| Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
|---|
| YJL076W | 6.09 | 5.75E-10 | 1.43 | NET1 | Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication |
| YKL195W | 5.78 | 3.76E-9 | 1.43 | MIA40 | Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p |
| YFL002C | 5.47 | 2.24E-8 | 1.43 | SPB4 | Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients |
| YLR197W | 4.04 | 2.71E-5 | 0.35 | NOP56 | Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects |
| YDL150W | 3.68 | 1.16E-4 | 0.14 | RPC53 | RNA polymerase III subunit C53 |
| YFR004W | 3.54 | 1.98E-4 | 0.11 | RPN11 | Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress |
| YBL105C | 3.43 | 2.99E-4 | 0.14 | PKC1 | Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) |
| YGR218W | 3.29 | 4.94E-4 | 0.03 | CRM1 | Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin |
| YPL204W | 3.27 | 5.40E-4 | 0.02 | HRR25 | Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta) |
| YNL152W | 3.25 | 5.80E-4 | 0.12 | INN1 | Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis |
| YMR033W | 3.13 | 8.78E-4 | 0.14 | ARP9 | Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation |
| YHR036W | 2.99 | 0.00140 | 0.07 | BRL1 | Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export |
| YDL152W_d | 2.92 | 0.00173 | 0.04 | YDL152W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome |
| YGL102C_d | 2.89 | 0.00195 | 0.14 | YGL102C_d | Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein |
| YDR361C | 2.75 | 0.00300 | 0.00 | BCP1 | Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport |
