| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YDR323C | 7.05 | 8.84E-13 | PEP7 | Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance |
| YMR245W_d | 6.18 | 3.29E-10 | YMR245W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YDL020C | 6.11 | 4.95E-10 | RPN4 | Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress |
| YCL008C | 6.04 | 7.74E-10 | STP22 | Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype |
| YNL090W | 5.30 | 5.89E-8 | RHO2 | Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly |
| YBL048W_d | 5.18 | 1.10E-7 | RRT1_d | Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data |
| YPR124W | 4.95 | 3.74E-7 | CTR1 | High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress |
| YPR119W | 4.87 | 5.65E-7 | CLB2 | B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
| YBR069C | 4.62 | 1.93E-6 | TAT1 | Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress |
| YFR032C-A | 4.42 | 4.90E-6 | RPL29 | Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog |
| YAR020C | 4.41 | 5.14E-6 | PAU7 | Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme |
| YMR186W | 4.28 | 9.54E-6 | HSC82 | Cytoplasmic chaperone of the Hsp90 family; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication |
| YOR049C | 4.21 | 1.26E-5 | RSB1 | Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane |
| YMR256C | 4.19 | 1.42E-5 | COX7 | Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain |
| YOR158W | 4.12 | 1.86E-5 | PET123 | Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator |
