Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YBR029C | 4.91 | 4.44E-7 | 0.50 | CDS1 | Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids |
YGR128C | 4.42 | 4.96E-6 | 0.48 | UTP8 | Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA |
YLR078C | 3.94 | 4.09E-5 | 0.42 | BOS1 | v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi |
YJR007W | 3.52 | 2.17E-4 | 0.05 | SUI2 | Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress |
YNL132W | 3.47 | 2.59E-4 | 0.09 | KRE33 | Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance |
YKL024C | 3.38 | 3.58E-4 | 0.01 | URA6 | Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP) |
YPR082C | 3.37 | 3.76E-4 | 0.14 | DIB1 | 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein |
YGR274C | 3.23 | 6.14E-4 | 0.20 | TAF1 | TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression |
YOL010W | 3.03 | 0.00121 | 0.00 | RCL1 | Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected |
YGL225W | 3.03 | 0.00123 | 0.33 | VRG4 | Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi |
YKL036C_d | 2.70 | 0.00350 | 0.10 | YKL036C_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W |
YHR148W | 2.60 | 0.00469 | 0.01 | IMP3 | Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA |
YDL209C | 2.59 | 0.00484 | 0.07 | CWC2 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2 |
YFL005W | 2.52 | 0.00584 | 0.09 | SEC4 | Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane |
YDL235C | 2.44 | 0.00744 | 0.01 | YPD1 | Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus |