Deletion Strain | FD score | P-value | Gene | Gene Description |
---|
YDR306C_p | 9.06 | 6.60E-20 | YDR306C_p | F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain |
YDR315C | 5.78 | 3.68E-9 | IPK1 | Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable |
YDR277C | 5.26 | 7.14E-8 | MTH1 | Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation |
YDL072C | 4.90 | 4.70E-7 | YET3 | Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress |
YKL030W_d | 4.83 | 6.87E-7 | YKL030W_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1 |
YGL203C | 4.74 | 1.08E-6 | KEX1 | Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins |
YDR068W | 4.54 | 2.86E-6 | DOS2 | Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
YDL019C | 4.49 | 3.54E-6 | OSH2 | Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability |
YLR441C | 4.49 | 3.58E-6 | RPS1A | Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication |
YGR058W | 4.25 | 1.08E-5 | PEF1 | Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly |
YGR201C_p | 4.07 | 2.32E-5 | YGR201C_p | Putative protein of unknown function |
YGL118C_d | 4.06 | 2.49E-5 | YGL118C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YGL017W | 4.05 | 2.52E-5 | ATE1 | Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway |
YBR024W | 4.05 | 2.54E-5 | SCO2 | Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication |
YOL061W | 4.04 | 2.71E-5 | PRS5 | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress |