Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
---|
YDR167W | 4.14 | 1.71E-5 | 0.26 | TAF10 | Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification |
YLL036C | 4.12 | 1.88E-5 | 0.26 | PRP19 | Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain |
YOL127W | 4.02 | 2.89E-5 | 0.26 | RPL25 | Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23 |
YFL039C | 3.86 | 5.58E-5 | 0.26 | ACT1 | Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions |
YIL063C | 3.81 | 7.07E-5 | 0.26 | YRB2 | Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential |
YGR116W | 3.68 | 1.18E-4 | 0.26 | SPT6 | Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region |
YDR172W | 3.57 | 1.77E-4 | 0.26 | SUP35 | Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype |
YMR235C | 3.57 | 1.79E-4 | 0.26 | RNA1 | GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport |
YNL313C | 3.46 | 2.75E-4 | 0.26 | EMW1 | Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress |
YLR249W | 3.20 | 6.93E-4 | 0.04 | YEF3 | Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog, HEF3, that arose from the whole genome duplication |
YNL114C_d | 3.16 | 7.98E-4 | 0.01 | YNL114C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit |
YDL148C | 3.15 | 8.13E-4 | 0.05 | NOP14 | Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA |
YAL034C-B_d | 3.10 | 9.65E-4 | 0.06 | YAL034C-B_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YFL005W | 3.04 | 0.00119 | 0.05 | SEC4 | Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane |
YKL018W | 2.99 | 0.00141 | 0.02 | SWD2 | Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination |