1326-1131

2-(dimethylamino)-1-(4-phenylphenyl)ethanone

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1509
Screen concentration 80.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 768313
SMILES CN(C)CC(=O)C1=CC=C(C=C1)C2=CC=CC=C2
Standardized SMILES CN(C)CC(=O)c1ccc(cc1)c2ccccc2
Molecular weight 239.3123
ALogP 3.09
H-bond donor count 0
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 7.23
% growth inhibition (Hom. pool) 2.73


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 768313
Download HIP data (tab-delimited text)  (excel)
Gene:ARP9(YMR033W)|FD-Score:3.65|P-value:1.31E-4|Clearance:0.12||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:CDC6(YJL194W)|FD-Score:4.9|P-value:4.67E-7|Clearance:0.91||SGD DESC:Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:CWC23(YGL128C)|FD-Score:-3.24|P-value:6.08E-4|Clearance:0||SGD DESC:Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p Gene:FAF1(YIL019W)|FD-Score:3.12|P-value:9.00E-4|Clearance:0.04||SGD DESC:Protein required for pre-rRNA processing and 40S ribosomal subunit assembly Gene:MMF1(YIL051C)|FD-Score:3.24|P-value:5.92E-4|Clearance:0.12||SGD DESC:Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes Gene:MYO2(YOR326W)|FD-Score:4.78|P-value:8.94E-7|Clearance:0.91||SGD DESC:Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication Gene:PRE10(YOR362C)|FD-Score:-4.94|P-value:3.88E-7|Clearance:0||SGD DESC:Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress Gene:RFC4(YOL094C)|FD-Score:4.56|P-value:2.59E-6|Clearance:0.91||SGD DESC:Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon Gene:RIO1(YOR119C)|FD-Score:-3.1|P-value:9.80E-4|Clearance:0||SGD DESC:Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA Gene:RPA43(YOR340C)|FD-Score:3.42|P-value:3.09E-4|Clearance:0.11||SGD DESC:RNA polymerase I subunit A43 Gene:RSC9(YML127W)|FD-Score:3.53|P-value:2.10E-4|Clearance:0.01||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:SEC8(YPR055W)|FD-Score:3.32|P-value:4.58E-4|Clearance:0.07||SGD DESC:Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress Gene:TFA1(YKL028W)|FD-Score:3.52|P-value:2.17E-4|Clearance:0.1||SGD DESC:TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening Gene:UFE1(YOR075W)|FD-Score:-3.13|P-value:8.61E-4|Clearance:0||SGD DESC:t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER Gene:ARP9(YMR033W)|FD-Score:3.65|P-value:1.31E-4|Clearance:0.12||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:CDC6(YJL194W)|FD-Score:4.9|P-value:4.67E-7|Clearance:0.91||SGD DESC:Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:CWC23(YGL128C)|FD-Score:-3.24|P-value:6.08E-4|Clearance:0||SGD DESC:Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p Gene:FAF1(YIL019W)|FD-Score:3.12|P-value:9.00E-4|Clearance:0.04||SGD DESC:Protein required for pre-rRNA processing and 40S ribosomal subunit assembly Gene:MMF1(YIL051C)|FD-Score:3.24|P-value:5.92E-4|Clearance:0.12||SGD DESC:Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes Gene:MYO2(YOR326W)|FD-Score:4.78|P-value:8.94E-7|Clearance:0.91||SGD DESC:Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication Gene:PRE10(YOR362C)|FD-Score:-4.94|P-value:3.88E-7|Clearance:0||SGD DESC:Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress Gene:RFC4(YOL094C)|FD-Score:4.56|P-value:2.59E-6|Clearance:0.91||SGD DESC:Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon Gene:RIO1(YOR119C)|FD-Score:-3.1|P-value:9.80E-4|Clearance:0||SGD DESC:Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA Gene:RPA43(YOR340C)|FD-Score:3.42|P-value:3.09E-4|Clearance:0.11||SGD DESC:RNA polymerase I subunit A43 Gene:RSC9(YML127W)|FD-Score:3.53|P-value:2.10E-4|Clearance:0.01||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:SEC8(YPR055W)|FD-Score:3.32|P-value:4.58E-4|Clearance:0.07||SGD DESC:Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress Gene:TFA1(YKL028W)|FD-Score:3.52|P-value:2.17E-4|Clearance:0.1||SGD DESC:TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening Gene:UFE1(YOR075W)|FD-Score:-3.13|P-value:8.61E-4|Clearance:0||SGD DESC:t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 768313
Download HOP data (tab-delimited text)  (excel)
Gene:ALD6(YPL061W)|FD-Score:-3.59|P-value:1.64E-4||SGD DESC:Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress Gene:ARI1(YGL157W)|FD-Score:3.55|P-value:1.94E-4||SGD DESC:NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily Gene:ATP17(YDR377W)|FD-Score:-3.13|P-value:8.70E-4||SGD DESC:Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Gene:AUA1(YFL010W-A)|FD-Score:3.93|P-value:4.27E-5||SGD DESC:Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease Gene:BOI2(YER114C)|FD-Score:4.33|P-value:7.58E-6||SGD DESC:Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication Gene:BUD21(YOR078W)|FD-Score:-3.35|P-value:4.04E-4||SGD DESC:Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern Gene:CAF130(YGR134W)|FD-Score:3.16|P-value:7.84E-4||SGD DESC:Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation Gene:CLN2(YPL256C)|FD-Score:3.19|P-value:7.23E-4||SGD DESC:G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) Gene:COX10(YPL172C)|FD-Score:-3.57|P-value:1.75E-4||SGD DESC:Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders Gene:CRS5(YOR031W)|FD-Score:4.3|P-value:8.55E-6||SGD DESC:Copper-binding metallothionein, required for wild-type copper resistance Gene:CUE2(YKL090W)|FD-Score:4.7|P-value:1.32E-6||SGD DESC:Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination Gene:CUP9(YPL177C)|FD-Score:3.17|P-value:7.53E-4||SGD DESC:Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:DIN7(YDR263C)|FD-Score:3.3|P-value:4.78E-4||SGD DESC:Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination Gene:ECM22(YLR228C)|FD-Score:3.31|P-value:4.61E-4||SGD DESC:Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication Gene:FRE8(YLR047C)|FD-Score:3.57|P-value:1.81E-4||SGD DESC:Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p Gene:GEP4(YHR100C)|FD-Score:5.52|P-value:1.72E-8||SGD DESC:Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT Gene:GLE2(YER107C)|FD-Score:7.4|P-value:6.98E-14||SGD DESC:RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 Gene:GRX6(YDL010W)|FD-Score:3.79|P-value:7.64E-5||SGD DESC:Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication Gene:IRC21(YMR073C)|FD-Score:-3.75|P-value:9.02E-5||SGD DESC:Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study Gene:IRC2(YDR112W_d)|FD-Score:3.43|P-value:3.03E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci Gene:MCH1(YDL054C)|FD-Score:-4.3|P-value:8.51E-6||SGD DESC:Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport Gene:MF(ALPHA)1(YPL187W)|FD-Score:-3.15|P-value:8.03E-4||SGD DESC:Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor Gene:MPD2(YOL088C)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p Gene:MRH1(YDR033W)|FD-Score:3.12|P-value:9.16E-4||SGD DESC:Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication Gene:MRH4(YGL064C)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function Gene:MRPL13(YKR006C)|FD-Score:6.18|P-value:3.21E-10||SGD DESC:Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation Gene:MTG1(YMR097C)|FD-Score:3.44|P-value:2.90E-4||SGD DESC:Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals Gene:NAP1(YKR048C)|FD-Score:3.98|P-value:3.47E-5||SGD DESC:Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress Gene:OCT1(YKL134C)|FD-Score:4.59|P-value:2.17E-6||SGD DESC:Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis Gene:OST6(YML019W)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p Gene:PAH1(YMR165C)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2 Gene:PHO80(YOL001W)|FD-Score:3.22|P-value:6.31E-4||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling Gene:PUT4(YOR348C)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells Gene:REI1(YBR267W)|FD-Score:-3.37|P-value:3.76E-4||SGD DESC:Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network Gene:SAC3(YDR159W)|FD-Score:3.2|P-value:6.78E-4||SGD DESC:Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP) Gene:SRO9(YCL037C)|FD-Score:5.95|P-value:1.35E-9||SGD DESC:Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication Gene:SUN4(YNL066W)|FD-Score:3.83|P-value:6.49E-5||SGD DESC:Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family Gene:TRP1(YDR007W)|FD-Score:4.08|P-value:2.26E-5||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP3(YKL211C)|FD-Score:3.51|P-value:2.25E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:UBX2(YML013W)|FD-Score:3.41|P-value:3.29E-4||SGD DESC:Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis Gene:UIP3(YAR027W)|FD-Score:3.49|P-value:2.40E-4||SGD DESC:Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family Gene:VMA1(YDL185W)|FD-Score:-3.71|P-value:1.03E-4||SGD DESC:Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease Gene:YER184C(YER184C_p)|FD-Score:3.48|P-value:2.53E-4||SGD DESC:Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source Gene:YFR054C(YFR054C_d)|FD-Score:4.09|P-value:2.19E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGL108C(YGL108C_p)|FD-Score:3.16|P-value:7.91E-4||SGD DESC:Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress Gene:YIL002W-A(YIL002W-A_p)|FD-Score:3.35|P-value:4.00E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YLR264C-A(YLR264C-A_p)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Putative protein of unknown function Gene:YLR434C(YLR434C_d)|FD-Score:-3.7|P-value:1.06E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W Gene:YMR294W-A(YMR294W-A_d)|FD-Score:-3.6|P-value:1.61E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents Gene:ALD6(YPL061W)|FD-Score:-3.59|P-value:1.64E-4||SGD DESC:Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress Gene:ARI1(YGL157W)|FD-Score:3.55|P-value:1.94E-4||SGD DESC:NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily Gene:ATP17(YDR377W)|FD-Score:-3.13|P-value:8.70E-4||SGD DESC:Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Gene:AUA1(YFL010W-A)|FD-Score:3.93|P-value:4.27E-5||SGD DESC:Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease Gene:BOI2(YER114C)|FD-Score:4.33|P-value:7.58E-6||SGD DESC:Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication Gene:BUD21(YOR078W)|FD-Score:-3.35|P-value:4.04E-4||SGD DESC:Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern Gene:CAF130(YGR134W)|FD-Score:3.16|P-value:7.84E-4||SGD DESC:Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation Gene:CLN2(YPL256C)|FD-Score:3.19|P-value:7.23E-4||SGD DESC:G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) Gene:COX10(YPL172C)|FD-Score:-3.57|P-value:1.75E-4||SGD DESC:Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders Gene:CRS5(YOR031W)|FD-Score:4.3|P-value:8.55E-6||SGD DESC:Copper-binding metallothionein, required for wild-type copper resistance Gene:CUE2(YKL090W)|FD-Score:4.7|P-value:1.32E-6||SGD DESC:Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination Gene:CUP9(YPL177C)|FD-Score:3.17|P-value:7.53E-4||SGD DESC:Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:DIN7(YDR263C)|FD-Score:3.3|P-value:4.78E-4||SGD DESC:Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination Gene:ECM22(YLR228C)|FD-Score:3.31|P-value:4.61E-4||SGD DESC:Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication Gene:FRE8(YLR047C)|FD-Score:3.57|P-value:1.81E-4||SGD DESC:Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p Gene:GEP4(YHR100C)|FD-Score:5.52|P-value:1.72E-8||SGD DESC:Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT Gene:GLE2(YER107C)|FD-Score:7.4|P-value:6.98E-14||SGD DESC:RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 Gene:GRX6(YDL010W)|FD-Score:3.79|P-value:7.64E-5||SGD DESC:Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication Gene:IRC21(YMR073C)|FD-Score:-3.75|P-value:9.02E-5||SGD DESC:Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study Gene:IRC2(YDR112W_d)|FD-Score:3.43|P-value:3.03E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci Gene:MCH1(YDL054C)|FD-Score:-4.3|P-value:8.51E-6||SGD DESC:Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport Gene:MF(ALPHA)1(YPL187W)|FD-Score:-3.15|P-value:8.03E-4||SGD DESC:Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor Gene:MPD2(YOL088C)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p Gene:MRH1(YDR033W)|FD-Score:3.12|P-value:9.16E-4||SGD DESC:Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication Gene:MRH4(YGL064C)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function Gene:MRPL13(YKR006C)|FD-Score:6.18|P-value:3.21E-10||SGD DESC:Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation Gene:MTG1(YMR097C)|FD-Score:3.44|P-value:2.90E-4||SGD DESC:Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals Gene:NAP1(YKR048C)|FD-Score:3.98|P-value:3.47E-5||SGD DESC:Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress Gene:OCT1(YKL134C)|FD-Score:4.59|P-value:2.17E-6||SGD DESC:Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis Gene:OST6(YML019W)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p Gene:PAH1(YMR165C)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2 Gene:PHO80(YOL001W)|FD-Score:3.22|P-value:6.31E-4||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling Gene:PUT4(YOR348C)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells Gene:REI1(YBR267W)|FD-Score:-3.37|P-value:3.76E-4||SGD DESC:Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network Gene:SAC3(YDR159W)|FD-Score:3.2|P-value:6.78E-4||SGD DESC:Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP) Gene:SRO9(YCL037C)|FD-Score:5.95|P-value:1.35E-9||SGD DESC:Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication Gene:SUN4(YNL066W)|FD-Score:3.83|P-value:6.49E-5||SGD DESC:Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family Gene:TRP1(YDR007W)|FD-Score:4.08|P-value:2.26E-5||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP3(YKL211C)|FD-Score:3.51|P-value:2.25E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:UBX2(YML013W)|FD-Score:3.41|P-value:3.29E-4||SGD DESC:Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis Gene:UIP3(YAR027W)|FD-Score:3.49|P-value:2.40E-4||SGD DESC:Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family Gene:VMA1(YDL185W)|FD-Score:-3.71|P-value:1.03E-4||SGD DESC:Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease Gene:YER184C(YER184C_p)|FD-Score:3.48|P-value:2.53E-4||SGD DESC:Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source Gene:YFR054C(YFR054C_d)|FD-Score:4.09|P-value:2.19E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGL108C(YGL108C_p)|FD-Score:3.16|P-value:7.91E-4||SGD DESC:Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress Gene:YIL002W-A(YIL002W-A_p)|FD-Score:3.35|P-value:4.00E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YLR264C-A(YLR264C-A_p)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Putative protein of unknown function Gene:YLR434C(YLR434C_d)|FD-Score:-3.7|P-value:1.06E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W Gene:YMR294W-A(YMR294W-A_d)|FD-Score:-3.6|P-value:1.61E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YJL194W4.904.67E-70.91CDC6Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress
YOR326W4.788.94E-70.91MYO2Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication
YOL094C4.562.59E-60.91RFC4Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YMR033W3.651.31E-40.12ARP9Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YML127W3.532.10E-40.01RSC9Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YKL028W3.522.17E-40.10TFA1TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YOR340C3.423.09E-40.11RPA43RNA polymerase I subunit A43
YPR055W3.324.58E-40.07SEC8Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
YIL051C3.245.92E-40.12MMF1Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes
YIL019W3.129.00E-40.04FAF1Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
YDL140C3.090.001010.06RPO21RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
YDR016C3.020.001250.02DAD1Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YKL154W3.000.001360.44SRP102Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
YLR129W2.560.005220.02DIP2Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
YER008C2.540.005470.03SEC3Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YER107C7.406.98E-14GLE2RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1
YKR006C6.183.21E-10MRPL13Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
YCL037C5.951.35E-9SRO9Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication
YHR100C5.521.72E-8GEP4Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT
YKL090W4.701.32E-6CUE2Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
YKL134C4.592.17E-6OCT1Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis
YER114C4.337.58E-6BOI2Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication
YOR031W4.308.55E-6CRS5Copper-binding metallothionein, required for wild-type copper resistance
YGL064C4.221.22E-5MRH4Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
YFR054C_d4.092.19E-5YFR054C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR007W4.082.26E-5TRP1Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
YKR048C3.983.47E-5NAP1Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress
YFL010W-A3.934.27E-5AUA1Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease
YNL066W3.836.49E-5SUN4Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YDL010W3.797.64E-5GRX6Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication

GO enrichment analysis for SGTC_1509
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0971.23E-13SGTC_18825615643 20.0 μMMiscellaneous22530750.0857143TRP & mitochondrial translation
0.0937.54E-13SGTC_14740330-0125 5.3 μMChemDiv (Drug-like library)X14740.135593
0.0912.70E-12SGTC_2607solasodine 47.4 μMMicrosource (Natural product library)67106420.0375
0.0872.67E-11SGTC_15412',3',6-trimethoxyflavone 64.0 μMTimTec (Pure natural product library)6888010.1
0.0864.31E-11SGTC_23017769476 200.0 μMChembridge (Fragment library)9778200.122807
0.0849.68E-11SGTC_20935331342 194.4 μMChembridge (Fragment library)338390.113208
0.0841.08E-10SGTC_1617st002906 78.0 μMTimTec (Natural product derivative library)51508590.116279
0.0832.32E-10SGTC_24545-benzylidenerhodanine 10.4 μMMiscellaneous12732100.148936TRP & mitochondrial translation
0.0823.28E-10SGTC_2409alverine citrate 64.0 μMMiscellaneous217180.225
0.0808.19E-10SGTC_1671st016596 74.5 μMTimTec (Natural product derivative library)28291670.109375
0.0791.59E-9SGTC_21986589944 200.0 μMChembridge (Fragment library)52902680.0847458
0.0774.19E-9SGTC_18835-benzylidenerhodanine 20.0 μMMiscellaneous12732100.148936TRP & mitochondrial translation
0.0764.81E-9SGTC_23849036245 200.0 μMChembridge (Fragment library)64627660.156863
0.0765.27E-9SGTC_22297354935 190.0 μMChembridge (Fragment library)3181120.163265RSC complex & mRNA processing
0.0766.91E-9SGTC_22547938975 95.2 μMChembridge (Fragment library)29692770.0892857

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_400327-010319.75 μM0.439024409036ChemDiv (Drug-like library)324.395125.11701
SGTC_680986-028482.83 μM0.439024423278ChemDiv (Drug-like library)324.395125.40801
SGTC_12420402-010360.1 μM0.416667432868ChemDiv (Drug-like library)191.269482.3102
SGTC_870100-005235.5 μM0.405405200187ChemDiv (Drug-like library)256.138962.57202
SGTC_390986-028358.35 μM0.3829793110600ChemDiv (Drug-like library)393.457144.99312calcium & mitochondrial duress
SGTC_12890976-007369.1 μM0.3753391136ChemDiv (Drug-like library)253.29582.7812
SGTC_9272425-1185123 μM0.357143730375ChemDiv (Drug-like library)316.353243.13522
SGTC_2970986-003224 μM0.3555562847425ChemDiv (Drug-like library)338.42175.6010160S ribosome export
SGTC_6090986-002686.3 μM0.3555562848610ChemDiv (Drug-like library)302.38965.17901calcium & mitochondrial duress
SGTC_6010986-002962.9 μM0.34782624747981ChemDiv (Drug-like library)367.259085.44101calcium & mitochondrial duress