Deletion Strain | FD score | P-value | Gene | Gene Description |
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YNL146C-A_p | 6.04 | 7.92E-10 | YNL146C-A_p | Putative protein of unknown function |
YGR290W_d | 5.70 | 6.00E-9 | YGR290W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter) |
YOR381W | 5.60 | 1.10E-8 | FRE3 | Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels |
YOR014W | 5.47 | 2.31E-8 | RTS1 | B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A |
YNL196C_p | 5.40 | 3.35E-8 | SLZ1_p | Sporulation-specific protein with a leucine zipper motif |
YNL266W_d | 4.74 | 1.05E-6 | YNL266W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C |
YLR035C | 4.22 | 1.22E-5 | MLH2 | Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p |
YHR116W | 4.21 | 1.26E-5 | COX23 | Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs |
YPL270W | 4.18 | 1.44E-5 | MDL2 | Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis |
YIL025C_d | 3.90 | 4.81E-5 | YIL025C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YDR369C | 3.88 | 5.16E-5 | XRS2 | Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling |
YNL072W | 3.65 | 1.29E-4 | RNH201 | Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome |
YHR080C | 3.63 | 1.40E-4 | YHR080C | Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication |
YBR095C | 3.55 | 1.92E-4 | RXT2 | Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth |
YMR052C-A_d | 3.53 | 2.04E-4 | YMR052C-A_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |