3',3',6'-trihydroxyflavone

3,6-dihydroxy-2-(3-hydroxyphenyl)chromen-4-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1582
Screen concentration 74.0 μM
Source TimTec (Pure natural product library)
PubChem CID 688803
SMILES C1=CC(=CC(=C1)O)C2=C(C(=O)C3=C(O2)C=CC(=C3)O)O
Standardized SMILES OC1=C(Oc2ccc(O)cc2C1=O)c3cccc(O)c3
Molecular weight 270.2369
ALogP 2.11
H-bond donor count 3
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 18.25
% growth inhibition (Hom. pool) 2.54


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 688803
Download HIP data (tab-delimited text)  (excel)
Gene:BBP1(YPL255W)|FD-Score:3.62|P-value:1.45E-4|Clearance:0.03||SGD DESC:Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p Gene:COG3(YER157W)|FD-Score:-3.8|P-value:7.24E-5|Clearance:0||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:KRI1(YNL308C)|FD-Score:3.34|P-value:4.12E-4|Clearance:0.02||SGD DESC:Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p Gene:NOG2(YNR053C)|FD-Score:4.88|P-value:5.22E-7|Clearance:0.26||SGD DESC:Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation Gene:NOP15(YNL110C)|FD-Score:3.8|P-value:7.30E-5|Clearance:0.17||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm Gene:NUP145(YGL092W)|FD-Score:3.59|P-value:1.65E-4|Clearance:0.25||SGD DESC:Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98 Gene:NUP49(YGL172W)|FD-Score:6.74|P-value:7.78E-12|Clearance:1.86||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) Gene:PKC1(YBL105C)|FD-Score:3.14|P-value:8.51E-4|Clearance:0.04||SGD DESC:Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) Gene:POL1(YNL102W)|FD-Score:-3.2|P-value:6.76E-4|Clearance:0||SGD DESC:Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis Gene:PRP45(YAL032C)|FD-Score:3.32|P-value:4.46E-4|Clearance:0.04||SGD DESC:Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene Gene:RLP24(YLR009W)|FD-Score:3.17|P-value:7.52E-4|Clearance:0.04||SGD DESC:Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp Gene:RPB3(YIL021W)|FD-Score:3.2|P-value:6.92E-4|Clearance:0.02||SGD DESC:RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit Gene:RPC82(YPR190C)|FD-Score:3.1|P-value:9.69E-4|Clearance:0.01||SGD DESC:RNA polymerase III subunit C82 Gene:RRP9(YPR137W)|FD-Score:3.28|P-value:5.20E-4|Clearance:0.08||SGD DESC:Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein Gene:RSC6(YCR052W)|FD-Score:4.62|P-value:1.88E-6|Clearance:0.12||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:STH1(YIL126W)|FD-Score:4.5|P-value:3.37E-6|Clearance:0.7||SGD DESC:ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p Gene:UGP1(YKL035W)|FD-Score:-3.71|P-value:1.02E-4|Clearance:0||SGD DESC:UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication Gene:YGR114C(YGR114C_d)|FD-Score:3.09|P-value:9.91E-4|Clearance:0.04||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6 Gene:BBP1(YPL255W)|FD-Score:3.62|P-value:1.45E-4|Clearance:0.03||SGD DESC:Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p Gene:COG3(YER157W)|FD-Score:-3.8|P-value:7.24E-5|Clearance:0||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:KRI1(YNL308C)|FD-Score:3.34|P-value:4.12E-4|Clearance:0.02||SGD DESC:Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p Gene:NOG2(YNR053C)|FD-Score:4.88|P-value:5.22E-7|Clearance:0.26||SGD DESC:Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation Gene:NOP15(YNL110C)|FD-Score:3.8|P-value:7.30E-5|Clearance:0.17||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm Gene:NUP145(YGL092W)|FD-Score:3.59|P-value:1.65E-4|Clearance:0.25||SGD DESC:Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98 Gene:NUP49(YGL172W)|FD-Score:6.74|P-value:7.78E-12|Clearance:1.86||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) Gene:PKC1(YBL105C)|FD-Score:3.14|P-value:8.51E-4|Clearance:0.04||SGD DESC:Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) Gene:POL1(YNL102W)|FD-Score:-3.2|P-value:6.76E-4|Clearance:0||SGD DESC:Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis Gene:PRP45(YAL032C)|FD-Score:3.32|P-value:4.46E-4|Clearance:0.04||SGD DESC:Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene Gene:RLP24(YLR009W)|FD-Score:3.17|P-value:7.52E-4|Clearance:0.04||SGD DESC:Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp Gene:RPB3(YIL021W)|FD-Score:3.2|P-value:6.92E-4|Clearance:0.02||SGD DESC:RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit Gene:RPC82(YPR190C)|FD-Score:3.1|P-value:9.69E-4|Clearance:0.01||SGD DESC:RNA polymerase III subunit C82 Gene:RRP9(YPR137W)|FD-Score:3.28|P-value:5.20E-4|Clearance:0.08||SGD DESC:Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein Gene:RSC6(YCR052W)|FD-Score:4.62|P-value:1.88E-6|Clearance:0.12||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:STH1(YIL126W)|FD-Score:4.5|P-value:3.37E-6|Clearance:0.7||SGD DESC:ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p Gene:UGP1(YKL035W)|FD-Score:-3.71|P-value:1.02E-4|Clearance:0||SGD DESC:UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication Gene:YGR114C(YGR114C_d)|FD-Score:3.09|P-value:9.91E-4|Clearance:0.04||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 688803
Download HOP data (tab-delimited text)  (excel)
Gene:AKL1(YBR059C)|FD-Score:6.65|P-value:1.43E-11||SGD DESC:Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization Gene:ALG6(YOR002W)|FD-Score:3.18|P-value:7.28E-4||SGD DESC:Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease Gene:ATG29(YPL166W)|FD-Score:-4.95|P-value:3.79E-7||SGD DESC:Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:AVT6(YER119C)|FD-Score:-3.12|P-value:9.05E-4||SGD DESC:Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication Gene:BIK1(YCL029C)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 Gene:DDI3(YNL335W_p)|FD-Score:-3.23|P-value:6.14E-4||SGD DESC:Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants Gene:FMP37(YGL080W)|FD-Score:4.59|P-value:2.18E-6||SGD DESC:Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia Gene:GAL3(YDR009W)|FD-Score:-3.91|P-value:4.54E-5||SGD DESC:Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication Gene:GYP6(YJL044C)|FD-Score:3.16|P-value:7.93E-4||SGD DESC:GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport Gene:HIS5(YIL116W)|FD-Score:4.56|P-value:2.54E-6||SGD DESC:Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts Gene:HRT3(YLR097C)|FD-Score:-4.1|P-value:2.05E-5||SGD DESC:Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies Gene:IMA5(YJL216C)|FD-Score:3.1|P-value:9.58E-4||SGD DESC:Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose Gene:IMG2(YCR071C)|FD-Score:3.31|P-value:4.74E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MAG2(YLR427W)|FD-Score:4.55|P-value:2.62E-6||SGD DESC:Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1 Gene:NSR1(YGR159C)|FD-Score:3.61|P-value:1.56E-4||SGD DESC:Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis Gene:NTG1(YAL015C)|FD-Score:-3.57|P-value:1.80E-4||SGD DESC:DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication Gene:PBA1(YLR199C)|FD-Score:-3.43|P-value:3.03E-4||SGD DESC:Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly Gene:PDA1(YER178W)|FD-Score:6.06|P-value:6.83E-10||SGD DESC:E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose Gene:POR2(YIL114C)|FD-Score:-3.3|P-value:4.87E-4||SGD DESC:Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication Gene:RIF2(YLR453C)|FD-Score:5.86|P-value:2.35E-9||SGD DESC:Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation Gene:RPL4A(YBR031W)|FD-Score:3.23|P-value:6.22E-4||SGD DESC:Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication Gene:RSM28(YDR494W)|FD-Score:4.21|P-value:1.26E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation Gene:SNQ2(YDR011W)|FD-Score:-3.25|P-value:5.87E-4||SGD DESC:Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species Gene:THP2(YHR167W)|FD-Score:5.83|P-value:2.79E-9||SGD DESC:Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance Gene:THP3(YPR045C)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes Gene:TOS4(YLR183C)|FD-Score:3.56|P-value:1.82E-4||SGD DESC:Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication Gene:UPC2(YDR213W)|FD-Score:-3.33|P-value:4.29E-4||SGD DESC:Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication Gene:YBP1(YBR216C)|FD-Score:-3.25|P-value:5.76E-4||SGD DESC:Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication Gene:YDL199C(YDL199C_p)|FD-Score:-3.54|P-value:1.96E-4||SGD DESC:Putative transporter, member of the sugar porter family Gene:YGL041C(YGL041C_d)|FD-Score:4.06|P-value:2.48E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIL166C(YIL166C_p)|FD-Score:3.16|P-value:7.76E-4||SGD DESC:Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene Gene:YLR184W(YLR184W_d)|FD-Score:3.33|P-value:4.38E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR202C(YLR202C_d)|FD-Score:3.1|P-value:9.55E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron Gene:YLR428C(YLR428C_d)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 Gene:YML089C(YML089C_d)|FD-Score:-4.03|P-value:2.74E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage Gene:YNL193W(YNL193W_p)|FD-Score:-3.24|P-value:6.03E-4||SGD DESC:Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis Gene:YPL225W(YPL225W)|FD-Score:-3.97|P-value:3.54E-5||SGD DESC:Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:ZEO1(YOL109W)|FD-Score:3.83|P-value:6.33E-5||SGD DESC:Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria Gene:AKL1(YBR059C)|FD-Score:6.65|P-value:1.43E-11||SGD DESC:Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization Gene:ALG6(YOR002W)|FD-Score:3.18|P-value:7.28E-4||SGD DESC:Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease Gene:ATG29(YPL166W)|FD-Score:-4.95|P-value:3.79E-7||SGD DESC:Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:AVT6(YER119C)|FD-Score:-3.12|P-value:9.05E-4||SGD DESC:Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication Gene:BIK1(YCL029C)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 Gene:DDI3(YNL335W_p)|FD-Score:-3.23|P-value:6.14E-4||SGD DESC:Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants Gene:FMP37(YGL080W)|FD-Score:4.59|P-value:2.18E-6||SGD DESC:Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia Gene:GAL3(YDR009W)|FD-Score:-3.91|P-value:4.54E-5||SGD DESC:Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication Gene:GYP6(YJL044C)|FD-Score:3.16|P-value:7.93E-4||SGD DESC:GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport Gene:HIS5(YIL116W)|FD-Score:4.56|P-value:2.54E-6||SGD DESC:Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts Gene:HRT3(YLR097C)|FD-Score:-4.1|P-value:2.05E-5||SGD DESC:Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies Gene:IMA5(YJL216C)|FD-Score:3.1|P-value:9.58E-4||SGD DESC:Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose Gene:IMG2(YCR071C)|FD-Score:3.31|P-value:4.74E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MAG2(YLR427W)|FD-Score:4.55|P-value:2.62E-6||SGD DESC:Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1 Gene:NSR1(YGR159C)|FD-Score:3.61|P-value:1.56E-4||SGD DESC:Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis Gene:NTG1(YAL015C)|FD-Score:-3.57|P-value:1.80E-4||SGD DESC:DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication Gene:PBA1(YLR199C)|FD-Score:-3.43|P-value:3.03E-4||SGD DESC:Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly Gene:PDA1(YER178W)|FD-Score:6.06|P-value:6.83E-10||SGD DESC:E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose Gene:POR2(YIL114C)|FD-Score:-3.3|P-value:4.87E-4||SGD DESC:Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication Gene:RIF2(YLR453C)|FD-Score:5.86|P-value:2.35E-9||SGD DESC:Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation Gene:RPL4A(YBR031W)|FD-Score:3.23|P-value:6.22E-4||SGD DESC:Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication Gene:RSM28(YDR494W)|FD-Score:4.21|P-value:1.26E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation Gene:SNQ2(YDR011W)|FD-Score:-3.25|P-value:5.87E-4||SGD DESC:Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species Gene:THP2(YHR167W)|FD-Score:5.83|P-value:2.79E-9||SGD DESC:Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance Gene:THP3(YPR045C)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes Gene:TOS4(YLR183C)|FD-Score:3.56|P-value:1.82E-4||SGD DESC:Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication Gene:UPC2(YDR213W)|FD-Score:-3.33|P-value:4.29E-4||SGD DESC:Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication Gene:YBP1(YBR216C)|FD-Score:-3.25|P-value:5.76E-4||SGD DESC:Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication Gene:YDL199C(YDL199C_p)|FD-Score:-3.54|P-value:1.96E-4||SGD DESC:Putative transporter, member of the sugar porter family Gene:YGL041C(YGL041C_d)|FD-Score:4.06|P-value:2.48E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIL166C(YIL166C_p)|FD-Score:3.16|P-value:7.76E-4||SGD DESC:Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene Gene:YLR184W(YLR184W_d)|FD-Score:3.33|P-value:4.38E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR202C(YLR202C_d)|FD-Score:3.1|P-value:9.55E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron Gene:YLR428C(YLR428C_d)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 Gene:YML089C(YML089C_d)|FD-Score:-4.03|P-value:2.74E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage Gene:YNL193W(YNL193W_p)|FD-Score:-3.24|P-value:6.03E-4||SGD DESC:Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis Gene:YPL225W(YPL225W)|FD-Score:-3.97|P-value:3.54E-5||SGD DESC:Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:ZEO1(YOL109W)|FD-Score:3.83|P-value:6.33E-5||SGD DESC:Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGL172W6.747.78E-121.86NUP49FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
YNR053C4.885.22E-70.26NOG2Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
YCR052W4.621.88E-60.12RSC6Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
YIL126W4.503.37E-60.70STH1ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
YNL110C3.807.30E-50.17NOP15Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
YPL255W3.621.45E-40.03BBP1Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
YGL092W3.591.65E-40.25NUP145Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98
YNL308C3.344.12E-40.02KRI1Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p
YAL032C3.324.46E-40.04PRP45Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene
YPR137W3.285.20E-40.08RRP9Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
YIL021W3.206.92E-40.02RPB3RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit
YLR009W3.177.52E-40.04RLP24Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
YBL105C3.148.51E-40.04PKC1Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
YPR190C3.109.69E-40.01RPC82RNA polymerase III subunit C82
YGR114C_d3.099.91E-40.04YGR114C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YBR059C6.651.43E-11AKL1Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization
YER178W6.066.83E-10PDA1E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose
YLR453C5.862.35E-9RIF2Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YHR167W5.832.79E-9THP2Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
YGL080W4.592.18E-6FMP37Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia
YIL116W4.562.54E-6HIS5Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YLR427W4.552.62E-6MAG2Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1
YDR494W4.211.26E-5RSM28Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation
YGL041C_d4.062.48E-5YGL041C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL109W3.836.33E-5ZEO1Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria
YPR045C3.681.15E-4THP3Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes
YGR159C3.611.56E-4NSR1Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
YCL029C3.581.74E-4BIK1Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170
YLR183C3.561.82E-4TOS4Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication
YLR428C_d3.532.05E-4YLR428C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1

GO enrichment analysis for SGTC_1582
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1156.58E-19SGTC_1578josamycin 24.2 μMTimTec (Pure natural product library)52821650.047619
0.1032.51E-15SGTC_1583clindamycin 39.6 μMTimTec (Pure natural product library)326030.0322581mitochondrial processes
0.0872.23E-11SGTC_11710368-0077 21.4 μMChemDiv (Drug-like library)32397790.0983607
0.0841.05E-10SGTC_1769st044406 64.4 μMTimTec (Natural product derivative library)6709030.0571429
0.0807.24E-10SGTC_11750741-0056 27.6 μMChemDiv (Drug-like library)7659270.117647
0.0756.58E-9SGTC_22907904846 200.0 μMChembridge (Fragment library)29621540.0461538
0.0672.81E-7SGTC_32089114115 49.5 μMChembridge (Drug-like library)6508950.0789474
0.0673.26E-7SGTC_1037k284-1091 78.7 μMChemDiv (Drug-like library)33347110.0769231
0.0648.73E-7SGTC_30279089541 49.5 μMChembridge (Drug-like library)99438190.0625fatty acid desaturase (OLE1)
0.0649.71E-7SGTC_1040074-0074 591.0 μMChemDiv (Drug-like library)39431240.163934
0.0631.35E-6SGTC_2617dihydrotanshinone i 20.8 μMMicrosource (Natural product library)53167430.180328copper-dependent oxidative stress
0.0603.61E-6SGTC_485niflumic acid 177.0 μMMiscellaneous44880.125
0.0595.17E-6SGTC_2710st078562 53.7 μMTimTec (Natural product derivative library)172509080.075
0.0595.97E-6SGTC_2510benzyl isothiocyanate 8.3 μMMicrosource (Natural product library)23460.0816327
0.0571.09E-5SGTC_31809109287 49.5 μMChembridge (Drug-like library)188912710.111111

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1109tnp00067928.26 nM0.783784676295TimTec (Natural product library)254.23752.35624
SGTC_18943',6'-dihydroxyflavone78.7 μM0.571429688662TimTec (Natural product derivative library)254.23752.65224
SGTC_1124fisetin1.16 μM0.558145281614TimTec (Natural product library)286.23631.87246
SGTC_11103-hydroxy-3'-methoxyflavone1.24 μM0.543478676296TimTec (Natural product library)268.264082.58214iron homeostasis
SGTC_1112tnp000691.17 μM0.534884145826TimTec (Natural product library)270.23692.11435
SGTC_1766st04541444.77 μM0.520833253960TimTec (Natural product derivative library)273.671222.11214RPP1 & pyrimidine depletion
SGTC_1115galangin695.68 nM0.4666675281616TimTec (Natural product library)270.23692.11435RPP1 & pyrimidine depletion
SGTC_2505galangin7.89 μM0.4666675281616Microsource (Natural product library)270.23692.11435RPP1 & pyrimidine depletion
SGTC_1830st05598250.3 μM0.452381455313TimTec (Natural product derivative library)254.23752.35624
SGTC_1780st03844824.54 μM0.44898728868TimTec (Natural product derivative library)278.710883.21614iron homeostasis
SGTC_15494'-methoxyflavonol74.6 μM0.44680997141TimTec (Pure natural product library)268.264082.58214