Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YHR058C | 6.59 | 2.21E-11 | 1.22 | MED6 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress |
YML031W | 6.19 | 2.98E-10 | 1.22 | NDC1 | Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1 |
YML127W | 4.97 | 3.30E-7 | 0.05 | RSC9 | Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway |
YBR152W | 4.92 | 4.24E-7 | 0.28 | SPP381 | mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p |
YKL195W | 4.64 | 1.73E-6 | 0.07 | MIA40 | Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p |
YJR013W | 4.57 | 2.42E-6 | 0.14 | GPI14 | Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M |
YMR268C | 4.43 | 4.66E-6 | 0.31 | PRP24 | Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling |
YER021W | 4.12 | 1.87E-5 | 0.03 | RPN3 | Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control |
YDR394W | 4.09 | 2.14E-5 | 0.04 | RPT3 | One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B |
YOR259C | 4.05 | 2.57E-5 | 0.26 | RPT4 | One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization |
YGR158C | 3.79 | 7.42E-5 | 0.03 | MTR3 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) |
YOR210W | 3.76 | 8.42E-5 | 0.24 | RPB10 | RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III |
YLL004W | 3.52 | 2.15E-4 | 0.04 | ORC3 | Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing |
YJL039C | 3.48 | 2.49E-4 | 0.19 | NUP192 | Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205 |
YLR088W | 3.29 | 4.93E-4 | 0.13 | GAA1 | Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER |