Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YJR013W | 41.10 | 0 | 18.80 | GPI14 | Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M |
YFL037W | 22.30 | 2.85E-110 | 0.05 | TUB2 | Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria |
YPR107C | 22.20 | 8.26E-110 | 2.84 | YTH1 | Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation |
YIR008C | 19.40 | 4.15E-84 | 6.23 | PRI1 | Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair |
YDR381W | 13.20 | 6.97E-40 | 0.03 | YRA1 | RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member |
YJL019W | 13.10 | 1.06E-39 | 0.75 | MPS3 | Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p |
YML085C | 12.40 | 1.64E-35 | 0.17 | TUB1 | Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication |
YHR172W | 12.20 | 1.31E-34 | 0.22 | SPC97 | Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque |
YBL034C | 12.00 | 1.89E-33 | 0.33 | STU1 | Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles |
YIR012W | 11.70 | 9.22E-32 | 0.23 | SQT1 | Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress |
YJR007W | 11.40 | 1.36E-30 | 0.33 | SUI2 | Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress |
YJL005W | 11.10 | 5.80E-29 | 0.18 | CYR1 | Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation |
YIL022W | 10.90 | 4.40E-28 | 0.13 | TIM44 | Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex) |
YIL046W | 10.80 | 1.75E-27 | 0.72 | MET30 | F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus |
YPL238C_d | 10.10 | 3.55E-24 | 0.04 | YPL238C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W |