4585-0012

(5-methyl-2-propan-2-ylcyclohexyl) 2-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]acetate

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1503
Screen concentration 61.3 μM
Source ChemDiv (Drug-like library)
PubChem CID 2922052
SMILES CC1CCC(C(C1)OC(=O)CSC2=NC(=O)C=C(N2)C)C(C)C
Standardized SMILES CC(C)C1CCC(C)CC1OC(=O)CSc2nc(C)cc(O)n2
Molecular weight 338.4649
ALogP 3.81
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.86
% growth inhibition (Hom. pool) 3.86


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2922052
Download HIP data (tab-delimited text)  (excel)
Gene:ACT1(YFL039C)|FD-Score:6.69|P-value:1.11E-11|Clearance:1.64||SGD DESC:Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions Gene:ARP7(YPR034W)|FD-Score:3.3|P-value:4.85E-4|Clearance:0.09||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:DIP2(YLR129W)|FD-Score:5.05|P-value:2.20E-7|Clearance:0.17||SGD DESC:Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex Gene:DML1(YMR211W)|FD-Score:3.75|P-value:8.78E-5|Clearance:0.11||SGD DESC:Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family Gene:DRS1(YLL008W)|FD-Score:3.19|P-value:7.14E-4|Clearance:0.06||SGD DESC:Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles Gene:ERG26(YGL001C)|FD-Score:3.19|P-value:7.06E-4|Clearance:0||SGD DESC:C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis Gene:GPI14(YJR013W)|FD-Score:3.21|P-value:6.72E-4|Clearance:0.01||SGD DESC:Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M Gene:LSM4(YER112W)|FD-Score:4.88|P-value:5.33E-7|Clearance:0.38||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress Gene:NAT2(YGR147C)|FD-Score:3.59|P-value:1.67E-4|Clearance:0.08||SGD DESC:Protein with an apparent role in acetylation of N-terminal methionine residues Gene:PIS1(YPR113W)|FD-Score:8.07|P-value:3.57E-16|Clearance:1.64||SGD DESC:Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins Gene:RPN9(YDR427W)|FD-Score:4.5|P-value:3.36E-6|Clearance:0.64||SGD DESC:Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress Gene:RPO26(YPR187W)|FD-Score:-4.36|P-value:6.61E-6|Clearance:0||SGD DESC:RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit Gene:RVB2(YPL235W)|FD-Score:3.09|P-value:9.84E-4|Clearance:0.01||SGD DESC:ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly Gene:SMC1(YFL008W)|FD-Score:3.86|P-value:5.61E-5|Clearance:0.11||SGD DESC:Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure Gene:TCP1(YDR212W)|FD-Score:3.13|P-value:8.65E-4|Clearance:0.04||SGD DESC:Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein Gene:TTI1(YKL033W)|FD-Score:-3.54|P-value:1.98E-4|Clearance:0||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies Gene:YDL196W(YDL196W_d)|FD-Score:-3.43|P-value:3.01E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Gene:YLL037W(YLL037W_d)|FD-Score:3.51|P-value:2.23E-4|Clearance:0.21||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor Gene:YPP1(YGR198W)|FD-Score:3.64|P-value:1.36E-4|Clearance:0.05||SGD DESC:Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene Gene:ACT1(YFL039C)|FD-Score:6.69|P-value:1.11E-11|Clearance:1.64||SGD DESC:Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions Gene:ARP7(YPR034W)|FD-Score:3.3|P-value:4.85E-4|Clearance:0.09||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:DIP2(YLR129W)|FD-Score:5.05|P-value:2.20E-7|Clearance:0.17||SGD DESC:Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex Gene:DML1(YMR211W)|FD-Score:3.75|P-value:8.78E-5|Clearance:0.11||SGD DESC:Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family Gene:DRS1(YLL008W)|FD-Score:3.19|P-value:7.14E-4|Clearance:0.06||SGD DESC:Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles Gene:ERG26(YGL001C)|FD-Score:3.19|P-value:7.06E-4|Clearance:0||SGD DESC:C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis Gene:GPI14(YJR013W)|FD-Score:3.21|P-value:6.72E-4|Clearance:0.01||SGD DESC:Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M Gene:LSM4(YER112W)|FD-Score:4.88|P-value:5.33E-7|Clearance:0.38||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress Gene:NAT2(YGR147C)|FD-Score:3.59|P-value:1.67E-4|Clearance:0.08||SGD DESC:Protein with an apparent role in acetylation of N-terminal methionine residues Gene:PIS1(YPR113W)|FD-Score:8.07|P-value:3.57E-16|Clearance:1.64||SGD DESC:Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins Gene:RPN9(YDR427W)|FD-Score:4.5|P-value:3.36E-6|Clearance:0.64||SGD DESC:Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress Gene:RPO26(YPR187W)|FD-Score:-4.36|P-value:6.61E-6|Clearance:0||SGD DESC:RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit Gene:RVB2(YPL235W)|FD-Score:3.09|P-value:9.84E-4|Clearance:0.01||SGD DESC:ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly Gene:SMC1(YFL008W)|FD-Score:3.86|P-value:5.61E-5|Clearance:0.11||SGD DESC:Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure Gene:TCP1(YDR212W)|FD-Score:3.13|P-value:8.65E-4|Clearance:0.04||SGD DESC:Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein Gene:TTI1(YKL033W)|FD-Score:-3.54|P-value:1.98E-4|Clearance:0||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies Gene:YDL196W(YDL196W_d)|FD-Score:-3.43|P-value:3.01E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Gene:YLL037W(YLL037W_d)|FD-Score:3.51|P-value:2.23E-4|Clearance:0.21||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor Gene:YPP1(YGR198W)|FD-Score:3.64|P-value:1.36E-4|Clearance:0.05||SGD DESC:Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2922052
Download HOP data (tab-delimited text)  (excel)
Gene:AIM46(YHR199C)|FD-Score:3.44|P-value:2.92E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:APD1(YBR151W)|FD-Score:3.49|P-value:2.42E-4||SGD DESC:Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus Gene:ARI1(YGL157W)|FD-Score:-4.23|P-value:1.19E-5||SGD DESC:NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily Gene:ATC1(YDR184C)|FD-Score:4.17|P-value:1.54E-5||SGD DESC:Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress Gene:ATG17(YLR423C)|FD-Score:4.67|P-value:1.54E-6||SGD DESC:Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells Gene:ATP22(YDR350C)|FD-Score:3.19|P-value:7.00E-4||SGD DESC:Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane Gene:BMH1(YER177W)|FD-Score:3.57|P-value:1.79E-4||SGD DESC:14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:BUB2(YMR055C)|FD-Score:3.21|P-value:6.61E-4||SGD DESC:Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage Gene:BUD21(YOR078W)|FD-Score:4.56|P-value:2.52E-6||SGD DESC:Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern Gene:COG1(YGL223C)|FD-Score:3.81|P-value:6.97E-5||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CTF4(YPR135W)|FD-Score:3.21|P-value:6.63E-4||SGD DESC:Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion Gene:CYS4(YGR155W)|FD-Score:3.6|P-value:1.62E-4||SGD DESC:Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria Gene:EUG1(YDR518W)|FD-Score:3.78|P-value:7.84E-5||SGD DESC:Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER Gene:FSF1(YOR271C_p)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis Gene:FYV7(YLR068W)|FD-Score:-3.39|P-value:3.46E-4||SGD DESC:Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin Gene:GAS4(YOL132W)|FD-Score:3.83|P-value:6.51E-5||SGD DESC:1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall Gene:GRE3(YHR104W)|FD-Score:3.09|P-value:9.90E-4||SGD DESC:Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress Gene:GTT2(YLL060C)|FD-Score:-3.25|P-value:5.81E-4||SGD DESC:Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress Gene:HPR1(YDR138W)|FD-Score:3.27|P-value:5.31E-4||SGD DESC:Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p Gene:ICL2(YPR006C)|FD-Score:3.98|P-value:3.44E-5||SGD DESC:2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol Gene:IRC21(YMR073C)|FD-Score:3.9|P-value:4.87E-5||SGD DESC:Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study Gene:LST4(YKL176C)|FD-Score:5.3|P-value:5.81E-8||SGD DESC:Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface Gene:MDM1(YML104C)|FD-Score:3.11|P-value:9.47E-4||SGD DESC:Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) Gene:MKT1(YNL085W)|FD-Score:-3.32|P-value:4.42E-4||SGD DESC:Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress Gene:MRE11(YMR224C)|FD-Score:4.33|P-value:7.33E-6||SGD DESC:Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress Gene:OCA2(YNL056W)|FD-Score:3.95|P-value:3.91E-5||SGD DESC:Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene Gene:PDH1(YPR002W)|FD-Score:3.68|P-value:1.18E-4||SGD DESC:Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Gene:PHB2(YGR231C)|FD-Score:3.21|P-value:6.75E-4||SGD DESC:Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation Gene:PRE9(YGR135W)|FD-Score:3.1|P-value:9.71E-4||SGD DESC:Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform Gene:RNQ1(YCL028W)|FD-Score:3.38|P-value:3.57E-4||SGD DESC:[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate Gene:RPN4(YDL020C)|FD-Score:-3.11|P-value:9.25E-4||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:SBP1(YHL034C)|FD-Score:3.22|P-value:6.44E-4||SGD DESC:Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11 Gene:SEG1(YMR086W)|FD-Score:-3.96|P-value:3.76E-5||SGD DESC:Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes Gene:SIF2(YBR103W)|FD-Score:3.75|P-value:8.98E-5||SGD DESC:WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus Gene:SUE1(YPR151C)|FD-Score:3.97|P-value:3.57E-5||SGD DESC:Mitochondrial protein required for degradation of unstable forms of cytochrome c Gene:URE2(YNL229C)|FD-Score:3.92|P-value:4.45E-5||SGD DESC:Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion Gene:URM1(YIL008W)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response Gene:VTC1(YER072W)|FD-Score:-3.5|P-value:2.34E-4||SGD DESC:Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress Gene:XYL2(YLR070C)|FD-Score:4.32|P-value:7.71E-6||SGD DESC:Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect Gene:YCL002C(YCL002C_p)|FD-Score:-3.19|P-value:7.15E-4||SGD DESC:Putative protein of unknown function; YCL002C is not an essential gene Gene:YCR043C(YCR043C_p)|FD-Score:3.41|P-value:3.23E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene Gene:YDL159W-A(YDL159W-A_p)|FD-Score:3.16|P-value:7.94E-4||SGD DESC:Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species Gene:YDR194W-A(YDR194W-A_p)|FD-Score:3.46|P-value:2.68E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDR249C(YDR249C_p)|FD-Score:4.16|P-value:1.59E-5||SGD DESC:Putative protein of unknown function Gene:YER121W(YER121W_p)|FD-Score:3.45|P-value:2.79E-4||SGD DESC:Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy Gene:YER184C(YER184C_p)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source Gene:YHL015W-A(YHL015W-A_p)|FD-Score:3.6|P-value:1.58E-4||SGD DESC:Putative protein of unknown function Gene:YHR138C(YHR138C_p)|FD-Score:3.43|P-value:3.06E-4||SGD DESC:Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress Gene:YHR182W(YHR182W_p)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:YIL002W-A(YIL002W-A_p)|FD-Score:-3.34|P-value:4.13E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YIL029C(YIL029C_p)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W Gene:YIL060W(YIL060W_p)|FD-Score:-3.16|P-value:7.81E-4||SGD DESC:Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene Gene:YIL165C(YIL165C_p)|FD-Score:4.31|P-value:8.22E-6||SGD DESC:Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene Gene:YJR061W(YJR061W_p)|FD-Score:3.82|P-value:6.74E-5||SGD DESC:Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication Gene:YLR173W(YLR173W_p)|FD-Score:5.07|P-value:2.01E-7||SGD DESC:Putative protein of unknown function Gene:YMR001C-A(YMR001C-A_p)|FD-Score:4.54|P-value:2.75E-6||SGD DESC:Putative protein of unknown function Gene:YNL043C(YNL043C_d)|FD-Score:-4.11|P-value:1.95E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W Gene:YOR225W(YOR225W_d)|FD-Score:3.24|P-value:5.90E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPL068C(YPL068C_p)|FD-Score:-3.61|P-value:1.51E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS Gene:YPR027C(YPR027C_p)|FD-Score:6.59|P-value:2.15E-11||SGD DESC:Putative protein of unknown function Gene:AIM46(YHR199C)|FD-Score:3.44|P-value:2.92E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:APD1(YBR151W)|FD-Score:3.49|P-value:2.42E-4||SGD DESC:Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus Gene:ARI1(YGL157W)|FD-Score:-4.23|P-value:1.19E-5||SGD DESC:NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily Gene:ATC1(YDR184C)|FD-Score:4.17|P-value:1.54E-5||SGD DESC:Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress Gene:ATG17(YLR423C)|FD-Score:4.67|P-value:1.54E-6||SGD DESC:Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells Gene:ATP22(YDR350C)|FD-Score:3.19|P-value:7.00E-4||SGD DESC:Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane Gene:BMH1(YER177W)|FD-Score:3.57|P-value:1.79E-4||SGD DESC:14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:BUB2(YMR055C)|FD-Score:3.21|P-value:6.61E-4||SGD DESC:Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage Gene:BUD21(YOR078W)|FD-Score:4.56|P-value:2.52E-6||SGD DESC:Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern Gene:COG1(YGL223C)|FD-Score:3.81|P-value:6.97E-5||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CTF4(YPR135W)|FD-Score:3.21|P-value:6.63E-4||SGD DESC:Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion Gene:CYS4(YGR155W)|FD-Score:3.6|P-value:1.62E-4||SGD DESC:Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria Gene:EUG1(YDR518W)|FD-Score:3.78|P-value:7.84E-5||SGD DESC:Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER Gene:FSF1(YOR271C_p)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis Gene:FYV7(YLR068W)|FD-Score:-3.39|P-value:3.46E-4||SGD DESC:Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin Gene:GAS4(YOL132W)|FD-Score:3.83|P-value:6.51E-5||SGD DESC:1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall Gene:GRE3(YHR104W)|FD-Score:3.09|P-value:9.90E-4||SGD DESC:Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress Gene:GTT2(YLL060C)|FD-Score:-3.25|P-value:5.81E-4||SGD DESC:Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress Gene:HPR1(YDR138W)|FD-Score:3.27|P-value:5.31E-4||SGD DESC:Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p Gene:ICL2(YPR006C)|FD-Score:3.98|P-value:3.44E-5||SGD DESC:2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol Gene:IRC21(YMR073C)|FD-Score:3.9|P-value:4.87E-5||SGD DESC:Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study Gene:LST4(YKL176C)|FD-Score:5.3|P-value:5.81E-8||SGD DESC:Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface Gene:MDM1(YML104C)|FD-Score:3.11|P-value:9.47E-4||SGD DESC:Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) Gene:MKT1(YNL085W)|FD-Score:-3.32|P-value:4.42E-4||SGD DESC:Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress Gene:MRE11(YMR224C)|FD-Score:4.33|P-value:7.33E-6||SGD DESC:Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress Gene:OCA2(YNL056W)|FD-Score:3.95|P-value:3.91E-5||SGD DESC:Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene Gene:PDH1(YPR002W)|FD-Score:3.68|P-value:1.18E-4||SGD DESC:Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Gene:PHB2(YGR231C)|FD-Score:3.21|P-value:6.75E-4||SGD DESC:Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation Gene:PRE9(YGR135W)|FD-Score:3.1|P-value:9.71E-4||SGD DESC:Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform Gene:RNQ1(YCL028W)|FD-Score:3.38|P-value:3.57E-4||SGD DESC:[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate Gene:RPN4(YDL020C)|FD-Score:-3.11|P-value:9.25E-4||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:SBP1(YHL034C)|FD-Score:3.22|P-value:6.44E-4||SGD DESC:Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11 Gene:SEG1(YMR086W)|FD-Score:-3.96|P-value:3.76E-5||SGD DESC:Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes Gene:SIF2(YBR103W)|FD-Score:3.75|P-value:8.98E-5||SGD DESC:WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus Gene:SUE1(YPR151C)|FD-Score:3.97|P-value:3.57E-5||SGD DESC:Mitochondrial protein required for degradation of unstable forms of cytochrome c Gene:URE2(YNL229C)|FD-Score:3.92|P-value:4.45E-5||SGD DESC:Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion Gene:URM1(YIL008W)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response Gene:VTC1(YER072W)|FD-Score:-3.5|P-value:2.34E-4||SGD DESC:Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress Gene:XYL2(YLR070C)|FD-Score:4.32|P-value:7.71E-6||SGD DESC:Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect Gene:YCL002C(YCL002C_p)|FD-Score:-3.19|P-value:7.15E-4||SGD DESC:Putative protein of unknown function; YCL002C is not an essential gene Gene:YCR043C(YCR043C_p)|FD-Score:3.41|P-value:3.23E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene Gene:YDL159W-A(YDL159W-A_p)|FD-Score:3.16|P-value:7.94E-4||SGD DESC:Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species Gene:YDR194W-A(YDR194W-A_p)|FD-Score:3.46|P-value:2.68E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDR249C(YDR249C_p)|FD-Score:4.16|P-value:1.59E-5||SGD DESC:Putative protein of unknown function Gene:YER121W(YER121W_p)|FD-Score:3.45|P-value:2.79E-4||SGD DESC:Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy Gene:YER184C(YER184C_p)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source Gene:YHL015W-A(YHL015W-A_p)|FD-Score:3.6|P-value:1.58E-4||SGD DESC:Putative protein of unknown function Gene:YHR138C(YHR138C_p)|FD-Score:3.43|P-value:3.06E-4||SGD DESC:Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress Gene:YHR182W(YHR182W_p)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:YIL002W-A(YIL002W-A_p)|FD-Score:-3.34|P-value:4.13E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YIL029C(YIL029C_p)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W Gene:YIL060W(YIL060W_p)|FD-Score:-3.16|P-value:7.81E-4||SGD DESC:Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene Gene:YIL165C(YIL165C_p)|FD-Score:4.31|P-value:8.22E-6||SGD DESC:Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene Gene:YJR061W(YJR061W_p)|FD-Score:3.82|P-value:6.74E-5||SGD DESC:Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication Gene:YLR173W(YLR173W_p)|FD-Score:5.07|P-value:2.01E-7||SGD DESC:Putative protein of unknown function Gene:YMR001C-A(YMR001C-A_p)|FD-Score:4.54|P-value:2.75E-6||SGD DESC:Putative protein of unknown function Gene:YNL043C(YNL043C_d)|FD-Score:-4.11|P-value:1.95E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W Gene:YOR225W(YOR225W_d)|FD-Score:3.24|P-value:5.90E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPL068C(YPL068C_p)|FD-Score:-3.61|P-value:1.51E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS Gene:YPR027C(YPR027C_p)|FD-Score:6.59|P-value:2.15E-11||SGD DESC:Putative protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YPR113W8.073.57E-161.64PIS1Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins
YFL039C6.691.11E-111.64ACT1Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YLR129W5.052.20E-70.17DIP2Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
YER112W4.885.33E-70.38LSM4Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress
YDR427W4.503.36E-60.64RPN9Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress
YFL008W3.865.61E-50.11SMC1Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
YMR211W3.758.78E-50.11DML1Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
YGR198W3.641.36E-40.05YPP1Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
YGR147C3.591.67E-40.08NAT2Protein with an apparent role in acetylation of N-terminal methionine residues
YLL037W_d3.512.23E-40.21YLL037W_dDubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor
YPR034W3.304.85E-40.09ARP7Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YJR013W3.216.72E-40.01GPI14Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
YGL001C3.197.06E-40.00ERG26C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
YLL008W3.197.14E-40.06DRS1Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles
YDR212W3.138.65E-40.04TCP1Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YPR027C_p6.592.15E-11YPR027C_pPutative protein of unknown function
YKL176C5.305.81E-8LST4Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
YLR173W_p5.072.01E-7YLR173W_pPutative protein of unknown function
YLR423C4.671.54E-6ATG17Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells
YOR078W4.562.52E-6BUD21Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
YMR001C-A_p4.542.75E-6YMR001C-A_pPutative protein of unknown function
YMR224C4.337.33E-6MRE11Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress
YLR070C4.327.71E-6XYL2Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect
YIL165C_p4.318.22E-6YIL165C_pPutative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene
YDR184C4.171.54E-5ATC1Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress
YDR249C_p4.161.59E-5YDR249C_pPutative protein of unknown function
YPR006C3.983.44E-5ICL22-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
YPR151C3.973.57E-5SUE1Mitochondrial protein required for degradation of unstable forms of cytochrome c
YNL056W3.953.91E-5OCA2Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
YNL229C3.924.45E-5URE2Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion

GO enrichment analysis for SGTC_1503
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0856.78E-11SGTC_2567aureobasidin a 60.0 nMMiscellaneous99634300.106557
0.0831.51E-10SGTC_20405100729 123.0 μMChembridge (Fragment library)118400.119403
0.0741.22E-8SGTC_25623',7'-dimethoxyflavone 64.9 μMMicrosource (Natural product library)6886640.0740741
0.0723.57E-8SGTC_316k060-0003 58.6 μMChemDiv (Drug-like library)61523140.0333333
0.0707.73E-8SGTC_266formosanin C 406.0 nMMiscellaneous735970.088sphingolipid biosynthesis & PDR1
0.0681.52E-7SGTC_1753793-3120 23.7 μMChemDiv (Drug-like library)53222970.0449438
0.0641.06E-6SGTC_1067clotrimazole 1.4 μMNIH Clinical Collection28120.0375azole & statin
0.0631.23E-6SGTC_13802291-0730 164.0 μMChemDiv (Drug-like library)29991910.0681818
0.0621.89E-6SGTC_1955wogonin 32.4 μMTimTec (Natural product derivative library)52817030.0853659
0.0571.04E-5SGTC_15064226-2149 212.0 μMChemDiv (Drug-like library)9911140.0526316
0.0561.63E-5SGTC_9801473-0395 201.0 μMChemDiv (Drug-like library)7688760.128205
0.0561.93E-5SGTC_1084voriconazole 435.0 nMNIH Clinical Collection716160.0752688azole & statin
0.0552.28E-5SGTC_1659st012954 42.1 μMTimTec (Natural product derivative library)242072620.0957447
0.0543.16E-5SGTC_30859117376 49.5 μMChembridge (Drug-like library)164803490.113636
0.0543.90E-5SGTC_28549024559 71.4 μMChembridge (Drug-like library)31635290.0967742

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_1621st00370532.4 μM0.38461524207032TimTec (Natural product derivative library)455.0324.5703calcium & mitochondrial duress
SGTC_1622st00370719.4 μM0.36585410140899TimTec (Natural product derivative library)485.057984.40504calcium & mitochondrial duress
SGTC_1620st00370416.5 μM0.36252834414TimTec (Natural product derivative library)519.901484.83203
SGTC_1623st00370920.3 μM0.35294116192618TimTec (Natural product derivative library)485.057984.40504calcium & mitochondrial duress
SGTC_1625st00371130.1 μM0.34939824207034TimTec (Natural product derivative library)501.057383.90205calcium & mitochondrial duress
SGTC_1627st00371325.6 μM0.34939816195070TimTec (Natural product derivative library)501.057383.90205calcium & mitochondrial duress
SGTC_1812st0520574.33 μM0.3461543645418TimTec (Natural product derivative library)422.664224.01203calcium & mitochondrial duress
SGTC_1624st0037106.25 μM0.34523824207033TimTec (Natural product derivative library)549.927464.66704calcium & mitochondrial duress
SGTC_1626st0037121.76 μM0.34523824207035TimTec (Natural product derivative library)505.476464.58304
SGTC_2641levomentholum100 μM0.26315816666Microsource (Natural product library)156.26522.77911