st051518

(7-chloro-4-methyl-2-oxochromen-6-yl) propanoate

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1526
Screen concentration 75.0 μM
Source TimTec (Pure natural product library)
PubChem CID 673993
SMILES CCC(=O)OC1=C(C=C2C(=C1)C(=CC(=O)O2)C)Cl
Standardized SMILES CCC(=O)Oc1cc2C(=CC(=O)Oc2cc1Cl)C
Molecular weight 266.677
ALogP 3.45
H-bond donor count 0
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 4.26
% growth inhibition (Hom. pool) 3.63


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 673993
Download HIP data (tab-delimited text)  (excel)
Gene:CDC8(YJR057W)|FD-Score:3.28|P-value:5.11E-4|Clearance:0.05||SGD DESC:Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p Gene:CEP3(YMR168C)|FD-Score:-3.81|P-value:6.84E-5|Clearance:0||SGD DESC:Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain Gene:CYR1(YJL005W)|FD-Score:-4.7|P-value:1.30E-6|Clearance:0||SGD DESC:Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation Gene:ECO1(YFR027W)|FD-Score:-4.28|P-value:9.31E-6|Clearance:0||SGD DESC:Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress Gene:MOB1(YIL106W)|FD-Score:3.99|P-value:3.30E-5|Clearance:0.11||SGD DESC:Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress Gene:MSL5(YLR116W)|FD-Score:5.52|P-value:1.69E-8|Clearance:0.47||SGD DESC:Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA Gene:MTW1(YAL034W-A)|FD-Score:-5.83|P-value:2.80E-9|Clearance:0||SGD DESC:Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly Gene:NAN1(YPL126W)|FD-Score:-4.42|P-value:4.94E-6|Clearance:0||SGD DESC:U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA Gene:NNF1(YJR112W)|FD-Score:-3.24|P-value:6.05E-4|Clearance:0||SGD DESC:Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation Gene:NOP15(YNL110C)|FD-Score:3.24|P-value:6.02E-4|Clearance:0.17||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm Gene:NUP57(YGR119C)|FD-Score:4.51|P-value:3.21E-6|Clearance:0.52||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) Gene:PSF1(YDR013W)|FD-Score:-3.39|P-value:3.46E-4|Clearance:0||SGD DESC:Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery Gene:SDS22(YKL193C)|FD-Score:-4.4|P-value:5.32E-6|Clearance:0||SGD DESC:Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function Gene:SEC13(YLR208W)|FD-Score:-3.19|P-value:7.01E-4|Clearance:0||SGD DESC:Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress Gene:SMC5(YOL034W)|FD-Score:7.26|P-value:1.88E-13|Clearance:1.74||SGD DESC:Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair Gene:SMD3(YLR147C)|FD-Score:3.54|P-value:2.00E-4|Clearance:0.23||SGD DESC:Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3 Gene:SPC42(YKL042W)|FD-Score:-3.11|P-value:9.32E-4|Clearance:0||SGD DESC:Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane Gene:TFA2(YKR062W)|FD-Score:5.05|P-value:2.21E-7|Clearance:0.54||SGD DESC:TFIIE small subunit, involved in RNA polymerase II transcription initiation Gene:UTP10(YJL109C)|FD-Score:3.85|P-value:6.02E-5|Clearance:0.16||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance Gene:UTP22(YGR090W)|FD-Score:-4.26|P-value:1.01E-5|Clearance:0||SGD DESC:Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals Gene:YDR396W(YDR396W_d)|FD-Score:3.88|P-value:5.14E-5|Clearance:0.04||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex Gene:YGR265W(YGR265W_d)|FD-Score:3.68|P-value:1.15E-4|Clearance:0.14||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase Gene:YOR146W(YOR146W_d)|FD-Score:3.31|P-value:4.66E-4|Clearance:0.03||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C Gene:CDC8(YJR057W)|FD-Score:3.28|P-value:5.11E-4|Clearance:0.05||SGD DESC:Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p Gene:CEP3(YMR168C)|FD-Score:-3.81|P-value:6.84E-5|Clearance:0||SGD DESC:Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain Gene:CYR1(YJL005W)|FD-Score:-4.7|P-value:1.30E-6|Clearance:0||SGD DESC:Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation Gene:ECO1(YFR027W)|FD-Score:-4.28|P-value:9.31E-6|Clearance:0||SGD DESC:Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress Gene:MOB1(YIL106W)|FD-Score:3.99|P-value:3.30E-5|Clearance:0.11||SGD DESC:Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress Gene:MSL5(YLR116W)|FD-Score:5.52|P-value:1.69E-8|Clearance:0.47||SGD DESC:Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA Gene:MTW1(YAL034W-A)|FD-Score:-5.83|P-value:2.80E-9|Clearance:0||SGD DESC:Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly Gene:NAN1(YPL126W)|FD-Score:-4.42|P-value:4.94E-6|Clearance:0||SGD DESC:U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA Gene:NNF1(YJR112W)|FD-Score:-3.24|P-value:6.05E-4|Clearance:0||SGD DESC:Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation Gene:NOP15(YNL110C)|FD-Score:3.24|P-value:6.02E-4|Clearance:0.17||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm Gene:NUP57(YGR119C)|FD-Score:4.51|P-value:3.21E-6|Clearance:0.52||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) Gene:PSF1(YDR013W)|FD-Score:-3.39|P-value:3.46E-4|Clearance:0||SGD DESC:Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery Gene:SDS22(YKL193C)|FD-Score:-4.4|P-value:5.32E-6|Clearance:0||SGD DESC:Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function Gene:SEC13(YLR208W)|FD-Score:-3.19|P-value:7.01E-4|Clearance:0||SGD DESC:Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress Gene:SMC5(YOL034W)|FD-Score:7.26|P-value:1.88E-13|Clearance:1.74||SGD DESC:Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair Gene:SMD3(YLR147C)|FD-Score:3.54|P-value:2.00E-4|Clearance:0.23||SGD DESC:Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3 Gene:SPC42(YKL042W)|FD-Score:-3.11|P-value:9.32E-4|Clearance:0||SGD DESC:Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane Gene:TFA2(YKR062W)|FD-Score:5.05|P-value:2.21E-7|Clearance:0.54||SGD DESC:TFIIE small subunit, involved in RNA polymerase II transcription initiation Gene:UTP10(YJL109C)|FD-Score:3.85|P-value:6.02E-5|Clearance:0.16||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance Gene:UTP22(YGR090W)|FD-Score:-4.26|P-value:1.01E-5|Clearance:0||SGD DESC:Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals Gene:YDR396W(YDR396W_d)|FD-Score:3.88|P-value:5.14E-5|Clearance:0.04||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex Gene:YGR265W(YGR265W_d)|FD-Score:3.68|P-value:1.15E-4|Clearance:0.14||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase Gene:YOR146W(YOR146W_d)|FD-Score:3.31|P-value:4.66E-4|Clearance:0.03||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 673993
Download HOP data (tab-delimited text)  (excel)
Gene:ADH5(YBR145W)|FD-Score:-3.3|P-value:4.85E-4||SGD DESC:Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication Gene:AIM11(YER093C-A)|FD-Score:3.1|P-value:9.77E-4||SGD DESC:Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication Gene:AIM34(YMR003W)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss Gene:ALG12(YNR030W)|FD-Score:4.79|P-value:8.37E-7||SGD DESC:Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation Gene:APD1(YBR151W)|FD-Score:-4.05|P-value:2.56E-5||SGD DESC:Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus Gene:ARL3(YPL051W)|FD-Score:-3.47|P-value:2.56E-4||SGD DESC:GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor Gene:ATG16(YMR159C)|FD-Score:3.92|P-value:4.44E-5||SGD DESC:Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:BLM10(YFL007W)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 Gene:CAF4(YKR036C)|FD-Score:-3.44|P-value:2.88E-4||SGD DESC:WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication Gene:CAT2(YML042W)|FD-Score:3.23|P-value:6.15E-4||SGD DESC:Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes Gene:CEM1(YER061C)|FD-Score:-3.31|P-value:4.65E-4||SGD DESC:Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration Gene:CPA2(YJR109C)|FD-Score:-3.21|P-value:6.68E-4||SGD DESC:Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor Gene:DBP3(YGL078C)|FD-Score:3.37|P-value:3.71E-4||SGD DESC:RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype Gene:DNM1(YLL001W)|FD-Score:-3.2|P-value:6.86E-4||SGD DESC:Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance Gene:DSF2(YBR007C_p)|FD-Score:3.85|P-value:5.87E-5||SGD DESC:Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:ERG3(YLR056W)|FD-Score:3.93|P-value:4.24E-5||SGD DESC:C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase Gene:FRE8(YLR047C)|FD-Score:3.99|P-value:3.25E-5||SGD DESC:Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p Gene:FYV1(YDR024W_d)|FD-Score:4.4|P-value:5.48E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin Gene:GET2(YER083C)|FD-Score:-3.58|P-value:1.70E-4||SGD DESC:Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division Gene:GIP4(YAL031C)|FD-Score:3.17|P-value:7.54E-4||SGD DESC:Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate Gene:HAM1(YJR069C)|FD-Score:-3.41|P-value:3.28E-4||SGD DESC:Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimadines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine; protein abundance increases in response to DNA replication stress Gene:HEH2(YDR458C)|FD-Score:-3.98|P-value:3.41E-5||SGD DESC:Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle Gene:HNT2(YDR305C)|FD-Score:-3.35|P-value:4.05E-4||SGD DESC:Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins Gene:HPR1(YDR138W)|FD-Score:4.12|P-value:1.92E-5||SGD DESC:Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p Gene:ICL2(YPR006C)|FD-Score:3.54|P-value:2.02E-4||SGD DESC:2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol Gene:ITC1(YGL133W)|FD-Score:-4.87|P-value:5.50E-7||SGD DESC:Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex Gene:KGD1(YIL125W)|FD-Score:4.46|P-value:4.13E-6||SGD DESC:Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA Gene:LST4(YKL176C)|FD-Score:-4.14|P-value:1.71E-5||SGD DESC:Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface Gene:LST7(YGR057C)|FD-Score:3.85|P-value:5.96E-5||SGD DESC:Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface Gene:MNL2(YLR057W)|FD-Score:-4.08|P-value:2.29E-5||SGD DESC:Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene Gene:MNN10(YDR245W)|FD-Score:-3.3|P-value:4.91E-4||SGD DESC:Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family Gene:MRPL23(YOR150W)|FD-Score:3.36|P-value:3.93E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL37(YBR268W)|FD-Score:4.68|P-value:1.42E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRS2(YOR334W)|FD-Score:3.77|P-value:8.26E-5||SGD DESC:Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns Gene:MSF1(YPR047W)|FD-Score:3.87|P-value:5.36E-5||SGD DESC:Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase Gene:NAT3(YPR131C)|FD-Score:-3.2|P-value:6.77E-4||SGD DESC:Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met Gene:OGG1(YML060W)|FD-Score:5.24|P-value:7.82E-8||SGD DESC:Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance Gene:OMA1(YKR087C)|FD-Score:3.89|P-value:5.11E-5||SGD DESC:Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes Gene:PBA1(YLR199C)|FD-Score:-3.47|P-value:2.60E-4||SGD DESC:Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly Gene:PDH1(YPR002W)|FD-Score:4.4|P-value:5.39E-6||SGD DESC:Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Gene:PEX4(YGR133W)|FD-Score:-3.19|P-value:7.09E-4||SGD DESC:Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis Gene:PMP2(YEL017C-A)|FD-Score:3.66|P-value:1.28E-4||SGD DESC:Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication Gene:PMU1(YKL128C)|FD-Score:5.54|P-value:1.53E-8||SGD DESC:Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant Gene:PSY2(YNL201C)|FD-Score:5.02|P-value:2.56E-7||SGD DESC:Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3 Gene:PSY3(YLR376C)|FD-Score:3.49|P-value:2.43E-4||SGD DESC:Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C Gene:RQC1(YDR333C_p)|FD-Score:-3.6|P-value:1.59E-4||SGD DESC:Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC Gene:RSF1(YMR030W)|FD-Score:3.16|P-value:7.78E-4||SGD DESC:Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes Gene:SAC7(YDR389W)|FD-Score:-3.13|P-value:8.78E-4||SGD DESC:GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate Gene:SAE2(YGL175C)|FD-Score:-3.47|P-value:2.65E-4||SGD DESC:Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents Gene:SHE1(YBL031W)|FD-Score:3.31|P-value:4.71E-4||SGD DESC:Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function Gene:SHE3(YBR130C)|FD-Score:-3.55|P-value:1.90E-4||SGD DESC:Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance Gene:SLM4(YBR077C)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 Gene:SPH1(YLR313C)|FD-Score:4.92|P-value:4.38E-7||SGD DESC:Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p Gene:SSE2(YBR169C)|FD-Score:-4.05|P-value:2.53E-5||SGD DESC:Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication Gene:SUC2(YIL162W)|FD-Score:-3.25|P-value:5.81E-4||SGD DESC:Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively Gene:THI12(YNL332W)|FD-Score:3.38|P-value:3.68E-4||SGD DESC:Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 Gene:THP3(YPR045C)|FD-Score:3.18|P-value:7.33E-4||SGD DESC:Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes Gene:TOM7(YNL070W)|FD-Score:3.49|P-value:2.40E-4||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex Gene:TRP2(YER090W)|FD-Score:3.55|P-value:1.94E-4||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TUF1(YOR187W)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans Gene:YAL067W-A(YAL067W-A_p)|FD-Score:-4.18|P-value:1.46E-5||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YBL029W(YBL029W_p)|FD-Score:4.79|P-value:8.54E-7||SGD DESC:Non-essential protein of unknown function Gene:YBR056W(YBR056W_p)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:Putative glycoside hydrolase of the mitochondrial intermembrane space Gene:YBR200W-A(YBR200W-A_p)|FD-Score:-10.6|P-value:1.14E-26||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YCR102C(YCR102C_p)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family Gene:YCT1(YLL055W)|FD-Score:-3.18|P-value:7.40E-4||SGD DESC:High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene Gene:YDL073W(YDL073W_p)|FD-Score:3.45|P-value:2.78E-4||SGD DESC:Putative protein of unknown function; YDL073W is not an essential gene Gene:YDR029W(YDR029W_d)|FD-Score:-3.11|P-value:9.32E-4||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR149C(YDR149C_d)|FD-Score:-3.18|P-value:7.30E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth Gene:YDR282C(YDR282C_p)|FD-Score:-4.12|P-value:1.86E-5||SGD DESC:Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation Gene:YEN1(YER041W)|FD-Score:5.3|P-value:5.80E-8||SGD DESC:Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p Gene:YGR137W(YGR137W_d)|FD-Score:4.46|P-value:4.11E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIM2(YMR151W_d)|FD-Score:4.8|P-value:7.80E-7||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1 Gene:YIP5(YGL161C)|FD-Score:-3.31|P-value:4.60E-4||SGD DESC:Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport Gene:YIR042C(YIR042C_p)|FD-Score:4.59|P-value:2.22E-6||SGD DESC:Putative protein of unknown function; YIR042C is a non-essential gene Gene:YKL027W(YKL027W)|FD-Score:4.02|P-value:2.88E-5||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YKL069W(YKL069W)|FD-Score:3.61|P-value:1.55E-4||SGD DESC:Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress Gene:YLR257W(YLR257W_p)|FD-Score:4.99|P-value:2.98E-7||SGD DESC:Protein of unknown function; protein abundance increases in response to DNA replication stress Gene:YML037C(YML037C_p)|FD-Score:3.43|P-value:3.04E-4||SGD DESC:Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene Gene:YOL114C(YOL114C_p)|FD-Score:6.81|P-value:4.80E-12||SGD DESC:Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene Gene:ADH5(YBR145W)|FD-Score:-3.3|P-value:4.85E-4||SGD DESC:Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication Gene:AIM11(YER093C-A)|FD-Score:3.1|P-value:9.77E-4||SGD DESC:Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication Gene:AIM34(YMR003W)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss Gene:ALG12(YNR030W)|FD-Score:4.79|P-value:8.37E-7||SGD DESC:Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation Gene:APD1(YBR151W)|FD-Score:-4.05|P-value:2.56E-5||SGD DESC:Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus Gene:ARL3(YPL051W)|FD-Score:-3.47|P-value:2.56E-4||SGD DESC:GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor Gene:ATG16(YMR159C)|FD-Score:3.92|P-value:4.44E-5||SGD DESC:Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:BLM10(YFL007W)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 Gene:CAF4(YKR036C)|FD-Score:-3.44|P-value:2.88E-4||SGD DESC:WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication Gene:CAT2(YML042W)|FD-Score:3.23|P-value:6.15E-4||SGD DESC:Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes Gene:CEM1(YER061C)|FD-Score:-3.31|P-value:4.65E-4||SGD DESC:Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration Gene:CPA2(YJR109C)|FD-Score:-3.21|P-value:6.68E-4||SGD DESC:Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor Gene:DBP3(YGL078C)|FD-Score:3.37|P-value:3.71E-4||SGD DESC:RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype Gene:DNM1(YLL001W)|FD-Score:-3.2|P-value:6.86E-4||SGD DESC:Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance Gene:DSF2(YBR007C_p)|FD-Score:3.85|P-value:5.87E-5||SGD DESC:Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:ERG3(YLR056W)|FD-Score:3.93|P-value:4.24E-5||SGD DESC:C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase Gene:FRE8(YLR047C)|FD-Score:3.99|P-value:3.25E-5||SGD DESC:Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p Gene:FYV1(YDR024W_d)|FD-Score:4.4|P-value:5.48E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin Gene:GET2(YER083C)|FD-Score:-3.58|P-value:1.70E-4||SGD DESC:Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division Gene:GIP4(YAL031C)|FD-Score:3.17|P-value:7.54E-4||SGD DESC:Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate Gene:HAM1(YJR069C)|FD-Score:-3.41|P-value:3.28E-4||SGD DESC:Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimadines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine; protein abundance increases in response to DNA replication stress Gene:HEH2(YDR458C)|FD-Score:-3.98|P-value:3.41E-5||SGD DESC:Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle Gene:HNT2(YDR305C)|FD-Score:-3.35|P-value:4.05E-4||SGD DESC:Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins Gene:HPR1(YDR138W)|FD-Score:4.12|P-value:1.92E-5||SGD DESC:Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p Gene:ICL2(YPR006C)|FD-Score:3.54|P-value:2.02E-4||SGD DESC:2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol Gene:ITC1(YGL133W)|FD-Score:-4.87|P-value:5.50E-7||SGD DESC:Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex Gene:KGD1(YIL125W)|FD-Score:4.46|P-value:4.13E-6||SGD DESC:Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA Gene:LST4(YKL176C)|FD-Score:-4.14|P-value:1.71E-5||SGD DESC:Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface Gene:LST7(YGR057C)|FD-Score:3.85|P-value:5.96E-5||SGD DESC:Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface Gene:MNL2(YLR057W)|FD-Score:-4.08|P-value:2.29E-5||SGD DESC:Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene Gene:MNN10(YDR245W)|FD-Score:-3.3|P-value:4.91E-4||SGD DESC:Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family Gene:MRPL23(YOR150W)|FD-Score:3.36|P-value:3.93E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL37(YBR268W)|FD-Score:4.68|P-value:1.42E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRS2(YOR334W)|FD-Score:3.77|P-value:8.26E-5||SGD DESC:Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns Gene:MSF1(YPR047W)|FD-Score:3.87|P-value:5.36E-5||SGD DESC:Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase Gene:NAT3(YPR131C)|FD-Score:-3.2|P-value:6.77E-4||SGD DESC:Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met Gene:OGG1(YML060W)|FD-Score:5.24|P-value:7.82E-8||SGD DESC:Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance Gene:OMA1(YKR087C)|FD-Score:3.89|P-value:5.11E-5||SGD DESC:Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes Gene:PBA1(YLR199C)|FD-Score:-3.47|P-value:2.60E-4||SGD DESC:Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly Gene:PDH1(YPR002W)|FD-Score:4.4|P-value:5.39E-6||SGD DESC:Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Gene:PEX4(YGR133W)|FD-Score:-3.19|P-value:7.09E-4||SGD DESC:Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis Gene:PMP2(YEL017C-A)|FD-Score:3.66|P-value:1.28E-4||SGD DESC:Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication Gene:PMU1(YKL128C)|FD-Score:5.54|P-value:1.53E-8||SGD DESC:Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant Gene:PSY2(YNL201C)|FD-Score:5.02|P-value:2.56E-7||SGD DESC:Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3 Gene:PSY3(YLR376C)|FD-Score:3.49|P-value:2.43E-4||SGD DESC:Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C Gene:RQC1(YDR333C_p)|FD-Score:-3.6|P-value:1.59E-4||SGD DESC:Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC Gene:RSF1(YMR030W)|FD-Score:3.16|P-value:7.78E-4||SGD DESC:Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes Gene:SAC7(YDR389W)|FD-Score:-3.13|P-value:8.78E-4||SGD DESC:GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate Gene:SAE2(YGL175C)|FD-Score:-3.47|P-value:2.65E-4||SGD DESC:Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents Gene:SHE1(YBL031W)|FD-Score:3.31|P-value:4.71E-4||SGD DESC:Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function Gene:SHE3(YBR130C)|FD-Score:-3.55|P-value:1.90E-4||SGD DESC:Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance Gene:SLM4(YBR077C)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 Gene:SPH1(YLR313C)|FD-Score:4.92|P-value:4.38E-7||SGD DESC:Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p Gene:SSE2(YBR169C)|FD-Score:-4.05|P-value:2.53E-5||SGD DESC:Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication Gene:SUC2(YIL162W)|FD-Score:-3.25|P-value:5.81E-4||SGD DESC:Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively Gene:THI12(YNL332W)|FD-Score:3.38|P-value:3.68E-4||SGD DESC:Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 Gene:THP3(YPR045C)|FD-Score:3.18|P-value:7.33E-4||SGD DESC:Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes Gene:TOM7(YNL070W)|FD-Score:3.49|P-value:2.40E-4||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex Gene:TRP2(YER090W)|FD-Score:3.55|P-value:1.94E-4||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TUF1(YOR187W)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans Gene:YAL067W-A(YAL067W-A_p)|FD-Score:-4.18|P-value:1.46E-5||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YBL029W(YBL029W_p)|FD-Score:4.79|P-value:8.54E-7||SGD DESC:Non-essential protein of unknown function Gene:YBR056W(YBR056W_p)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:Putative glycoside hydrolase of the mitochondrial intermembrane space Gene:YBR200W-A(YBR200W-A_p)|FD-Score:-10.6|P-value:1.14E-26||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YCR102C(YCR102C_p)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family Gene:YCT1(YLL055W)|FD-Score:-3.18|P-value:7.40E-4||SGD DESC:High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene Gene:YDL073W(YDL073W_p)|FD-Score:3.45|P-value:2.78E-4||SGD DESC:Putative protein of unknown function; YDL073W is not an essential gene Gene:YDR029W(YDR029W_d)|FD-Score:-3.11|P-value:9.32E-4||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR149C(YDR149C_d)|FD-Score:-3.18|P-value:7.30E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth Gene:YDR282C(YDR282C_p)|FD-Score:-4.12|P-value:1.86E-5||SGD DESC:Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation Gene:YEN1(YER041W)|FD-Score:5.3|P-value:5.80E-8||SGD DESC:Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p Gene:YGR137W(YGR137W_d)|FD-Score:4.46|P-value:4.11E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIM2(YMR151W_d)|FD-Score:4.8|P-value:7.80E-7||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1 Gene:YIP5(YGL161C)|FD-Score:-3.31|P-value:4.60E-4||SGD DESC:Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport Gene:YIR042C(YIR042C_p)|FD-Score:4.59|P-value:2.22E-6||SGD DESC:Putative protein of unknown function; YIR042C is a non-essential gene Gene:YKL027W(YKL027W)|FD-Score:4.02|P-value:2.88E-5||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YKL069W(YKL069W)|FD-Score:3.61|P-value:1.55E-4||SGD DESC:Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress Gene:YLR257W(YLR257W_p)|FD-Score:4.99|P-value:2.98E-7||SGD DESC:Protein of unknown function; protein abundance increases in response to DNA replication stress Gene:YML037C(YML037C_p)|FD-Score:3.43|P-value:3.04E-4||SGD DESC:Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene Gene:YOL114C(YOL114C_p)|FD-Score:6.81|P-value:4.80E-12||SGD DESC:Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YOL034W7.261.88E-131.74SMC5Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
YLR116W5.521.69E-80.47MSL5Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA
YKR062W5.052.21E-70.54TFA2TFIIE small subunit, involved in RNA polymerase II transcription initiation
YGR119C4.513.21E-60.52NUP57FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)
YIL106W3.993.30E-50.11MOB1Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
YDR396W_d3.885.14E-50.04YDR396W_dDubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex
YJL109C3.856.02E-50.16UTP10Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance
YGR265W_d3.681.15E-40.14YGR265W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YLR147C3.542.00E-40.23SMD3Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3
YOR146W_d3.314.66E-40.03YOR146W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C
YJR057W3.285.11E-40.05CDC8Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
YNL110C3.246.02E-40.17NOP15Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
YOR098C3.060.001090.01NUP1FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153
YLR355C3.050.001130.07ILV5Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids
YDR224C2.980.001420.03HTB1Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOL114C_p6.814.80E-12YOL114C_pPutative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene
YKL128C5.541.53E-8PMU1Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YER041W5.305.80E-8YEN1Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
YML060W5.247.82E-8OGG1Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance
YNL201C5.022.56E-7PSY2Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3
YLR257W_p4.992.98E-7YLR257W_pProtein of unknown function; protein abundance increases in response to DNA replication stress
YLR313C4.924.38E-7SPH1Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p
YMR151W_d4.807.80E-7YIM2_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
YNR030W4.798.37E-7ALG12Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation
YBL029W_p4.798.54E-7YBL029W_pNon-essential protein of unknown function
YBR268W4.681.42E-6MRPL37Mitochondrial ribosomal protein of the large subunit
YIR042C_p4.592.22E-6YIR042C_pPutative protein of unknown function; YIR042C is a non-essential gene
YGR137W_d4.464.11E-6YGR137W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL125W4.464.13E-6KGD1Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YPR002W4.405.39E-6PDH1Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate

GO enrichment analysis for SGTC_1526
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0543.49E-5SGTC_1457k015-0032 57.3 μMChemDiv (Drug-like library)43026600.135135
0.0526.45E-5SGTC_23047443016 91.4 μMChembridge (Fragment library)9398540.0714286
0.0517.63E-5SGTC_10214476-0760 85.3 μMChemDiv (Drug-like library)7467680.0958904
0.0482.51E-4SGTC_32599138485 49.5 μMChembridge (Drug-like library)176461530.056338
0.0472.87E-4SGTC_14554262-0120 131.0 μMChemDiv (Drug-like library)15295870.105263plasma membrane duress
0.0473.48E-4SGTC_10114112-3381 17.4 μMChemDiv (Drug-like library)28771390.0759494
0.0463.78E-4SGTC_29789011784 43.0 μMChembridge (Drug-like library)29949340.101449
0.0446.59E-4SGTC_1528arabinosylhypoxanthine 74.6 μMTimTec (Pure natural product library)8040.08
0.0447.22E-4SGTC_29097941780 10.5 μMChembridge (Drug-like library)12432150.162162
0.0448.20E-4SGTC_12450418-0076 17.2 μMChemDiv (Drug-like library)67901140.0365854ERG2
0.0438.46E-4SGTC_31849108758 49.5 μMChembridge (Drug-like library)9028850.15873
0.0410.00160SGTC_20945332512 191.7 μMChembridge (Fragment library)7557740.147541
0.0410.00168SGTC_1025k007-0731 70.0 μMChemDiv (Drug-like library)62561180.0923077
0.0410.00185SGTC_22877945887 168.8 μMChembridge (Fragment library)12458530.163934
0.0400.00193SGTC_12941000-1494 117.0 μMChemDiv (Drug-like library)7127970.084507

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1518st03856790.8 μM0.52272777966TimTec (Pure natural product library)220.221282.31304
SGTC_25534-methylesculetin85.09 μM0.4444445319502Microsource (Natural product library)192.168121.86224
SGTC_1900st06020072.8 μM0.44688945TimTec (Natural product derivative library)204.221882.67803
SGTC_1904st06022578 μM0.4466595TimTec (Natural product derivative library)204.221882.67803
SGTC_1976st07060963.5 μM0.431034682556TimTec (Natural product derivative library)314.719844.44204
SGTC_15447-methoxy-4-methylcoumarin105 μM0.408163390807TimTec (Pure natural product library)190.19532.32903
SGTC_15666,7-dimethoxy-4-ethylcoumarin85.4 μM0.4688761TimTec (Pure natural product library)234.247862.76904
SGTC_1905st06020784.5 μM0.3818181948547TimTec (Natural product derivative library)216.232582.94603
SGTC_7844579-0127173 μM0.3818181948547ChemDiv (Drug-like library)216.232582.94603
SGTC_1815st05165558.2 μM0.3809525984156TimTec (Natural product derivative library)343.761064.31715TSC3-RPN4