Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDR354W | 6.18 | 3.16E-10 | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis |
YJL105W | 6.02 | 8.49E-10 | SET4 | Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication |
YDR033W | 5.53 | 1.58E-8 | MRH1 | Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication |
YDL035C | 5.52 | 1.68E-8 | GPR1 | Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis |
YHR115C | 5.06 | 2.09E-7 | DMA1 | Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma2p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8 protein, similar to human Chfr; contains FHA and RING finger |
YML055W | 4.72 | 1.19E-6 | SPC2 | Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 |
YBR099C_d | 4.67 | 1.48E-6 | YBR099C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4 |
YIL009W | 4.50 | 3.42E-6 | FAA3 | Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
YOR316C | 4.40 | 5.53E-6 | COT1 | Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication |
YML076C | 4.34 | 7.27E-6 | WAR1 | Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively |
YCL046W_d | 4.23 | 1.15E-5 | YCL046W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C |
YDL200C | 4.03 | 2.74E-5 | MGT1 | DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage |
YOR154W_p | 3.93 | 4.16E-5 | SLP1_p | Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p |
YPL163C | 3.77 | 8.13E-5 | SVS1 | Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication |
YDR008C_d | 3.73 | 9.45E-5 | YDR008C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |