Deletion Strain | FD score | P-value | Gene | Gene Description |
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YGR078C | 7.41 | 6.26E-14 | PAC10 | Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding |
YOL033W | 4.98 | 3.21E-7 | MSE1 | Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated |
YEL044W | 4.90 | 4.75E-7 | IES6 | Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes |
YCR002C | 4.88 | 5.40E-7 | CDC10 | Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress |
YER139C | 4.84 | 6.63E-7 | RTR1 | CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication |
YPL064C | 4.67 | 1.54E-6 | CWC27 | Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress |
YJR050W | 4.38 | 5.89E-6 | ISY1 | Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles |
YPL166W | 4.25 | 1.07E-5 | ATG29 | Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
YML107C | 4.21 | 1.26E-5 | PML39 | Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes |
YML007W | 4.17 | 1.52E-5 | YAP1 | Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress |
YDR185C | 4.10 | 2.07E-5 | UPS3 | Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations |
YIL162W | 4.01 | 3.01E-5 | SUC2 | Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively |
YLR109W | 3.76 | 8.52E-5 | AHP1 | Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p |
YDL116W | 3.75 | 8.76E-5 | NUP84 | Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107 |
YMR274C | 3.73 | 9.74E-5 | RCE1 | Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone |