Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPL210C | 6.11 | 4.89E-10 | 1.38 | SRP72 | Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane |
YMR093W | 4.73 | 1.12E-6 | 0.30 | UTP15 | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA |
YNL113W | 4.43 | 4.67E-6 | 0.08 | RPC19 | RNA polymerase subunit AC19, common to RNA polymerases I and III |
YDL150W | 4.35 | 6.68E-6 | 0.09 | RPC53 | RNA polymerase III subunit C53 |
YIL075C | 4.26 | 1.02E-5 | 0.27 | RPN2 | Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress |
YER018C | 4.00 | 3.23E-5 | 0.17 | SPC25 | Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering |
YHR083W | 3.82 | 6.55E-5 | 0.12 | SAM35 | Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane |
YLR029C | 3.70 | 1.08E-4 | 0.02 | RPL15A | Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication |
YBL092W | 3.68 | 1.19E-4 | 0.28 | RPL32 | Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog |
YDR045C | 3.40 | 3.41E-4 | 0.11 | RPC11 | RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS |
YLR275W | 3.29 | 5.08E-4 | 0.05 | SMD2 | Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 |
YDR166C | 3.23 | 6.15E-4 | 0.11 | SEC5 | Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip |
YPL235W | 3.12 | 8.97E-4 | 0.08 | RVB2 | ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly |
YLR438C-A | 3.04 | 0.00119 | 0.03 | LSM3 | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
YDL014W | 3.01 | 0.00130 | 0.01 | NOP1 | Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin |