Deletion Strain | FD score | P-value | Gene | Gene Description |
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YBR058C-A | 26.00 | 9.91E-150 | TSC3 | Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis |
YNL283C | 7.28 | 1.67E-13 | WSC2 | Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response |
YER183C | 6.53 | 3.27E-11 | FAU1 | 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis |
YJL036W | 6.28 | 1.70E-10 | SNX4 | Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p |
YJR104C | 5.66 | 7.63E-9 | SOD1 | Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid |
YER057C | 5.63 | 9.25E-9 | HMF1 | Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro |
YBR062C_p | 5.62 | 9.63E-9 | YBR062C_p | Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway. |
YML078W | 5.29 | 6.08E-8 | CPR3 | Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria |
YOR042W | 5.11 | 1.58E-7 | CUE5 | Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern |
YJR043C | 4.71 | 1.25E-6 | POL32 | Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p |
YIR027C | 4.59 | 2.20E-6 | DAL1 | Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression |
YGL077C | 4.49 | 3.59E-6 | HNM1 | Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol |
YOR223W | 4.40 | 5.49E-6 | YOR223W | Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3 |
YDL020C | 4.35 | 6.79E-6 | RPN4 | Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress |
YNL148C | 4.30 | 8.62E-6 | ALF1 | Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance |