library)310.390183.86713