chlormadinone acetate FDA approved compound

[(8R,9S,10R,13S,14S,17R)-17-acetyl-17-acetyloxy-6-chloro-10,13-dimethyl-1,2,3,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-yl] acetate

A steroidal progestin.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1579
Screen concentration 49.4 μM
Source Miscellaneous
PubChem CID 45114258
SMILES CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(CCC34C)OC(=O)C)Cl)C)OC(=O)C
Standardized SMILES CC(=O)OC1CCC2(C)C3CCC4(C)C(CCC4(OC(=O)C)C(=O)C)C3C=C(Cl)C2=C1
Molecular weight 448.9795
ALogP 3.71
H-bond donor count 0
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 4.02
% growth inhibition (Hom. pool) 1.56


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 45114258
Download HIP data (tab-delimited text)  (excel)
Gene:CAB1(YDR531W)|FD-Score:3.88|P-value:5.21E-5|Clearance:0.24||SGD DESC:Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element Gene:FAL1(YDR021W)|FD-Score:3.14|P-value:8.39E-4|Clearance:0.03||SGD DESC:Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases Gene:GCR1(YPL075W)|FD-Score:-3.26|P-value:5.64E-4|Clearance:0||SGD DESC:Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p Gene:IMP3(YHR148W)|FD-Score:-3.09|P-value:9.87E-4|Clearance:0||SGD DESC:Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA Gene:NOP58(YOR310C)|FD-Score:6.29|P-value:1.62E-10|Clearance:1.39||SGD DESC:Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA Gene:POP3(YNL282W)|FD-Score:3.12|P-value:9.20E-4|Clearance:0.16||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:PRP31(YGR091W)|FD-Score:3.64|P-value:1.38E-4|Clearance:0.14||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RPP1(YHR062C)|FD-Score:3.5|P-value:2.34E-4|Clearance:0.13||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:RSC58(YLR033W)|FD-Score:3.36|P-value:3.84E-4|Clearance:0.11||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:RSC9(YML127W)|FD-Score:7.73|P-value:5.37E-15|Clearance:1.44||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:SPB4(YFL002C)|FD-Score:3.26|P-value:5.64E-4|Clearance:0.11||SGD DESC:Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients Gene:TIF6(YPR016C)|FD-Score:-3.51|P-value:2.21E-4|Clearance:0||SGD DESC:Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits Gene:TOP2(YNL088W)|FD-Score:4.39|P-value:5.68E-6|Clearance:0.13||SGD DESC:Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation Gene:TRS20(YBR254C)|FD-Score:4.26|P-value:1.04E-5|Clearance:0.38||SGD DESC:One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder Gene:TSC10(YBR265W)|FD-Score:-3.87|P-value:5.50E-5|Clearance:0||SGD DESC:3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family Gene:UFE1(YOR075W)|FD-Score:4.89|P-value:4.96E-7|Clearance:0.5||SGD DESC:t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER Gene:CAB1(YDR531W)|FD-Score:3.88|P-value:5.21E-5|Clearance:0.24||SGD DESC:Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element Gene:FAL1(YDR021W)|FD-Score:3.14|P-value:8.39E-4|Clearance:0.03||SGD DESC:Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases Gene:GCR1(YPL075W)|FD-Score:-3.26|P-value:5.64E-4|Clearance:0||SGD DESC:Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p Gene:IMP3(YHR148W)|FD-Score:-3.09|P-value:9.87E-4|Clearance:0||SGD DESC:Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA Gene:NOP58(YOR310C)|FD-Score:6.29|P-value:1.62E-10|Clearance:1.39||SGD DESC:Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA Gene:POP3(YNL282W)|FD-Score:3.12|P-value:9.20E-4|Clearance:0.16||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:PRP31(YGR091W)|FD-Score:3.64|P-value:1.38E-4|Clearance:0.14||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RPP1(YHR062C)|FD-Score:3.5|P-value:2.34E-4|Clearance:0.13||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:RSC58(YLR033W)|FD-Score:3.36|P-value:3.84E-4|Clearance:0.11||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:RSC9(YML127W)|FD-Score:7.73|P-value:5.37E-15|Clearance:1.44||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:SPB4(YFL002C)|FD-Score:3.26|P-value:5.64E-4|Clearance:0.11||SGD DESC:Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients Gene:TIF6(YPR016C)|FD-Score:-3.51|P-value:2.21E-4|Clearance:0||SGD DESC:Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits Gene:TOP2(YNL088W)|FD-Score:4.39|P-value:5.68E-6|Clearance:0.13||SGD DESC:Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation Gene:TRS20(YBR254C)|FD-Score:4.26|P-value:1.04E-5|Clearance:0.38||SGD DESC:One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder Gene:TSC10(YBR265W)|FD-Score:-3.87|P-value:5.50E-5|Clearance:0||SGD DESC:3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family Gene:UFE1(YOR075W)|FD-Score:4.89|P-value:4.96E-7|Clearance:0.5||SGD DESC:t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 45114258
Download HOP data (tab-delimited text)  (excel)
Gene:ADR1(YDR216W)|FD-Score:4.06|P-value:2.41E-5||SGD DESC:Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization Gene:ATG16(YMR159C)|FD-Score:3.37|P-value:3.76E-4||SGD DESC:Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:AVT1(YJR001W)|FD-Score:3.34|P-value:4.14E-4||SGD DESC:Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BRE5(YNR051C)|FD-Score:4.52|P-value:3.10E-6||SGD DESC:Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A Gene:CHA4(YLR098C)|FD-Score:3.75|P-value:8.69E-5||SGD DESC:DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain Gene:CIT1(YNR001C)|FD-Score:3.28|P-value:5.19E-4||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication Gene:CSM2(YIL132C)|FD-Score:3.17|P-value:7.73E-4||SGD DESC:Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis Gene:CSR2(YPR030W)|FD-Score:-3.27|P-value:5.33E-4||SGD DESC:Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication Gene:DMA2(YNL116W)|FD-Score:-3.68|P-value:1.18E-4||SGD DESC:Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains Gene:ECL1(YGR146C)|FD-Score:3.15|P-value:8.09E-4||SGD DESC:Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:ELG1(YOR144C)|FD-Score:3.53|P-value:2.11E-4||SGD DESC:Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication Gene:FCY1(YPR062W)|FD-Score:3.81|P-value:6.99E-5||SGD DESC:Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) Gene:FIS1(YIL065C)|FD-Score:3.47|P-value:2.63E-4||SGD DESC:Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation Gene:GAS5(YOL030W)|FD-Score:3.37|P-value:3.70E-4||SGD DESC:1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall Gene:GID8(YMR135C)|FD-Score:3.34|P-value:4.20E-4||SGD DESC:Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START Gene:IES2(YNL215W)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress Gene:ILM1(YJR118C)|FD-Score:5.78|P-value:3.71E-9||SGD DESC:Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth Gene:ISA2(YPR067W)|FD-Score:-3.34|P-value:4.12E-4||SGD DESC:Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations Gene:MHP1(YJL042W)|FD-Score:3.82|P-value:6.67E-5||SGD DESC:Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins Gene:MPA43(YNL249C)|FD-Score:3.38|P-value:3.57E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:MRS4(YKR052C)|FD-Score:3.33|P-value:4.27E-4||SGD DESC:Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication Gene:PIN3(YPR154W)|FD-Score:4.63|P-value:1.82E-6||SGD DESC:Protein that induces appearance of [PIN+] prion when overproduced Gene:PMT2(YAL023C)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication Gene:PUF4(YGL014W)|FD-Score:5.25|P-value:7.58E-8||SGD DESC:Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors Gene:SAY1(YGR263C)|FD-Score:-3.99|P-value:3.24E-5||SGD DESC:Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum Gene:THP2(YHR167W)|FD-Score:3.41|P-value:3.26E-4||SGD DESC:Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance Gene:UPC2(YDR213W)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication Gene:VPS68(YOL129W)|FD-Score:3.44|P-value:2.90E-4||SGD DESC:Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria Gene:YAP3(YHL009C)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Basic leucine zipper (bZIP) transcription factor Gene:YBL055C(YBL055C)|FD-Score:3.72|P-value:9.98E-5||SGD DESC:3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases Gene:YBR200W-A(YBR200W-A_p)|FD-Score:3.34|P-value:4.23E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBR206W(YBR206W_d)|FD-Score:3.28|P-value:5.16E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3 Gene:YDR015C(YDR015C_d)|FD-Score:3.35|P-value:4.09E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A Gene:YDR124W(YDR124W_p)|FD-Score:4.37|P-value:6.10E-6||SGD DESC:Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor Gene:YGR127W(YGR127W_p)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response Gene:YKL136W(YKL136W_d)|FD-Score:-3.77|P-value:8.08E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C Gene:YMR181C(YMR181C_p)|FD-Score:3.2|P-value:6.88E-4||SGD DESC:Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication Gene:YMR196W(YMR196W_p)|FD-Score:3.47|P-value:2.64E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene Gene:YOL079W(YOL079W_d)|FD-Score:4.43|P-value:4.64E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPL034W(YPL034W_p)|FD-Score:-3.16|P-value:7.88E-4||SGD DESC:Putative protein of unknown function; YPL034W is not essential gene Gene:YPR022C(YPR022C_p)|FD-Score:-3.13|P-value:8.63E-4||SGD DESC:Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS Gene:YPR077C(YPR077C_d)|FD-Score:3.73|P-value:9.52E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1 Gene:ADR1(YDR216W)|FD-Score:4.06|P-value:2.41E-5||SGD DESC:Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization Gene:ATG16(YMR159C)|FD-Score:3.37|P-value:3.76E-4||SGD DESC:Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:AVT1(YJR001W)|FD-Score:3.34|P-value:4.14E-4||SGD DESC:Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BRE5(YNR051C)|FD-Score:4.52|P-value:3.10E-6||SGD DESC:Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A Gene:CHA4(YLR098C)|FD-Score:3.75|P-value:8.69E-5||SGD DESC:DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain Gene:CIT1(YNR001C)|FD-Score:3.28|P-value:5.19E-4||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication Gene:CSM2(YIL132C)|FD-Score:3.17|P-value:7.73E-4||SGD DESC:Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis Gene:CSR2(YPR030W)|FD-Score:-3.27|P-value:5.33E-4||SGD DESC:Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication Gene:DMA2(YNL116W)|FD-Score:-3.68|P-value:1.18E-4||SGD DESC:Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains Gene:ECL1(YGR146C)|FD-Score:3.15|P-value:8.09E-4||SGD DESC:Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:ELG1(YOR144C)|FD-Score:3.53|P-value:2.11E-4||SGD DESC:Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication Gene:FCY1(YPR062W)|FD-Score:3.81|P-value:6.99E-5||SGD DESC:Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) Gene:FIS1(YIL065C)|FD-Score:3.47|P-value:2.63E-4||SGD DESC:Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation Gene:GAS5(YOL030W)|FD-Score:3.37|P-value:3.70E-4||SGD DESC:1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall Gene:GID8(YMR135C)|FD-Score:3.34|P-value:4.20E-4||SGD DESC:Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START Gene:IES2(YNL215W)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress Gene:ILM1(YJR118C)|FD-Score:5.78|P-value:3.71E-9||SGD DESC:Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth Gene:ISA2(YPR067W)|FD-Score:-3.34|P-value:4.12E-4||SGD DESC:Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations Gene:MHP1(YJL042W)|FD-Score:3.82|P-value:6.67E-5||SGD DESC:Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins Gene:MPA43(YNL249C)|FD-Score:3.38|P-value:3.57E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:MRS4(YKR052C)|FD-Score:3.33|P-value:4.27E-4||SGD DESC:Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication Gene:PIN3(YPR154W)|FD-Score:4.63|P-value:1.82E-6||SGD DESC:Protein that induces appearance of [PIN+] prion when overproduced Gene:PMT2(YAL023C)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication Gene:PUF4(YGL014W)|FD-Score:5.25|P-value:7.58E-8||SGD DESC:Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors Gene:SAY1(YGR263C)|FD-Score:-3.99|P-value:3.24E-5||SGD DESC:Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum Gene:THP2(YHR167W)|FD-Score:3.41|P-value:3.26E-4||SGD DESC:Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance Gene:UPC2(YDR213W)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication Gene:VPS68(YOL129W)|FD-Score:3.44|P-value:2.90E-4||SGD DESC:Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria Gene:YAP3(YHL009C)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Basic leucine zipper (bZIP) transcription factor Gene:YBL055C(YBL055C)|FD-Score:3.72|P-value:9.98E-5||SGD DESC:3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases Gene:YBR200W-A(YBR200W-A_p)|FD-Score:3.34|P-value:4.23E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBR206W(YBR206W_d)|FD-Score:3.28|P-value:5.16E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3 Gene:YDR015C(YDR015C_d)|FD-Score:3.35|P-value:4.09E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A Gene:YDR124W(YDR124W_p)|FD-Score:4.37|P-value:6.10E-6||SGD DESC:Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor Gene:YGR127W(YGR127W_p)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response Gene:YKL136W(YKL136W_d)|FD-Score:-3.77|P-value:8.08E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C Gene:YMR181C(YMR181C_p)|FD-Score:3.2|P-value:6.88E-4||SGD DESC:Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication Gene:YMR196W(YMR196W_p)|FD-Score:3.47|P-value:2.64E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene Gene:YOL079W(YOL079W_d)|FD-Score:4.43|P-value:4.64E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPL034W(YPL034W_p)|FD-Score:-3.16|P-value:7.88E-4||SGD DESC:Putative protein of unknown function; YPL034W is not essential gene Gene:YPR022C(YPR022C_p)|FD-Score:-3.13|P-value:8.63E-4||SGD DESC:Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS Gene:YPR077C(YPR077C_d)|FD-Score:3.73|P-value:9.52E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YML127W7.735.37E-151.44RSC9Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YOR310C6.291.62E-101.39NOP58Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
YOR075W4.894.96E-70.50UFE1t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER
YNL088W4.395.68E-60.13TOP2Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation
YBR254C4.261.04E-50.38TRS20One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder
YDR531W3.885.21E-50.24CAB1Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element
YGR091W3.641.38E-40.14PRP31Splicing factor, component of the U4/U6-U5 snRNP complex
YHR062C3.502.34E-40.13RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YLR033W3.363.84E-40.11RSC58Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
YFL002C3.265.64E-40.12SPB4Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
YDR021W3.148.39E-40.03FAL1Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
YNL282W3.129.20E-40.16POP3Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YBR202W2.950.001580.03MCM7Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex
YJL081C2.920.001760.02ARP4Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
YPR165W2.900.001850.03RHO1GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YJR118C5.783.71E-9ILM1Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth
YGL014W5.257.58E-8PUF4Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors
YPR154W4.631.82E-6PIN3Protein that induces appearance of [PIN+] prion when overproduced
YNR051C4.523.10E-6BRE5Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
YOL079W_d4.434.64E-6YOL079W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR124W_p4.376.10E-6YDR124W_pPutative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
YDR213W4.241.11E-5UPC2Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
YDR216W4.062.41E-5ADR1Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YJL042W3.826.67E-5MHP1Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
YPR062W3.816.99E-5FCY1Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
YLR098C3.758.69E-5CHA4DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain
YPR077C_d3.739.52E-5YPR077C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1
YBL055C3.729.98E-5YBL055C3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases
YNL215W3.681.16E-4IES2Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
YAL023C3.681.17E-4PMT2Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication

GO enrichment analysis for SGTC_1579
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1286.01E-23SGTC_2534helenine 20.1 μMMicrosource (Natural product library)727240.141026RSC complex & mRNA processing
0.1189.29E-20SGTC_21866124449 200.0 μMChembridge (Fragment library)38341820.0595238RSC complex & mRNA processing
0.1171.91E-19SGTC_2525harmine 47.9 μMMiscellaneous52809530.0506329ergosterol biosynthesis
0.1158.32E-19SGTC_643k048-0106 28.4 μMChemDiv (Drug-like library)67639200.0714286RSC & ERG11
0.1087.91E-17SGTC_1651st011928 86.1 μMTimTec (Natural product derivative library)7201980.0493827RSC complex & mRNA processing
0.1063.10E-16SGTC_21095483026 200.0 μMChembridge (Fragment library)7593350.0704225RSC complex & mRNA processing
0.1041.12E-15SGTC_22297354935 190.0 μMChembridge (Fragment library)3181120.0384615RSC complex & mRNA processing
0.1018.99E-15SGTC_322k048-0136 19.3 μMChemDiv (Drug-like library)68232820.0555556RSC & ERG11
0.0921.06E-12SGTC_23469031566 143.8 μMChembridge (Fragment library)47710860.0571429Golgi
0.0921.40E-12SGTC_1652st011932 78.0 μMTimTec (Natural product derivative library)15510760.0963855RSC complex & mRNA processing
0.0904.19E-12SGTC_9282764-0428 58.7 μMChemDiv (Drug-like library)6625780.0595238cell wall
0.0872.26E-11SGTC_15846-fluoro-dl-tryptophan 90.0 μMTimTec (Pure natural product library)949370.0609756mitochondrial processes
0.0855.85E-11SGTC_12290139-0193 12.2 μMChemDiv (Drug-like library)30907520.0441176RSC complex & mRNA processing
0.0856.51E-11SGTC_2746daunorubicin 9.9 μMMiscellaneous303230.11215anthracycline transcription coupled DNA repair
0.0857.74E-11SGTC_10503232-1156 69.3 μMChemDiv (Drug-like library)7005290.0921053RSC complex & mRNA processing

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1575cyproterone acetate48 μM0.593759880Miscellaneous416.937663.31404
SGTC_387norethindrone acetate66.7 μM0.265823541197Miscellaneous340.455924.69403
SGTC_1757st04162031.84 μM0.2531655289815TimTec (Natural product derivative library)329.476342.42223
SGTC_1609st00157446.4 μM0.2470593960012TimTec (Natural product derivative library)430.576923.5615
SGTC_1715st03216010.23 μM0.2469145289825TimTec (Natural product derivative library)371.513022.21813
SGTC_1586deoxycorticosterone acetate53.7 μM0.2195125952TimTec (Pure natural product library)372.497783.56704
SGTC_26373-alpha-acetoxydihydrodeoxygedunin100 μM0.2087916708514Microsource (Natural product library)512.63444.51907
SGTC_2653dihydrofissinolide100 μM0.196857746Microsource (Natural product library)514.607223.40808
SGTC_2650prasterone100 μM0.18918916759247Microsource (Natural product library)288.424423.33812
SGTC_2758dehydroepiandrosterone69.35 μM0.1891895881Miscellaneous288.424423.33812