| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YLR453C | 6.51 | 3.67E-11 | RIF2 | Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation |
| YHR167W | 5.99 | 1.06E-9 | THP2 | Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance |
| YOR044W | 5.44 | 2.59E-8 | IRC23 | Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication |
| YGL078C | 5.25 | 7.58E-8 | DBP3 | RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype |
| YCR086W | 5.17 | 1.18E-7 | CSM1 | Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation |
| YOL062C | 5.16 | 1.24E-7 | APM4 | Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport |
| YJR040W | 4.56 | 2.56E-6 | GEF1 | Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism |
| YHR210C_p | 4.38 | 6.01E-6 | YHR210C_p | Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions |
| YPL101W | 4.25 | 1.07E-5 | ELP4 | Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity |
| YJL071W | 4.07 | 2.40E-5 | ARG2 | Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p |
| YHR142W | 4.05 | 2.62E-5 | CHS7 | Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress |
| YNL072W | 4.02 | 2.87E-5 | RNH201 | Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome |
| YJL055W_p | 4.00 | 3.14E-5 | YJL055W_p | Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU |
| YLR019W | 3.97 | 3.56E-5 | PSR2 | Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p |
| YLR183C | 3.81 | 6.99E-5 | TOS4 | Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication |
