Deletion Strain | FD score | P-value | Gene | Gene Description |
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YKL126W | 10.90 | 3.98E-28 | YPK1 | Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication |
YBR058C-A | 9.41 | 2.55E-21 | TSC3 | Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis |
YLR372W | 7.48 | 3.69E-14 | SUR4 | Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis |
YNL323W | 6.34 | 1.12E-10 | LEM3 | Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane |
YDR138W | 5.75 | 4.44E-9 | HPR1 | Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p |
YOR035C | 5.64 | 8.49E-9 | SHE4 | Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization |
YGR225W | 5.00 | 2.88E-7 | AMA1 | Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis |
YHR108W | 5.00 | 2.90E-7 | GGA2 | Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin |
YNL130C-A_p | 4.90 | 4.80E-7 | DGR1_p | Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose |
YLR371W | 4.71 | 1.26E-6 | ROM2 | GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p |
YAL040C | 4.67 | 1.51E-6 | CLN3 | G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis |
YFL025C | 4.49 | 3.63E-6 | BST1 | GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules |
YCR049C_d | 4.41 | 5.23E-6 | YCR049C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YJL067W_d | 4.36 | 6.36E-6 | YJL067W_d | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YPL006W | 4.31 | 8.30E-6 | NCR1 | Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein |