Deletion Strain | FD score | P-value | Gene | Gene Description |
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YNL229C | 6.46 | 5.21E-11 | URE2 | Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion |
YIR031C | 6.32 | 1.34E-10 | DAL7 | Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation |
YLR390W | 5.81 | 3.15E-9 | ECM19 | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YHR007C-A_p | 5.21 | 9.23E-8 | YHR007C-A_p | Putative protein of unknown function; identified by expression profiling and mass spectrometry |
YHR001W-A | 4.85 | 6.10E-7 | QCR10 | Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain |
YPL058C | 4.76 | 9.77E-7 | PDR12 | Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity |
YGL194C | 4.56 | 2.62E-6 | HOS2 | Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS |
YHL043W | 4.33 | 7.61E-6 | ECM34 | Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins |
YBR244W | 4.21 | 1.30E-5 | GPX2 | Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress |
YPL250C | 4.17 | 1.50E-5 | ICY2 | Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate |
YPR121W | 4.09 | 2.17E-5 | THI22 | Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis |
YNL056W | 4.06 | 2.49E-5 | OCA2 | Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene |
YKL204W | 3.94 | 4.02E-5 | EAP1 | eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade |
YAR035C-A_p | 3.94 | 4.09E-5 | YAR035C-A_p | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis |
YER158C_p | 3.83 | 6.38E-5 | YER158C_p | Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication |