Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YJL194W | 4.90 | 4.67E-7 | 0.91 | CDC6 | Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress |
YOR326W | 4.78 | 8.94E-7 | 0.91 | MYO2 | Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication |
YOL094C | 4.56 | 2.59E-6 | 0.91 | RFC4 | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon |
YMR033W | 3.65 | 1.31E-4 | 0.12 | ARP9 | Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation |
YML127W | 3.53 | 2.10E-4 | 0.01 | RSC9 | Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway |
YKL028W | 3.52 | 2.17E-4 | 0.10 | TFA1 | TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening |
YOR340C | 3.42 | 3.09E-4 | 0.11 | RPA43 | RNA polymerase I subunit A43 |
YPR055W | 3.32 | 4.58E-4 | 0.07 | SEC8 | Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress |
YIL051C | 3.24 | 5.92E-4 | 0.12 | MMF1 | Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes |
YIL019W | 3.12 | 9.00E-4 | 0.04 | FAF1 | Protein required for pre-rRNA processing and 40S ribosomal subunit assembly |
YDL140C | 3.09 | 0.00101 | 0.06 | RPO21 | RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime |
YDR016C | 3.02 | 0.00125 | 0.02 | DAD1 | Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis |
YKL154W | 3.00 | 0.00136 | 0.44 | SRP102 | Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane |
YLR129W | 2.56 | 0.00522 | 0.02 | DIP2 | Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex |
YER008C | 2.54 | 0.00547 | 0.03 | SEC3 | Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress |