Cervolide

1,6-dioxacycloheptadecan-7-one

A fragrance.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1645
Screen concentration 78.0 μM
Source TimTec (Natural product derivative library)
PubChem CID 23173
SMILES C1CCCCCOCCCCOC(=O)CCCC1
Standardized SMILES O=C1CCCCCCCCCCOCCCCO1
Molecular weight 256.381
ALogP 3.98
H-bond donor count 0
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.48
% growth inhibition (Hom. pool) 2.17


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 23173
Download HIP data (tab-delimited text)  (excel)
Gene:CDC20(YGL116W)|FD-Score:-3.56|P-value:1.82E-4|Clearance:0||SGD DESC:Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress Gene:ERG11(YHR007C)|FD-Score:7.41|P-value:6.44E-14|Clearance:2.62||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:ESF1(YDR365C)|FD-Score:3.21|P-value:6.54E-4|Clearance:0.14||SGD DESC:Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels Gene:FIP1(YJR093C)|FD-Score:3.67|P-value:1.19E-4|Clearance:0.05||SGD DESC:Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p Gene:HEM3(YDL205C)|FD-Score:-3.5|P-value:2.35E-4|Clearance:0||SGD DESC:Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme Gene:IPP1(YBR011C)|FD-Score:3.23|P-value:6.13E-4|Clearance:0.02||SGD DESC:Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase Gene:MAS2(YHR024C)|FD-Score:4.79|P-value:8.32E-7|Clearance:0.73||SGD DESC:Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins Gene:NUP57(YGR119C)|FD-Score:3.62|P-value:1.47E-4|Clearance:0.16||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) Gene:PRP28(YDR243C)|FD-Score:3.42|P-value:3.12E-4|Clearance:0.19||SGD DESC:RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site Gene:PRP9(YDL030W)|FD-Score:-3.55|P-value:1.90E-4|Clearance:0||SGD DESC:Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex Gene:RPA43(YOR340C)|FD-Score:4.06|P-value:2.47E-5|Clearance:0.38||SGD DESC:RNA polymerase I subunit A43 Gene:TSC11(YER093C)|FD-Score:3.46|P-value:2.68E-4|Clearance:0.04||SGD DESC:Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain Gene:CDC20(YGL116W)|FD-Score:-3.56|P-value:1.82E-4|Clearance:0||SGD DESC:Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress Gene:ERG11(YHR007C)|FD-Score:7.41|P-value:6.44E-14|Clearance:2.62||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:ESF1(YDR365C)|FD-Score:3.21|P-value:6.54E-4|Clearance:0.14||SGD DESC:Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels Gene:FIP1(YJR093C)|FD-Score:3.67|P-value:1.19E-4|Clearance:0.05||SGD DESC:Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p Gene:HEM3(YDL205C)|FD-Score:-3.5|P-value:2.35E-4|Clearance:0||SGD DESC:Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme Gene:IPP1(YBR011C)|FD-Score:3.23|P-value:6.13E-4|Clearance:0.02||SGD DESC:Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase Gene:MAS2(YHR024C)|FD-Score:4.79|P-value:8.32E-7|Clearance:0.73||SGD DESC:Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins Gene:NUP57(YGR119C)|FD-Score:3.62|P-value:1.47E-4|Clearance:0.16||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) Gene:PRP28(YDR243C)|FD-Score:3.42|P-value:3.12E-4|Clearance:0.19||SGD DESC:RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site Gene:PRP9(YDL030W)|FD-Score:-3.55|P-value:1.90E-4|Clearance:0||SGD DESC:Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex Gene:RPA43(YOR340C)|FD-Score:4.06|P-value:2.47E-5|Clearance:0.38||SGD DESC:RNA polymerase I subunit A43 Gene:TSC11(YER093C)|FD-Score:3.46|P-value:2.68E-4|Clearance:0.04||SGD DESC:Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 23173
Download HOP data (tab-delimited text)  (excel)
Gene:ACB1(YGR037C)|FD-Score:3.2|P-value:6.93E-4||SGD DESC:Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress Gene:AIM21(YIR003W)|FD-Score:3.15|P-value:8.23E-4||SGD DESC:Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton Gene:AMN1(YBR158W)|FD-Score:3.44|P-value:2.96E-4||SGD DESC:Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) Gene:ATP22(YDR350C)|FD-Score:3.2|P-value:6.98E-4||SGD DESC:Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane Gene:BEM3(YPL115C)|FD-Score:3.23|P-value:6.28E-4||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly Gene:GAD1(YMR250W)|FD-Score:3.15|P-value:8.21E-4||SGD DESC:Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress Gene:ICT1(YLR099C)|FD-Score:4.21|P-value:1.30E-5||SGD DESC:Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication Gene:IML2(YJL082W)|FD-Score:3.24|P-value:5.98E-4||SGD DESC:Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication Gene:LCB4(YOR171C)|FD-Score:3.46|P-value:2.70E-4||SGD DESC:Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes Gene:MLS1(YNL117W)|FD-Score:4.33|P-value:7.61E-6||SGD DESC:Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic Gene:MPP6(YNR024W)|FD-Score:-3.45|P-value:2.78E-4||SGD DESC:Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes Gene:MSN1(YOL116W)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:NMA111(YNL123W)|FD-Score:3.81|P-value:7.01E-5||SGD DESC:Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases Gene:PAA1(YDR071C)|FD-Score:-3.6|P-value:1.60E-4||SGD DESC:Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication Gene:PAD1(YDR538W)|FD-Score:3.31|P-value:4.66E-4||SGD DESC:Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX Gene:PMP3(YDR276C)|FD-Score:-3.33|P-value:4.35E-4||SGD DESC:Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential Gene:RAD17(YOR368W)|FD-Score:-3.62|P-value:1.45E-4||SGD DESC:Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins Gene:RHR2(YIL053W)|FD-Score:3.72|P-value:9.87E-5||SGD DESC:Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication Gene:RMD9(YGL107C)|FD-Score:3.17|P-value:7.61E-4||SGD DESC:Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes Gene:RSB1(YOR049C)|FD-Score:-3.13|P-value:8.67E-4||SGD DESC:Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane Gene:SIS2(YKR072C)|FD-Score:3.45|P-value:2.79E-4||SGD DESC:Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis Gene:SWC3(YAL011W)|FD-Score:3.21|P-value:6.67E-4||SGD DESC:Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae Gene:THI22(YPR121W)|FD-Score:3.1|P-value:9.69E-4||SGD DESC:Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis Gene:TPP1(YMR156C)|FD-Score:3.11|P-value:9.41E-4||SGD DESC:DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3′-phosphatase Gene:YDL068W(YDL068W_d)|FD-Score:3.75|P-value:8.90E-5||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YKL162C(YKL162C_p)|FD-Score:3.54|P-value:2.02E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion Gene:YLR358C(YLR358C_p)|FD-Score:4.37|P-value:6.18E-6||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W Gene:YNL043C(YNL043C_d)|FD-Score:4.92|P-value:4.27E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W Gene:YOL153C(YOL153C)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Hypothetical protein Gene:YOR325W(YOR325W_d)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1 Gene:YPL216W(YPL216W_p)|FD-Score:3.2|P-value:6.85E-4||SGD DESC:Putative protein of unknown function; YPL216W is not an essential gene Gene:ACB1(YGR037C)|FD-Score:3.2|P-value:6.93E-4||SGD DESC:Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress Gene:AIM21(YIR003W)|FD-Score:3.15|P-value:8.23E-4||SGD DESC:Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton Gene:AMN1(YBR158W)|FD-Score:3.44|P-value:2.96E-4||SGD DESC:Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) Gene:ATP22(YDR350C)|FD-Score:3.2|P-value:6.98E-4||SGD DESC:Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane Gene:BEM3(YPL115C)|FD-Score:3.23|P-value:6.28E-4||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly Gene:GAD1(YMR250W)|FD-Score:3.15|P-value:8.21E-4||SGD DESC:Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress Gene:ICT1(YLR099C)|FD-Score:4.21|P-value:1.30E-5||SGD DESC:Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication Gene:IML2(YJL082W)|FD-Score:3.24|P-value:5.98E-4||SGD DESC:Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication Gene:LCB4(YOR171C)|FD-Score:3.46|P-value:2.70E-4||SGD DESC:Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes Gene:MLS1(YNL117W)|FD-Score:4.33|P-value:7.61E-6||SGD DESC:Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic Gene:MPP6(YNR024W)|FD-Score:-3.45|P-value:2.78E-4||SGD DESC:Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes Gene:MSN1(YOL116W)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:NMA111(YNL123W)|FD-Score:3.81|P-value:7.01E-5||SGD DESC:Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases Gene:PAA1(YDR071C)|FD-Score:-3.6|P-value:1.60E-4||SGD DESC:Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication Gene:PAD1(YDR538W)|FD-Score:3.31|P-value:4.66E-4||SGD DESC:Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX Gene:PMP3(YDR276C)|FD-Score:-3.33|P-value:4.35E-4||SGD DESC:Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential Gene:RAD17(YOR368W)|FD-Score:-3.62|P-value:1.45E-4||SGD DESC:Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins Gene:RHR2(YIL053W)|FD-Score:3.72|P-value:9.87E-5||SGD DESC:Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication Gene:RMD9(YGL107C)|FD-Score:3.17|P-value:7.61E-4||SGD DESC:Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes Gene:RSB1(YOR049C)|FD-Score:-3.13|P-value:8.67E-4||SGD DESC:Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane Gene:SIS2(YKR072C)|FD-Score:3.45|P-value:2.79E-4||SGD DESC:Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis Gene:SWC3(YAL011W)|FD-Score:3.21|P-value:6.67E-4||SGD DESC:Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae Gene:THI22(YPR121W)|FD-Score:3.1|P-value:9.69E-4||SGD DESC:Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis Gene:TPP1(YMR156C)|FD-Score:3.11|P-value:9.41E-4||SGD DESC:DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3′-phosphatase Gene:YDL068W(YDL068W_d)|FD-Score:3.75|P-value:8.90E-5||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YKL162C(YKL162C_p)|FD-Score:3.54|P-value:2.02E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion Gene:YLR358C(YLR358C_p)|FD-Score:4.37|P-value:6.18E-6||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W Gene:YNL043C(YNL043C_d)|FD-Score:4.92|P-value:4.27E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W Gene:YOL153C(YOL153C)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Hypothetical protein Gene:YOR325W(YOR325W_d)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1 Gene:YPL216W(YPL216W_p)|FD-Score:3.2|P-value:6.85E-4||SGD DESC:Putative protein of unknown function; YPL216W is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR007C7.416.44E-142.62ERG11Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
YHR024C4.798.32E-70.73MAS2Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YOR340C4.062.47E-50.38RPA43RNA polymerase I subunit A43
YJR093C3.671.19E-40.05FIP1Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
YGR119C3.621.47E-40.16NUP57FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)
YER093C3.462.68E-40.04TSC11Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain
YDR243C3.423.12E-40.19PRP28RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
YBR011C3.236.13E-40.02IPP1Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YDR365C3.216.54E-40.14ESF1Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
YHR058C3.070.001070.09MED6Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress
YNL038W2.980.001430.11GPI15Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein
YDL209C2.870.002060.01CWC2Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2
YKL195W2.860.002110.01MIA40Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
YDR166C2.850.002160.01SEC5Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip
YCR052W2.840.002260.04RSC6Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YNL043C_d4.924.27E-7YNL043C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YLR358C_p4.376.18E-6YLR358C_pProtein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W
YNL117W4.337.61E-6MLS1Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic
YLR099C4.211.30E-5ICT1Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
YNL123W3.817.01E-5NMA111Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
YDL068W_d3.758.90E-5YDL068W_dDubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YIL053W3.729.87E-5RHR2Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication
YOR325W_d3.661.27E-4YOR325W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1
YOL153C3.631.43E-4YOL153CHypothetical protein
YKL162C_p3.542.02E-4YKL162C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YOL116W3.512.26E-4MSN1Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress
YOR171C3.462.70E-4LCB4Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes
YKR072C3.452.79E-4SIS2Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis
YBR158W3.442.96E-4AMN1Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YDR538W3.314.66E-4PAD1Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX

GO enrichment analysis for SGTC_1645
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1477.56E-30SGTC_659k018-0002 107.0 μMChemDiv (Drug-like library)67978790.0416667
0.1225.55E-21SGTC_185k048-0037 25.5 μMChemDiv (Drug-like library)68275890.0338983RSC & ERG11
0.1133.74E-18SGTC_7830848-0141 92.7 μMChemDiv (Drug-like library)67550760.0166667RSC & ERG11
0.1102.65E-17SGTC_203k066-0004 30.9 μMChemDiv (Drug-like library)67954120.12963RSC & ERG11
0.0945.43E-13SGTC_1539benzyladenosine 56.0 μMTimTec (Pure natural product library)922080.0298507
0.0921.40E-12SGTC_643k048-0106 28.4 μMChemDiv (Drug-like library)67639200.0169492RSC & ERG11
0.0895.70E-12SGTC_31279126946 49.5 μMChembridge (Drug-like library)272432490.0204082ERG2
0.0862.99E-11SGTC_29919074669 71.4 μMChembridge (Drug-like library)173331090.0322581azole & statin
0.0864.20E-11SGTC_9701315-0089 19.5 μMChemDiv (Drug-like library)68110830.0294118RSC & ERG11
0.0864.66E-11SGTC_2648atorvastatin 78.7 μMMiscellaneous608230.025641azole & statin
0.0857.44E-11SGTC_2765myclobutanil 7.7 μMMiscellaneous63360.0163934azole & statin
0.0831.60E-10SGTC_2546rhodinyl acetate 100.0 μMMicrosource (Natural product library)67086820.0217391
0.0831.68E-10SGTC_8680527-0199 213.0 μMChemDiv (Drug-like library)28494500.0333333fatty acid desaturase (OLE1)
0.0823.04E-10SGTC_1731st035964 63.0 μMTimTec (Natural product derivative library)67395750.0338983
0.0806.00E-10SGTC_14904089-0339 670.0 nMChemDiv (Drug-like library)7425420.0625

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1250133-000711.75 μM0.23333326541ChemDiv (Drug-like library)360.400962.96906DNA intercalators
SGTC_13181280-3875124 μM0.233333373245ChemDiv (Drug-like library)316.34843.105
SGTC_213453248361.46 μM0.210526699272Chembridge (Fragment library)258.272561.23804
SGTC_1360097-0015404.48 μM0.24861337ChemDiv (Drug-like library)494.448642.62701160S ribosome export
SGTC_6851278-003354.9 μM0.1944443590572ChemDiv (Drug-like library)518.193084.4660660S ribosome export
SGTC_2808794646845.46 μM0.1864412970879Chembridge (Drug-like library)404.546163.75115
SGTC_8720588-0139234 μM0.1836732047100ChemDiv (Drug-like library)289.395862.8405
SGTC_13973532-019020.1 μM0.1818185322280ChemDiv (Drug-like library)230.259163.57713
SGTC_235890371574 μM0.1739132388925Chembridge (Fragment library)231.250520.20513
SGTC_2435hr heat shock (37°C) + splitomicin1 μM0.1707325269Miscellaneous198.21732.83102heat shock/prefoldin