Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YGL172W | 7.04 | 9.39E-13 | 1.09 | NUP49 | FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) |
YHR005C-A | 5.95 | 1.33E-9 | 0.41 | TIM10 | Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane |
YHR062C | 5.54 | 1.53E-8 | 0.37 | RPP1 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
YJR065C | 5.17 | 1.20E-7 | 0.12 | ARP3 | Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity |
YOR256C | 5.05 | 2.25E-7 | 0.51 | TRE2 | Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication |
YOR362C | 4.54 | 2.81E-6 | 0.04 | PRE10 | Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress |
YMR281W | 4.50 | 3.35E-6 | 0.52 | GPI12 | ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp |
YOR335C | 3.98 | 3.42E-5 | 0.01 | ALA1 | Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog |
YDR243C | 3.98 | 3.51E-5 | 0.34 | PRP28 | RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site |
YPL235W | 3.64 | 1.38E-4 | 0.17 | RVB2 | ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly |
YDR429C | 3.47 | 2.62E-4 | 0.06 | TIF35 | eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation |
YOR098C | 3.41 | 3.26E-4 | 0.13 | NUP1 | FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153 |
YOL146W | 3.28 | 5.18E-4 | 0.05 | PSF3 | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery |
YDR328C | 3.23 | 6.14E-4 | 0.01 | SKP1 | Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress |
YDR373W | 3.22 | 6.40E-4 | 0.09 | FRQ1 | N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily |