Deletion Strain | FD score | P-value | Gene | Gene Description |
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YNL099C | 6.70 | 1.03E-11 | OCA1 | Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA |
YGL219C | 6.29 | 1.59E-10 | MDM34 | Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth |
YBR048W | 6.02 | 8.91E-10 | RPS11B | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication |
YBR139W | 5.82 | 2.98E-9 | YBR139W | Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner |
YKR001C | 5.67 | 7.12E-9 | VPS1 | Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis |
YLR119W | 5.52 | 1.67E-8 | SRN2 | Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus |
YPR020W | 5.11 | 1.59E-7 | ATP20 | Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex |
YMR062C | 4.33 | 7.58E-6 | ARG7 | Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine |
YGR130C | 4.28 | 9.41E-6 | YGR130C | Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) |
YKR070W_p | 4.19 | 1.42E-5 | YKR070W_p | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YBR077C | 3.96 | 3.74E-5 | SLM4 | Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 |
YGR078C | 3.96 | 3.80E-5 | PAC10 | Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding |
YML009C-A_d | 3.88 | 5.15E-5 | YML009C-A_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YIL053W | 3.87 | 5.34E-5 | RHR2 | Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication |
YBR146W | 3.77 | 8.08E-5 | MRPS9 | Mitochondrial ribosomal protein of the small subunit |