Deletion Strain | FD score | P-value | Gene | Gene Description |
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YBR006W | 9.59 | 4.30E-22 | UGA2 | Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm |
YIL036W | 7.40 | 6.79E-14 | CST6 | Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication |
YOR246C | 6.12 | 4.66E-10 | ENV9 | Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts |
YOL126C | 5.46 | 2.38E-8 | MDH2 | Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1 |
YMR306C-A_d | 5.33 | 4.81E-8 | YMR306C-A_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YMR264W | 5.18 | 1.12E-7 | CUE1 | Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication |
YHL005C_d | 5.16 | 1.25E-7 | YHL005C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W |
YNR065C_p | 4.85 | 6.19E-7 | YNR065C_p | Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene |
YNL099C | 4.76 | 9.56E-7 | OCA1 | Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA |
YKR077W | 4.74 | 1.09E-6 | MSA2 | Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation |
YJL170C | 4.72 | 1.19E-6 | ASG7 | Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor |
YOR140W | 4.59 | 2.22E-6 | SFL1 | Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p |
YOR277C_d | 4.41 | 5.26E-6 | YOR277C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 |
YHR125W_d | 4.31 | 8.00E-6 | YHR125W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YNL051W | 4.31 | 8.01E-6 | COG5 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |