st013856

1-methyl-9H-pyrido[3,4-b]indole

A mutagen and neurotoxin.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 

PubChem MeSH terms: Mutagens;Neurotoxins



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1516
Screen concentration 110.0 μM
Source TimTec (Pure natural product library)
PubChem CID 5281404
SMILES CC1=NC=CC2=C1NC3=CC=CC=C23
Standardized SMILES Cc1[nH]ccc2c3ccccc3nc12
Molecular weight 182.2212
ALogP 2.46
H-bond donor count 1
H-bond acceptor count 1
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.74
% growth inhibition (Hom. pool) 1.13


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5281404
Download HIP data (tab-delimited text)  (excel)
Gene:ARP9(YMR033W)|FD-Score:3.13|P-value:8.78E-4|Clearance:0.14||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:CRM1(YGR218W)|FD-Score:3.29|P-value:4.94E-4|Clearance:0.03||SGD DESC:Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin Gene:ERG11(YHR007C)|FD-Score:-3.92|P-value:4.42E-5|Clearance:0||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:HRR25(YPL204W)|FD-Score:3.27|P-value:5.40E-4|Clearance:0.02||SGD DESC:Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta) Gene:INN1(YNL152W)|FD-Score:3.25|P-value:5.80E-4|Clearance:0.12||SGD DESC:Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis Gene:LSG1(YGL099W)|FD-Score:-5.73|P-value:5.04E-9|Clearance:0||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MIA40(YKL195W)|FD-Score:5.78|P-value:3.76E-9|Clearance:1.43||SGD DESC:Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p Gene:NET1(YJL076W)|FD-Score:6.09|P-value:5.75E-10|Clearance:1.43||SGD DESC:Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication Gene:NMD3(YHR170W)|FD-Score:-3.83|P-value:6.31E-5|Clearance:0||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:NOP56(YLR197W)|FD-Score:4.04|P-value:2.71E-5|Clearance:0.35||SGD DESC:Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects Gene:PKC1(YBL105C)|FD-Score:3.43|P-value:2.99E-4|Clearance:0.14||SGD DESC:Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) Gene:RPC53(YDL150W)|FD-Score:3.68|P-value:1.16E-4|Clearance:0.14||SGD DESC:RNA polymerase III subunit C53 Gene:RPN11(YFR004W)|FD-Score:3.54|P-value:1.98E-4|Clearance:0.11||SGD DESC:Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress Gene:SPB4(YFL002C)|FD-Score:5.47|P-value:2.24E-8|Clearance:1.43||SGD DESC:Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients Gene:YPL238C(YPL238C_d)|FD-Score:-3.37|P-value:3.81E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W Gene:ARP9(YMR033W)|FD-Score:3.13|P-value:8.78E-4|Clearance:0.14||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:CRM1(YGR218W)|FD-Score:3.29|P-value:4.94E-4|Clearance:0.03||SGD DESC:Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin Gene:ERG11(YHR007C)|FD-Score:-3.92|P-value:4.42E-5|Clearance:0||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:HRR25(YPL204W)|FD-Score:3.27|P-value:5.40E-4|Clearance:0.02||SGD DESC:Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta) Gene:INN1(YNL152W)|FD-Score:3.25|P-value:5.80E-4|Clearance:0.12||SGD DESC:Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis Gene:LSG1(YGL099W)|FD-Score:-5.73|P-value:5.04E-9|Clearance:0||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MIA40(YKL195W)|FD-Score:5.78|P-value:3.76E-9|Clearance:1.43||SGD DESC:Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p Gene:NET1(YJL076W)|FD-Score:6.09|P-value:5.75E-10|Clearance:1.43||SGD DESC:Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication Gene:NMD3(YHR170W)|FD-Score:-3.83|P-value:6.31E-5|Clearance:0||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:NOP56(YLR197W)|FD-Score:4.04|P-value:2.71E-5|Clearance:0.35||SGD DESC:Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects Gene:PKC1(YBL105C)|FD-Score:3.43|P-value:2.99E-4|Clearance:0.14||SGD DESC:Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) Gene:RPC53(YDL150W)|FD-Score:3.68|P-value:1.16E-4|Clearance:0.14||SGD DESC:RNA polymerase III subunit C53 Gene:RPN11(YFR004W)|FD-Score:3.54|P-value:1.98E-4|Clearance:0.11||SGD DESC:Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress Gene:SPB4(YFL002C)|FD-Score:5.47|P-value:2.24E-8|Clearance:1.43||SGD DESC:Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients Gene:YPL238C(YPL238C_d)|FD-Score:-3.37|P-value:3.81E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5281404
Download HOP data (tab-delimited text)  (excel)
Gene:ADE4(YMR300C)|FD-Score:-3.81|P-value:6.95E-5||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:ASF1(YJL115W)|FD-Score:-3.33|P-value:4.37E-4||SGD DESC:Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition Gene:ATP11(YNL315C)|FD-Score:3.4|P-value:3.41E-4||SGD DESC:Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase Gene:AVT2(YEL064C)|FD-Score:3.54|P-value:2.02E-4||SGD DESC:Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BUD21(YOR078W)|FD-Score:-3.49|P-value:2.45E-4||SGD DESC:Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern Gene:COQ8(YGL119W)|FD-Score:-4.62|P-value:1.91E-6||SGD DESC:Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication Gene:CSG2(YBR036C)|FD-Score:3.22|P-value:6.49E-4||SGD DESC:Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress Gene:DBF2(YGR092W)|FD-Score:-4.8|P-value:8.10E-7||SGD DESC:Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis Gene:DMC1(YER179W)|FD-Score:3.29|P-value:5.02E-4||SGD DESC:Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p Gene:ENT1(YDL161W)|FD-Score:-3.97|P-value:3.55E-5||SGD DESC:Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:FYV4(YHR059W)|FD-Score:4.31|P-value:8.02E-6||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin Gene:GET3(YDL100C)|FD-Score:-4.25|P-value:1.09E-5||SGD DESC:Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress Gene:GIC1(YHR061C)|FD-Score:-4.02|P-value:2.95E-5||SGD DESC:Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress Gene:HYR1(YIR037W)|FD-Score:4.14|P-value:1.77E-5||SGD DESC:Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor Gene:IDS2(YJL146W)|FD-Score:3.31|P-value:4.74E-4||SGD DESC:Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation Gene:IRE1(YHR079C)|FD-Score:-3.13|P-value:8.61E-4||SGD DESC:Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress Gene:LOC1(YFR001W)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:LYS20(YDL182W)|FD-Score:-3.31|P-value:4.68E-4||SGD DESC:Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication Gene:MAG1(YER142C)|FD-Score:4.08|P-value:2.27E-5||SGD DESC:3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress Gene:MMR1(YLR190W)|FD-Score:-3.22|P-value:6.48E-4||SGD DESC:Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p Gene:MNN5(YJL186W)|FD-Score:4.53|P-value:2.94E-6||SGD DESC:Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment Gene:MOT2(YER068W)|FD-Score:4.11|P-value:1.94E-5||SGD DESC:Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications Gene:MRM2(YGL136C)|FD-Score:4.3|P-value:8.57E-6||SGD DESC:Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ Gene:MRP7(YNL005C)|FD-Score:4.73|P-value:1.11E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL31(YKL138C)|FD-Score:3.34|P-value:4.25E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSC1(YML128C)|FD-Score:3.98|P-value:3.47E-5||SGD DESC:Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated Gene:MUM3(YOR298W)|FD-Score:3.41|P-value:3.25E-4||SGD DESC:Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases Gene:NOP13(YNL175C)|FD-Score:-3.96|P-value:3.72E-5||SGD DESC:Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress Gene:NUP60(YAR002W)|FD-Score:4.97|P-value:3.28E-7||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153 Gene:OCA2(YNL056W)|FD-Score:-3.88|P-value:5.33E-5||SGD DESC:Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene Gene:OPI9(YLR338W_d)|FD-Score:3.29|P-value:5.09E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C Gene:OXP1(YKL215C)|FD-Score:3.12|P-value:9.01E-4||SGD DESC:5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:PGM3(YMR278W)|FD-Score:-3.2|P-value:6.99E-4||SGD DESC:Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential Gene:RAD24(YER173W)|FD-Score:4.47|P-value:3.84E-6||SGD DESC:Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein Gene:REH1(YLR387C)|FD-Score:3.1|P-value:9.81E-4||SGD DESC:Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains Gene:RSM24(YDR175C)|FD-Score:3.56|P-value:1.83E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:SAC7(YDR389W)|FD-Score:3.31|P-value:4.65E-4||SGD DESC:GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate Gene:SGA1(YIL099W)|FD-Score:5.04|P-value:2.39E-7||SGD DESC:Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation Gene:SLG1(YOR008C)|FD-Score:4.84|P-value:6.37E-7||SGD DESC:Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response Gene:SLM4(YBR077C)|FD-Score:-4.28|P-value:9.29E-6||SGD DESC:Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 Gene:SOH1(YGL127C)|FD-Score:3.95|P-value:3.93E-5||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits Gene:SRO7(YPR032W)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication Gene:SSD1(YDR293C)|FD-Score:3.15|P-value:8.17E-4||SGD DESC:Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function Gene:TLG2(YOL018C)|FD-Score:3.56|P-value:1.86E-4||SGD DESC:Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) Gene:TMA20(YER007C-A)|FD-Score:4.28|P-value:9.43E-6||SGD DESC:Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress Gene:TOM7(YNL070W)|FD-Score:5.25|P-value:7.45E-8||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex Gene:UBX7(YBR273C)|FD-Score:-3.27|P-value:5.41E-4||SGD DESC:UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication Gene:YBL028C(YBL028C)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis Gene:YBR200W-A(YBR200W-A_p)|FD-Score:-4.85|P-value:6.15E-7||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGL117W(YGL117W_p)|FD-Score:-4.23|P-value:1.18E-5||SGD DESC:Putative protein of unknown function Gene:YGR054W(YGR054W)|FD-Score:-3.92|P-value:4.49E-5||SGD DESC:Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A Gene:YMR001C-A(YMR001C-A_p)|FD-Score:3.77|P-value:8.20E-5||SGD DESC:Putative protein of unknown function Gene:YPR027C(YPR027C_p)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Putative protein of unknown function Gene:ADE4(YMR300C)|FD-Score:-3.81|P-value:6.95E-5||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:ASF1(YJL115W)|FD-Score:-3.33|P-value:4.37E-4||SGD DESC:Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition Gene:ATP11(YNL315C)|FD-Score:3.4|P-value:3.41E-4||SGD DESC:Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase Gene:AVT2(YEL064C)|FD-Score:3.54|P-value:2.02E-4||SGD DESC:Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BUD21(YOR078W)|FD-Score:-3.49|P-value:2.45E-4||SGD DESC:Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern Gene:COQ8(YGL119W)|FD-Score:-4.62|P-value:1.91E-6||SGD DESC:Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication Gene:CSG2(YBR036C)|FD-Score:3.22|P-value:6.49E-4||SGD DESC:Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress Gene:DBF2(YGR092W)|FD-Score:-4.8|P-value:8.10E-7||SGD DESC:Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis Gene:DMC1(YER179W)|FD-Score:3.29|P-value:5.02E-4||SGD DESC:Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p Gene:ENT1(YDL161W)|FD-Score:-3.97|P-value:3.55E-5||SGD DESC:Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:FYV4(YHR059W)|FD-Score:4.31|P-value:8.02E-6||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin Gene:GET3(YDL100C)|FD-Score:-4.25|P-value:1.09E-5||SGD DESC:Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress Gene:GIC1(YHR061C)|FD-Score:-4.02|P-value:2.95E-5||SGD DESC:Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress Gene:HYR1(YIR037W)|FD-Score:4.14|P-value:1.77E-5||SGD DESC:Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor Gene:IDS2(YJL146W)|FD-Score:3.31|P-value:4.74E-4||SGD DESC:Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation Gene:IRE1(YHR079C)|FD-Score:-3.13|P-value:8.61E-4||SGD DESC:Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress Gene:LOC1(YFR001W)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:LYS20(YDL182W)|FD-Score:-3.31|P-value:4.68E-4||SGD DESC:Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication Gene:MAG1(YER142C)|FD-Score:4.08|P-value:2.27E-5||SGD DESC:3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress Gene:MMR1(YLR190W)|FD-Score:-3.22|P-value:6.48E-4||SGD DESC:Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p Gene:MNN5(YJL186W)|FD-Score:4.53|P-value:2.94E-6||SGD DESC:Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment Gene:MOT2(YER068W)|FD-Score:4.11|P-value:1.94E-5||SGD DESC:Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications Gene:MRM2(YGL136C)|FD-Score:4.3|P-value:8.57E-6||SGD DESC:Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ Gene:MRP7(YNL005C)|FD-Score:4.73|P-value:1.11E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL31(YKL138C)|FD-Score:3.34|P-value:4.25E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSC1(YML128C)|FD-Score:3.98|P-value:3.47E-5||SGD DESC:Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated Gene:MUM3(YOR298W)|FD-Score:3.41|P-value:3.25E-4||SGD DESC:Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases Gene:NOP13(YNL175C)|FD-Score:-3.96|P-value:3.72E-5||SGD DESC:Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress Gene:NUP60(YAR002W)|FD-Score:4.97|P-value:3.28E-7||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153 Gene:OCA2(YNL056W)|FD-Score:-3.88|P-value:5.33E-5||SGD DESC:Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene Gene:OPI9(YLR338W_d)|FD-Score:3.29|P-value:5.09E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C Gene:OXP1(YKL215C)|FD-Score:3.12|P-value:9.01E-4||SGD DESC:5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:PGM3(YMR278W)|FD-Score:-3.2|P-value:6.99E-4||SGD DESC:Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential Gene:RAD24(YER173W)|FD-Score:4.47|P-value:3.84E-6||SGD DESC:Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein Gene:REH1(YLR387C)|FD-Score:3.1|P-value:9.81E-4||SGD DESC:Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains Gene:RSM24(YDR175C)|FD-Score:3.56|P-value:1.83E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:SAC7(YDR389W)|FD-Score:3.31|P-value:4.65E-4||SGD DESC:GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate Gene:SGA1(YIL099W)|FD-Score:5.04|P-value:2.39E-7||SGD DESC:Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation Gene:SLG1(YOR008C)|FD-Score:4.84|P-value:6.37E-7||SGD DESC:Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response Gene:SLM4(YBR077C)|FD-Score:-4.28|P-value:9.29E-6||SGD DESC:Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 Gene:SOH1(YGL127C)|FD-Score:3.95|P-value:3.93E-5||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits Gene:SRO7(YPR032W)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication Gene:SSD1(YDR293C)|FD-Score:3.15|P-value:8.17E-4||SGD DESC:Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function Gene:TLG2(YOL018C)|FD-Score:3.56|P-value:1.86E-4||SGD DESC:Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) Gene:TMA20(YER007C-A)|FD-Score:4.28|P-value:9.43E-6||SGD DESC:Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress Gene:TOM7(YNL070W)|FD-Score:5.25|P-value:7.45E-8||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex Gene:UBX7(YBR273C)|FD-Score:-3.27|P-value:5.41E-4||SGD DESC:UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication Gene:YBL028C(YBL028C)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis Gene:YBR200W-A(YBR200W-A_p)|FD-Score:-4.85|P-value:6.15E-7||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGL117W(YGL117W_p)|FD-Score:-4.23|P-value:1.18E-5||SGD DESC:Putative protein of unknown function Gene:YGR054W(YGR054W)|FD-Score:-3.92|P-value:4.49E-5||SGD DESC:Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A Gene:YMR001C-A(YMR001C-A_p)|FD-Score:3.77|P-value:8.20E-5||SGD DESC:Putative protein of unknown function Gene:YPR027C(YPR027C_p)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Putative protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YJL076W6.095.75E-101.43NET1Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication
YKL195W5.783.76E-91.43MIA40Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
YFL002C5.472.24E-81.43SPB4Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
YLR197W4.042.71E-50.35NOP56Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
YDL150W3.681.16E-40.14RPC53RNA polymerase III subunit C53
YFR004W3.541.98E-40.11RPN11Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress
YBL105C3.432.99E-40.14PKC1Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
YGR218W3.294.94E-40.03CRM1Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin
YPL204W3.275.40E-40.02HRR25Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
YNL152W3.255.80E-40.12INN1Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
YMR033W3.138.78E-40.14ARP9Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YHR036W2.990.001400.07BRL1Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
YDL152W_d2.920.001730.04YDL152W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
YGL102C_d2.890.001950.14YGL102C_dDubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
YDR361C2.750.003000.00BCP1Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YNL070W5.257.45E-8TOM7Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
YIL099W5.042.39E-7SGA1Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YAR002W4.973.28E-7NUP60FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153
YOR008C4.846.37E-7SLG1Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
YNL005C4.731.11E-6MRP7Mitochondrial ribosomal protein of the large subunit
YJL186W4.532.94E-6MNN5Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YER173W4.473.84E-6RAD24Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
YHR059W4.318.02E-6FYV4Protein of unknown function, required for survival upon exposure to K1 killer toxin
YGL136C4.308.57E-6MRM2Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ
YER007C-A4.289.43E-6TMA20Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress
YIR037W4.141.77E-5HYR1Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor
YER068W4.111.94E-5MOT2Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
YER142C4.082.27E-5MAG13-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress
YML128C3.983.47E-5MSC1Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YGL127C3.953.93E-5SOH1Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits

GO enrichment analysis for SGTC_1516
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0871.81E-11SGTC_33229139058 2.1 μMChembridge (Drug-like library)49089260.115942cell wall
0.0806.69E-10SGTC_15130337-0559 19.0 μMChemDiv (Drug-like library)7750730.12
0.0782.12E-9SGTC_9282764-0428 58.7 μMChemDiv (Drug-like library)6625780.03125cell wall
0.0772.78E-9SGTC_22297354935 190.0 μMChembridge (Fragment library)3181120.115385RSC complex & mRNA processing
0.0681.42E-7SGTC_1556plumbagin 1.5 μMTimTec (Pure natural product library)102050.125superoxide
0.0681.77E-7SGTC_23447990960 77.0 μMChembridge (Fragment library)1408130.113636
0.0663.80E-7SGTC_22206782180 200.0 μMChembridge (Fragment library)8338030.0701754RNA processing & uracil transport
0.0622.24E-6SGTC_700141-0289 43.3 μMChemDiv (Drug-like library)3524080.0517241mitochondrial stress
0.0604.06E-6SGTC_23679070478 135.4 μMChembridge (Fragment library)5728020.22449cell wall
0.0594.94E-6SGTC_1090efavirenz 20.7 μMMiscellaneous641390.0441176
0.0596.10E-6SGTC_2534helenine 20.1 μMMicrosource (Natural product library)727240.047619RSC complex & mRNA processing
0.0587.18E-6SGTC_8184072-2707 53.5 μMChemDiv (Drug-like library)8828710.0363636
0.0588.02E-6SGTC_1547harmine 94.2 μMMiscellaneous52809530.578947ergosterol biosynthesis
0.0571.04E-5SGTC_8800833-0487 87.2 μMChemDiv (Drug-like library)760750.130435mitochondrial processes
0.0571.16E-5SGTC_1631benzylvanillin 81.9 μMTimTec (Natural product derivative library)755060.111111Golgi

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1547harmine94.2 μM0.5789475280953Miscellaneous212.247182.43812ergosterol biosynthesis
SGTC_2525harmine47.85 μM0.5789475280953Miscellaneous212.247182.43812ergosterol biosynthesis
SGTC_2716st08085838.62 μM0.4565225296050TimTec (Natural product derivative library)295.337324.4661260S ribosome export
SGTC_1721st0821529.27 μM0.425296051TimTec (Natural product derivative library)314.337364.3551360S ribosome export
SGTC_2591skatole100 μM0.3428576736Microsource (Natural product library)131.174462.60910
SGTC_1774st04837148.47 μM0.284242727TimTec (Natural product derivative library)318.415483.47412RNA processing & uracil transport
SGTC_7800109-0199192 μM0.27907610414ChemDiv (Drug-like library)208.258483.75611
SGTC_1953st07680012.1 μM0.27907297591TimTec (Natural product derivative library)219.281124.53410
SGTC_20155119600184 μM0.2765962828786Chembridge (Fragment library)200.236482.07521
SGTC_2115tiliquinol12.77 μM0.26829371208Chembridge (Fragment library)159.184562.2612
SGTC_452diindolylmethane8 μM0.2631583071ICCB bioactive library246.306464.39120RNA processing & uracil transport