gossypol

7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde

Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 

PubChem MeSH terms: Contraceptive Agents, Male



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1553
Screen concentration 38.6 μM
Source TimTec (Pure natural product library)
PubChem CID 3503
SMILES CC1=C(C(=C2C(=C1)C(=C(C(=C2C=O)O)O)C(C)C)O)C3=C(C=C4C(=C3O)C(=C(C(=C4C(C)C)O)O)C=O)C
Standardized SMILES CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O
Molecular weight 518.5544
ALogP 6.59
H-bond donor count 6
H-bond acceptor count 8
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 5.21
% growth inhibition (Hom. pool) 4.2


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3503
Download HIP data (tab-delimited text)  (excel)
Gene:ATP16(YDL004W)|FD-Score:-4.25|P-value:1.07E-5|Clearance:0||SGD DESC:Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Gene:BET5(YML077W)|FD-Score:3.49|P-value:2.42E-4|Clearance:0.58||SGD DESC:Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi Gene:MEX67(YPL169C)|FD-Score:-4.25|P-value:1.08E-5|Clearance:0||SGD DESC:Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP Gene:PSF1(YDR013W)|FD-Score:3.53|P-value:2.09E-4|Clearance:0.58||SGD DESC:Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery Gene:RIB2(YOL066C)|FD-Score:3.88|P-value:5.25E-5|Clearance:0.58||SGD DESC:Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs Gene:RSC6(YCR052W)|FD-Score:-3.19|P-value:7.09E-4|Clearance:0||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:YOR146W(YOR146W_d)|FD-Score:3.76|P-value:8.41E-5|Clearance:0.58||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C Gene:ATP16(YDL004W)|FD-Score:-4.25|P-value:1.07E-5|Clearance:0||SGD DESC:Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Gene:BET5(YML077W)|FD-Score:3.49|P-value:2.42E-4|Clearance:0.58||SGD DESC:Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi Gene:MEX67(YPL169C)|FD-Score:-4.25|P-value:1.08E-5|Clearance:0||SGD DESC:Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP Gene:PSF1(YDR013W)|FD-Score:3.53|P-value:2.09E-4|Clearance:0.58||SGD DESC:Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery Gene:RIB2(YOL066C)|FD-Score:3.88|P-value:5.25E-5|Clearance:0.58||SGD DESC:Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs Gene:RSC6(YCR052W)|FD-Score:-3.19|P-value:7.09E-4|Clearance:0||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:YOR146W(YOR146W_d)|FD-Score:3.76|P-value:8.41E-5|Clearance:0.58||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3503
Download HOP data (tab-delimited text)  (excel)
Gene:AFT1(YGL071W)|FD-Score:4.97|P-value:3.29E-7||SGD DESC:Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:APA2(YDR530C)|FD-Score:3.19|P-value:7.02E-4||SGD DESC:Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication Gene:BRE1(YDL074C)|FD-Score:-3.21|P-value:6.57E-4||SGD DESC:E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control Gene:BUD16(YEL029C)|FD-Score:-3.21|P-value:6.59E-4||SGD DESC:Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) Gene:CCS1(YMR038C)|FD-Score:-3.35|P-value:4.10E-4||SGD DESC:Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress Gene:CMC1(YKL137W)|FD-Score:3.13|P-value:8.65E-4||SGD DESC:Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif Gene:HEM14(YER014W)|FD-Score:-4.11|P-value:1.96E-5||SGD DESC:Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides Gene:HMI1(YOL095C)|FD-Score:-3.68|P-value:1.14E-4||SGD DESC:Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD Gene:IRC25(YLR021W)|FD-Score:3.75|P-value:9.01E-5||SGD DESC:Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions Gene:ISA2(YPR067W)|FD-Score:3.68|P-value:1.18E-4||SGD DESC:Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations Gene:SHE4(YOR035C)|FD-Score:-3.25|P-value:5.78E-4||SGD DESC:Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization Gene:SHP1(YBL058W)|FD-Score:-3.51|P-value:2.26E-4||SGD DESC:UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate Gene:SIN4(YNL236W)|FD-Score:-3.14|P-value:8.47E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription Gene:SMM1(YNR015W)|FD-Score:3.22|P-value:6.36E-4||SGD DESC:Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs Gene:STP1(YDR463W)|FD-Score:-3.24|P-value:6.00E-4||SGD DESC:Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication Gene:TPN1(YGL186C)|FD-Score:-4.75|P-value:1.01E-6||SGD DESC:Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p Gene:YCR061W(YCR061W_p)|FD-Score:-3.1|P-value:9.69E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:YDR524C-B(YDR524C-B_p)|FD-Score:-3.39|P-value:3.48E-4||SGD DESC:Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication Gene:YGR169C-A(YGR169C-A_p)|FD-Score:-3.13|P-value:8.76E-4||SGD DESC:Putative protein of unknown function; YGR169C-A has a paralog, YJR005C-A, that arose from the whole genome duplication Gene:YIL163C(YIL163C_p)|FD-Score:3.87|P-value:5.35E-5||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YOL106W(YOL106W_d)|FD-Score:3.47|P-value:2.64E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR200W(YOR200W_d)|FD-Score:-3.12|P-value:9.05E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c Gene:AFT1(YGL071W)|FD-Score:4.97|P-value:3.29E-7||SGD DESC:Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:APA2(YDR530C)|FD-Score:3.19|P-value:7.02E-4||SGD DESC:Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication Gene:BRE1(YDL074C)|FD-Score:-3.21|P-value:6.57E-4||SGD DESC:E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control Gene:BUD16(YEL029C)|FD-Score:-3.21|P-value:6.59E-4||SGD DESC:Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) Gene:CCS1(YMR038C)|FD-Score:-3.35|P-value:4.10E-4||SGD DESC:Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress Gene:CMC1(YKL137W)|FD-Score:3.13|P-value:8.65E-4||SGD DESC:Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif Gene:HEM14(YER014W)|FD-Score:-4.11|P-value:1.96E-5||SGD DESC:Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides Gene:HMI1(YOL095C)|FD-Score:-3.68|P-value:1.14E-4||SGD DESC:Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD Gene:IRC25(YLR021W)|FD-Score:3.75|P-value:9.01E-5||SGD DESC:Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions Gene:ISA2(YPR067W)|FD-Score:3.68|P-value:1.18E-4||SGD DESC:Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations Gene:SHE4(YOR035C)|FD-Score:-3.25|P-value:5.78E-4||SGD DESC:Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization Gene:SHP1(YBL058W)|FD-Score:-3.51|P-value:2.26E-4||SGD DESC:UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate Gene:SIN4(YNL236W)|FD-Score:-3.14|P-value:8.47E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription Gene:SMM1(YNR015W)|FD-Score:3.22|P-value:6.36E-4||SGD DESC:Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs Gene:STP1(YDR463W)|FD-Score:-3.24|P-value:6.00E-4||SGD DESC:Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication Gene:TPN1(YGL186C)|FD-Score:-4.75|P-value:1.01E-6||SGD DESC:Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p Gene:YCR061W(YCR061W_p)|FD-Score:-3.1|P-value:9.69E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:YDR524C-B(YDR524C-B_p)|FD-Score:-3.39|P-value:3.48E-4||SGD DESC:Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication Gene:YGR169C-A(YGR169C-A_p)|FD-Score:-3.13|P-value:8.76E-4||SGD DESC:Putative protein of unknown function; YGR169C-A has a paralog, YJR005C-A, that arose from the whole genome duplication Gene:YIL163C(YIL163C_p)|FD-Score:3.87|P-value:5.35E-5||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YOL106W(YOL106W_d)|FD-Score:3.47|P-value:2.64E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR200W(YOR200W_d)|FD-Score:-3.12|P-value:9.05E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YOL066C3.885.25E-50.58RIB2Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs
YOR146W_d3.768.41E-50.58YOR146W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C
YDR013W3.532.09E-40.58PSF1Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YML077W3.492.42E-40.58BET5Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi
YOL040C2.910.001830.15RPS15Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
YEL058W2.760.002920.01PCM1Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
YFR050C2.750.003010.01PRE4Beta 7 subunit of the 20S proteasome
YBR153W2.740.003110.11RIB7Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
YER172C2.630.004299.21E-4BRR2RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
YOL139C2.630.004300.00CDC33mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth
YLL018C2.620.004350.04DPS1Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation
YFR052W2.580.004870.13RPN12Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress
YPL122C2.450.007060.01TFB2Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH
YFR051C2.440.007360.01RET2Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YOR287C2.430.007480.06RRP36Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGL071W4.973.29E-7AFT1Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
YIL163C_p3.875.35E-5YIL163C_pProtein of unknown function; mRNA identified as translated by ribosome profiling data
YLR021W3.759.01E-5IRC25Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
YPR067W3.681.18E-4ISA2Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations
YOL106W_d3.472.64E-4YOL106W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNR015W3.226.36E-4SMM1Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs
YDR530C3.197.02E-4APA2Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
YKL137W3.138.65E-4CMC1Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
YHL046C3.060.00110PAU13Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock
YHL014C3.010.00130YLF2Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL134W3.010.00132LCB3Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
YNL045W2.970.00151LAP2Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YDL124W2.960.00154YDL124WNADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress
YGR141W2.910.00183VPS62Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins
YOR015W_d2.860.00215YOR015W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

GO enrichment analysis for SGTC_1553
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1292.42E-23SGTC_1554st069299 38.7 μMTimTec (Pure natural product library)242079990.458333
0.0991.94E-14SGTC_15615-methoxyflavone 52.9 μMTimTec (Pure natural product library)945250.0806452
0.0936.31E-13SGTC_1550gossypolone 36.6 μMTimTec (Pure natural product library)54786220.444444
0.0912.64E-12SGTC_1560lithocholic acid 53.1 μMTimTec (Pure natural product library)99030.0675676
0.0856.97E-11SGTC_12600700-1617 7.8 μMChemDiv (Drug-like library)28530780.0677966calcium & mitochondrial duress
0.0741.04E-8SGTC_1555citronellol 128.0 μMTimTec (Pure natural product library)88420.1
0.0706.81E-8SGTC_14790549-0158 134.0 μMChemDiv (Drug-like library)54402020.111111
0.0707.16E-8SGTC_7161683-5115 658.0 μMChemDiv (Drug-like library)7235970.0757576
0.0691.23E-7SGTC_21986589944 200.0 μMChembridge (Fragment library)52902680.0757576
0.0681.43E-7SGTC_25787,8-dihydroxyflavone 64.4 μMMicrosource (Natural product library)18800.101695
0.0663.37E-7SGTC_1830st055982 50.3 μMTimTec (Natural product derivative library)4553130.0892857
0.0663.41E-7SGTC_1682st012968 530.0 nMTimTec (Natural product derivative library)242072700.0454545
0.0663.58E-7SGTC_1616st002734 56.1 μMTimTec (Natural product derivative library)40261010.0727273
0.0656.62E-7SGTC_1823448-4371 550.5 μMChemDiv (Drug-like library)34914030.0684932
0.0648.13E-7SGTC_24375741531 144.2 μMMiscellaneous22629900.103896

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2516gossypol71.55 μM13503TimTec (Pure natural product library)518.55446.59268
SGTC_1554st06929938.7 μM0.45833324207999TimTec (Pure natural product library)516.584885.77368
SGTC_1550gossypolone36.6 μM0.4444445478622TimTec (Pure natural product library)546.521444.956410
SGTC_1558st06930045.6 μM0.30612224208000TimTec (Pure natural product library)438.51284.44746
SGTC_2506ethyl hematommate54.16 μM0.2884623940691Microsource (Natural product library)224.209981.79525RPP1 & pyrimidine depletion
SGTC_3561634-001232.5 μM0.244898735457ChemDiv (Drug-like library)251.076083.00412
SGTC_2644guaiazulene100 μM0.2272733515Microsource (Natural product library)198.303424.90500
SGTC_2718lomofungin53.02 μM0.203395351222Miscellaneous314.24970.47238mitochondrial processes
SGTC_6304356-0227183 μM0.189655779312ChemDiv (Drug-like library)234.247862.61814
SGTC_22597964009200 μM0.188679313134Chembridge (Fragment library)216.232582.7513superoxide