Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPR082C | 4.05 | 2.58E-5 | 0.36 | DIB1 | 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein |
YGR030C | 4.03 | 2.84E-5 | 0.36 | POP6 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
YKL125W | 3.92 | 4.41E-5 | 0.36 | RRN3 | Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo |
YJL009W_d | 3.56 | 1.88E-4 | 0.03 | YJL009W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex |
YLR230W_d | 3.53 | 2.09E-4 | 0.06 | YLR230W_d | Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity |
YJR042W | 3.46 | 2.67E-4 | 0.03 | NUP85 | Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75 |
YDL058W | 3.43 | 2.99E-4 | 0.07 | USO1 | Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex |
YGL075C | 3.37 | 3.81E-4 | 0.04 | MPS2 | Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p |
YPR085C | 3.32 | 4.43E-4 | 0.12 | ASA1 | Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 |
YLR355C | 3.20 | 6.84E-4 | 0.02 | ILV5 | Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids |
YML093W | 3.18 | 7.43E-4 | 0.01 | UTP14 | Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit |
YGR145W | 3.16 | 7.79E-4 | 0.06 | ENP2 | Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p |
YMR208W | 3.11 | 9.49E-4 | 0.21 | ERG12 | Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate |
YMR079W | 2.90 | 0.00187 | 0.01 | SEC14 | Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs |
YIL021W | 2.89 | 0.00193 | 0.08 | RPB3 | RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit |