st014849

3-(4-tert-butylphenoxy)-7-hydroxy-8-(morpholin-4-ylmethyl)chromen-4-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1667
Screen concentration 34.6 μM
Source TimTec (Natural product derivative library)
PubChem CID 5348460
SMILES CC(C)(C)C1=CC=C(C=C1)OC2=COC3=C(C2=O)C=CC(=C3CN4CCOCC4)O
Standardized SMILES CC(C)(C)c1ccc(OC2=COc3c(CN4CCOCC4)c(O)ccc3C2=O)cc1
Molecular weight 409.4749
ALogP 3.57
H-bond donor count 1
H-bond acceptor count 6
Response signature Golgi

Pool Growth Kinetics
% growth inhibition (Het. pool) 4.3
% growth inhibition (Hom. pool) 8.22


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5348460
Download HIP data (tab-delimited text)  (excel)
Gene:ESF1(YDR365C)|FD-Score:-3.19|P-value:7.13E-4|Clearance:0||SGD DESC:Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels Gene:MEX67(YPL169C)|FD-Score:3.11|P-value:9.38E-4|Clearance:0.03||SGD DESC:Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP Gene:NFS1(YCL017C)|FD-Score:4.61|P-value:2.02E-6|Clearance:0.2||SGD DESC:Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria Gene:OLE1(YGL055W)|FD-Score:6|P-value:9.88E-10|Clearance:1.39||SGD DESC:Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria Gene:PXR1(YGR280C)|FD-Score:3.2|P-value:6.99E-4|Clearance:0.09||SGD DESC:Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain Gene:RPT6(YGL048C)|FD-Score:-3.56|P-value:1.86E-4|Clearance:0||SGD DESC:ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress Gene:RRN11(YML043C)|FD-Score:3.54|P-value:2.02E-4|Clearance:0.05||SGD DESC:Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p Gene:SEC18(YBR080C)|FD-Score:-4.03|P-value:2.73E-5|Clearance:0||SGD DESC:ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF Gene:SHR3(YDL212W)|FD-Score:4.41|P-value:5.21E-6|Clearance:0.87||SGD DESC:Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface Gene:SPC98(YNL126W)|FD-Score:-3.26|P-value:5.60E-4|Clearance:0||SGD DESC:Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque Gene:TAF11(YML015C)|FD-Score:3.49|P-value:2.43E-4|Clearance:0.29||SGD DESC:TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors Gene:UBA2(YDR390C)|FD-Score:-3.88|P-value:5.22E-5|Clearance:0||SGD DESC:Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability Gene:YDR355C(YDR355C_d)|FD-Score:-3.76|P-value:8.55E-5|Clearance:0||SGD DESC:Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W Gene:YKL111C(YKL111C_d)|FD-Score:-3.29|P-value:4.93E-4|Clearance:0||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified essential gene ABF1 Gene:ESF1(YDR365C)|FD-Score:-3.19|P-value:7.13E-4|Clearance:0||SGD DESC:Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels Gene:MEX67(YPL169C)|FD-Score:3.11|P-value:9.38E-4|Clearance:0.03||SGD DESC:Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP Gene:NFS1(YCL017C)|FD-Score:4.61|P-value:2.02E-6|Clearance:0.2||SGD DESC:Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria Gene:OLE1(YGL055W)|FD-Score:6|P-value:9.88E-10|Clearance:1.39||SGD DESC:Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria Gene:PXR1(YGR280C)|FD-Score:3.2|P-value:6.99E-4|Clearance:0.09||SGD DESC:Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain Gene:RPT6(YGL048C)|FD-Score:-3.56|P-value:1.86E-4|Clearance:0||SGD DESC:ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress Gene:RRN11(YML043C)|FD-Score:3.54|P-value:2.02E-4|Clearance:0.05||SGD DESC:Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p Gene:SEC18(YBR080C)|FD-Score:-4.03|P-value:2.73E-5|Clearance:0||SGD DESC:ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF Gene:SHR3(YDL212W)|FD-Score:4.41|P-value:5.21E-6|Clearance:0.87||SGD DESC:Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface Gene:SPC98(YNL126W)|FD-Score:-3.26|P-value:5.60E-4|Clearance:0||SGD DESC:Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque Gene:TAF11(YML015C)|FD-Score:3.49|P-value:2.43E-4|Clearance:0.29||SGD DESC:TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors Gene:UBA2(YDR390C)|FD-Score:-3.88|P-value:5.22E-5|Clearance:0||SGD DESC:Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability Gene:YDR355C(YDR355C_d)|FD-Score:-3.76|P-value:8.55E-5|Clearance:0||SGD DESC:Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W Gene:YKL111C(YKL111C_d)|FD-Score:-3.29|P-value:4.93E-4|Clearance:0||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified essential gene ABF1

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5348460
Download HOP data (tab-delimited text)  (excel)
Gene:AHA1(YDR214W)|FD-Score:-3.65|P-value:1.29E-4||SGD DESC:Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress Gene:ALG6(YOR002W)|FD-Score:3.5|P-value:2.35E-4||SGD DESC:Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease Gene:ARG1(YOL058W)|FD-Score:3.18|P-value:7.36E-4||SGD DESC:Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate Gene:ASR1(YPR093C)|FD-Score:3.19|P-value:7.16E-4||SGD DESC:Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein Gene:COG6(YNL041C)|FD-Score:3.84|P-value:6.10E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG7(YGL005C)|FD-Score:5.59|P-value:1.12E-8||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG8(YML071C)|FD-Score:5.88|P-value:2.11E-9||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CRC1(YOR100C)|FD-Score:3.12|P-value:8.93E-4||SGD DESC:Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation Gene:DID2(YKR035W-A)|FD-Score:3.1|P-value:9.82E-4||SGD DESC:Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors Gene:ECM8(YBR076W)|FD-Score:3.99|P-value:3.33E-5||SGD DESC:Non-essential protein of unknown function Gene:FSH3(YOR280C)|FD-Score:3.31|P-value:4.59E-4||SGD DESC:Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2 Gene:GCV1(YDR019C)|FD-Score:3.84|P-value:6.27E-5||SGD DESC:T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm Gene:GCV3(YAL044C)|FD-Score:3.57|P-value:1.77E-4||SGD DESC:H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF Gene:LOA1(YPR139C)|FD-Score:3.12|P-value:9.04E-4||SGD DESC:Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA Gene:NHP10(YDL002C)|FD-Score:3.23|P-value:6.19E-4||SGD DESC:Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair Gene:PHO80(YOL001W)|FD-Score:5.17|P-value:1.18E-7||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling Gene:RCY1(YJL204C)|FD-Score:4.23|P-value:1.17E-5||SGD DESC:F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth Gene:RIM101(YHL027W)|FD-Score:3.87|P-value:5.37E-5||SGD DESC:Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC Gene:RPS10B(YMR230W)|FD-Score:3.12|P-value:9.19E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication Gene:RRT12(YCR045C)|FD-Score:3.14|P-value:8.40E-4||SGD DESC:Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores Gene:SAC3(YDR159W)|FD-Score:3.18|P-value:7.33E-4||SGD DESC:Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP) Gene:SIA1(YOR137C)|FD-Score:3.12|P-value:8.94E-4||SGD DESC:Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose Gene:TGL4(YKR089C)|FD-Score:3.1|P-value:9.67E-4||SGD DESC:Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p Gene:TRP3(YKL211C)|FD-Score:5.38|P-value:3.79E-8||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:VID28(YIL017C)|FD-Score:4.21|P-value:1.25E-5||SGD DESC:GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm Gene:YDR379C-A(YDR379C-A)|FD-Score:3.18|P-value:7.45E-4||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy Gene:YDR535C(YDR535C_d)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. Gene:YNL319W(YNL319W_d)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 Gene:AHA1(YDR214W)|FD-Score:-3.65|P-value:1.29E-4||SGD DESC:Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress Gene:ALG6(YOR002W)|FD-Score:3.5|P-value:2.35E-4||SGD DESC:Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease Gene:ARG1(YOL058W)|FD-Score:3.18|P-value:7.36E-4||SGD DESC:Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate Gene:ASR1(YPR093C)|FD-Score:3.19|P-value:7.16E-4||SGD DESC:Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein Gene:COG6(YNL041C)|FD-Score:3.84|P-value:6.10E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG7(YGL005C)|FD-Score:5.59|P-value:1.12E-8||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG8(YML071C)|FD-Score:5.88|P-value:2.11E-9||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CRC1(YOR100C)|FD-Score:3.12|P-value:8.93E-4||SGD DESC:Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation Gene:DID2(YKR035W-A)|FD-Score:3.1|P-value:9.82E-4||SGD DESC:Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors Gene:ECM8(YBR076W)|FD-Score:3.99|P-value:3.33E-5||SGD DESC:Non-essential protein of unknown function Gene:FSH3(YOR280C)|FD-Score:3.31|P-value:4.59E-4||SGD DESC:Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2 Gene:GCV1(YDR019C)|FD-Score:3.84|P-value:6.27E-5||SGD DESC:T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm Gene:GCV3(YAL044C)|FD-Score:3.57|P-value:1.77E-4||SGD DESC:H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF Gene:LOA1(YPR139C)|FD-Score:3.12|P-value:9.04E-4||SGD DESC:Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA Gene:NHP10(YDL002C)|FD-Score:3.23|P-value:6.19E-4||SGD DESC:Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair Gene:PHO80(YOL001W)|FD-Score:5.17|P-value:1.18E-7||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling Gene:RCY1(YJL204C)|FD-Score:4.23|P-value:1.17E-5||SGD DESC:F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth Gene:RIM101(YHL027W)|FD-Score:3.87|P-value:5.37E-5||SGD DESC:Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC Gene:RPS10B(YMR230W)|FD-Score:3.12|P-value:9.19E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication Gene:RRT12(YCR045C)|FD-Score:3.14|P-value:8.40E-4||SGD DESC:Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores Gene:SAC3(YDR159W)|FD-Score:3.18|P-value:7.33E-4||SGD DESC:Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP) Gene:SIA1(YOR137C)|FD-Score:3.12|P-value:8.94E-4||SGD DESC:Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose Gene:TGL4(YKR089C)|FD-Score:3.1|P-value:9.67E-4||SGD DESC:Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p Gene:TRP3(YKL211C)|FD-Score:5.38|P-value:3.79E-8||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:VID28(YIL017C)|FD-Score:4.21|P-value:1.25E-5||SGD DESC:GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm Gene:YDR379C-A(YDR379C-A)|FD-Score:3.18|P-value:7.45E-4||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy Gene:YDR535C(YDR535C_d)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. Gene:YNL319W(YNL319W_d)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGL055W6.009.88E-101.39OLE1Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YCL017C4.612.02E-60.20NFS1Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria
YDL212W4.415.21E-60.87SHR3Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
YML043C3.542.02E-40.05RRN11Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
YML015C3.492.43E-40.29TAF11TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors
YGR280C3.206.99E-40.09PXR1Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YPL169C3.119.38E-40.03MEX67Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP
YDR052C3.080.001050.00DBF4Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress
YOR336W3.070.001060.01KRE5Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects
YBR254C3.070.001080.01TRS20One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder
YBR004C3.050.001130.05GPI18Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria
YGR195W3.000.001350.04SKI6Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
YIL026C2.960.001540.06IRR1Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
YLR340W2.900.001880.05RPP0Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10
YER038C2.850.002190.04KRE29Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YML071C5.882.11E-9COG8Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YGL005C5.591.12E-8COG7Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YKL211C5.383.79E-8TRP3Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
YOL001W5.171.18E-7PHO80Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling
YJL204C4.231.17E-5RCY1F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
YIL017C4.211.25E-5VID28GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
YBR076W3.993.33E-5ECM8Non-essential protein of unknown function
YHL027W3.875.37E-5RIM101Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
YNL041C3.846.10E-5COG6Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YDR019C3.846.27E-5GCV1T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
YAL044C3.571.77E-4GCV3H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF
YNL319W_d3.512.21E-4YNL319W_dDubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14
YOR002W3.502.35E-4ALG6Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
YDR535C_d3.413.20E-4YDR535C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YOR280C3.314.59E-4FSH3Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2

GO enrichment analysis for SGTC_1667
biological processes

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1711.01E-39SGTC_624k048-0052 28.0 μMChemDiv (Drug-like library)68355310.0674157Golgi
0.1602.81E-35SGTC_1078idebenone 36.1 μMMiscellaneous36860.108108Golgi
0.1596.62E-35SGTC_2737bleomycin 30.5 nMMiscellaneous162113180.0425532Golgi
0.1576.66E-34SGTC_13061185-0270 9.0 μMChemDiv (Drug-like library)15480760.0493827Golgi
0.1547.71E-33SGTC_1162k048-0130 20.1 μMChemDiv (Drug-like library)67974060.0609756Golgi
0.1521.01E-31SGTC_1669st015249 58.4 μMTimTec (Natural product derivative library)7227930.0941176Golgi
0.1511.76E-31SGTC_6320781-2353 4.7 μMChemDiv (Drug-like library)68115150.0520833Golgi
0.1457.10E-29SGTC_40960-0234 25.7 μMChemDiv (Drug-like library)68211120.0729167Golgi
0.1432.36E-28SGTC_6841140-0066 328.0 μMChemDiv (Drug-like library)68135340.0873786Golgi
0.1396.20E-27SGTC_21945927483 104.5 μMChembridge (Fragment library)7609790.0789474
0.1399.60E-27SGTC_2231micatex 6.9 μMMiscellaneous207370.0746269
0.1399.47E-27SGTC_2766oltipraz 83.9 μMMiscellaneous473180.0384615heme requiring
0.1373.07E-26SGTC_2409alverine citrate 64.0 μMMiscellaneous217180.0704225
0.1369.55E-26SGTC_6880527-0193 473.0 μMChemDiv (Drug-like library)40071540.0568182fatty acid desaturase (OLE1)
0.1351.42E-25SGTC_1671st016596 74.5 μMTimTec (Natural product derivative library)28291670.0888889

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1775st08158835.17 μM0.3918921426443TimTec (Natural product derivative library)367.395142.6391660S ribosome export
SGTC_20935331342194.4 μM0.36507933839Chembridge (Fragment library)243.300982.25713
SGTC_1603453-0671289.7 μM0.36255322268ChemDiv (Drug-like library)512.316355.77818
SGTC_3334914281221.92 μM0.31506845283678Chembridge (Drug-like library)385.968444.31224
SGTC_12033992-3522103 μM0.2891575322312ChemDiv (Drug-like library)429.388534.56418
SGTC_3048909315549.47 μM0.26666725236002Chembridge (Drug-like library)318.45372.73313
SGTC_3084092-1169104 μM0.2465752268590ChemDiv (Drug-like library)346.851123.8514plasma membrane duress
SGTC_2784756767372.73 μM0.2465753471247Chembridge (Drug-like library)343.42011.29616iron homeostasis
SGTC_10543429-0080167 μM0.23751162877ChemDiv (Drug-like library)399.281063.20113
SGTC_14394092-116846 μM0.2368422886240ChemDiv (Drug-like library)346.851123.8514