| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YBR058C-A | 13.30 | 8.00E-41 | TSC3 | Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis |
| YLR131C | 4.73 | 1.12E-6 | ACE2 | Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication |
| YBR293W | 3.97 | 3.56E-5 | VBA2 | Permease of basic amino acids in the vacuolar membrane |
| YJR119C | 3.72 | 1.00E-4 | JHD2 | JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation |
| YER130C_p | 3.65 | 1.31E-4 | YER130C_p | Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress |
| YPL202C | 3.61 | 1.54E-4 | AFT2 | Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication |
| YML004C | 3.51 | 2.26E-4 | GLO1 | Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress |
| YNL080C | 3.45 | 2.80E-4 | EOS1 | Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene |
| YLR289W | 3.44 | 2.92E-4 | GUF1 | Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor |
| YHR034C | 3.42 | 3.18E-4 | PIH1 | Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II |
| YDR509W_d | 3.39 | 3.46E-4 | YDR509W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YPR087W_d | 3.32 | 4.58E-4 | VPS69_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect |
| YER107C | 3.29 | 5.06E-4 | GLE2 | RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 |
| YML047W-A_d | 3.27 | 5.30E-4 | YML047W-A_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YAL044C | 3.26 | 5.55E-4 | GCV3 | H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF |
