Deletion Strain | FD score | P-value | Gene | Gene Description |
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YPR009W | 10.70 | 4.11E-27 | SUT2 | Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p |
YNL298W | 7.71 | 6.47E-15 | CLA4 | Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p |
YBR028C | 6.53 | 3.35E-11 | YPK3 | An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner |
YLR415C_p | 6.48 | 4.48E-11 | YLR415C_p | Putative protein of unknown function; YLR415C is not an essential gene |
YNL099C | 6.03 | 8.15E-10 | OCA1 | Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA |
YLR020C | 5.62 | 9.80E-9 | YEH2 | Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism |
YLR342W | 5.16 | 1.26E-7 | FKS1 | Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling |
YIL016W | 5.14 | 1.41E-7 | SNL1 | Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein |
YKL015W | 5.06 | 2.13E-7 | PUT3 | Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain |
YMR294W | 5.02 | 2.54E-7 | JNM1 | Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B |
YER169W | 5.01 | 2.79E-7 | RPH1 | JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication |
YKL218C | 4.93 | 4.10E-7 | SRY1 | 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity |
YLR425W | 4.68 | 1.41E-6 | TUS1 | Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate |
YER097W_d | 4.58 | 2.38E-6 | YER097W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YLR270W | 4.35 | 6.73E-6 | DCS1 | Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress |