deoxycorticosterone acetate

[2-[(8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate

Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1586
Screen concentration 53.7 μM
Source TimTec (Pure natural product library)
PubChem CID 5952
SMILES CC(=O)OCC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
Standardized SMILES CC(=O)OCC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C
Molecular weight 372.4978
ALogP 3.57
H-bond donor count 0
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.73
% growth inhibition (Hom. pool) 4.89


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5952
Download HIP data (tab-delimited text)  (excel)
Gene:ACC1(YNR016C)|FD-Score:6.49|P-value:4.42E-11|Clearance:2.06||SGD DESC:Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; Gene:PRE1(YER012W)|FD-Score:-3.15|P-value:8.07E-4|Clearance:0||SGD DESC:Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle Gene:RSC9(YML127W)|FD-Score:3.14|P-value:8.49E-4|Clearance:0.25||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:SRB6(YBR253W)|FD-Score:-3.61|P-value:1.52E-4|Clearance:0||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:TAP42(YMR028W)|FD-Score:4.43|P-value:4.79E-6|Clearance:0.94||SGD DESC:Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits Gene:URB1(YKL014C)|FD-Score:3.48|P-value:2.49E-4|Clearance:0.34||SGD DESC:Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit Gene:YDL196W(YDL196W_d)|FD-Score:-3.16|P-value:7.79E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Gene:ACC1(YNR016C)|FD-Score:6.49|P-value:4.42E-11|Clearance:2.06||SGD DESC:Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; Gene:PRE1(YER012W)|FD-Score:-3.15|P-value:8.07E-4|Clearance:0||SGD DESC:Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle Gene:RSC9(YML127W)|FD-Score:3.14|P-value:8.49E-4|Clearance:0.25||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:SRB6(YBR253W)|FD-Score:-3.61|P-value:1.52E-4|Clearance:0||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:TAP42(YMR028W)|FD-Score:4.43|P-value:4.79E-6|Clearance:0.94||SGD DESC:Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits Gene:URB1(YKL014C)|FD-Score:3.48|P-value:2.49E-4|Clearance:0.34||SGD DESC:Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit Gene:YDL196W(YDL196W_d)|FD-Score:-3.16|P-value:7.79E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5952
Download HOP data (tab-delimited text)  (excel)
Gene:AAD4(YDL243C)|FD-Score:-3.77|P-value:8.20E-5||SGD DESC:Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin Gene:ADE12(YNL220W)|FD-Score:3.18|P-value:7.44E-4||SGD DESC:Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence Gene:ADK2(YER170W)|FD-Score:3.79|P-value:7.67E-5||SGD DESC:Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background Gene:AIM25(YJR100C)|FD-Score:3.26|P-value:5.59E-4||SGD DESC:Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:APM1(YPL259C)|FD-Score:4.06|P-value:2.41E-5||SGD DESC:Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting Gene:APM4(YOL062C)|FD-Score:-3.09|P-value:9.87E-4||SGD DESC:Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport Gene:AQY1(YPR192W)|FD-Score:3.58|P-value:1.75E-4||SGD DESC:Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance Gene:ARF3(YOR094W)|FD-Score:3.74|P-value:9.17E-5||SGD DESC:Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity Gene:BOP3(YNL042W)|FD-Score:3.72|P-value:9.88E-5||SGD DESC:Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury Gene:BSC5(YNR069C)|FD-Score:3.84|P-value:6.13E-5||SGD DESC:Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro Gene:BTS1(YPL069C)|FD-Score:5.72|P-value:5.37E-9||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:COG6(YNL041C)|FD-Score:-3.96|P-value:3.67E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DMA2(YNL116W)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains Gene:ENO1(YGR254W)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress Gene:ERC1(YHR032W)|FD-Score:-3.74|P-value:9.25E-5||SGD DESC:Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine Gene:FCY21(YER060W)|FD-Score:3.94|P-value:4.14E-5||SGD DESC:Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function Gene:FLC1(YPL221W)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance Gene:HOP2(YGL033W)|FD-Score:-4.2|P-value:1.35E-5||SGD DESC:Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair Gene:ILM1(YJR118C)|FD-Score:5.39|P-value:3.44E-8||SGD DESC:Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth Gene:IRC23(YOR044W)|FD-Score:4|P-value:3.16E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication Gene:MEF2(YJL102W)|FD-Score:-3.16|P-value:7.80E-4||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:MPA43(YNL249C)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:MRS1(YIR021W)|FD-Score:3.48|P-value:2.51E-4||SGD DESC:Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA Gene:MSG5(YNL053W)|FD-Score:3.14|P-value:8.41E-4||SGD DESC:Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p Gene:OMA1(YKR087C)|FD-Score:4.11|P-value:1.98E-5||SGD DESC:Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes Gene:OPI3(YJR073C)|FD-Score:3.45|P-value:2.82E-4||SGD DESC:Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis Gene:ORT1(YOR130C)|FD-Score:3.11|P-value:9.39E-4||SGD DESC:Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome Gene:PEX18(YHR160C)|FD-Score:3.19|P-value:7.13E-4||SGD DESC:Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p Gene:PHO23(YNL097C)|FD-Score:3.49|P-value:2.38E-4||SGD DESC:Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3 Gene:PKR1(YMR123W)|FD-Score:-4.15|P-value:1.64E-5||SGD DESC:V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress Gene:SHE1(YBL031W)|FD-Score:5.18|P-value:1.10E-7||SGD DESC:Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function Gene:UBP11(YKR098C)|FD-Score:3.13|P-value:8.64E-4||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins Gene:VEL1(YGL258W)|FD-Score:-3.96|P-value:3.71E-5||SGD DESC:Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C Gene:YAL066W(YAL066W_d)|FD-Score:-3.11|P-value:9.21E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDC1(YPL087W)|FD-Score:3.8|P-value:7.28E-5||SGD DESC:Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication Gene:YDL057W(YDL057W_p)|FD-Score:3.12|P-value:9.00E-4||SGD DESC:Putative protein of unknown function; YDL057W is not an essential gene Gene:YDR102C(YDR102C_d)|FD-Score:3.28|P-value:5.16E-4||SGD DESC:Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index Gene:YDR220C(YDR220C_d)|FD-Score:-3.78|P-value:7.74E-5||SGD DESC:Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein Gene:YEL068C(YEL068C_p)|FD-Score:3.87|P-value:5.34E-5||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YER039C-A(YER039C-A_p)|FD-Score:4.34|P-value:7.22E-6||SGD DESC:Putative protein of unknown function; YER039C-A is not an essential gene Gene:YER067C-A(YER067C-A_d)|FD-Score:3.25|P-value:5.84E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W Gene:YHR112C(YHR112C)|FD-Score:3.71|P-value:1.03E-4||SGD DESC:Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway Gene:YJL067W(YJL067W_d)|FD-Score:3.26|P-value:5.60E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJL119C(YJL119C_d)|FD-Score:3.63|P-value:1.42E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YKL096C-B(YKL096C-B_p)|FD-Score:-4.43|P-value:4.77E-6||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YNL058C(YNL058C_p)|FD-Score:3.91|P-value:4.66E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene Gene:YOL162W(YOL162W_p)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YOR062C(YOR062C_p)|FD-Score:4.2|P-value:1.33E-5||SGD DESC:Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS Gene:YPR150W(YPR150W_d)|FD-Score:3.12|P-value:9.04E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C Gene:AAD4(YDL243C)|FD-Score:-3.77|P-value:8.20E-5||SGD DESC:Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin Gene:ADE12(YNL220W)|FD-Score:3.18|P-value:7.44E-4||SGD DESC:Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence Gene:ADK2(YER170W)|FD-Score:3.79|P-value:7.67E-5||SGD DESC:Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background Gene:AIM25(YJR100C)|FD-Score:3.26|P-value:5.59E-4||SGD DESC:Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:APM1(YPL259C)|FD-Score:4.06|P-value:2.41E-5||SGD DESC:Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting Gene:APM4(YOL062C)|FD-Score:-3.09|P-value:9.87E-4||SGD DESC:Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport Gene:AQY1(YPR192W)|FD-Score:3.58|P-value:1.75E-4||SGD DESC:Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance Gene:ARF3(YOR094W)|FD-Score:3.74|P-value:9.17E-5||SGD DESC:Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity Gene:BOP3(YNL042W)|FD-Score:3.72|P-value:9.88E-5||SGD DESC:Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury Gene:BSC5(YNR069C)|FD-Score:3.84|P-value:6.13E-5||SGD DESC:Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro Gene:BTS1(YPL069C)|FD-Score:5.72|P-value:5.37E-9||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:COG6(YNL041C)|FD-Score:-3.96|P-value:3.67E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DMA2(YNL116W)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains Gene:ENO1(YGR254W)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress Gene:ERC1(YHR032W)|FD-Score:-3.74|P-value:9.25E-5||SGD DESC:Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine Gene:FCY21(YER060W)|FD-Score:3.94|P-value:4.14E-5||SGD DESC:Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function Gene:FLC1(YPL221W)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance Gene:HOP2(YGL033W)|FD-Score:-4.2|P-value:1.35E-5||SGD DESC:Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair Gene:ILM1(YJR118C)|FD-Score:5.39|P-value:3.44E-8||SGD DESC:Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth Gene:IRC23(YOR044W)|FD-Score:4|P-value:3.16E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication Gene:MEF2(YJL102W)|FD-Score:-3.16|P-value:7.80E-4||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:MPA43(YNL249C)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:MRS1(YIR021W)|FD-Score:3.48|P-value:2.51E-4||SGD DESC:Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA Gene:MSG5(YNL053W)|FD-Score:3.14|P-value:8.41E-4||SGD DESC:Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p Gene:OMA1(YKR087C)|FD-Score:4.11|P-value:1.98E-5||SGD DESC:Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes Gene:OPI3(YJR073C)|FD-Score:3.45|P-value:2.82E-4||SGD DESC:Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis Gene:ORT1(YOR130C)|FD-Score:3.11|P-value:9.39E-4||SGD DESC:Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome Gene:PEX18(YHR160C)|FD-Score:3.19|P-value:7.13E-4||SGD DESC:Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p Gene:PHO23(YNL097C)|FD-Score:3.49|P-value:2.38E-4||SGD DESC:Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3 Gene:PKR1(YMR123W)|FD-Score:-4.15|P-value:1.64E-5||SGD DESC:V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress Gene:SHE1(YBL031W)|FD-Score:5.18|P-value:1.10E-7||SGD DESC:Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function Gene:UBP11(YKR098C)|FD-Score:3.13|P-value:8.64E-4||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins Gene:VEL1(YGL258W)|FD-Score:-3.96|P-value:3.71E-5||SGD DESC:Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C Gene:YAL066W(YAL066W_d)|FD-Score:-3.11|P-value:9.21E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDC1(YPL087W)|FD-Score:3.8|P-value:7.28E-5||SGD DESC:Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication Gene:YDL057W(YDL057W_p)|FD-Score:3.12|P-value:9.00E-4||SGD DESC:Putative protein of unknown function; YDL057W is not an essential gene Gene:YDR102C(YDR102C_d)|FD-Score:3.28|P-value:5.16E-4||SGD DESC:Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index Gene:YDR220C(YDR220C_d)|FD-Score:-3.78|P-value:7.74E-5||SGD DESC:Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein Gene:YEL068C(YEL068C_p)|FD-Score:3.87|P-value:5.34E-5||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YER039C-A(YER039C-A_p)|FD-Score:4.34|P-value:7.22E-6||SGD DESC:Putative protein of unknown function; YER039C-A is not an essential gene Gene:YER067C-A(YER067C-A_d)|FD-Score:3.25|P-value:5.84E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W Gene:YHR112C(YHR112C)|FD-Score:3.71|P-value:1.03E-4||SGD DESC:Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway Gene:YJL067W(YJL067W_d)|FD-Score:3.26|P-value:5.60E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJL119C(YJL119C_d)|FD-Score:3.63|P-value:1.42E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YKL096C-B(YKL096C-B_p)|FD-Score:-4.43|P-value:4.77E-6||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YNL058C(YNL058C_p)|FD-Score:3.91|P-value:4.66E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene Gene:YOL162W(YOL162W_p)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YOR062C(YOR062C_p)|FD-Score:4.2|P-value:1.33E-5||SGD DESC:Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS Gene:YPR150W(YPR150W_d)|FD-Score:3.12|P-value:9.04E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YNR016C6.494.42E-112.06ACC1Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
YMR028W4.434.79E-60.94TAP42Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits
YKL014C3.482.49E-40.34URB1Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
YML127W3.148.49E-40.25RSC9Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YPL094C2.890.001950.05SEC62Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YGR190C_d2.830.002300.12YGR190C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YDL008W2.710.003350.01APC11Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
YER159C2.700.003420.04BUR6Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
YKL112W2.670.003810.12ABF1DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
YER157W2.550.005370.03COG3Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YNR053C2.530.005780.08NOG2Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
YMR094W2.440.007310.05CTF13Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
YDL102W2.400.008300.01POL3Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
YDL030W2.380.008560.04PRP9Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
YGL001C2.340.009590.02ERG26C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YPL069C5.725.37E-9BTS1Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic
YJR118C5.393.44E-8ILM1Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth
YBL031W5.181.10E-7SHE1Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function
YER039C-A_p4.347.22E-6YER039C-A_pPutative protein of unknown function; YER039C-A is not an essential gene
YOR062C_p4.201.33E-5YOR062C_pProtein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YKR087C4.111.98E-5OMA1Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes
YPL259C4.062.41E-5APM1Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting
YOR044W4.003.16E-5IRC23Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication
YER060W3.944.14E-5FCY21Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
YNL058C_p3.914.66E-5YNL058C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene
YEL068C_p3.875.34E-5YEL068C_pProtein of unknown function; expressed at both mRNA and protein levels
YNR069C3.846.13E-5BSC5Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro
YPL087W3.807.28E-5YDC1Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication
YER170W3.797.67E-5ADK2Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background
YOR094W3.749.17E-5ARF3Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity

GO enrichment analysis for SGTC_1586
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1164.97E-19SGTC_1974st069448 26.9 μMTimTec (Natural product derivative library)63235870.239437
0.1124.90E-18SGTC_15846-fluoro-dl-tryptophan 90.0 μMTimTec (Pure natural product library)949370.0740741mitochondrial processes
0.1031.98E-15SGTC_610978-8327 98.6 μMChemDiv (Drug-like library)61500590.0617284ergosterol biosynthesis
0.1017.78E-15SGTC_269exalamide 29.0 μMMiscellaneous33160.108108ergosterol biosynthesis
0.0991.92E-14SGTC_15956-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 μMTimTec (Pure natural product library)6887880.0833333
0.0983.44E-14SGTC_2736butenafine 14.7 μMMiscellaneous24840.05
0.0912.16E-12SGTC_1752st044819 83.0 μMTimTec (Natural product derivative library)4412090.112676
0.0863.60E-11SGTC_1638st008370 60.6 μMTimTec (Natural product derivative library)242071340.135802ergosterol biosynthesis
0.0814.44E-10SGTC_2525harmine 47.9 μMMiscellaneous52809530.0506329ergosterol biosynthesis
0.0781.65E-9SGTC_31059121040 49.5 μMChembridge (Drug-like library)414489070.0853659
0.0781.73E-9SGTC_24875918373 44.0 μMMiscellaneous28762790.139535
0.0782.10E-9SGTC_2961222-0039 74.9 μMChemDiv (Drug-like library)59841760.109589
0.0772.73E-9SGTC_20315180455 200.0 μMChembridge (Fragment library)299490.0333333
0.0773.24E-9SGTC_2534helenine 20.1 μMMicrosource (Natural product library)727240.141026RSC complex & mRNA processing
0.0732.28E-8SGTC_482fipronil 114.0 μMICCB bioactive library33520.0333333

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1580hydrocortisone 21-hemisuccinate43.2 μM0.40506316623TimTec (Pure natural product library)462.532661.50738
SGTC_1654st01243641.8 μM0.3194444323132TimTec (Natural product derivative library)372.540843.80613
SGTC_387norethindrone acetate66.7 μM0.315789541197Miscellaneous340.455924.69403
SGTC_1609st00157446.4 μM0.3086423960012TimTec (Natural product derivative library)430.576923.5615
SGTC_1572epiandrosterone68.9 μM0.294118441302TimTec (Pure natural product library)290.44033.58812
SGTC_2540epiandrosterone100 μM0.294118441302TimTec (Pure natural product library)290.44033.58812
SGTC_2584androsterone48.74 μM0.2941182754130Microsource (Natural product library)290.44033.58812cell wall
SGTC_25005-alpha-androstan-3,17-dione61.44 μM0.2835826710655Microsource (Natural product library)288.424423.40202
SGTC_2650prasterone100 μM0.27536216759247Microsource (Natural product library)288.424423.33812
SGTC_2758dehydroepiandrosterone69.35 μM0.2753625881Miscellaneous288.424423.33812
SGTC_1587estradiol valerate56.1 μM0.2650613791TimTec (Pure natural product library)356.498385.79613