st021091

7-amino-5-(5-methyl-4-nitrothiophen-2-yl)-2,4-dioxo-1,5-dihydropyrano[2,3-d]pyrimidine-6-carbonitrile

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1688
Screen concentration 57.6 μM
Source TimTec (Natural product derivative library)
PubChem CID 3656366
SMILES CC1=C(C=C(S1)C2C(=C(OC3=C2C(=O)NC(=O)N3)N)C#N)[N+](=O)[O-]
Standardized SMILES Cc1sc(cc1[N+](=O)[O-])C2C(=C(N)Oc3nc(O)nc(O)c23)C#N
Molecular weight 347.3061
ALogP 0.44
H-bond donor count 3
H-bond acceptor count 8
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 0
% growth inhibition (Hom. pool) 2.56


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3656366
Download HIP data (tab-delimited text)  (excel)
Gene:ABD1(YBR236C)|FD-Score:3.62|P-value:1.48E-4|Clearance:0.13||SGD DESC:Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA Gene:APC1(YNL172W)|FD-Score:3.4|P-value:3.37E-4|Clearance:0.39||SGD DESC:Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress Gene:NAB2(YGL122C)|FD-Score:3.49|P-value:2.46E-4|Clearance:0.09||SGD DESC:Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress Gene:POP8(YBL018C)|FD-Score:3.74|P-value:9.21E-5|Clearance:0.12||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:TAF10(YDR167W)|FD-Score:-3.67|P-value:1.23E-4|Clearance:0||SGD DESC:Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification Gene:TFC8(YPL007C)|FD-Score:4.58|P-value:2.29E-6|Clearance:0.61||SGD DESC:One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 Gene:YDR327W(YDR327W_d)|FD-Score:3.98|P-value:3.50E-5|Clearance:0.24||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1 Gene:ABD1(YBR236C)|FD-Score:3.62|P-value:1.48E-4|Clearance:0.13||SGD DESC:Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA Gene:APC1(YNL172W)|FD-Score:3.4|P-value:3.37E-4|Clearance:0.39||SGD DESC:Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress Gene:NAB2(YGL122C)|FD-Score:3.49|P-value:2.46E-4|Clearance:0.09||SGD DESC:Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress Gene:POP8(YBL018C)|FD-Score:3.74|P-value:9.21E-5|Clearance:0.12||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:TAF10(YDR167W)|FD-Score:-3.67|P-value:1.23E-4|Clearance:0||SGD DESC:Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification Gene:TFC8(YPL007C)|FD-Score:4.58|P-value:2.29E-6|Clearance:0.61||SGD DESC:One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 Gene:YDR327W(YDR327W_d)|FD-Score:3.98|P-value:3.50E-5|Clearance:0.24||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3656366
Download HOP data (tab-delimited text)  (excel)
Gene:AIF1(YNR074C)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase Gene:BEM2(YER155C)|FD-Score:-3.1|P-value:9.74E-4||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence Gene:CNL1(YDR357C_p)|FD-Score:4.3|P-value:8.65E-6||SGD DESC:Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:DSF2(YBR007C_p)|FD-Score:3.54|P-value:2.02E-4||SGD DESC:Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:EDC3(YEL015W)|FD-Score:-3.5|P-value:2.28E-4||SGD DESC:Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress Gene:HSP26(YBR072W)|FD-Score:4.69|P-value:1.35E-6||SGD DESC:Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity Gene:KIN3(YAR018C)|FD-Score:-4.1|P-value:2.11E-5||SGD DESC:Nonessential serine/threonine protein kinase; possible role in DNA damage response Gene:MBA1(YBR185C)|FD-Score:3.62|P-value:1.49E-4||SGD DESC:Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane Gene:RNR4(YGR180C)|FD-Score:3.78|P-value:7.72E-5||SGD DESC:Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:RPL16B(YNL069C)|FD-Score:4.04|P-value:2.63E-5||SGD DESC:Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication Gene:RPS21B(YJL136C)|FD-Score:-3.8|P-value:7.25E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication Gene:RRT6(YGL146C_p)|FD-Score:3.56|P-value:1.86E-4||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins Gene:SPO23(YBR250W)|FD-Score:-3.94|P-value:4.01E-5||SGD DESC:Protein of unknown function; associates with meiosis-specific protein Spo1p Gene:TPO4(YOR273C)|FD-Score:4.45|P-value:4.24E-6||SGD DESC:Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane Gene:TUL1(YKL034W)|FD-Score:3.46|P-value:2.73E-4||SGD DESC:Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1 Gene:UBI4(YLL039C)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress Gene:UGA1(YGR019W)|FD-Score:3.74|P-value:9.36E-5||SGD DESC:Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress Gene:VID24(YBR105C)|FD-Score:3.37|P-value:3.75E-4||SGD DESC:GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles Gene:YAL018C(YAL018C_p)|FD-Score:-3.1|P-value:9.84E-4||SGD DESC:Putative protein of unknown function Gene:YAL037C-A(YAL037C-A_p)|FD-Score:3.9|P-value:4.87E-5||SGD DESC:Putative protein of unknown function Gene:YBR012C(YBR012C_d)|FD-Score:3.27|P-value:5.39E-4||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p Gene:YGR054W(YGR054W)|FD-Score:4.75|P-value:1.02E-6||SGD DESC:Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A Gene:YHR007C-A(YHR007C-A_p)|FD-Score:3.63|P-value:1.40E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YLR278C(YLR278C_p)|FD-Score:3.09|P-value:9.95E-4||SGD DESC:Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene Gene:YNL217W(YNL217W_p)|FD-Score:3.21|P-value:6.63E-4||SGD DESC:Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate Gene:AIF1(YNR074C)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase Gene:BEM2(YER155C)|FD-Score:-3.1|P-value:9.74E-4||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence Gene:CNL1(YDR357C_p)|FD-Score:4.3|P-value:8.65E-6||SGD DESC:Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:DSF2(YBR007C_p)|FD-Score:3.54|P-value:2.02E-4||SGD DESC:Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:EDC3(YEL015W)|FD-Score:-3.5|P-value:2.28E-4||SGD DESC:Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress Gene:HSP26(YBR072W)|FD-Score:4.69|P-value:1.35E-6||SGD DESC:Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity Gene:KIN3(YAR018C)|FD-Score:-4.1|P-value:2.11E-5||SGD DESC:Nonessential serine/threonine protein kinase; possible role in DNA damage response Gene:MBA1(YBR185C)|FD-Score:3.62|P-value:1.49E-4||SGD DESC:Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane Gene:RNR4(YGR180C)|FD-Score:3.78|P-value:7.72E-5||SGD DESC:Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:RPL16B(YNL069C)|FD-Score:4.04|P-value:2.63E-5||SGD DESC:Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication Gene:RPS21B(YJL136C)|FD-Score:-3.8|P-value:7.25E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication Gene:RRT6(YGL146C_p)|FD-Score:3.56|P-value:1.86E-4||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins Gene:SPO23(YBR250W)|FD-Score:-3.94|P-value:4.01E-5||SGD DESC:Protein of unknown function; associates with meiosis-specific protein Spo1p Gene:TPO4(YOR273C)|FD-Score:4.45|P-value:4.24E-6||SGD DESC:Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane Gene:TUL1(YKL034W)|FD-Score:3.46|P-value:2.73E-4||SGD DESC:Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1 Gene:UBI4(YLL039C)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress Gene:UGA1(YGR019W)|FD-Score:3.74|P-value:9.36E-5||SGD DESC:Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress Gene:VID24(YBR105C)|FD-Score:3.37|P-value:3.75E-4||SGD DESC:GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles Gene:YAL018C(YAL018C_p)|FD-Score:-3.1|P-value:9.84E-4||SGD DESC:Putative protein of unknown function Gene:YAL037C-A(YAL037C-A_p)|FD-Score:3.9|P-value:4.87E-5||SGD DESC:Putative protein of unknown function Gene:YBR012C(YBR012C_d)|FD-Score:3.27|P-value:5.39E-4||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p Gene:YGR054W(YGR054W)|FD-Score:4.75|P-value:1.02E-6||SGD DESC:Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A Gene:YHR007C-A(YHR007C-A_p)|FD-Score:3.63|P-value:1.40E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YLR278C(YLR278C_p)|FD-Score:3.09|P-value:9.95E-4||SGD DESC:Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene Gene:YNL217W(YNL217W_p)|FD-Score:3.21|P-value:6.63E-4||SGD DESC:Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YPL007C4.582.29E-60.61TFC8One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90
YDR327W_d3.983.50E-50.24YDR327W_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1
YBL018C3.749.21E-50.12POP8Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YBR236C3.621.48E-40.13ABD1Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
YGL122C3.492.46E-40.09NAB2Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
YNL172W3.403.37E-40.39APC1Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress
YFL002C3.010.001290.07SPB4Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
YBL014C2.950.001590.05RRN6Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
YPL122C2.900.001890.08TFB2Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH
YHR062C2.810.002450.07RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YLR045C2.740.003060.02STU2Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
YDL064W2.720.003260.03UBC9SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
YNR003C2.690.003530.04RPC34RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
YDL003W2.650.003980.05MCD1Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase
YDL165W2.600.004610.04CDC36Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGR054W4.751.02E-6YGR054WEukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A
YBR072W4.691.35E-6HSP26Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity
YOR273C4.454.24E-6TPO4Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane
YDR357C_p4.308.65E-6CNL1_pProtein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YNL069C4.042.63E-5RPL16BRibosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication
YAL037C-A_p3.904.87E-5YAL037C-A_pPutative protein of unknown function
YGR180C3.787.72E-5RNR4Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress
YGR019W3.749.36E-5UGA1Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress
YHR007C-A_p3.631.40E-4YHR007C-A_pPutative protein of unknown function; identified by expression profiling and mass spectrometry
YLL039C3.631.44E-4UBI4Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress
YBR185C3.621.49E-4MBA1Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane
YNR074C3.581.69E-4AIF1Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase
YGL146C_p3.561.86E-4RRT6_pPutative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
YBR007C_p3.542.02E-4DSF2_pDeletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress
YKL034W3.462.73E-4TUL1Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1

GO enrichment analysis for SGTC_1688
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0722.84E-8SGTC_28699037858 32.5 μMChembridge (Drug-like library)271870420.0555556
0.0723.50E-8SGTC_615k087-0205 167.0 μMChemDiv (Drug-like library)96427730.0892857
0.0588.01E-6SGTC_2652actinonin 100.0 μMMicrosource (Natural product library)4436000.029703
0.0571.29E-5SGTC_21015377231 179.2 μMChembridge (Fragment library)28442130.0487805
0.0561.87E-5SGTC_20855307070 144.0 μMChembridge (Fragment library)28403510.366197superoxide
0.0533.99E-5SGTC_10214476-0760 85.3 μMChemDiv (Drug-like library)7467680.0333333
0.0491.59E-4SGTC_484loperamide 105.0 μMMiscellaneous39550.0416667
0.0482.08E-4SGTC_2674ligustilide 100.0 μMMicrosource (Natural product library)53190220.0886076
0.0482.33E-4SGTC_6164092-0450 108.0 μMChemDiv (Drug-like library)7871650.0481928
0.0472.74E-4SGTC_22827944268 200.0 μMChembridge (Fragment library)29704140.0365854RPP1 & pyrimidine depletion
0.0464.23E-4SGTC_1703st026983 48.3 μMTimTec (Natural product derivative library)11040230.175824
0.0454.80E-4SGTC_414piperonyl butoxide 100.0 μMMiscellaneous57940.0617284
0.0455.73E-4SGTC_24565770359 74.5 μMMiscellaneous31187870.0638298
0.0447.73E-4SGTC_11473809-1045 12.3 μMChemDiv (Drug-like library)3259250.0540541
0.0448.04E-4SGTC_29005328528 85.3 μMChembridge (Drug-like library)7953590.0609756Golgi

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_20855307070144.05 μM0.3661972840351Chembridge (Fragment library)286.348861.7415superoxide
SGTC_20895281248129.67 μM0.3150682737878Chembridge (Fragment library)272.322281.59515superoxide
SGTC_20705230947200 μM0.3055562835538Chembridge (Fragment library)260.311581.23215
SGTC_1634st00657641 μM0.2976193915356TimTec (Natural product derivative library)427.365823.48518TSC3-RPN4
SGTC_1643st00986620.2 μM0.2857143156273TimTec (Natural product derivative library)320.298881.92616
SGTC_2035515446394.6 μM0.2857142769623Chembridge (Fragment library)254.283861.48914
SGTC_1719st03222749.2 μM0.2716053125804TimTec (Natural product derivative library)406.388122.54718
SGTC_2067522462934.08 μM0.270272835000Chembridge (Fragment library)288.728922.15414
SGTC_23286201408200 μM0.2692312890418Chembridge (Fragment library)283.325081.48524
SGTC_1663st01414055.4 μM0.26254207120TimTec (Natural product derivative library)361.307742.311760S ribosome export