| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YIL154C | 10.20 | 1.65E-24 | IMP2' | Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat |
| YNL323W | 5.61 | 9.83E-9 | LEM3 | Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane |
| YGR167W | 5.22 | 9.15E-8 | CLC1 | Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W |
| YPL096W | 4.99 | 2.98E-7 | PNG1 | Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p |
| YPL214C | 4.41 | 5.15E-6 | THI6 | Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern |
| YEL023C_p | 4.20 | 1.35E-5 | YEL023C_p | Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene |
| YMR171C | 4.17 | 1.52E-5 | EAR1 | Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p |
| YJL129C | 3.92 | 4.34E-5 | TRK1 | Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication |
| YOR345C_d | 3.88 | 5.20E-5 | YOR345C_d | Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 |
| YCR102W-A_d | 3.86 | 5.57E-5 | YCR102W-A_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| YDR263C | 3.83 | 6.41E-5 | DIN7 | Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination |
| YHR030C | 3.72 | 9.95E-5 | SLT2 | Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway |
| YHR064C | 3.69 | 1.13E-4 | SSZ1 | Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP |
| YEL041W | 3.57 | 1.77E-4 | YEF1 | ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication |
| YER031C | 3.53 | 2.09E-4 | YPT31 | Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication |
