4478-3555

2-[(2-hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)-(5-methylthiophen-2-yl)methyl]-5,5-dimethylcyclohexane-1,3-dione

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1498
Screen concentration 97.6 μM
Source ChemDiv (Drug-like library)
PubChem CID 3437919
SMILES CC1=CC=C(S1)C(C2C(=O)CC(CC2=O)(C)C)C3=C(CC(CC3=O)(C)C)O
Standardized SMILES Cc1ccc(s1)C(C2C(=O)CC(C)(C)CC2=O)C3=C(O)CC(C)(C)CC3=O
Molecular weight 388.5203
ALogP 3.1
H-bond donor count 1
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.36
% growth inhibition (Hom. pool) 7.12


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3437919
Download HIP data (tab-delimited text)  (excel)

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3437919
Download HOP data (tab-delimited text)  (excel)
Gene:AAP1(YHR047C)|FD-Score:4.1|P-value:2.10E-5||SGD DESC:Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication Gene:ARO4(YBR249C)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress Gene:ATP15(YPL271W)|FD-Score:-3.34|P-value:4.21E-4||SGD DESC:Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Gene:BNA1(YJR025C)|FD-Score:3.37|P-value:3.77E-4||SGD DESC:3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p Gene:COG7(YGL005C)|FD-Score:-3.27|P-value:5.33E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DBR1(YKL149C)|FD-Score:3.49|P-value:2.38E-4||SGD DESC:RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition Gene:DSS4(YPR017C)|FD-Score:3.58|P-value:1.75E-4||SGD DESC:Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol Gene:FRE8(YLR047C)|FD-Score:3.15|P-value:8.14E-4||SGD DESC:Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p Gene:IMP2'(YIL154C)|FD-Score:-3.46|P-value:2.72E-4||SGD DESC:Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat Gene:IRC21(YMR073C)|FD-Score:-3.37|P-value:3.81E-4||SGD DESC:Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study Gene:MDR1(YGR100W)|FD-Score:3.19|P-value:7.10E-4||SGD DESC:Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function Gene:OYE2(YHR179W)|FD-Score:4.72|P-value:1.18E-6||SGD DESC:Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress Gene:PEX28(YHR150W)|FD-Score:-3.09|P-value:9.94E-4||SGD DESC:Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p Gene:PKH3(YDR466W)|FD-Score:6.1|P-value:5.29E-10||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:PTK2(YJR059W)|FD-Score:-3.14|P-value:8.38E-4||SGD DESC:Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake Gene:RPL4A(YBR031W)|FD-Score:3.26|P-value:5.51E-4||SGD DESC:Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication Gene:RRT1(YBL048W_d)|FD-Score:3.36|P-value:3.87E-4||SGD DESC:Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Gene:SAC6(YDR129C)|FD-Score:3.14|P-value:8.42E-4||SGD DESC:Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:SER2(YGR208W)|FD-Score:4.04|P-value:2.63E-5||SGD DESC:Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source Gene:SPL2(YHR136C)|FD-Score:3.1|P-value:9.63E-4||SGD DESC:Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm Gene:SPO19(YPL130W)|FD-Score:4.39|P-value:5.56E-6||SGD DESC:Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation Gene:TAT1(YBR069C)|FD-Score:-3.25|P-value:5.81E-4||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TEX1(YNL253W)|FD-Score:3.48|P-value:2.48E-4||SGD DESC:Protein involved in mRNA export, component of the transcription export (TREX) complex Gene:TRP4(YDR354W)|FD-Score:-3.36|P-value:3.84E-4||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:UNG1(YML021C)|FD-Score:3.15|P-value:8.05E-4||SGD DESC:Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus Gene:YBL071C-B(YBL071C-B_p)|FD-Score:-3.43|P-value:3.06E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YIM1(YMR152W)|FD-Score:3.17|P-value:7.52E-4||SGD DESC:Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:YLR072W(YLR072W_p)|FD-Score:3.38|P-value:3.56E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene Gene:YPL185W(YPL185W_d)|FD-Score:3.61|P-value:1.54E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C Gene:YPR146C(YPR146C_d)|FD-Score:4.38|P-value:5.83E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YTP1(YNL237W)|FD-Score:-3.83|P-value:6.31E-5||SGD DESC:Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins Gene:AAP1(YHR047C)|FD-Score:4.1|P-value:2.10E-5||SGD DESC:Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication Gene:ARO4(YBR249C)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress Gene:ATP15(YPL271W)|FD-Score:-3.34|P-value:4.21E-4||SGD DESC:Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Gene:BNA1(YJR025C)|FD-Score:3.37|P-value:3.77E-4||SGD DESC:3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p Gene:COG7(YGL005C)|FD-Score:-3.27|P-value:5.33E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DBR1(YKL149C)|FD-Score:3.49|P-value:2.38E-4||SGD DESC:RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition Gene:DSS4(YPR017C)|FD-Score:3.58|P-value:1.75E-4||SGD DESC:Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol Gene:FRE8(YLR047C)|FD-Score:3.15|P-value:8.14E-4||SGD DESC:Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p Gene:IMP2'(YIL154C)|FD-Score:-3.46|P-value:2.72E-4||SGD DESC:Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat Gene:IRC21(YMR073C)|FD-Score:-3.37|P-value:3.81E-4||SGD DESC:Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study Gene:MDR1(YGR100W)|FD-Score:3.19|P-value:7.10E-4||SGD DESC:Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function Gene:OYE2(YHR179W)|FD-Score:4.72|P-value:1.18E-6||SGD DESC:Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress Gene:PEX28(YHR150W)|FD-Score:-3.09|P-value:9.94E-4||SGD DESC:Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p Gene:PKH3(YDR466W)|FD-Score:6.1|P-value:5.29E-10||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:PTK2(YJR059W)|FD-Score:-3.14|P-value:8.38E-4||SGD DESC:Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake Gene:RPL4A(YBR031W)|FD-Score:3.26|P-value:5.51E-4||SGD DESC:Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication Gene:RRT1(YBL048W_d)|FD-Score:3.36|P-value:3.87E-4||SGD DESC:Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Gene:SAC6(YDR129C)|FD-Score:3.14|P-value:8.42E-4||SGD DESC:Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:SER2(YGR208W)|FD-Score:4.04|P-value:2.63E-5||SGD DESC:Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source Gene:SPL2(YHR136C)|FD-Score:3.1|P-value:9.63E-4||SGD DESC:Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm Gene:SPO19(YPL130W)|FD-Score:4.39|P-value:5.56E-6||SGD DESC:Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation Gene:TAT1(YBR069C)|FD-Score:-3.25|P-value:5.81E-4||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TEX1(YNL253W)|FD-Score:3.48|P-value:2.48E-4||SGD DESC:Protein involved in mRNA export, component of the transcription export (TREX) complex Gene:TRP4(YDR354W)|FD-Score:-3.36|P-value:3.84E-4||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:UNG1(YML021C)|FD-Score:3.15|P-value:8.05E-4||SGD DESC:Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus Gene:YBL071C-B(YBL071C-B_p)|FD-Score:-3.43|P-value:3.06E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YIM1(YMR152W)|FD-Score:3.17|P-value:7.52E-4||SGD DESC:Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:YLR072W(YLR072W_p)|FD-Score:3.38|P-value:3.56E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene Gene:YPL185W(YPL185W_d)|FD-Score:3.61|P-value:1.54E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C Gene:YPR146C(YPR146C_d)|FD-Score:4.38|P-value:5.83E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YTP1(YNL237W)|FD-Score:-3.83|P-value:6.31E-5||SGD DESC:Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR340W2.740.003050.17RPP0Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10
YNL232W2.730.003170.17CSL4Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
YKL035W2.730.003180.17UGP1UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication
YMR033W2.630.004210.17ARP9Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YLR339C_d2.560.005160.17YLR339C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0
YDR468C2.400.008210.01TLG1Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p
YHR190W2.390.008480.02ERG9Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
YBL014C2.370.008910.10RRN6Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
YCR054C2.270.011700.01CTR86Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress
YDR246W2.250.012100.10TRS23One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
YLR208W2.150.015600.02SEC13Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress
YOL022C2.130.016600.02TSR4Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2
YPL010W2.110.017500.03RET3Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YNL158W2.080.018800.01PGA1Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes
YJR065C2.070.019400.01ARP3Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDR466W6.105.29E-10PKH3Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
YHR179W4.721.18E-6OYE2Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress
YPL130W4.395.56E-6SPO19Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation
YPR146C_d4.385.83E-6YPR146C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR047C4.102.10E-5AAP1Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication
YGR208W4.042.63E-5SER2Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
YBR249C3.621.48E-4ARO43-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress
YPL185W_d3.611.54E-4YPL185W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YPR017C3.581.75E-4DSS4Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol
YKL149C3.492.38E-4DBR1RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition
YNL253W3.482.48E-4TEX1Protein involved in mRNA export, component of the transcription export (TREX) complex
YLR072W_p3.383.56E-4YLR072W_pProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene
YJR025C3.373.77E-4BNA13-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YBL048W_d3.363.87E-4RRT1_dIdentified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YBR031W3.265.51E-4RPL4ARibosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication

GO enrichment analysis for SGTC_1498
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0976.91E-14SGTC_15024534-4282 27.7 μMChemDiv (Drug-like library)32789490.0506329
0.0961.21E-13SGTC_15014491-0275 38.4 μMChemDiv (Drug-like library)51047180.0657895
0.0953.30E-13SGTC_30519093778 49.5 μMChembridge (Drug-like library)172173780.103896
0.0921.33E-12SGTC_1711st032263 62.8 μMTimTec (Natural product derivative library)39589790.101266
0.0813.89E-10SGTC_30849116877 49.5 μMChembridge (Drug-like library)272413250.0987654
0.0808.20E-10SGTC_597k018-0003 82.8 μMChemDiv (Drug-like library)67862340.114943RNA pol III & RNase P/MRP
0.0791.52E-9SGTC_30199081971 49.5 μMChembridge (Drug-like library)164518030.0487805
0.0723.04E-8SGTC_6811642-0006 26.6 μMChemDiv (Drug-like library)44465300.103896
0.0691.10E-7SGTC_1709st033179 39.1 μMTimTec (Natural product derivative library)5733810.0649351
0.0655.78E-7SGTC_14904089-0339 670.0 nMChemDiv (Drug-like library)7425420.107692
0.0641.03E-6SGTC_12103013-0140 750.0 nMChemDiv (Drug-like library)9059730.0972222
0.0631.37E-6SGTC_9781416-0512 87.4 μMChemDiv (Drug-like library)68140030.0945946redox potentiating
0.0604.40E-6SGTC_29619083290 32.5 μMChembridge (Drug-like library)177414900.0857143
0.0589.67E-6SGTC_13551499-0035 1.7 μMChemDiv (Drug-like library)15485380.078125
0.0589.67E-6SGTC_14764112-3294 3.3 μMChemDiv (Drug-like library)7043690.055555660S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_9093448-9333149 μM0.2878793344074ChemDiv (Drug-like library)445.34624.22214
SGTC_23799035213200 μM0.222222646551Chembridge (Fragment library)240.300342.32213
SGTC_10613448-9325110 μM0.215385723482ChemDiv (Drug-like library)277.360263.65812
SGTC_20855307070144.05 μM0.2112682840351Chembridge (Fragment library)286.348861.7415superoxide
SGTC_22095-(5-methyl-2-thenylidene)-Barbituric acid122.83 μM0.210526616764Chembridge (Fragment library)236.247120.96324
SGTC_23286201408200 μM0.2054792890418Chembridge (Fragment library)283.325081.48524
SGTC_21335320837200 μM0.2028992841355Chembridge (Fragment library)274.358082.44214ERG2
SGTC_3244913448949.47 μM0.20270316584271Chembridge (Drug-like library)340.806783.51604
SGTC_2114549191081.25 μM0.18752849228Chembridge (Fragment library)246.182572.6216
SGTC_1570verbenone133 μM0.18518529025TimTec (Pure natural product library)150.217562.08201