st038134

6-chloro-3-[3-(6-chloro-2-oxo-1,3-benzoxazol-3-yl)-3-oxopropyl]-1,3-benzoxazol-2-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1741
Screen concentration 10.2 μM
Source TimTec (Natural product derivative library)
PubChem CID 1272587
SMILES C1=CC2=C(C=C1Cl)OC(=O)N2CCC(=O)N3C4=C(C=C(C=C4)Cl)OC3=O
Standardized SMILES Clc1ccc2N(CCC(=O)N3C(=O)Oc4cc(Cl)ccc34)C(=O)Oc2c1
Molecular weight 393.1777
ALogP 4.14
H-bond donor count 0
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.53
% growth inhibition (Hom. pool) 3.53


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 1272587
Download HIP data (tab-delimited text)  (excel)
Gene:CDC48(YDL126C)|FD-Score:5.48|P-value:2.18E-8|Clearance:1.1||SGD DESC:AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP Gene:COP1(YDL145C)|FD-Score:3.4|P-value:3.38E-4|Clearance:0.08||SGD DESC:Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway Gene:ERG10(YPL028W)|FD-Score:3.64|P-value:1.38E-4|Clearance:0.11||SGD DESC:Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis Gene:GPI14(YJR013W)|FD-Score:3.79|P-value:7.43E-5|Clearance:0.16||SGD DESC:Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M Gene:MCM5(YLR274W)|FD-Score:3.32|P-value:4.53E-4|Clearance:0.04||SGD DESC:Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase Gene:NAT2(YGR147C)|FD-Score:3.18|P-value:7.44E-4|Clearance:0.04||SGD DESC:Protein with an apparent role in acetylation of N-terminal methionine residues Gene:NHP2(YDL208W)|FD-Score:-3.13|P-value:8.68E-4|Clearance:0||SGD DESC:Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing Gene:NOP58(YOR310C)|FD-Score:4.01|P-value:2.99E-5|Clearance:0.22||SGD DESC:Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA Gene:RNR2(YJL026W)|FD-Score:4.37|P-value:6.10E-6|Clearance:0.36||SGD DESC:Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits Gene:SPP382(YLR424W)|FD-Score:-3.22|P-value:6.33E-4|Clearance:0||SGD DESC:Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation Gene:SPT16(YGL207W)|FD-Score:-3.45|P-value:2.85E-4|Clearance:0||SGD DESC:Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome Gene:STU2(YLR045C)|FD-Score:3.13|P-value:8.64E-4|Clearance:0.23||SGD DESC:Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p Gene:TFC3(YAL001C)|FD-Score:3.52|P-value:2.12E-4|Clearance:0.13||SGD DESC:Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding Gene:TIM44(YIL022W)|FD-Score:3.28|P-value:5.22E-4|Clearance:0.07||SGD DESC:Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex) Gene:TSC13(YDL015C)|FD-Score:3.21|P-value:6.69E-4|Clearance:0.03||SGD DESC:Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress Gene:UTP11(YKL099C)|FD-Score:-3.28|P-value:5.19E-4|Clearance:0||SGD DESC:Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit Gene:WRS1(YOL097C)|FD-Score:7.33|P-value:1.17E-13|Clearance:1.85||SGD DESC:Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA Gene:CDC48(YDL126C)|FD-Score:5.48|P-value:2.18E-8|Clearance:1.1||SGD DESC:AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP Gene:COP1(YDL145C)|FD-Score:3.4|P-value:3.38E-4|Clearance:0.08||SGD DESC:Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway Gene:ERG10(YPL028W)|FD-Score:3.64|P-value:1.38E-4|Clearance:0.11||SGD DESC:Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis Gene:GPI14(YJR013W)|FD-Score:3.79|P-value:7.43E-5|Clearance:0.16||SGD DESC:Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M Gene:MCM5(YLR274W)|FD-Score:3.32|P-value:4.53E-4|Clearance:0.04||SGD DESC:Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase Gene:NAT2(YGR147C)|FD-Score:3.18|P-value:7.44E-4|Clearance:0.04||SGD DESC:Protein with an apparent role in acetylation of N-terminal methionine residues Gene:NHP2(YDL208W)|FD-Score:-3.13|P-value:8.68E-4|Clearance:0||SGD DESC:Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing Gene:NOP58(YOR310C)|FD-Score:4.01|P-value:2.99E-5|Clearance:0.22||SGD DESC:Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA Gene:RNR2(YJL026W)|FD-Score:4.37|P-value:6.10E-6|Clearance:0.36||SGD DESC:Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits Gene:SPP382(YLR424W)|FD-Score:-3.22|P-value:6.33E-4|Clearance:0||SGD DESC:Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation Gene:SPT16(YGL207W)|FD-Score:-3.45|P-value:2.85E-4|Clearance:0||SGD DESC:Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome Gene:STU2(YLR045C)|FD-Score:3.13|P-value:8.64E-4|Clearance:0.23||SGD DESC:Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p Gene:TFC3(YAL001C)|FD-Score:3.52|P-value:2.12E-4|Clearance:0.13||SGD DESC:Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding Gene:TIM44(YIL022W)|FD-Score:3.28|P-value:5.22E-4|Clearance:0.07||SGD DESC:Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex) Gene:TSC13(YDL015C)|FD-Score:3.21|P-value:6.69E-4|Clearance:0.03||SGD DESC:Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress Gene:UTP11(YKL099C)|FD-Score:-3.28|P-value:5.19E-4|Clearance:0||SGD DESC:Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit Gene:WRS1(YOL097C)|FD-Score:7.33|P-value:1.17E-13|Clearance:1.85||SGD DESC:Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 1272587
Download HOP data (tab-delimited text)  (excel)
Gene:ADE5,7(YGL234W)|FD-Score:3.44|P-value:2.96E-4||SGD DESC:Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities Gene:ADY4(YLR227C)|FD-Score:-4.45|P-value:4.32E-6||SGD DESC:Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane Gene:AGP3(YFL055W)|FD-Score:3.61|P-value:1.56E-4||SGD DESC:Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition Gene:AIM18(YHR198C)|FD-Score:-3.48|P-value:2.54E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:AIM2(YAL049C)|FD-Score:3.81|P-value:7.03E-5||SGD DESC:Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor Gene:AIM34(YMR003W)|FD-Score:-5.19|P-value:1.03E-7||SGD DESC:Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss Gene:ANP1(YEL036C)|FD-Score:3.13|P-value:8.79E-4||SGD DESC:Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol Gene:ATG33(YLR356W)|FD-Score:3.86|P-value:5.75E-5||SGD DESC:Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes Gene:BDH1(YAL060W)|FD-Score:4.61|P-value:2.04E-6||SGD DESC:NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source Gene:BEM1(YBR200W)|FD-Score:-3.38|P-value:3.66E-4||SGD DESC:Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p Gene:BIT61(YJL058C)|FD-Score:4.66|P-value:1.59E-6||SGD DESC:Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication Gene:CAC2(YML102W)|FD-Score:4.75|P-value:1.04E-6||SGD DESC:Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription Gene:CIN2(YPL241C)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 Gene:CNE1(YAL058W)|FD-Score:3.34|P-value:4.21E-4||SGD DESC:Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast Gene:COS6(YGR295C)|FD-Score:3.41|P-value:3.28E-4||SGD DESC:Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:CRC1(YOR100C)|FD-Score:3.41|P-value:3.21E-4||SGD DESC:Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation Gene:CUP2(YGL166W)|FD-Score:7.68|P-value:7.73E-15||SGD DESC:Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication Gene:DAL5(YJR152W)|FD-Score:4.33|P-value:7.48E-6||SGD DESC:Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression Gene:DAP2(YHR028C)|FD-Score:-5.54|P-value:1.53E-8||SGD DESC:Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p Gene:DCN1(YLR128W)|FD-Score:3.24|P-value:6.03E-4||SGD DESC:Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation Gene:DJP1(YIR004W)|FD-Score:-3.33|P-value:4.27E-4||SGD DESC:Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ Gene:DSE2(YHR143W)|FD-Score:3.99|P-value:3.30E-5||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:EPS1(YIL005W)|FD-Score:8.57|P-value:5.38E-18||SGD DESC:ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family Gene:FLO1(YAR050W)|FD-Score:3.32|P-value:4.58E-4||SGD DESC:Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p Gene:FRT1(YOR324C)|FD-Score:-3.32|P-value:4.49E-4||SGD DESC:Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication Gene:GAT3(YLR013W)|FD-Score:3.19|P-value:7.17E-4||SGD DESC:Protein containing GATA family zinc finger motifs Gene:GCS1(YDL226C)|FD-Score:-4.1|P-value:2.10E-5||SGD DESC:ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p Gene:GTT2(YLL060C)|FD-Score:3.17|P-value:7.65E-4||SGD DESC:Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress Gene:GYP5(YPL249C)|FD-Score:3.96|P-value:3.82E-5||SGD DESC:GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:HAA1(YPR008W)|FD-Score:3.38|P-value:3.66E-4||SGD DESC:Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress Gene:HIS3(YOR202W)|FD-Score:9.57|P-value:5.29E-22||SGD DESC:Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p Gene:HNT1(YDL125C)|FD-Score:-3.5|P-value:2.30E-4||SGD DESC:Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress Gene:HXT17(YNR072W)|FD-Score:6.67|P-value:1.32E-11||SGD DESC:Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose Gene:IES4(YOR189W)|FD-Score:-4.03|P-value:2.78E-5||SGD DESC:Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses Gene:INP51(YIL002C)|FD-Score:3.2|P-value:6.81E-4||SGD DESC:Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth Gene:ISA1(YLL027W)|FD-Score:3.18|P-value:7.30E-4||SGD DESC:Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins Gene:JHD1(YER051W)|FD-Score:-4.1|P-value:2.10E-5||SGD DESC:JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe Gene:KTR4(YBR199W)|FD-Score:5.53|P-value:1.65E-8||SGD DESC:Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family Gene:LIF1(YGL090W)|FD-Score:-4.63|P-value:1.82E-6||SGD DESC:Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein Gene:MHT1(YLL062C)|FD-Score:4.07|P-value:2.31E-5||SGD DESC:S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio Gene:MRPL7(YDR237W)|FD-Score:3.37|P-value:3.70E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein Gene:NAT4(YMR069W)|FD-Score:4.7|P-value:1.29E-6||SGD DESC:N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A Gene:NPY1(YGL067W)|FD-Score:3.18|P-value:7.45E-4||SGD DESC:NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member Gene:NTG1(YAL015C)|FD-Score:-4.83|P-value:6.74E-7||SGD DESC:DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication Gene:PET54(YGR222W)|FD-Score:-4.95|P-value:3.76E-7||SGD DESC:Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing Gene:PGM1(YKL127W)|FD-Score:-3.35|P-value:4.05E-4||SGD DESC:Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism Gene:PRM5(YIL117C)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling Gene:PSP1(YDR505C)|FD-Score:4.3|P-value:8.43E-6||SGD DESC:Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication Gene:QCR2(YPR191W)|FD-Score:-4.29|P-value:8.98E-6||SGD DESC:Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme Gene:RAD5(YLR032W)|FD-Score:-3.3|P-value:4.92E-4||SGD DESC:DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress Gene:REV3(YPL167C)|FD-Score:-4.57|P-value:2.39E-6||SGD DESC:Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair Gene:RIM13(YMR154C)|FD-Score:4.06|P-value:2.43E-5||SGD DESC:Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB Gene:RSM7(YJR113C)|FD-Score:3.99|P-value:3.26E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein Gene:SAP185(YJL098W)|FD-Score:3.47|P-value:2.64E-4||SGD DESC:Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication Gene:SCO1(YBR037C)|FD-Score:3.19|P-value:7.17E-4||SGD DESC:Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication Gene:SGF11(YPL047W)|FD-Score:-5.06|P-value:2.08E-7||SGD DESC:Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation Gene:SNF4(YGL115W)|FD-Score:-3.43|P-value:3.07E-4||SGD DESC:Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress Gene:SOD2(YHR008C)|FD-Score:3.47|P-value:2.58E-4||SGD DESC:Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated Gene:SOL3(YHR163W)|FD-Score:5.26|P-value:7.17E-8||SGD DESC:6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication Gene:SPS100(YHR139C)|FD-Score:5.83|P-value:2.72E-9||SGD DESC:Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin Gene:SRB5(YGR104C)|FD-Score:3.76|P-value:8.57E-5||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance Gene:SWD3(YBR175W)|FD-Score:3.87|P-value:5.36E-5||SGD DESC:Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 Gene:TDA5(YLR426W_p)|FD-Score:3.83|P-value:6.40E-5||SGD DESC:Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele Gene:TDH2(YJR009C)|FD-Score:3.28|P-value:5.18E-4||SGD DESC:Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; TDH2 has a paralog, TDH3, that arose from the whole genome duplication Gene:THI20(YOL055C)|FD-Score:3.26|P-value:5.63E-4||SGD DESC:Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p Gene:TMA17(YDL110C)|FD-Score:5|P-value:2.92E-7||SGD DESC:Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion Gene:TRP1(YDR007W)|FD-Score:-3.51|P-value:2.22E-4||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:VCX1(YDL128W)|FD-Score:3.4|P-value:3.41E-4||SGD DESC:Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter Gene:VPS71(YML041C)|FD-Score:5.56|P-value:1.35E-8||SGD DESC:Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting Gene:WSC3(YOL105C)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis Gene:YAL065C(YAL065C_p)|FD-Score:3.19|P-value:7.13E-4||SGD DESC:Putative protein of unknown function; has homology to FLO1; possible pseudogene Gene:YAT2(YER024W)|FD-Score:-5.98|P-value:1.09E-9||SGD DESC:Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane Gene:YBR134W(YBR134W_d)|FD-Score:4.58|P-value:2.36E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YCK2(YNL154C)|FD-Score:-4.2|P-value:1.34E-5||SGD DESC:Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication Gene:YDL086W(YDL086W_p)|FD-Score:4.28|P-value:9.34E-6||SGD DESC:Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene Gene:YDL114W(YDL114W_p)|FD-Score:4.17|P-value:1.54E-5||SGD DESC:Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene Gene:YDL177C(YDL177C_p)|FD-Score:4.34|P-value:7.11E-6||SGD DESC:Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene Gene:YDR132C(YDR132C_p)|FD-Score:3.29|P-value:5.09E-4||SGD DESC:Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication Gene:YER135C(YER135C_d)|FD-Score:-3.59|P-value:1.67E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Gene:YER184C(YER184C_p)|FD-Score:3.41|P-value:3.26E-4||SGD DESC:Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source Gene:YFL051C(YFL051C_p)|FD-Score:4.65|P-value:1.67E-6||SGD DESC:Putative protein of unknown function; YFL051C is not an essential gene Gene:YGL010W(YGL010W_p)|FD-Score:3.37|P-value:3.77E-4||SGD DESC:Putative protein of unknown function; YGL010W is not an essential gene Gene:YGR111W(YGR111W_p)|FD-Score:3.23|P-value:6.30E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:YHL012W(YHL012W_p)|FD-Score:4.92|P-value:4.27E-7||SGD DESC:Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication Gene:YHL015W-A(YHL015W-A_p)|FD-Score:3.17|P-value:7.60E-4||SGD DESC:Putative protein of unknown function Gene:YHR125W(YHR125W_d)|FD-Score:-3.18|P-value:7.37E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIL001W(YIL001W_p)|FD-Score:3.25|P-value:5.67E-4||SGD DESC:Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm Gene:YIL086C(YIL086C_d)|FD-Score:4.32|P-value:7.84E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJL045W(YJL045W)|FD-Score:3.19|P-value:7.21E-4||SGD DESC:Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner Gene:YJR061W(YJR061W_p)|FD-Score:3.5|P-value:2.31E-4||SGD DESC:Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication Gene:YKL096C-B(YKL096C-B_p)|FD-Score:-3.58|P-value:1.71E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YKL106C-A(YKL106C-A_p)|FD-Score:4.53|P-value:3.01E-6||SGD DESC:Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi Gene:YMR099C(YMR099C)|FD-Score:-3.45|P-value:2.77E-4||SGD DESC:Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS Gene:YMR141C(YMR141C_d)|FD-Score:3.26|P-value:5.51E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR182W-A(YMR182W-A_p)|FD-Score:4.11|P-value:2.00E-5||SGD DESC:Putative protein of unknown function Gene:YNL295W(YNL295W_p)|FD-Score:4.8|P-value:8.08E-7||SGD DESC:Putative protein of unknown function Gene:YOL106W(YOL106W_d)|FD-Score:3.23|P-value:6.18E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOL160W(YOL160W_d)|FD-Score:6.27|P-value:1.83E-10||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YOL164W-A(YOL164W-A_p)|FD-Score:4.46|P-value:4.14E-6||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YOR055W(YOR055W_d)|FD-Score:-4.56|P-value:2.51E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR304C-A(YOR304C-A_p)|FD-Score:3.55|P-value:1.96E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck Gene:YOR314W(YOR314W_d)|FD-Score:3.32|P-value:4.42E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YPL108W(YPL108W_p)|FD-Score:-4.24|P-value:1.10E-5||SGD DESC:Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS Gene:ADE5,7(YGL234W)|FD-Score:3.44|P-value:2.96E-4||SGD DESC:Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities Gene:ADY4(YLR227C)|FD-Score:-4.45|P-value:4.32E-6||SGD DESC:Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane Gene:AGP3(YFL055W)|FD-Score:3.61|P-value:1.56E-4||SGD DESC:Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition Gene:AIM18(YHR198C)|FD-Score:-3.48|P-value:2.54E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:AIM2(YAL049C)|FD-Score:3.81|P-value:7.03E-5||SGD DESC:Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor Gene:AIM34(YMR003W)|FD-Score:-5.19|P-value:1.03E-7||SGD DESC:Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss Gene:ANP1(YEL036C)|FD-Score:3.13|P-value:8.79E-4||SGD DESC:Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol Gene:ATG33(YLR356W)|FD-Score:3.86|P-value:5.75E-5||SGD DESC:Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes Gene:BDH1(YAL060W)|FD-Score:4.61|P-value:2.04E-6||SGD DESC:NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source Gene:BEM1(YBR200W)|FD-Score:-3.38|P-value:3.66E-4||SGD DESC:Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p Gene:BIT61(YJL058C)|FD-Score:4.66|P-value:1.59E-6||SGD DESC:Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication Gene:CAC2(YML102W)|FD-Score:4.75|P-value:1.04E-6||SGD DESC:Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription Gene:CIN2(YPL241C)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 Gene:CNE1(YAL058W)|FD-Score:3.34|P-value:4.21E-4||SGD DESC:Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast Gene:COS6(YGR295C)|FD-Score:3.41|P-value:3.28E-4||SGD DESC:Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:CRC1(YOR100C)|FD-Score:3.41|P-value:3.21E-4||SGD DESC:Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation Gene:CUP2(YGL166W)|FD-Score:7.68|P-value:7.73E-15||SGD DESC:Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication Gene:DAL5(YJR152W)|FD-Score:4.33|P-value:7.48E-6||SGD DESC:Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression Gene:DAP2(YHR028C)|FD-Score:-5.54|P-value:1.53E-8||SGD DESC:Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p Gene:DCN1(YLR128W)|FD-Score:3.24|P-value:6.03E-4||SGD DESC:Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation Gene:DJP1(YIR004W)|FD-Score:-3.33|P-value:4.27E-4||SGD DESC:Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ Gene:DSE2(YHR143W)|FD-Score:3.99|P-value:3.30E-5||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:EPS1(YIL005W)|FD-Score:8.57|P-value:5.38E-18||SGD DESC:ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family Gene:FLO1(YAR050W)|FD-Score:3.32|P-value:4.58E-4||SGD DESC:Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p Gene:FRT1(YOR324C)|FD-Score:-3.32|P-value:4.49E-4||SGD DESC:Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication Gene:GAT3(YLR013W)|FD-Score:3.19|P-value:7.17E-4||SGD DESC:Protein containing GATA family zinc finger motifs Gene:GCS1(YDL226C)|FD-Score:-4.1|P-value:2.10E-5||SGD DESC:ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p Gene:GTT2(YLL060C)|FD-Score:3.17|P-value:7.65E-4||SGD DESC:Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress Gene:GYP5(YPL249C)|FD-Score:3.96|P-value:3.82E-5||SGD DESC:GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:HAA1(YPR008W)|FD-Score:3.38|P-value:3.66E-4||SGD DESC:Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress Gene:HIS3(YOR202W)|FD-Score:9.57|P-value:5.29E-22||SGD DESC:Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p Gene:HNT1(YDL125C)|FD-Score:-3.5|P-value:2.30E-4||SGD DESC:Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress Gene:HXT17(YNR072W)|FD-Score:6.67|P-value:1.32E-11||SGD DESC:Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose Gene:IES4(YOR189W)|FD-Score:-4.03|P-value:2.78E-5||SGD DESC:Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses Gene:INP51(YIL002C)|FD-Score:3.2|P-value:6.81E-4||SGD DESC:Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth Gene:ISA1(YLL027W)|FD-Score:3.18|P-value:7.30E-4||SGD DESC:Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins Gene:JHD1(YER051W)|FD-Score:-4.1|P-value:2.10E-5||SGD DESC:JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe Gene:KTR4(YBR199W)|FD-Score:5.53|P-value:1.65E-8||SGD DESC:Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family Gene:LIF1(YGL090W)|FD-Score:-4.63|P-value:1.82E-6||SGD DESC:Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein Gene:MHT1(YLL062C)|FD-Score:4.07|P-value:2.31E-5||SGD DESC:S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio Gene:MRPL7(YDR237W)|FD-Score:3.37|P-value:3.70E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein Gene:NAT4(YMR069W)|FD-Score:4.7|P-value:1.29E-6||SGD DESC:N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A Gene:NPY1(YGL067W)|FD-Score:3.18|P-value:7.45E-4||SGD DESC:NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member Gene:NTG1(YAL015C)|FD-Score:-4.83|P-value:6.74E-7||SGD DESC:DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication Gene:PET54(YGR222W)|FD-Score:-4.95|P-value:3.76E-7||SGD DESC:Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing Gene:PGM1(YKL127W)|FD-Score:-3.35|P-value:4.05E-4||SGD DESC:Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism Gene:PRM5(YIL117C)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling Gene:PSP1(YDR505C)|FD-Score:4.3|P-value:8.43E-6||SGD DESC:Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication Gene:QCR2(YPR191W)|FD-Score:-4.29|P-value:8.98E-6||SGD DESC:Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme Gene:RAD5(YLR032W)|FD-Score:-3.3|P-value:4.92E-4||SGD DESC:DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress Gene:REV3(YPL167C)|FD-Score:-4.57|P-value:2.39E-6||SGD DESC:Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair Gene:RIM13(YMR154C)|FD-Score:4.06|P-value:2.43E-5||SGD DESC:Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB Gene:RSM7(YJR113C)|FD-Score:3.99|P-value:3.26E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein Gene:SAP185(YJL098W)|FD-Score:3.47|P-value:2.64E-4||SGD DESC:Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication Gene:SCO1(YBR037C)|FD-Score:3.19|P-value:7.17E-4||SGD DESC:Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication Gene:SGF11(YPL047W)|FD-Score:-5.06|P-value:2.08E-7||SGD DESC:Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation Gene:SNF4(YGL115W)|FD-Score:-3.43|P-value:3.07E-4||SGD DESC:Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress Gene:SOD2(YHR008C)|FD-Score:3.47|P-value:2.58E-4||SGD DESC:Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated Gene:SOL3(YHR163W)|FD-Score:5.26|P-value:7.17E-8||SGD DESC:6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication Gene:SPS100(YHR139C)|FD-Score:5.83|P-value:2.72E-9||SGD DESC:Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin Gene:SRB5(YGR104C)|FD-Score:3.76|P-value:8.57E-5||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance Gene:SWD3(YBR175W)|FD-Score:3.87|P-value:5.36E-5||SGD DESC:Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 Gene:TDA5(YLR426W_p)|FD-Score:3.83|P-value:6.40E-5||SGD DESC:Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele Gene:TDH2(YJR009C)|FD-Score:3.28|P-value:5.18E-4||SGD DESC:Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; TDH2 has a paralog, TDH3, that arose from the whole genome duplication Gene:THI20(YOL055C)|FD-Score:3.26|P-value:5.63E-4||SGD DESC:Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p Gene:TMA17(YDL110C)|FD-Score:5|P-value:2.92E-7||SGD DESC:Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion Gene:TRP1(YDR007W)|FD-Score:-3.51|P-value:2.22E-4||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:VCX1(YDL128W)|FD-Score:3.4|P-value:3.41E-4||SGD DESC:Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter Gene:VPS71(YML041C)|FD-Score:5.56|P-value:1.35E-8||SGD DESC:Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting Gene:WSC3(YOL105C)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis Gene:YAL065C(YAL065C_p)|FD-Score:3.19|P-value:7.13E-4||SGD DESC:Putative protein of unknown function; has homology to FLO1; possible pseudogene Gene:YAT2(YER024W)|FD-Score:-5.98|P-value:1.09E-9||SGD DESC:Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane Gene:YBR134W(YBR134W_d)|FD-Score:4.58|P-value:2.36E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YCK2(YNL154C)|FD-Score:-4.2|P-value:1.34E-5||SGD DESC:Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication Gene:YDL086W(YDL086W_p)|FD-Score:4.28|P-value:9.34E-6||SGD DESC:Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene Gene:YDL114W(YDL114W_p)|FD-Score:4.17|P-value:1.54E-5||SGD DESC:Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene Gene:YDL177C(YDL177C_p)|FD-Score:4.34|P-value:7.11E-6||SGD DESC:Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene Gene:YDR132C(YDR132C_p)|FD-Score:3.29|P-value:5.09E-4||SGD DESC:Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication Gene:YER135C(YER135C_d)|FD-Score:-3.59|P-value:1.67E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Gene:YER184C(YER184C_p)|FD-Score:3.41|P-value:3.26E-4||SGD DESC:Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source Gene:YFL051C(YFL051C_p)|FD-Score:4.65|P-value:1.67E-6||SGD DESC:Putative protein of unknown function; YFL051C is not an essential gene Gene:YGL010W(YGL010W_p)|FD-Score:3.37|P-value:3.77E-4||SGD DESC:Putative protein of unknown function; YGL010W is not an essential gene Gene:YGR111W(YGR111W_p)|FD-Score:3.23|P-value:6.30E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:YHL012W(YHL012W_p)|FD-Score:4.92|P-value:4.27E-7||SGD DESC:Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication Gene:YHL015W-A(YHL015W-A_p)|FD-Score:3.17|P-value:7.60E-4||SGD DESC:Putative protein of unknown function Gene:YHR125W(YHR125W_d)|FD-Score:-3.18|P-value:7.37E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIL001W(YIL001W_p)|FD-Score:3.25|P-value:5.67E-4||SGD DESC:Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm Gene:YIL086C(YIL086C_d)|FD-Score:4.32|P-value:7.84E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJL045W(YJL045W)|FD-Score:3.19|P-value:7.21E-4||SGD DESC:Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner Gene:YJR061W(YJR061W_p)|FD-Score:3.5|P-value:2.31E-4||SGD DESC:Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication Gene:YKL096C-B(YKL096C-B_p)|FD-Score:-3.58|P-value:1.71E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YKL106C-A(YKL106C-A_p)|FD-Score:4.53|P-value:3.01E-6||SGD DESC:Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi Gene:YMR099C(YMR099C)|FD-Score:-3.45|P-value:2.77E-4||SGD DESC:Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS Gene:YMR141C(YMR141C_d)|FD-Score:3.26|P-value:5.51E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR182W-A(YMR182W-A_p)|FD-Score:4.11|P-value:2.00E-5||SGD DESC:Putative protein of unknown function Gene:YNL295W(YNL295W_p)|FD-Score:4.8|P-value:8.08E-7||SGD DESC:Putative protein of unknown function Gene:YOL106W(YOL106W_d)|FD-Score:3.23|P-value:6.18E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOL160W(YOL160W_d)|FD-Score:6.27|P-value:1.83E-10||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YOL164W-A(YOL164W-A_p)|FD-Score:4.46|P-value:4.14E-6||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YOR055W(YOR055W_d)|FD-Score:-4.56|P-value:2.51E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR304C-A(YOR304C-A_p)|FD-Score:3.55|P-value:1.96E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck Gene:YOR314W(YOR314W_d)|FD-Score:3.32|P-value:4.42E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YPL108W(YPL108W_p)|FD-Score:-4.24|P-value:1.10E-5||SGD DESC:Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YOL097C7.331.17E-131.85WRS1Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA
YDL126C5.482.18E-81.10CDC48AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
YJL026W4.376.10E-60.36RNR2Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YOR310C4.012.99E-50.22NOP58Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
YJR013W3.797.43E-50.16GPI14Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
YPL028W3.641.38E-40.11ERG10Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
YAL001C3.522.12E-40.12TFC3Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
YDL145C3.403.38E-40.08COP1Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
YLR274W3.324.53E-40.04MCM5Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YIL022W3.285.22E-40.07TIM44Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
YDL015C3.216.69E-40.03TSC13Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress
YGR147C3.187.44E-40.04NAT2Protein with an apparent role in acetylation of N-terminal methionine residues
YLR045C3.138.64E-40.23STU2Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
YLR355C2.900.001860.05ILV5Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids
YNR011C2.850.002210.01PRP2RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOR202W9.575.29E-22HIS3Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
YIL005W8.575.38E-18EPS1ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family
YGL166W7.687.73E-15CUP2Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
YNR072W6.671.32E-11HXT17Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
YOL160W_d6.271.83E-10YOL160W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR139C5.832.72E-9SPS100Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin
YML041C5.561.35E-8VPS71Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
YBR199W5.531.65E-8KTR4Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YHR163W5.267.17E-8SOL36-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication
YDL110C5.002.92E-7TMA17Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
YHL012W_p4.924.27E-7YHL012W_pPutative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication
YNL295W_p4.808.08E-7YNL295W_pPutative protein of unknown function
YML102W4.751.04E-6CAC2Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
YMR069W4.701.29E-6NAT4N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A
YJL058C4.661.59E-6BIT61Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication

GO enrichment analysis for SGTC_1741
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0831.88E-10SGTC_14013807-4679 7.6 μMChemDiv (Drug-like library)32914560.084507tubulin folding & SWR complex
0.0612.37E-6SGTC_9913996-0057 64.7 μMChemDiv (Drug-like library)7153430.173913
0.0586.89E-6SGTC_14334060-0023 7.6 μMChemDiv (Drug-like library)38406270.1tubulin folding & SWR complex
0.0571.21E-5SGTC_2693st077581 40.7 μMTimTec (Natural product derivative library)252387610.150538
0.0534.42E-5SGTC_13261431-2094 10.8 μMChemDiv (Drug-like library)6162780.0634921tubulin folding & SWR complex
0.0525.73E-5SGTC_23196033012 152.6 μMChembridge (Fragment library)8472460.0923077tubulin folding & SWR complex
0.0518.07E-5SGTC_2568diosmetin 100.0 μMMicrosource (Natural product library)52816120.130435
0.0472.68E-4SGTC_23529027995 87.8 μMChembridge (Fragment library)29973470.125tubulin folding & SWR complex
0.0473.03E-4SGTC_13641653-0028 37.6 μMChemDiv (Drug-like library)57186520.0909091
0.0473.14E-4SGTC_21745790901 200.0 μMChembridge (Fragment library)7860200.106061tubulin folding & SWR complex
0.0455.59E-4SGTC_15081080-0625 72.9 μMChemDiv (Drug-like library)7671110.123077
0.0455.58E-4SGTC_30019076041 71.4 μMChembridge (Drug-like library)160042110.108108
0.0455.60E-4SGTC_33139133968 57.0 μMChembridge (Drug-like library)14946430.0595238
0.0446.29E-4SGTC_30229087993 49.5 μMChembridge (Drug-like library)171736440.0769231
0.0447.48E-4SGTC_32579139206 33.0 μMChembridge (Drug-like library)49100410.0675676

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_8760720-096356.8 μM0.366667765861ChemDiv (Drug-like library)319.76285.59904
SGTC_7450469-0705296 μM0.3571433486736ChemDiv (Drug-like library)238.153741.86706mitochondrial processes
SGTC_23369001819198.65 μM0.3137262989602Chembridge (Fragment library)209.629021.88902heme biosynthesis & mitochondrial translocase
SGTC_2376907292281.32 μM0.31034517087968Chembridge (Fragment library)281.78112.2513
SGTC_22677931562200 μM0.298246934880Chembridge (Fragment library)267.754521.79313
SGTC_12480469-068758.6 μM0.2931034017482ChemDiv (Drug-like library)284.223722.88805
SGTC_22667929956200 μM0.2807022967153Chembridge (Fragment library)238.670240.76912
SGTC_2001402350257.66 μM0.28108941Chembridge (Fragment library)195.602441.5402mitochondrial processes
SGTC_13561502-078185.8 μM0.271186567702ChemDiv (Drug-like library)284.761823.53804fatty acid desaturase (OLE1)
SGTC_430570-010572.5 μM0.2656251114046ChemDiv (Drug-like library)380.890484.73913ERG2