Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YMR220W | 4.71 | 1.25E-6 | 0.70 | ERG8 | Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate |
YJL026W | 4.00 | 3.12E-5 | 0.05 | RNR2 | Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits |
YLR076C_d | 3.95 | 3.92E-5 | 0.01 | YLR076C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 |
YNR003C | 3.94 | 4.11E-5 | 0.27 | RPC34 | RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex |
YBL050W | 3.67 | 1.23E-4 | 0.08 | SEC17 | Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP |
YER168C | 3.58 | 1.71E-4 | 0.07 | CCA1 | ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites |
YKR062W | 3.51 | 2.21E-4 | 0.10 | TFA2 | TFIIE small subunit, involved in RNA polymerase II transcription initiation |
YLR075W | 3.42 | 3.15E-4 | 0.04 | RPL10 | Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects |
YPL143W | 3.38 | 3.67E-4 | 0.00 | RPL33A | Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication |
YMR033W | 3.37 | 3.73E-4 | 0.01 | ARP9 | Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation |
YOR336W | 3.36 | 3.86E-4 | 0.02 | KRE5 | Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects |
YBR004C | 3.35 | 4.09E-4 | 0.06 | GPI18 | Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria |
YLR105C | 3.28 | 5.15E-4 | 0.03 | SEN2 | Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease |
YBR002C | 3.25 | 5.75E-4 | 0.04 | RER2 | Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting |
YKL089W | 3.21 | 6.61E-4 | 2.51E-4 | MIF2 | Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3 |