k030-0015

5,7-dibromo-1H-indole-2,3-dione

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_162
Screen concentration 37.8 μM
Source ChemDiv (Drug-like library)
PubChem CID 1809920
SMILES C1=C(C=C2C(=C1Br)NC(=O)C2=O)Br
Standardized SMILES Brc1cc(Br)c2NC(=O)C(=O)c2c1
Molecular weight 304.9229
ALogP 2.17
H-bond donor count 1
H-bond acceptor count 2
Response signature iron homeostasis

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.61
% growth inhibition (Hom. pool) 4.12


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 1809920
Download HIP data (tab-delimited text)  (excel)
Gene:ARP3(YJR065C)|FD-Score:-3.7|P-value:1.07E-4|Clearance:0||SGD DESC:Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity Gene:CSL4(YNL232W)|FD-Score:-3.12|P-value:9.11E-4|Clearance:0||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1) Gene:DRE2(YKR071C)|FD-Score:3.11|P-value:9.48E-4|Clearance:0.02||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:ERG11(YHR007C)|FD-Score:4.1|P-value:2.04E-5|Clearance:0.77||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:ERG29(YMR134W_p)|FD-Score:29.4|P-value:9.97E-191|Clearance:24.08||SGD DESC:Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes Gene:GPI11(YDR302W)|FD-Score:4.47|P-value:3.94E-6|Clearance:0.37||SGD DESC:ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog Gene:GUS1(YGL245W)|FD-Score:3.09|P-value:9.99E-4|Clearance:0.02||SGD DESC:Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:NSA1(YGL111W)|FD-Score:5.35|P-value:4.31E-8|Clearance:0.87||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis Gene:PRP6(YBR055C)|FD-Score:3.31|P-value:4.60E-4|Clearance:0.21||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RPC17(YJL011C)|FD-Score:-3.71|P-value:1.02E-4|Clearance:0||SGD DESC:RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress Gene:SRP14(YDL092W)|FD-Score:4.49|P-value:3.60E-6|Clearance:0.02||SGD DESC:Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14 Gene:TAF1(YGR274C)|FD-Score:3.33|P-value:4.33E-4|Clearance:0.02||SGD DESC:TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression Gene:ARP3(YJR065C)|FD-Score:-3.7|P-value:1.07E-4|Clearance:0||SGD DESC:Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity Gene:CSL4(YNL232W)|FD-Score:-3.12|P-value:9.11E-4|Clearance:0||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1) Gene:DRE2(YKR071C)|FD-Score:3.11|P-value:9.48E-4|Clearance:0.02||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:ERG11(YHR007C)|FD-Score:4.1|P-value:2.04E-5|Clearance:0.77||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:ERG29(YMR134W_p)|FD-Score:29.4|P-value:9.97E-191|Clearance:24.08||SGD DESC:Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes Gene:GPI11(YDR302W)|FD-Score:4.47|P-value:3.94E-6|Clearance:0.37||SGD DESC:ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog Gene:GUS1(YGL245W)|FD-Score:3.09|P-value:9.99E-4|Clearance:0.02||SGD DESC:Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:NSA1(YGL111W)|FD-Score:5.35|P-value:4.31E-8|Clearance:0.87||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis Gene:PRP6(YBR055C)|FD-Score:3.31|P-value:4.60E-4|Clearance:0.21||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RPC17(YJL011C)|FD-Score:-3.71|P-value:1.02E-4|Clearance:0||SGD DESC:RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress Gene:SRP14(YDL092W)|FD-Score:4.49|P-value:3.60E-6|Clearance:0.02||SGD DESC:Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14 Gene:TAF1(YGR274C)|FD-Score:3.33|P-value:4.33E-4|Clearance:0.02||SGD DESC:TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 1809920
Download HOP data (tab-delimited text)  (excel)
Gene:ADA2(YDR448W)|FD-Score:5.41|P-value:3.13E-8||SGD DESC:Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes Gene:APT1(YML022W)|FD-Score:-3.29|P-value:5.05E-4||SGD DESC:Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication Gene:ATG5(YPL149W)|FD-Score:-4.09|P-value:2.14E-5||SGD DESC:Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation Gene:BDH1(YAL060W)|FD-Score:3.79|P-value:7.60E-5||SGD DESC:NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source Gene:BRP1(YGL007W_d)|FD-Score:3.64|P-value:1.36E-4||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:CPS1(YJL172W)|FD-Score:3.3|P-value:4.87E-4||SGD DESC:Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions Gene:CTR1(YPR124W)|FD-Score:3.31|P-value:4.68E-4||SGD DESC:High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress Gene:CWC21(YDR482C)|FD-Score:5.19|P-value:1.04E-7||SGD DESC:Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p Gene:GAP1(YKR039W)|FD-Score:4.09|P-value:2.14E-5||SGD DESC:General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth Gene:GLE2(YER107C)|FD-Score:-4.2|P-value:1.32E-5||SGD DESC:RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 Gene:GLN3(YER040W)|FD-Score:-3.41|P-value:3.27E-4||SGD DESC:Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source Gene:HEL1(YKR017C_p)|FD-Score:5.54|P-value:1.56E-8||SGD DESC:RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU) Gene:HSP82(YPL240C)|FD-Score:3.21|P-value:6.56E-4||SGD DESC:Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication Gene:HVG1(YER039C)|FD-Score:-3.17|P-value:7.62E-4||SGD DESC:Protein of unknown function, has homology to Vrg4p Gene:IES5(YER092W)|FD-Score:-3.7|P-value:1.06E-4||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions Gene:JNM1(YMR294W)|FD-Score:5.09|P-value:1.78E-7||SGD DESC:Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B Gene:KDX1(YKL161C)|FD-Score:6.7|P-value:1.03E-11||SGD DESC:Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p Gene:MAC1(YMR021C)|FD-Score:3.28|P-value:5.17E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MDM36(YPR083W)|FD-Score:3.31|P-value:4.66E-4||SGD DESC:Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission Gene:MLP1(YKR095W)|FD-Score:4.21|P-value:1.26E-5||SGD DESC:Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs Gene:MSC7(YHR039C)|FD-Score:4.4|P-value:5.40E-6||SGD DESC:Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids Gene:NRK1(YNL129W)|FD-Score:-3.1|P-value:9.79E-4||SGD DESC:Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis Gene:PIR1(YKL164C)|FD-Score:4.95|P-value:3.67E-7||SGD DESC:O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication Gene:PRE9(YGR135W)|FD-Score:-3.45|P-value:2.82E-4||SGD DESC:Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform Gene:PRM6(YML047C)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family Gene:PRY2(YKR013W)|FD-Score:3.83|P-value:6.39E-5||SGD DESC:Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication Gene:RCN2(YOR220W_p)|FD-Score:3.45|P-value:2.78E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress Gene:REV7(YIL139C)|FD-Score:-3.67|P-value:1.21E-4||SGD DESC:Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair Gene:REX2(YLR059C)|FD-Score:-3.11|P-value:9.28E-4||SGD DESC:3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease Gene:RPS14B(YJL191W)|FD-Score:4.25|P-value:1.08E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication Gene:RTC1(YOL138C)|FD-Score:8.54|P-value:6.48E-18||SGD DESC:Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif Gene:SOD1(YJR104C)|FD-Score:4.87|P-value:5.54E-7||SGD DESC:Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid Gene:SOD2(YHR008C)|FD-Score:3.43|P-value:3.01E-4||SGD DESC:Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated Gene:SPE1(YKL184W)|FD-Score:3.19|P-value:7.20E-4||SGD DESC:Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation Gene:SSF1(YHR066W)|FD-Score:-4.21|P-value:1.25E-5||SGD DESC:Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication Gene:SSK1(YLR006C)|FD-Score:-4.4|P-value:5.33E-6||SGD DESC:Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate Gene:STE50(YCL032W)|FD-Score:-3.73|P-value:9.71E-5||SGD DESC:Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction Gene:STF2(YGR008C)|FD-Score:4.64|P-value:1.78E-6||SGD DESC:Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress Gene:TKL1(YPR074C)|FD-Score:4.83|P-value:6.87E-7||SGD DESC:Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication Gene:TSR3(YOR006C)|FD-Score:-3.21|P-value:6.73E-4||SGD DESC:Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:UBC7(YMR022W)|FD-Score:5.23|P-value:8.62E-8||SGD DESC:Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly Gene:ULI1(YFR026C)|FD-Score:5.43|P-value:2.78E-8||SGD DESC:Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response Gene:VMA13(YPR036W)|FD-Score:3.12|P-value:9.07E-4||SGD DESC:Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase Gene:YBL029W(YBL029W_p)|FD-Score:3.37|P-value:3.77E-4||SGD DESC:Non-essential protein of unknown function Gene:YBR027C(YBR027C_d)|FD-Score:3.22|P-value:6.44E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDL041W(YDL041W_d)|FD-Score:4.38|P-value:5.84E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C Gene:YGL109W(YGL109W_d)|FD-Score:3.62|P-value:1.46E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Gene:YGL118C(YGL118C_d)|FD-Score:5.18|P-value:1.10E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGL152C(YGL152C_d)|FD-Score:4.38|P-value:5.97E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W Gene:YGR069W(YGR069W_d)|FD-Score:3.17|P-value:7.53E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGR125W(YGR125W_p)|FD-Score:3.76|P-value:8.47E-5||SGD DESC:Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YIL077C(YIL077C_p)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:YJR005C-A(YJR005C-A_p)|FD-Score:5.42|P-value:3.04E-8||SGD DESC:Putative protein of unknown function; originally identified as a syntenic homolog of an <i>Ashbya gossypii</i> gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication Gene:YKR040C(YKR040C_d)|FD-Score:3.54|P-value:2.02E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W Gene:YLR255C(YLR255C_d)|FD-Score:3.11|P-value:9.39E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL162W-A(YNL162W-A_p)|FD-Score:3.94|P-value:4.04E-5||SGD DESC:Putative protein of unknown function; identified by homology Gene:YOX1(YML027W)|FD-Score:4.33|P-value:7.59E-6||SGD DESC:Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication Gene:YPL168W(YPL168W_p)|FD-Score:3.34|P-value:4.24E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated Gene:YPR063C(YPR063C_p)|FD-Score:-3.11|P-value:9.50E-4||SGD DESC:ER-localized protein of unknown function Gene:ADA2(YDR448W)|FD-Score:5.41|P-value:3.13E-8||SGD DESC:Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes Gene:APT1(YML022W)|FD-Score:-3.29|P-value:5.05E-4||SGD DESC:Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication Gene:ATG5(YPL149W)|FD-Score:-4.09|P-value:2.14E-5||SGD DESC:Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation Gene:BDH1(YAL060W)|FD-Score:3.79|P-value:7.60E-5||SGD DESC:NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source Gene:BRP1(YGL007W_d)|FD-Score:3.64|P-value:1.36E-4||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:CPS1(YJL172W)|FD-Score:3.3|P-value:4.87E-4||SGD DESC:Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions Gene:CTR1(YPR124W)|FD-Score:3.31|P-value:4.68E-4||SGD DESC:High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress Gene:CWC21(YDR482C)|FD-Score:5.19|P-value:1.04E-7||SGD DESC:Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p Gene:GAP1(YKR039W)|FD-Score:4.09|P-value:2.14E-5||SGD DESC:General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth Gene:GLE2(YER107C)|FD-Score:-4.2|P-value:1.32E-5||SGD DESC:RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 Gene:GLN3(YER040W)|FD-Score:-3.41|P-value:3.27E-4||SGD DESC:Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source Gene:HEL1(YKR017C_p)|FD-Score:5.54|P-value:1.56E-8||SGD DESC:RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU) Gene:HSP82(YPL240C)|FD-Score:3.21|P-value:6.56E-4||SGD DESC:Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication Gene:HVG1(YER039C)|FD-Score:-3.17|P-value:7.62E-4||SGD DESC:Protein of unknown function, has homology to Vrg4p Gene:IES5(YER092W)|FD-Score:-3.7|P-value:1.06E-4||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions Gene:JNM1(YMR294W)|FD-Score:5.09|P-value:1.78E-7||SGD DESC:Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B Gene:KDX1(YKL161C)|FD-Score:6.7|P-value:1.03E-11||SGD DESC:Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p Gene:MAC1(YMR021C)|FD-Score:3.28|P-value:5.17E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MDM36(YPR083W)|FD-Score:3.31|P-value:4.66E-4||SGD DESC:Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission Gene:MLP1(YKR095W)|FD-Score:4.21|P-value:1.26E-5||SGD DESC:Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs Gene:MSC7(YHR039C)|FD-Score:4.4|P-value:5.40E-6||SGD DESC:Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids Gene:NRK1(YNL129W)|FD-Score:-3.1|P-value:9.79E-4||SGD DESC:Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis Gene:PIR1(YKL164C)|FD-Score:4.95|P-value:3.67E-7||SGD DESC:O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication Gene:PRE9(YGR135W)|FD-Score:-3.45|P-value:2.82E-4||SGD DESC:Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform Gene:PRM6(YML047C)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family Gene:PRY2(YKR013W)|FD-Score:3.83|P-value:6.39E-5||SGD DESC:Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication Gene:RCN2(YOR220W_p)|FD-Score:3.45|P-value:2.78E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress Gene:REV7(YIL139C)|FD-Score:-3.67|P-value:1.21E-4||SGD DESC:Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair Gene:REX2(YLR059C)|FD-Score:-3.11|P-value:9.28E-4||SGD DESC:3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease Gene:RPS14B(YJL191W)|FD-Score:4.25|P-value:1.08E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication Gene:RTC1(YOL138C)|FD-Score:8.54|P-value:6.48E-18||SGD DESC:Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif Gene:SOD1(YJR104C)|FD-Score:4.87|P-value:5.54E-7||SGD DESC:Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid Gene:SOD2(YHR008C)|FD-Score:3.43|P-value:3.01E-4||SGD DESC:Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated Gene:SPE1(YKL184W)|FD-Score:3.19|P-value:7.20E-4||SGD DESC:Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation Gene:SSF1(YHR066W)|FD-Score:-4.21|P-value:1.25E-5||SGD DESC:Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication Gene:SSK1(YLR006C)|FD-Score:-4.4|P-value:5.33E-6||SGD DESC:Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate Gene:STE50(YCL032W)|FD-Score:-3.73|P-value:9.71E-5||SGD DESC:Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction Gene:STF2(YGR008C)|FD-Score:4.64|P-value:1.78E-6||SGD DESC:Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress Gene:TKL1(YPR074C)|FD-Score:4.83|P-value:6.87E-7||SGD DESC:Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication Gene:TSR3(YOR006C)|FD-Score:-3.21|P-value:6.73E-4||SGD DESC:Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:UBC7(YMR022W)|FD-Score:5.23|P-value:8.62E-8||SGD DESC:Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly Gene:ULI1(YFR026C)|FD-Score:5.43|P-value:2.78E-8||SGD DESC:Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response Gene:VMA13(YPR036W)|FD-Score:3.12|P-value:9.07E-4||SGD DESC:Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase Gene:YBL029W(YBL029W_p)|FD-Score:3.37|P-value:3.77E-4||SGD DESC:Non-essential protein of unknown function Gene:YBR027C(YBR027C_d)|FD-Score:3.22|P-value:6.44E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDL041W(YDL041W_d)|FD-Score:4.38|P-value:5.84E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C Gene:YGL109W(YGL109W_d)|FD-Score:3.62|P-value:1.46E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Gene:YGL118C(YGL118C_d)|FD-Score:5.18|P-value:1.10E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGL152C(YGL152C_d)|FD-Score:4.38|P-value:5.97E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W Gene:YGR069W(YGR069W_d)|FD-Score:3.17|P-value:7.53E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGR125W(YGR125W_p)|FD-Score:3.76|P-value:8.47E-5||SGD DESC:Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YIL077C(YIL077C_p)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:YJR005C-A(YJR005C-A_p)|FD-Score:5.42|P-value:3.04E-8||SGD DESC:Putative protein of unknown function; originally identified as a syntenic homolog of an <i>Ashbya gossypii</i> gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication Gene:YKR040C(YKR040C_d)|FD-Score:3.54|P-value:2.02E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W Gene:YLR255C(YLR255C_d)|FD-Score:3.11|P-value:9.39E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL162W-A(YNL162W-A_p)|FD-Score:3.94|P-value:4.04E-5||SGD DESC:Putative protein of unknown function; identified by homology Gene:YOX1(YML027W)|FD-Score:4.33|P-value:7.59E-6||SGD DESC:Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication Gene:YPL168W(YPL168W_p)|FD-Score:3.34|P-value:4.24E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated Gene:YPR063C(YPR063C_p)|FD-Score:-3.11|P-value:9.50E-4||SGD DESC:ER-localized protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YMR134W_p29.409.97E-19124.10ERG29_pProtein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
YGL111W5.354.31E-80.87NSA1Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YDL092W4.493.60E-60.02SRP14Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14
YDR302W4.473.94E-60.37GPI11ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
YHR007C4.102.04E-50.77ERG11Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
YGR274C3.334.33E-40.02TAF1TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression
YBR055C3.314.60E-40.21PRP6Splicing factor, component of the U4/U6-U5 snRNP complex
YKR071C3.119.48E-40.02DRE2Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress
YGL245W3.099.99E-40.02GUS1Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
YBR038W3.070.001050.10CHS2Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis
YGR246C2.970.001490.01BRF1TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
YOL026C2.960.001530.05MIM1Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex
YDR324C2.920.001770.07UTP4Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
YDL087C2.840.002230.06LUC7Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA
YBR089W_d2.780.002700.00YBR089W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOL138C8.546.48E-18RTC1Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif
YKL161C6.701.03E-11KDX1Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p
YKR017C_p5.541.56E-8HEL1_pRING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)
YFR026C5.432.78E-8ULI1Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response
YJR005C-A_p5.423.04E-8YJR005C-A_pPutative protein of unknown function; originally identified as a syntenic homolog of an Ashbya gossypii gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication
YDR448W5.413.13E-8ADA2Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
YMR022W5.238.62E-8UBC7Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
YDR482C5.191.04E-7CWC21Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p
YGL118C_d5.181.10E-7YGL118C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR294W5.091.78E-7JNM1Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B
YKL164C4.953.67E-7PIR1O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
YJR104C4.875.54E-7SOD1Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
YPR074C4.836.87E-7TKL1Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
YGR008C4.641.78E-6STF2Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
YHR039C4.405.40E-6MSC7Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids

GO enrichment analysis for SGTC_162
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.2796.99E-106SGTC_23985228213 48.8 μMMiscellaneous807710.454545iron homeostasis
0.2388.98E-77SGTC_20464110841 106.0 μMChembridge (Fragment library)441196300.0681818iron homeostasis
0.2131.16E-61SGTC_12300170-0365 3.8 μMChemDiv (Drug-like library)40189320.0327869endomembrane recycling
0.1904.60E-49SGTC_1704197-0004 226.0 μMChemDiv (Drug-like library)2186920.0483871
0.1741.98E-41SGTC_7680384-0033 77.3 μMChemDiv (Drug-like library)39653050.0769231fatty acid desaturase (OLE1)
0.1404.94E-27SGTC_8460335-0850 148.0 μMChemDiv (Drug-like library)68195980.0344828ubiquinone biosynthesis & proteasome
0.1397.74E-27SGTC_22667929956 200.0 μMChembridge (Fragment library)29671530.0925926
0.1375.97E-26SGTC_8340312-0008 75.7 μMChemDiv (Drug-like library)63855730.0638298NEO1
0.1301.29E-23SGTC_6371181-0519 7.3 μMChemDiv (Drug-like library)62520910.0535714fatty acid desaturase (OLE1)
0.1301.52E-23SGTC_1974544-0043 41.6 μMChemDiv (Drug-like library)8965230.0483871endomembrane recycling
0.1271.38E-22SGTC_7323970-1727 52.7 μMChemDiv (Drug-like library)12756990.1
0.1202.29E-20SGTC_8750709-0210 25.7 μMChemDiv (Drug-like library)62513640.0909091fatty acid desaturase (OLE1)
0.1193.69E-20SGTC_577r071-0003 38.6 μMChemDiv (Drug-like library)45685170.0652174fatty acid desaturase (OLE1)
0.1017.24E-15SGTC_1987st072290 61.9 μMTimTec (Natural product derivative library)54697379NA
0.0977.74E-14SGTC_2170morpholine 200.0 μMChembridge (Fragment library)1211710.0740741

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_1459k035-003135.7 μM0.6666673877128ChemDiv (Drug-like library)260.471922.08312DNA intercalators
SGTC_20545233173129 μM0.56889Chembridge (Fragment library)226.026861.41812mitochondrial response to ROS
SGTC_2398522821348.84 μM0.45454580771Miscellaneous216.020921.99912iron homeostasis
SGTC_20405100729123 μM0.33333311840Chembridge (Fragment library)161.157381.15612
SGTC_12850929-006965.5 μM0.3181821206237ChemDiv (Drug-like library)379.02463.19724
SGTC_20685226020147 μM0.2820511810509Chembridge (Fragment library)195.602441.82112
SGTC_13241418-002634.4 μM0.260871372513ChemDiv (Drug-like library)394.06073.79712
SGTC_10483161-030024.5 μM0.2444442165101ChemDiv (Drug-like library)266.090722.24102
SGTC_505gw-507463.9 μM0.245924208ICCB bioactive library520.941994.56422
SGTC_169k015-001716.03 μM0.2291671840002ChemDiv (Drug-like library)334.1398633.41303