st026914

3-[2-(4-methylphenyl)-2,3-dihydro-1H-1,5-benzodiazepin-4-yl]chromen-2-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1695
Screen concentration 34.5 μM
Source TimTec (Natural product derivative library)
PubChem CID 3289191
SMILES CC1=CC=C(C=C1)C2CC(=NC3=CC=CC=C3N2)C4=CC5=CC=CC=C5OC4=O
Standardized SMILES Cc1ccc(cc1)C2CC(=Nc3ccccc3N2)C4=Cc5ccccc5OC4=O
Molecular weight 380.4385
ALogP 5.27
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.94
% growth inhibition (Hom. pool) 9.88


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3289191
Download HIP data (tab-delimited text)  (excel)
Gene:ARP4(YJL081C)|FD-Score:-4.62|P-value:1.93E-6|Clearance:0||SGD DESC:Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes Gene:KAR1(YNL188W)|FD-Score:3.11|P-value:9.35E-4|Clearance:0.04||SGD DESC:Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p Gene:KOG1(YHR186C)|FD-Score:3.39|P-value:3.52E-4|Clearance:0.02||SGD DESC:Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors Gene:NCB2(YDR397C)|FD-Score:4.62|P-value:1.96E-6|Clearance:0.41||SGD DESC:Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta Gene:NOP4(YPL043W)|FD-Score:3.42|P-value:3.14E-4|Clearance:0.03||SGD DESC:Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs) Gene:RER2(YBR002C)|FD-Score:4.2|P-value:1.32E-5|Clearance:0.37||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RSC6(YCR052W)|FD-Score:4.88|P-value:5.27E-7|Clearance:0.41||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:SAH1(YER043C)|FD-Score:3.12|P-value:9.12E-4|Clearance:0.01||SGD DESC:S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor Gene:TIF6(YPR016C)|FD-Score:3.37|P-value:3.80E-4|Clearance:0.25||SGD DESC:Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits Gene:USE1(YGL098W)|FD-Score:3.83|P-value:6.38E-5|Clearance:0.41||SGD DESC:Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p Gene:ARP4(YJL081C)|FD-Score:-4.62|P-value:1.93E-6|Clearance:0||SGD DESC:Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes Gene:KAR1(YNL188W)|FD-Score:3.11|P-value:9.35E-4|Clearance:0.04||SGD DESC:Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p Gene:KOG1(YHR186C)|FD-Score:3.39|P-value:3.52E-4|Clearance:0.02||SGD DESC:Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors Gene:NCB2(YDR397C)|FD-Score:4.62|P-value:1.96E-6|Clearance:0.41||SGD DESC:Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta Gene:NOP4(YPL043W)|FD-Score:3.42|P-value:3.14E-4|Clearance:0.03||SGD DESC:Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs) Gene:RER2(YBR002C)|FD-Score:4.2|P-value:1.32E-5|Clearance:0.37||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RSC6(YCR052W)|FD-Score:4.88|P-value:5.27E-7|Clearance:0.41||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:SAH1(YER043C)|FD-Score:3.12|P-value:9.12E-4|Clearance:0.01||SGD DESC:S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor Gene:TIF6(YPR016C)|FD-Score:3.37|P-value:3.80E-4|Clearance:0.25||SGD DESC:Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits Gene:USE1(YGL098W)|FD-Score:3.83|P-value:6.38E-5|Clearance:0.41||SGD DESC:Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3289191
Download HOP data (tab-delimited text)  (excel)
Gene:ACE2(YLR131C)|FD-Score:3.18|P-value:7.48E-4||SGD DESC:Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Gene:AEP3(YPL005W)|FD-Score:5.06|P-value:2.13E-7||SGD DESC:Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA Gene:AGA2(YGL032C)|FD-Score:5.58|P-value:1.23E-8||SGD DESC:Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds Gene:AIM10(YER087W)|FD-Score:3.32|P-value:4.49E-4||SGD DESC:Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:ATP15(YPL271W)|FD-Score:4.08|P-value:2.23E-5||SGD DESC:Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Gene:ATP5(YDR298C)|FD-Score:3.77|P-value:8.28E-5||SGD DESC:Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated Gene:BAS1(YKR099W)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes Gene:BUD7(YOR299W)|FD-Score:-3.16|P-value:7.86E-4||SGD DESC:Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication Gene:BUR2(YLR226W)|FD-Score:3.29|P-value:5.06E-4||SGD DESC:Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II Gene:COS111(YBR203W)|FD-Score:-3.25|P-value:5.83E-4||SGD DESC:Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:COX16(YJL003W)|FD-Score:3.12|P-value:9.08E-4||SGD DESC:Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase Gene:CRS5(YOR031W)|FD-Score:4.17|P-value:1.51E-5||SGD DESC:Copper-binding metallothionein, required for wild-type copper resistance Gene:DEG1(YFL001W)|FD-Score:3.2|P-value:6.84E-4||SGD DESC:tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability Gene:DIA4(YHR011W)|FD-Score:4.14|P-value:1.77E-5||SGD DESC:Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth Gene:ENV10(YLR065C)|FD-Score:4.23|P-value:1.15E-5||SGD DESC:Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene Gene:FAA2(YER015W)|FD-Score:3.18|P-value:7.44E-4||SGD DESC:Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome Gene:FRM2(YCL026C-A)|FD-Score:4.12|P-value:1.93E-5||SGD DESC:Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin Gene:GCN20(YFR009W)|FD-Score:4.04|P-value:2.68E-5||SGD DESC:Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA Gene:GSH2(YOL049W)|FD-Score:3.26|P-value:5.50E-4||SGD DESC:Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock Gene:GTT2(YLL060C)|FD-Score:-3.11|P-value:9.40E-4||SGD DESC:Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress Gene:IMG2(YCR071C)|FD-Score:4|P-value:3.23E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:KCH1(YJR054W_p)|FD-Score:3.84|P-value:6.22E-5||SGD DESC:Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate Gene:MAC1(YMR021C)|FD-Score:-3.85|P-value:5.90E-5||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MBP1(YDL056W)|FD-Score:3.33|P-value:4.34E-4||SGD DESC:Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes Gene:MEF1(YLR069C)|FD-Score:3.16|P-value:7.85E-4||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:MIG3(YER028C)|FD-Score:3.49|P-value:2.44E-4||SGD DESC:Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication Gene:MRM1(YOR201C)|FD-Score:3.72|P-value:9.94E-5||SGD DESC:Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA Gene:MRPL16(YBL038W)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL20(YKR085C)|FD-Score:3.23|P-value:6.28E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSH1(YHR120W)|FD-Score:3.35|P-value:4.04E-4||SGD DESC:DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis Gene:MSK1(YNL073W)|FD-Score:3.31|P-value:4.69E-4||SGD DESC:Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys) Gene:MSR1(YHR091C)|FD-Score:3.23|P-value:6.09E-4||SGD DESC:Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 Gene:MTG1(YMR097C)|FD-Score:4.55|P-value:2.70E-6||SGD DESC:Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals Gene:NHP10(YDL002C)|FD-Score:4.93|P-value:4.20E-7||SGD DESC:Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair Gene:NTH2(YBR001C)|FD-Score:4.45|P-value:4.28E-6||SGD DESC:Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication Gene:PET117(YER058W)|FD-Score:3.33|P-value:4.39E-4||SGD DESC:Protein required for assembly of cytochrome c oxidase Gene:PPA2(YMR267W)|FD-Score:4.29|P-value:9.11E-6||SGD DESC:Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate Gene:QCR6(YFR033C)|FD-Score:4.33|P-value:7.60E-6||SGD DESC:Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space Gene:RIC1(YLR039C)|FD-Score:3.5|P-value:2.34E-4||SGD DESC:Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes Gene:RPL35A(YDL191W)|FD-Score:4.91|P-value:4.57E-7||SGD DESC:Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication Gene:RPL7A(YGL076C)|FD-Score:4.18|P-value:1.45E-5||SGD DESC:Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication Gene:RRG8(YPR116W)|FD-Score:3.26|P-value:5.59E-4||SGD DESC:Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport Gene:RTC6(YPL183W-A)|FD-Score:3.77|P-value:8.24E-5||SGD DESC:Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress Gene:SEG1(YMR086W)|FD-Score:3.19|P-value:7.05E-4||SGD DESC:Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes Gene:SSA3(YBL075C)|FD-Score:4.67|P-value:1.54E-6||SGD DESC:ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication Gene:SWA2(YDR320C)|FD-Score:4.61|P-value:1.99E-6||SGD DESC:Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles Gene:TMA10(YLR327C)|FD-Score:-3.13|P-value:8.87E-4||SGD DESC:Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress Gene:YAR029W(YAR029W_p)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:YAR035C-A(YAR035C-A_p)|FD-Score:3.74|P-value:9.14E-5||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis Gene:YCR025C(YCR025C_d)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene Gene:YCR095W-A(YCR095W-A_p)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Putative protein of unknown function Gene:YDL159W-A(YDL159W-A_p)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species Gene:YDR114C(YDR114C_p)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium Gene:YER077C(YER077C_p)|FD-Score:4.17|P-value:1.49E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport Gene:YGR079W(YGR079W_p)|FD-Score:3.15|P-value:8.04E-4||SGD DESC:Putative protein of unknown function; YGR079W is not an essential gene Gene:YJL070C(YJL070C_p)|FD-Score:3.29|P-value:5.01E-4||SGD DESC:Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication Gene:YKL118W(YKL118W_d)|FD-Score:3.26|P-value:5.58E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Gene:YLR063W(YLR063W_p)|FD-Score:4.02|P-value:2.91E-5||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene Gene:YML119W(YML119W_p)|FD-Score:-3.47|P-value:2.61E-4||SGD DESC:Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate Gene:YMR027W(YMR027W_p)|FD-Score:3.47|P-value:2.65E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene Gene:YOL038C-A(YOL038C-A_p)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Putative protein of unknown function; identified by SAGE analysis Gene:YPT6(YLR262C)|FD-Score:3.55|P-value:1.91E-4||SGD DESC:Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 Gene:YTA12(YMR089C)|FD-Score:3.32|P-value:4.55E-4||SGD DESC:Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes Gene:ACE2(YLR131C)|FD-Score:3.18|P-value:7.48E-4||SGD DESC:Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Gene:AEP3(YPL005W)|FD-Score:5.06|P-value:2.13E-7||SGD DESC:Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA Gene:AGA2(YGL032C)|FD-Score:5.58|P-value:1.23E-8||SGD DESC:Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds Gene:AIM10(YER087W)|FD-Score:3.32|P-value:4.49E-4||SGD DESC:Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:ATP15(YPL271W)|FD-Score:4.08|P-value:2.23E-5||SGD DESC:Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Gene:ATP5(YDR298C)|FD-Score:3.77|P-value:8.28E-5||SGD DESC:Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated Gene:BAS1(YKR099W)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes Gene:BUD7(YOR299W)|FD-Score:-3.16|P-value:7.86E-4||SGD DESC:Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication Gene:BUR2(YLR226W)|FD-Score:3.29|P-value:5.06E-4||SGD DESC:Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II Gene:COS111(YBR203W)|FD-Score:-3.25|P-value:5.83E-4||SGD DESC:Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:COX16(YJL003W)|FD-Score:3.12|P-value:9.08E-4||SGD DESC:Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase Gene:CRS5(YOR031W)|FD-Score:4.17|P-value:1.51E-5||SGD DESC:Copper-binding metallothionein, required for wild-type copper resistance Gene:DEG1(YFL001W)|FD-Score:3.2|P-value:6.84E-4||SGD DESC:tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability Gene:DIA4(YHR011W)|FD-Score:4.14|P-value:1.77E-5||SGD DESC:Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth Gene:ENV10(YLR065C)|FD-Score:4.23|P-value:1.15E-5||SGD DESC:Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene Gene:FAA2(YER015W)|FD-Score:3.18|P-value:7.44E-4||SGD DESC:Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome Gene:FRM2(YCL026C-A)|FD-Score:4.12|P-value:1.93E-5||SGD DESC:Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin Gene:GCN20(YFR009W)|FD-Score:4.04|P-value:2.68E-5||SGD DESC:Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA Gene:GSH2(YOL049W)|FD-Score:3.26|P-value:5.50E-4||SGD DESC:Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock Gene:GTT2(YLL060C)|FD-Score:-3.11|P-value:9.40E-4||SGD DESC:Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress Gene:IMG2(YCR071C)|FD-Score:4|P-value:3.23E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:KCH1(YJR054W_p)|FD-Score:3.84|P-value:6.22E-5||SGD DESC:Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate Gene:MAC1(YMR021C)|FD-Score:-3.85|P-value:5.90E-5||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MBP1(YDL056W)|FD-Score:3.33|P-value:4.34E-4||SGD DESC:Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes Gene:MEF1(YLR069C)|FD-Score:3.16|P-value:7.85E-4||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:MIG3(YER028C)|FD-Score:3.49|P-value:2.44E-4||SGD DESC:Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication Gene:MRM1(YOR201C)|FD-Score:3.72|P-value:9.94E-5||SGD DESC:Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA Gene:MRPL16(YBL038W)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL20(YKR085C)|FD-Score:3.23|P-value:6.28E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSH1(YHR120W)|FD-Score:3.35|P-value:4.04E-4||SGD DESC:DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis Gene:MSK1(YNL073W)|FD-Score:3.31|P-value:4.69E-4||SGD DESC:Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys) Gene:MSR1(YHR091C)|FD-Score:3.23|P-value:6.09E-4||SGD DESC:Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 Gene:MTG1(YMR097C)|FD-Score:4.55|P-value:2.70E-6||SGD DESC:Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals Gene:NHP10(YDL002C)|FD-Score:4.93|P-value:4.20E-7||SGD DESC:Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair Gene:NTH2(YBR001C)|FD-Score:4.45|P-value:4.28E-6||SGD DESC:Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication Gene:PET117(YER058W)|FD-Score:3.33|P-value:4.39E-4||SGD DESC:Protein required for assembly of cytochrome c oxidase Gene:PPA2(YMR267W)|FD-Score:4.29|P-value:9.11E-6||SGD DESC:Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate Gene:QCR6(YFR033C)|FD-Score:4.33|P-value:7.60E-6||SGD DESC:Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space Gene:RIC1(YLR039C)|FD-Score:3.5|P-value:2.34E-4||SGD DESC:Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes Gene:RPL35A(YDL191W)|FD-Score:4.91|P-value:4.57E-7||SGD DESC:Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication Gene:RPL7A(YGL076C)|FD-Score:4.18|P-value:1.45E-5||SGD DESC:Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication Gene:RRG8(YPR116W)|FD-Score:3.26|P-value:5.59E-4||SGD DESC:Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport Gene:RTC6(YPL183W-A)|FD-Score:3.77|P-value:8.24E-5||SGD DESC:Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress Gene:SEG1(YMR086W)|FD-Score:3.19|P-value:7.05E-4||SGD DESC:Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes Gene:SSA3(YBL075C)|FD-Score:4.67|P-value:1.54E-6||SGD DESC:ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication Gene:SWA2(YDR320C)|FD-Score:4.61|P-value:1.99E-6||SGD DESC:Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles Gene:TMA10(YLR327C)|FD-Score:-3.13|P-value:8.87E-4||SGD DESC:Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress Gene:YAR029W(YAR029W_p)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:YAR035C-A(YAR035C-A_p)|FD-Score:3.74|P-value:9.14E-5||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis Gene:YCR025C(YCR025C_d)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene Gene:YCR095W-A(YCR095W-A_p)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Putative protein of unknown function Gene:YDL159W-A(YDL159W-A_p)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species Gene:YDR114C(YDR114C_p)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium Gene:YER077C(YER077C_p)|FD-Score:4.17|P-value:1.49E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport Gene:YGR079W(YGR079W_p)|FD-Score:3.15|P-value:8.04E-4||SGD DESC:Putative protein of unknown function; YGR079W is not an essential gene Gene:YJL070C(YJL070C_p)|FD-Score:3.29|P-value:5.01E-4||SGD DESC:Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication Gene:YKL118W(YKL118W_d)|FD-Score:3.26|P-value:5.58E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Gene:YLR063W(YLR063W_p)|FD-Score:4.02|P-value:2.91E-5||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene Gene:YML119W(YML119W_p)|FD-Score:-3.47|P-value:2.61E-4||SGD DESC:Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate Gene:YMR027W(YMR027W_p)|FD-Score:3.47|P-value:2.65E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene Gene:YOL038C-A(YOL038C-A_p)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Putative protein of unknown function; identified by SAGE analysis Gene:YPT6(YLR262C)|FD-Score:3.55|P-value:1.91E-4||SGD DESC:Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 Gene:YTA12(YMR089C)|FD-Score:3.32|P-value:4.55E-4||SGD DESC:Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YCR052W4.885.27E-70.41RSC6Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
YDR397C4.621.96E-60.41NCB2Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
YBR002C4.201.32E-50.37RER2Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
YGL098W3.836.38E-50.41USE1Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
YPL043W3.423.14E-40.03NOP4Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
YHR186C3.393.52E-40.02KOG1Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
YPR016C3.373.80E-40.25TIF6Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits
YER043C3.129.12E-40.01SAH1S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
YNL188W3.119.35E-40.04KAR1Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
YDR170C3.070.001080.03SEC7Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
YKR008W3.040.001190.01RSC4Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p
YPR180W3.030.001220.03AOS1Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
YDR196C3.000.001370.00CAB5Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies
YFR052W2.990.001390.07RPN12Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress
YBR192W2.920.001770.03RIM2Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGL032C5.581.23E-8AGA2Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
YPL005W5.062.13E-7AEP3Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA
YDL002C4.934.20E-7NHP10Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
YDL191W4.914.57E-7RPL35ARibosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication
YBL075C4.671.54E-6SSA3ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication
YDR320C4.611.99E-6SWA2Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
YMR097C4.552.70E-6MTG1Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
YBR001C4.454.28E-6NTH2Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication
YFR033C4.337.60E-6QCR6Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space
YMR267W4.299.11E-6PPA2Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
YLR065C4.231.15E-5ENV10Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene
YGL076C4.181.45E-5RPL7ARibosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication
YER077C_p4.171.49E-5YER077C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
YOR031W4.171.51E-5CRS5Copper-binding metallothionein, required for wild-type copper resistance
YHR011W4.141.77E-5DIA4Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth

GO enrichment analysis for SGTC_1695
biological processes

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1713.74E-40SGTC_1731273-0061 2.7 μMChemDiv (Drug-like library)28474140.0769231mitochondrial stress
0.1612.12E-35SGTC_100279-0212 42.6 μMChemDiv (Drug-like library)398510.119403TRP & mitochondrial translation
0.1612.17E-35SGTC_1742st038235 28.9 μMTimTec (Natural product derivative library)5641030.101124mitochondrial stress
0.1278.30E-23SGTC_13712421-0008 32.7 μMChemDiv (Drug-like library)28275520.0853659mitochondrial processes
0.1257.49E-22SGTC_3101273-0058 1.1 μMChemDiv (Drug-like library)27342320.0273973mitochondrial stress
0.1241.54E-21SGTC_7670929-0023 86.0 μMChemDiv (Drug-like library)12045630.0875TRP & mitochondrial translation
0.1193.83E-20SGTC_1627st003713 25.6 μMTimTec (Natural product derivative library)161950700.0882353calcium & mitochondrial duress
0.1195.35E-20SGTC_275trichlorophene 5.7 μMMiscellaneous626160.0422535mitochondrial stress
0.1162.86E-19SGTC_630099-0242 26.7 μMChemDiv (Drug-like library)38985020.0555556mitochondrial stress
0.1102.28E-17SGTC_28pentachloropyridine N-oxide 1.6 μMChemDiv (Drug-like library)1402500.016129TSC3-RPN4
0.1041.20E-15SGTC_11881403-0014 4.6 μMChemDiv (Drug-like library)96148670.05mitochondrial stress
0.0991.82E-14SGTC_8920929-0076 29.0 μMChemDiv (Drug-like library)57510380.164179TRP & mitochondrial translation
0.0992.27E-14SGTC_5961155-0152 116.0 μMChemDiv (Drug-like library)2803130.0833333TRP & mitochondrial translation
0.0983.58E-14SGTC_2361509-0011 5.3 μMChemDiv (Drug-like library)31072800.0632911
0.0983.93E-14SGTC_190279-0214 38.4 μMChemDiv (Drug-like library)35662740.102941TRP & mitochondrial translation

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1820st05376518.6 μM0.4857143690829TimTec (Natural product derivative library)428.459845.4106RPP1 & pyrimidine depletion
SGTC_2981391-072910 μM0.3492063237558ChemDiv (Drug-like library)263.247563.3104calcium & mitochondrial duress
SGTC_1958st07651341.9 μM0.34375732122TimTec (Natural product derivative library)262.26283.31360S ribosome export
SGTC_1655st01254655.1 μM0.33871720985TimTec (Natural product derivative library)237.253342.63113
SGTC_1971st06942963.5 μM0.3333331246522TimTec (Natural product derivative library)280.278082.5191460S ribosome export
SGTC_1628st00425277.7 μM0.298507692968TimTec (Natural product derivative library)257.28452.4713
SGTC_9041141-0088396 μM0.2972971378119ChemDiv (Drug-like library)371.385384.14614
SGTC_1703st02698348.3 μM0.2804881104023TimTec (Natural product derivative library)414.410125.02915
SGTC_1856st05705455.7 μM0.2763161266018TimTec (Natural product derivative library)359.3498634.36814
SGTC_13671812-051076.9 μM0.2727271142582ChemDiv (Drug-like library)410.217584.12614