st019653

1,4-dimethylquinolin-2-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1686
Screen concentration 115.5 μM
Source TimTec (Natural product derivative library)
PubChem CID 97252
SMILES CC1=CC(=O)N(C2=CC=CC=C12)C
Standardized SMILES CN1C(=O)C=C(C)c2ccccc12
Molecular weight 173.2111
ALogP 1.9
H-bond donor count 0
H-bond acceptor count 1
Response signature mitochondrial processes

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.45
% growth inhibition (Hom. pool) 1.28


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 97252
Download HIP data (tab-delimited text)  (excel)
Gene:ARP7(YPR034W)|FD-Score:4.83|P-value:7.00E-7|Clearance:0.68||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:CLP1(YOR250C)|FD-Score:3.14|P-value:8.33E-4|Clearance:0.07||SGD DESC:Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation Gene:RPB7(YDR404C)|FD-Score:4.15|P-value:1.68E-5|Clearance:0.4||SGD DESC:RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation Gene:RPN11(YFR004W)|FD-Score:3.72|P-value:1.01E-4|Clearance:0.25||SGD DESC:Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress Gene:RSC8(YFR037C)|FD-Score:3.47|P-value:2.65E-4|Clearance:0.27||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:RSC9(YML127W)|FD-Score:6.74|P-value:7.86E-12|Clearance:1.92||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:TUB2(YFL037W)|FD-Score:3.2|P-value:6.91E-4|Clearance:0.05||SGD DESC:Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria Gene:YCG1(YDR325W)|FD-Score:3.74|P-value:9.05E-5|Clearance:0.03||SGD DESC:Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation Gene:ARP7(YPR034W)|FD-Score:4.83|P-value:7.00E-7|Clearance:0.68||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:CLP1(YOR250C)|FD-Score:3.14|P-value:8.33E-4|Clearance:0.07||SGD DESC:Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation Gene:RPB7(YDR404C)|FD-Score:4.15|P-value:1.68E-5|Clearance:0.4||SGD DESC:RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation Gene:RPN11(YFR004W)|FD-Score:3.72|P-value:1.01E-4|Clearance:0.25||SGD DESC:Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress Gene:RSC8(YFR037C)|FD-Score:3.47|P-value:2.65E-4|Clearance:0.27||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:RSC9(YML127W)|FD-Score:6.74|P-value:7.86E-12|Clearance:1.92||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:TUB2(YFL037W)|FD-Score:3.2|P-value:6.91E-4|Clearance:0.05||SGD DESC:Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria Gene:YCG1(YDR325W)|FD-Score:3.74|P-value:9.05E-5|Clearance:0.03||SGD DESC:Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 97252
Download HOP data (tab-delimited text)  (excel)
Gene:AIM4(YBR194W)|FD-Score:4.77|P-value:9.27E-7||SGD DESC:Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress Gene:APM1(YPL259C)|FD-Score:-3.36|P-value:3.92E-4||SGD DESC:Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting Gene:ATP19(YOL077W-A)|FD-Score:4.26|P-value:1.02E-5||SGD DESC:Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase Gene:ATP5(YDR298C)|FD-Score:3.18|P-value:7.47E-4||SGD DESC:Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated Gene:CCP1(YKR066C)|FD-Score:4.19|P-value:1.40E-5||SGD DESC:Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress Gene:COQ8(YGL119W)|FD-Score:4.9|P-value:4.73E-7||SGD DESC:Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication Gene:DMC1(YER179W)|FD-Score:4.19|P-value:1.39E-5||SGD DESC:Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p Gene:EHT1(YBR177C)|FD-Score:3.21|P-value:6.56E-4||SGD DESC:Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication Gene:FAA2(YER015W)|FD-Score:3.66|P-value:1.25E-4||SGD DESC:Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome Gene:FIG4(YNL325C)|FD-Score:3.24|P-value:6.04E-4||SGD DESC:Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain Gene:FMP33(YJL161W_p)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:GET3(YDL100C)|FD-Score:3.58|P-value:1.72E-4||SGD DESC:Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress Gene:HSL7(YBR133C)|FD-Score:3.98|P-value:3.39E-5||SGD DESC:Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress Gene:MCM21(YDR318W)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2 Gene:MLH3(YPL164C)|FD-Score:3.24|P-value:6.02E-4||SGD DESC:Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability Gene:MON1(YGL124C)|FD-Score:-3.18|P-value:7.25E-4||SGD DESC:Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate Gene:NDL1(YLR254C)|FD-Score:3.51|P-value:2.23E-4||SGD DESC:Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends Gene:PAU24(YBR301W)|FD-Score:3.64|P-value:1.38E-4||SGD DESC:Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth Gene:PEP3(YLR148W)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis Gene:PET494(YNR045W)|FD-Score:3.42|P-value:3.13E-4||SGD DESC:Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane Gene:PEX2(YJL210W)|FD-Score:3.38|P-value:3.68E-4||SGD DESC:RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import Gene:RTC5(YOR118W)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity Gene:SRV2(YNL138W)|FD-Score:3.26|P-value:5.59E-4||SGD DESC:CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis Gene:SWT21(YNL187W)|FD-Score:3.87|P-value:5.49E-5||SGD DESC:Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats Gene:SYC1(YOR179C)|FD-Score:5.17|P-value:1.20E-7||SGD DESC:Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication Gene:THI73(YLR004C)|FD-Score:3.39|P-value:3.51E-4||SGD DESC:Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs Gene:VBA3(YCL069W)|FD-Score:3.12|P-value:8.94E-4||SGD DESC:Permease of basic amino acids in the vacuolar membrane Gene:WHI2(YOR043W)|FD-Score:4.15|P-value:1.64E-5||SGD DESC:Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression Gene:YAR035C-A(YAR035C-A_p)|FD-Score:3.34|P-value:4.25E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis Gene:YBR196C-B(YBR196C-B_p)|FD-Score:4.59|P-value:2.23E-6||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YJR038C(YJR038C_d)|FD-Score:4.35|P-value:6.87E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR114W(YPR114W_p)|FD-Score:4.04|P-value:2.68E-5||SGD DESC:Putative protein of unknown function Gene:YPR148C(YPR148C)|FD-Score:-3.59|P-value:1.64E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:AIM4(YBR194W)|FD-Score:4.77|P-value:9.27E-7||SGD DESC:Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress Gene:APM1(YPL259C)|FD-Score:-3.36|P-value:3.92E-4||SGD DESC:Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting Gene:ATP19(YOL077W-A)|FD-Score:4.26|P-value:1.02E-5||SGD DESC:Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase Gene:ATP5(YDR298C)|FD-Score:3.18|P-value:7.47E-4||SGD DESC:Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated Gene:CCP1(YKR066C)|FD-Score:4.19|P-value:1.40E-5||SGD DESC:Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress Gene:COQ8(YGL119W)|FD-Score:4.9|P-value:4.73E-7||SGD DESC:Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication Gene:DMC1(YER179W)|FD-Score:4.19|P-value:1.39E-5||SGD DESC:Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p Gene:EHT1(YBR177C)|FD-Score:3.21|P-value:6.56E-4||SGD DESC:Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication Gene:FAA2(YER015W)|FD-Score:3.66|P-value:1.25E-4||SGD DESC:Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome Gene:FIG4(YNL325C)|FD-Score:3.24|P-value:6.04E-4||SGD DESC:Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain Gene:FMP33(YJL161W_p)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:GET3(YDL100C)|FD-Score:3.58|P-value:1.72E-4||SGD DESC:Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress Gene:HSL7(YBR133C)|FD-Score:3.98|P-value:3.39E-5||SGD DESC:Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress Gene:MCM21(YDR318W)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2 Gene:MLH3(YPL164C)|FD-Score:3.24|P-value:6.02E-4||SGD DESC:Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability Gene:MON1(YGL124C)|FD-Score:-3.18|P-value:7.25E-4||SGD DESC:Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate Gene:NDL1(YLR254C)|FD-Score:3.51|P-value:2.23E-4||SGD DESC:Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends Gene:PAU24(YBR301W)|FD-Score:3.64|P-value:1.38E-4||SGD DESC:Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth Gene:PEP3(YLR148W)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis Gene:PET494(YNR045W)|FD-Score:3.42|P-value:3.13E-4||SGD DESC:Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane Gene:PEX2(YJL210W)|FD-Score:3.38|P-value:3.68E-4||SGD DESC:RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import Gene:RTC5(YOR118W)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity Gene:SRV2(YNL138W)|FD-Score:3.26|P-value:5.59E-4||SGD DESC:CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis Gene:SWT21(YNL187W)|FD-Score:3.87|P-value:5.49E-5||SGD DESC:Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats Gene:SYC1(YOR179C)|FD-Score:5.17|P-value:1.20E-7||SGD DESC:Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication Gene:THI73(YLR004C)|FD-Score:3.39|P-value:3.51E-4||SGD DESC:Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs Gene:VBA3(YCL069W)|FD-Score:3.12|P-value:8.94E-4||SGD DESC:Permease of basic amino acids in the vacuolar membrane Gene:WHI2(YOR043W)|FD-Score:4.15|P-value:1.64E-5||SGD DESC:Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression Gene:YAR035C-A(YAR035C-A_p)|FD-Score:3.34|P-value:4.25E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis Gene:YBR196C-B(YBR196C-B_p)|FD-Score:4.59|P-value:2.23E-6||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YJR038C(YJR038C_d)|FD-Score:4.35|P-value:6.87E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR114W(YPR114W_p)|FD-Score:4.04|P-value:2.68E-5||SGD DESC:Putative protein of unknown function Gene:YPR148C(YPR148C)|FD-Score:-3.59|P-value:1.64E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YML127W6.747.86E-121.92RSC9Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YPR034W4.837.00E-70.68ARP7Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YDR404C4.151.68E-50.40RPB7RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
YDR325W3.749.05E-50.03YCG1Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
YFR004W3.721.01E-40.25RPN11Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress
YFR037C3.472.65E-40.27RSC8Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
YFL037W3.206.91E-40.05TUB2Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
YOR250C3.148.33E-40.07CLP1Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation
YMR033W3.070.001070.04ARP9Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YDL008W3.030.001240.01APC11Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
YER127W3.020.001270.00LCP5Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
YIR012W3.020.001280.02SQT1Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
YGL172W3.000.001360.03NUP49FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
YBL092W2.970.001480.05RPL32Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
YGR216C2.920.001750.01GPI1Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOR179C5.171.20E-7SYC1Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication
YGL119W4.904.73E-7COQ8Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
YBR194W4.779.27E-7AIM4Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress
YBR196C-B_p4.592.23E-6YBR196C-B_pPutative protein of unknown function; identified by expression profiling and mass spectrometry
YJR038C_d4.356.87E-6YJR038C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL077W-A4.261.02E-5ATP19Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase
YER179W4.191.39E-5DMC1Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p
YKR066C4.191.40E-5CCP1Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YOR043W4.151.64E-5WHI2Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
YPR114W_p4.042.68E-5YPR114W_pPutative protein of unknown function
YBR133C3.983.39E-5HSL7Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress
YNL187W3.875.49E-5SWT21Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats
YOR118W3.701.07E-4RTC5Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity
YER015W3.661.25E-4FAA2Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome
YBR301W3.641.38E-4PAU24Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth

GO enrichment analysis for SGTC_1686
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1604.94E-35SGTC_21866124449 200.0 μMChembridge (Fragment library)38341820.122807RSC complex & mRNA processing
0.1582.27E-34SGTC_22297354935 190.0 μMChembridge (Fragment library)3181120.191489RSC complex & mRNA processing
0.1581.94E-34SGTC_21095483026 200.0 μMChembridge (Fragment library)7593350.186047RSC complex & mRNA processing
0.1547.75E-33SGTC_643k048-0106 28.4 μMChemDiv (Drug-like library)67639200.0655738RSC & ERG11
0.1475.22E-30SGTC_12290139-0193 12.2 μMChemDiv (Drug-like library)30907520.0222222RSC complex & mRNA processing
0.1432.70E-28SGTC_23619034121 116.0 μMChembridge (Fragment library)64969170.163265RSC complex & mRNA processing
0.1411.57E-27SGTC_1651st011928 86.1 μMTimTec (Natural product derivative library)7201980.0526316RSC complex & mRNA processing
0.1403.60E-27SGTC_1693xanthone 101.9 μMTimTec (Natural product derivative library)70200.264706DNA damage response
0.1399.75E-27SGTC_10503232-1156 69.3 μMChemDiv (Drug-like library)7005290.16RSC complex & mRNA processing
0.1391.10E-26SGTC_9282764-0428 58.7 μMChemDiv (Drug-like library)6625780.0322581cell wall
0.1344.77E-25SGTC_23789074213 121.4 μMChembridge (Fragment library)6577140.0851064RSC complex & mRNA processing
0.1339.28E-25SGTC_13742889-5571 141.0 μMChemDiv (Drug-like library)28532810.0655738RSC complex & mRNA processing
0.1271.16E-22SGTC_2747doxorubicin 7.6 μMMiscellaneous317030.102273anthracycline transcription coupled DNA repair
0.1255.71E-22SGTC_23469031566 143.8 μMChembridge (Fragment library)47710860.225Golgi
0.1218.07E-21SGTC_1652st011932 78.0 μMTimTec (Natural product derivative library)15510760.0819672RSC complex & mRNA processing

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_20335192550145 μM0.606061182073Chembridge (Fragment library)189.210541.14602
SGTC_1915st06710530.6 μM0.55172469751TimTec (Natural product derivative library)209.243243.1602RNA pol III & RNase P/MRP
SGTC_22607964312200 μM0.410256231951Chembridge (Fragment library)213.2753.13502
SGTC_1783st03945987.52 μM0.4729761TimTec (Natural product derivative library)185.221841.97901Golgi
SGTC_2681menadione3.18 μM0.3939394055Miscellaneous172.180022.20402superoxide
SGTC_394menadione8.33 μM0.3939394055Miscellaneous172.180022.20402superoxide
SGTC_13111190-0148100 μM0.3913041961333ChemDiv (Drug-like library)344.40643.5903azole & statin
SGTC_20124023501200 μM0.3513513477460Chembridge (Fragment library)175.183961.36202
SGTC_20225136654200 μM0.3251713771Chembridge (Fragment library)204.225180.99703
SGTC_21685727979200 μM0.317073695210Chembridge (Fragment library)206.26422.23603
SGTC_2001402350257.66 μM0.307692108941Chembridge (Fragment library)195.602441.5402mitochondrial processes