Deletion Strain | FD score | P-value | Gene | Gene Description |
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YLR032W | 10.10 | 3.56E-24 | RAD5 | DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress |
YKR017C_p | 6.46 | 5.34E-11 | HEL1_p | RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU) |
YGR008C | 5.73 | 5.00E-9 | STF2 | Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress |
YDR479C | 5.48 | 2.18E-8 | PEX29 | Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress |
YBR027C_d | 5.15 | 1.28E-7 | YBR027C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YJL108C | 5.15 | 1.30E-7 | PRM10 | Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation |
YOR321W | 5.03 | 2.46E-7 | PMT3 | Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication |
YFR026C | 4.83 | 6.88E-7 | ULI1 | Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response |
YNR008W | 4.70 | 1.27E-6 | LRO1 | Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase |
YKL161C | 4.54 | 2.76E-6 | KDX1 | Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p |
YOR096W | 4.44 | 4.58E-6 | RPS7A | Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication |
YGR069W_d | 4.43 | 4.72E-6 | YGR069W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YGL152C_d | 4.35 | 6.71E-6 | YGL152C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W |
YOL001W | 4.29 | 8.81E-6 | PHO80 | Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling |
YOR053W_d | 4.04 | 2.66E-5 | YOR053W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C |