Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YOR254C | 19.00 | 8.98E-81 | 4.87 | SEC63 | Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER |
YPR107C | 16.70 | 3.77E-63 | 4.87 | YTH1 | Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation |
YGL093W | 11.90 | 9.58E-33 | 0.53 | SPC105 | Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components |
YLR378C | 11.30 | 4.91E-30 | 1.32 | SEC61 | Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER |
YER012W | 10.00 | 6.86E-24 | 0.71 | PRE1 | Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle |
YDR086C | 9.30 | 6.86E-21 | 1.23 | SSS1 | Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p |
YFR037C | 8.07 | 3.42E-16 | 0.99 | RSC8 | Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters |
YJL072C | 7.09 | 6.83E-13 | 0.12 | PSF2 | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery |
YPR034W | 6.97 | 1.56E-12 | 0.22 | ARP7 | Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation |
YFR050C | 6.76 | 7.14E-12 | 0.04 | PRE4 | Beta 7 subunit of the 20S proteasome |
YJL074C | 6.72 | 9.11E-12 | 0.08 | SMC3 | Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member |
YMR268C | 6.64 | 1.62E-11 | 0.27 | PRP24 | Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling |
YLR153C | 6.37 | 9.40E-11 | 0.30 | ACS2 | Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions |
YLR355C | 6.07 | 6.49E-10 | 0.47 | ILV5 | Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids |
YML092C | 5.59 | 1.11E-8 | 0.07 | PRE8 | Alpha 2 subunit of the 20S proteasome |