Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YMR134W_p | 29.40 | 9.97E-191 | 24.10 | ERG29_p | Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes |
YGL111W | 5.35 | 4.31E-8 | 0.87 | NSA1 | Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis |
YDL092W | 4.49 | 3.60E-6 | 0.02 | SRP14 | Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14 |
YDR302W | 4.47 | 3.94E-6 | 0.37 | GPI11 | ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog |
YHR007C | 4.10 | 2.04E-5 | 0.77 | ERG11 | Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p |
YGR274C | 3.33 | 4.33E-4 | 0.02 | TAF1 | TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression |
YBR055C | 3.31 | 4.60E-4 | 0.21 | PRP6 | Splicing factor, component of the U4/U6-U5 snRNP complex |
YKR071C | 3.11 | 9.48E-4 | 0.02 | DRE2 | Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress |
YGL245W | 3.09 | 9.99E-4 | 0.02 | GUS1 | Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress |
YBR038W | 3.07 | 0.00105 | 0.10 | CHS2 | Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis |
YGR246C | 2.97 | 0.00149 | 0.01 | BRF1 | TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB |
YOL026C | 2.96 | 0.00153 | 0.05 | MIM1 | Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex |
YDR324C | 2.92 | 0.00177 | 0.07 | UTP4 | Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript |
YDL087C | 2.84 | 0.00223 | 0.06 | LUC7 | Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA |
YBR089W_d | 2.78 | 0.00270 | 0.00 | YBR089W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30 |