Deletion Strain | FD score | P-value | Gene | Gene Description |
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YNL099C | 6.99 | 1.35E-12 | OCA1 | Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA |
YGL043W | 6.70 | 1.08E-11 | DST1 | General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress |
YPL042C | 6.13 | 4.49E-10 | SSN3 | Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression |
YKL170W | 6.13 | 4.50E-10 | MRPL38 | Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress |
YGL175C | 5.93 | 1.53E-9 | SAE2 | Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents |
YNL139C | 5.20 | 1.01E-7 | THO2 | Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids |
YKR020W | 4.95 | 3.80E-7 | VPS51 | Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p |
YBL053W_d | 4.85 | 6.06E-7 | YBL053W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YMR097C | 4.85 | 6.12E-7 | MTG1 | Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals |
YIL009C-A | 4.66 | 1.59E-6 | EST3 | Component of the telomerase holoenzyme, involved in telomere replication |
YHL020C | 4.63 | 1.84E-6 | OPI1 | Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance |
YNL123W | 4.55 | 2.73E-6 | NMA111 | Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases |
YHR059W | 4.50 | 3.33E-6 | FYV4 | Protein of unknown function, required for survival upon exposure to K1 killer toxin |
YNL300W_p | 4.42 | 4.89E-6 | TOS6_p | Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid |
YGR063C | 4.36 | 6.64E-6 | SPT4 | Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions |