st038567

6,7-dimethoxy-4-methylchromen-2-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1518
Screen concentration 90.8 μM
Source TimTec (Pure natural product library)
PubChem CID 77966
SMILES CC1=CC(=O)OC2=CC(=C(C=C12)OC)OC
Standardized SMILES COc1cc2OC(=O)C=C(C)c2cc1OC
Molecular weight 220.2213
ALogP 2.31
H-bond donor count 0
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 0.21
% growth inhibition (Hom. pool) -1.45


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 77966
Download HIP data (tab-delimited text)  (excel)
Gene:CCT3(YJL014W)|FD-Score:3.9|P-value:4.83E-5|Clearance:0.19||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:NAT2(YGR147C)|FD-Score:4.72|P-value:1.19E-6|Clearance:0.82||SGD DESC:Protein with an apparent role in acetylation of N-terminal methionine residues Gene:NOP15(YNL110C)|FD-Score:3.6|P-value:1.62E-4|Clearance:0.07||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm Gene:PRE5(YMR314W)|FD-Score:-3.1|P-value:9.59E-4|Clearance:0||SGD DESC:Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress Gene:RNR2(YJL026W)|FD-Score:-4.95|P-value:3.73E-7|Clearance:0||SGD DESC:Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits Gene:RPA43(YOR340C)|FD-Score:3.7|P-value:1.08E-4|Clearance:0.1||SGD DESC:RNA polymerase I subunit A43 Gene:RPN6(YDL097C)|FD-Score:3.2|P-value:6.90E-4|Clearance:0.19||SGD DESC:Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress Gene:RPN8(YOR261C)|FD-Score:-3.85|P-value:5.99E-5|Clearance:0||SGD DESC:Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p Gene:SWD2(YKL018W)|FD-Score:-4.85|P-value:6.09E-7|Clearance:0||SGD DESC:Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination Gene:TAF8(YML114C)|FD-Score:-3.18|P-value:7.40E-4|Clearance:0||SGD DESC:TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation Gene:TIF34(YMR146C)|FD-Score:-5.34|P-value:4.69E-8|Clearance:0||SGD DESC:eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation Gene:UTP21(YLR409C)|FD-Score:3.71|P-value:1.05E-4|Clearance:0.01||SGD DESC:Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma Gene:UTP4(YDR324C)|FD-Score:5.09|P-value:1.74E-7|Clearance:0.82||SGD DESC:Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript Gene:YGR265W(YGR265W_d)|FD-Score:3.52|P-value:2.14E-4|Clearance:0.32||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase Gene:CCT3(YJL014W)|FD-Score:3.9|P-value:4.83E-5|Clearance:0.19||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:NAT2(YGR147C)|FD-Score:4.72|P-value:1.19E-6|Clearance:0.82||SGD DESC:Protein with an apparent role in acetylation of N-terminal methionine residues Gene:NOP15(YNL110C)|FD-Score:3.6|P-value:1.62E-4|Clearance:0.07||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm Gene:PRE5(YMR314W)|FD-Score:-3.1|P-value:9.59E-4|Clearance:0||SGD DESC:Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress Gene:RNR2(YJL026W)|FD-Score:-4.95|P-value:3.73E-7|Clearance:0||SGD DESC:Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits Gene:RPA43(YOR340C)|FD-Score:3.7|P-value:1.08E-4|Clearance:0.1||SGD DESC:RNA polymerase I subunit A43 Gene:RPN6(YDL097C)|FD-Score:3.2|P-value:6.90E-4|Clearance:0.19||SGD DESC:Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress Gene:RPN8(YOR261C)|FD-Score:-3.85|P-value:5.99E-5|Clearance:0||SGD DESC:Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p Gene:SWD2(YKL018W)|FD-Score:-4.85|P-value:6.09E-7|Clearance:0||SGD DESC:Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination Gene:TAF8(YML114C)|FD-Score:-3.18|P-value:7.40E-4|Clearance:0||SGD DESC:TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation Gene:TIF34(YMR146C)|FD-Score:-5.34|P-value:4.69E-8|Clearance:0||SGD DESC:eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation Gene:UTP21(YLR409C)|FD-Score:3.71|P-value:1.05E-4|Clearance:0.01||SGD DESC:Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma Gene:UTP4(YDR324C)|FD-Score:5.09|P-value:1.74E-7|Clearance:0.82||SGD DESC:Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript Gene:YGR265W(YGR265W_d)|FD-Score:3.52|P-value:2.14E-4|Clearance:0.32||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 77966
Download HOP data (tab-delimited text)  (excel)
Gene:AAD4(YDL243C)|FD-Score:-4.06|P-value:2.50E-5||SGD DESC:Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin Gene:AAT2(YLR027C)|FD-Score:3.53|P-value:2.12E-4||SGD DESC:Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells Gene:AFG1(YEL052W)|FD-Score:-3.68|P-value:1.16E-4||SGD DESC:Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain Gene:ALD6(YPL061W)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress Gene:AQY2(YLL052C)|FD-Score:-4.54|P-value:2.88E-6||SGD DESC:Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains Gene:ARG7(YMR062C)|FD-Score:4.33|P-value:7.58E-6||SGD DESC:Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine Gene:ATO3(YDR384C)|FD-Score:-4.89|P-value:5.10E-7||SGD DESC:Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters Gene:ATP20(YPR020W)|FD-Score:5.11|P-value:1.59E-7||SGD DESC:Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex Gene:ATP4(YPL078C)|FD-Score:3.29|P-value:5.00E-4||SGD DESC:Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated Gene:CAD1(YDR423C)|FD-Score:-4.18|P-value:1.49E-5||SGD DESC:AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication Gene:COX10(YPL172C)|FD-Score:3.54|P-value:2.02E-4||SGD DESC:Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders Gene:CPR4(YCR069W)|FD-Score:3.42|P-value:3.18E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway Gene:DAL81(YIR023W)|FD-Score:-3.69|P-value:1.14E-4||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:DCS1(YLR270W)|FD-Score:3.1|P-value:9.59E-4||SGD DESC:Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress Gene:DLD2(YDL178W)|FD-Score:3.39|P-value:3.55E-4||SGD DESC:D-lactate dehydrogenase, located in the mitochondrial matrix Gene:EMC6(YLL014W)|FD-Score:3.11|P-value:9.35E-4||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 Gene:FAU1(YER183C)|FD-Score:-3.39|P-value:3.54E-4||SGD DESC:5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis Gene:FMP40(YPL222W_p)|FD-Score:-4.03|P-value:2.74E-5||SGD DESC:Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FMP52(YER004W)|FD-Score:3.16|P-value:7.86E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:GEA1(YJR031C)|FD-Score:-3.14|P-value:8.47E-4||SGD DESC:Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication Gene:GGA1(YDR358W)|FD-Score:-3.36|P-value:3.89E-4||SGD DESC:Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi Gene:GTT2(YLL060C)|FD-Score:-3.58|P-value:1.75E-4||SGD DESC:Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress Gene:HHY1(YEL059W_d)|FD-Score:-3.34|P-value:4.19E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking Gene:HIR3(YJR140C)|FD-Score:-3.18|P-value:7.35E-4||SGD DESC:Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein Gene:HSP30(YCR021C)|FD-Score:-3.19|P-value:7.11E-4||SGD DESC:Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase Gene:KIN4(YOR233W)|FD-Score:-4.33|P-value:7.49E-6||SGD DESC:Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication Gene:MDM34(YGL219C)|FD-Score:6.29|P-value:1.59E-10||SGD DESC:Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Gene:MET13(YGL125W)|FD-Score:3.41|P-value:3.28E-4||SGD DESC:Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway Gene:MRPS9(YBR146W)|FD-Score:3.77|P-value:8.08E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:NAB6(YML117W)|FD-Score:-5.9|P-value:1.85E-9||SGD DESC:Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP Gene:NTA1(YJR062C)|FD-Score:-3.32|P-value:4.44E-4||SGD DESC:Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation Gene:OCA1(YNL099C)|FD-Score:6.7|P-value:1.03E-11||SGD DESC:Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA Gene:PAC10(YGR078C)|FD-Score:3.96|P-value:3.80E-5||SGD DESC:Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding Gene:PBS2(YJL128C)|FD-Score:3.72|P-value:9.80E-5||SGD DESC:MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition Gene:PHM6(YDR281C)|FD-Score:3.29|P-value:4.98E-4||SGD DESC:Protein of unknown function, expression is regulated by phosphate levels Gene:PMR1(YGL167C)|FD-Score:3.39|P-value:3.55E-4||SGD DESC:High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease Gene:PMU1(YKL128C)|FD-Score:-3.44|P-value:2.93E-4||SGD DESC:Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant Gene:PRS1(YKL181W)|FD-Score:3.25|P-value:5.68E-4||SGD DESC:5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes Gene:PUF4(YGL014W)|FD-Score:3.13|P-value:8.60E-4||SGD DESC:Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors Gene:RCO1(YMR075W)|FD-Score:3.12|P-value:9.08E-4||SGD DESC:Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p Gene:RHR2(YIL053W)|FD-Score:3.87|P-value:5.34E-5||SGD DESC:Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication Gene:RPS11B(YBR048W)|FD-Score:6.02|P-value:8.91E-10||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication Gene:RRT14(YIL127C_p)|FD-Score:-3.14|P-value:8.53E-4||SGD DESC:Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis Gene:SDS23(YGL056C)|FD-Score:3.63|P-value:1.40E-4||SGD DESC:One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication Gene:SLM4(YBR077C)|FD-Score:3.96|P-value:3.74E-5||SGD DESC:Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 Gene:SMM1(YNR015W)|FD-Score:-4.06|P-value:2.48E-5||SGD DESC:Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs Gene:SNA2(YDR525W-A)|FD-Score:3.28|P-value:5.28E-4||SGD DESC:Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:SRN2(YLR119W)|FD-Score:5.52|P-value:1.67E-8||SGD DESC:Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus Gene:SSH1(YBR283C)|FD-Score:3.53|P-value:2.08E-4||SGD DESC:Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential Gene:STE20(YHL007C)|FD-Score:3.21|P-value:6.59E-4||SGD DESC:Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p Gene:USV1(YPL230W)|FD-Score:-3.23|P-value:6.18E-4||SGD DESC:Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication Gene:VAM6(YDL077C)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p Gene:VPS1(YKR001C)|FD-Score:5.67|P-value:7.12E-9||SGD DESC:Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis Gene:YBR139W(YBR139W)|FD-Score:5.82|P-value:2.98E-9||SGD DESC:Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner Gene:YCF1(YDR135C)|FD-Score:3.66|P-value:1.24E-4||SGD DESC:Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR Gene:YDL057W(YDL057W_p)|FD-Score:-3.13|P-value:8.73E-4||SGD DESC:Putative protein of unknown function; YDL057W is not an essential gene Gene:YDL183C(YDL183C)|FD-Score:3.39|P-value:3.47E-4||SGD DESC:Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene Gene:YDR455C(YDR455C_d)|FD-Score:-3.2|P-value:6.81E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W Gene:YDR467C(YDR467C_d)|FD-Score:-3.97|P-value:3.63E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGR064W(YGR064W_d)|FD-Score:3.54|P-value:2.03E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C Gene:YGR130C(YGR130C)|FD-Score:4.28|P-value:9.41E-6||SGD DESC:Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) Gene:YHP1(YDR451C)|FD-Score:3.18|P-value:7.39E-4||SGD DESC:Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication Gene:YJR015W(YJR015W_p)|FD-Score:-3.62|P-value:1.45E-4||SGD DESC:Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene Gene:YKR070W(YKR070W_p)|FD-Score:4.19|P-value:1.42E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YLR177W(YLR177W_p)|FD-Score:-3.28|P-value:5.16E-4||SGD DESC:Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication Gene:YLR264C-A(YLR264C-A_p)|FD-Score:3.21|P-value:6.64E-4||SGD DESC:Putative protein of unknown function Gene:YML009C-A(YML009C-A_d)|FD-Score:3.88|P-value:5.15E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YML090W(YML090W_d)|FD-Score:-3.18|P-value:7.36E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source Gene:YOL098C(YOL098C_p)|FD-Score:3.64|P-value:1.39E-4||SGD DESC:Putative metalloprotease Gene:YOR331C(YOR331C_d)|FD-Score:3.45|P-value:2.77E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W Gene:AAD4(YDL243C)|FD-Score:-4.06|P-value:2.50E-5||SGD DESC:Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin Gene:AAT2(YLR027C)|FD-Score:3.53|P-value:2.12E-4||SGD DESC:Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells Gene:AFG1(YEL052W)|FD-Score:-3.68|P-value:1.16E-4||SGD DESC:Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain Gene:ALD6(YPL061W)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress Gene:AQY2(YLL052C)|FD-Score:-4.54|P-value:2.88E-6||SGD DESC:Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains Gene:ARG7(YMR062C)|FD-Score:4.33|P-value:7.58E-6||SGD DESC:Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine Gene:ATO3(YDR384C)|FD-Score:-4.89|P-value:5.10E-7||SGD DESC:Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters Gene:ATP20(YPR020W)|FD-Score:5.11|P-value:1.59E-7||SGD DESC:Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex Gene:ATP4(YPL078C)|FD-Score:3.29|P-value:5.00E-4||SGD DESC:Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated Gene:CAD1(YDR423C)|FD-Score:-4.18|P-value:1.49E-5||SGD DESC:AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication Gene:COX10(YPL172C)|FD-Score:3.54|P-value:2.02E-4||SGD DESC:Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders Gene:CPR4(YCR069W)|FD-Score:3.42|P-value:3.18E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway Gene:DAL81(YIR023W)|FD-Score:-3.69|P-value:1.14E-4||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:DCS1(YLR270W)|FD-Score:3.1|P-value:9.59E-4||SGD DESC:Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress Gene:DLD2(YDL178W)|FD-Score:3.39|P-value:3.55E-4||SGD DESC:D-lactate dehydrogenase, located in the mitochondrial matrix Gene:EMC6(YLL014W)|FD-Score:3.11|P-value:9.35E-4||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 Gene:FAU1(YER183C)|FD-Score:-3.39|P-value:3.54E-4||SGD DESC:5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis Gene:FMP40(YPL222W_p)|FD-Score:-4.03|P-value:2.74E-5||SGD DESC:Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FMP52(YER004W)|FD-Score:3.16|P-value:7.86E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:GEA1(YJR031C)|FD-Score:-3.14|P-value:8.47E-4||SGD DESC:Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication Gene:GGA1(YDR358W)|FD-Score:-3.36|P-value:3.89E-4||SGD DESC:Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi Gene:GTT2(YLL060C)|FD-Score:-3.58|P-value:1.75E-4||SGD DESC:Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress Gene:HHY1(YEL059W_d)|FD-Score:-3.34|P-value:4.19E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking Gene:HIR3(YJR140C)|FD-Score:-3.18|P-value:7.35E-4||SGD DESC:Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein Gene:HSP30(YCR021C)|FD-Score:-3.19|P-value:7.11E-4||SGD DESC:Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase Gene:KIN4(YOR233W)|FD-Score:-4.33|P-value:7.49E-6||SGD DESC:Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication Gene:MDM34(YGL219C)|FD-Score:6.29|P-value:1.59E-10||SGD DESC:Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Gene:MET13(YGL125W)|FD-Score:3.41|P-value:3.28E-4||SGD DESC:Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway Gene:MRPS9(YBR146W)|FD-Score:3.77|P-value:8.08E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:NAB6(YML117W)|FD-Score:-5.9|P-value:1.85E-9||SGD DESC:Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP Gene:NTA1(YJR062C)|FD-Score:-3.32|P-value:4.44E-4||SGD DESC:Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation Gene:OCA1(YNL099C)|FD-Score:6.7|P-value:1.03E-11||SGD DESC:Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA Gene:PAC10(YGR078C)|FD-Score:3.96|P-value:3.80E-5||SGD DESC:Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding Gene:PBS2(YJL128C)|FD-Score:3.72|P-value:9.80E-5||SGD DESC:MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition Gene:PHM6(YDR281C)|FD-Score:3.29|P-value:4.98E-4||SGD DESC:Protein of unknown function, expression is regulated by phosphate levels Gene:PMR1(YGL167C)|FD-Score:3.39|P-value:3.55E-4||SGD DESC:High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease Gene:PMU1(YKL128C)|FD-Score:-3.44|P-value:2.93E-4||SGD DESC:Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant Gene:PRS1(YKL181W)|FD-Score:3.25|P-value:5.68E-4||SGD DESC:5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes Gene:PUF4(YGL014W)|FD-Score:3.13|P-value:8.60E-4||SGD DESC:Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors Gene:RCO1(YMR075W)|FD-Score:3.12|P-value:9.08E-4||SGD DESC:Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p Gene:RHR2(YIL053W)|FD-Score:3.87|P-value:5.34E-5||SGD DESC:Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication Gene:RPS11B(YBR048W)|FD-Score:6.02|P-value:8.91E-10||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication Gene:RRT14(YIL127C_p)|FD-Score:-3.14|P-value:8.53E-4||SGD DESC:Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis Gene:SDS23(YGL056C)|FD-Score:3.63|P-value:1.40E-4||SGD DESC:One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication Gene:SLM4(YBR077C)|FD-Score:3.96|P-value:3.74E-5||SGD DESC:Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 Gene:SMM1(YNR015W)|FD-Score:-4.06|P-value:2.48E-5||SGD DESC:Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs Gene:SNA2(YDR525W-A)|FD-Score:3.28|P-value:5.28E-4||SGD DESC:Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:SRN2(YLR119W)|FD-Score:5.52|P-value:1.67E-8||SGD DESC:Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus Gene:SSH1(YBR283C)|FD-Score:3.53|P-value:2.08E-4||SGD DESC:Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential Gene:STE20(YHL007C)|FD-Score:3.21|P-value:6.59E-4||SGD DESC:Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p Gene:USV1(YPL230W)|FD-Score:-3.23|P-value:6.18E-4||SGD DESC:Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication Gene:VAM6(YDL077C)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p Gene:VPS1(YKR001C)|FD-Score:5.67|P-value:7.12E-9||SGD DESC:Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis Gene:YBR139W(YBR139W)|FD-Score:5.82|P-value:2.98E-9||SGD DESC:Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner Gene:YCF1(YDR135C)|FD-Score:3.66|P-value:1.24E-4||SGD DESC:Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR Gene:YDL057W(YDL057W_p)|FD-Score:-3.13|P-value:8.73E-4||SGD DESC:Putative protein of unknown function; YDL057W is not an essential gene Gene:YDL183C(YDL183C)|FD-Score:3.39|P-value:3.47E-4||SGD DESC:Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene Gene:YDR455C(YDR455C_d)|FD-Score:-3.2|P-value:6.81E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W Gene:YDR467C(YDR467C_d)|FD-Score:-3.97|P-value:3.63E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGR064W(YGR064W_d)|FD-Score:3.54|P-value:2.03E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C Gene:YGR130C(YGR130C)|FD-Score:4.28|P-value:9.41E-6||SGD DESC:Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) Gene:YHP1(YDR451C)|FD-Score:3.18|P-value:7.39E-4||SGD DESC:Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication Gene:YJR015W(YJR015W_p)|FD-Score:-3.62|P-value:1.45E-4||SGD DESC:Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene Gene:YKR070W(YKR070W_p)|FD-Score:4.19|P-value:1.42E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YLR177W(YLR177W_p)|FD-Score:-3.28|P-value:5.16E-4||SGD DESC:Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication Gene:YLR264C-A(YLR264C-A_p)|FD-Score:3.21|P-value:6.64E-4||SGD DESC:Putative protein of unknown function Gene:YML009C-A(YML009C-A_d)|FD-Score:3.88|P-value:5.15E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YML090W(YML090W_d)|FD-Score:-3.18|P-value:7.36E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source Gene:YOL098C(YOL098C_p)|FD-Score:3.64|P-value:1.39E-4||SGD DESC:Putative metalloprotease Gene:YOR331C(YOR331C_d)|FD-Score:3.45|P-value:2.77E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDR324C5.091.74E-70.82UTP4Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
YGR147C4.721.19E-60.82NAT2Protein with an apparent role in acetylation of N-terminal methionine residues
YJL014W3.904.83E-50.19CCT3Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YLR409C3.711.05E-40.01UTP21Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma
YOR340C3.701.08E-40.10RPA43RNA polymerase I subunit A43
YNL110C3.601.62E-40.07NOP15Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
YGR265W_d3.522.14E-40.32YGR265W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YDL097C3.206.90E-40.19RPN6Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress
YDL132W3.010.001310.07CDC53Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
YLR198C_d2.940.001649.48E-4YLR198C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
YKL195W2.940.001640.02MIA40Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
YBR196C2.920.001750.00PGI1Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation
YKR062W2.920.001770.23TFA2TFIIE small subunit, involved in RNA polymerase II transcription initiation
YDL150W2.680.003670.01RPC53RNA polymerase III subunit C53
YDR280W2.670.003780.02RRP45Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YNL099C6.701.03E-11OCA1Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA
YGL219C6.291.59E-10MDM34Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth
YBR048W6.028.91E-10RPS11BProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
YBR139W5.822.98E-9YBR139WPutative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
YKR001C5.677.12E-9VPS1Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis
YLR119W5.521.67E-8SRN2Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
YPR020W5.111.59E-7ATP20Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex
YMR062C4.337.58E-6ARG7Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine
YGR130C4.289.41E-6YGR130CComponent of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
YKR070W_p4.191.42E-5YKR070W_pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR077C3.963.74E-5SLM4Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YGR078C3.963.80E-5PAC10Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
YML009C-A_d3.885.15E-5YML009C-A_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL053W3.875.34E-5RHR2Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication
YBR146W3.778.08E-5MRPS9Mitochondrial ribosomal protein of the small subunit

GO enrichment analysis for SGTC_1518
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0691.28E-7SGTC_15153460-0031 42.1 μMChemDiv (Drug-like library)28765960.128571DNA intercalators
0.0672.61E-7SGTC_11991638-0010 4.5 μMChemDiv (Drug-like library)31111360.0327869endomembrane recycling
0.0641.29E-6SGTC_1463k081-0032 34.1 μMChemDiv (Drug-like library)9777550.0634921
0.0631.34E-6SGTC_14404100-1550 40.0 μMChemDiv (Drug-like library)7428060.09375
0.0622.09E-6SGTC_1981st071826 47.0 μMTimTec (Natural product derivative library)118386000.116883
0.0605.56E-6SGTC_1462k081-0014 26.5 μMChemDiv (Drug-like library)32706340.0645161
0.0595.87E-6SGTC_587k089-0003 57.0 μMChemDiv (Drug-like library)96596960.126437
0.0596.25E-6SGTC_1092toremifene 6.3 μMNIH Clinical Collection30055730.0645161
0.0589.68E-6SGTC_14843473-2379 286.0 μMChemDiv (Drug-like library)6719170.078125
0.0571.07E-5SGTC_2705st078069 42.8 μMTimTec (Natural product derivative library)15300610.174603
0.0561.42E-5SGTC_12850929-0069 65.5 μMChemDiv (Drug-like library)12062370.0877193
0.0543.87E-5SGTC_2435hr heat shock (37°C) + splitomicin 1.0 μMMiscellaneous52690.142857heat shock/prefoldin
0.0534.80E-5SGTC_15324',5'-dihydroxyflavone 78.7 μMTimTec (Pure natural product library)1655210.153846Golgi
0.0535.10E-5SGTC_831k061-1017 217.0 μMChemDiv (Drug-like library)12401530.126984translation
0.0527.44E-5SGTC_1519esterone 74.0 μMTimTec (Pure natural product library)6980.0952381DNA intercalators

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_15666,7-dimethoxy-4-ethylcoumarin85.4 μM0.638889688761TimTec (Pure natural product library)234.247862.76904
SGTC_15447-methoxy-4-methylcoumarin105 μM0.611111390807TimTec (Pure natural product library)190.19532.32903
SGTC_25534-methylesculetin85.09 μM0.5882355319502Microsource (Natural product library)192.168121.86224
SGTC_1548st06146890.8 μM0.552632390799TimTec (Pure natural product library)220.221282.31304
SGTC_1526st05151875 μM0.522727673993TimTec (Pure natural product library)266.677043.44504
SGTC_1900st06020072.8 μM0.487805688945TimTec (Natural product derivative library)204.221882.67803
SGTC_1904st06022578 μM0.48780566595TimTec (Natural product derivative library)204.221882.67803
SGTC_1905st06020784.5 μM0.4444441948547TimTec (Natural product derivative library)216.232582.94603
SGTC_7844579-0127173 μM0.4444441948547ChemDiv (Drug-like library)216.232582.94603
SGTC_1912st06020990.8 μM0.4688787TimTec (Natural product derivative library)220.221281.9204