Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YHR007C | 22.20 | 3.77E-109 | 15.40 | ERG11 | Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p |
YGR267C | 6.78 | 5.84E-12 | 0.18 | FOL2 | GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway |
YOL034W | 6.61 | 1.98E-11 | 1.22 | SMC5 | Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair |
YPR094W | 5.39 | 3.58E-8 | 0.34 | RDS3 | Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance |
YIL078W | 5.05 | 2.23E-7 | 0.82 | THS1 | Threonyl-tRNA synthetase, essential cytoplasmic protein |
YEL055C | 4.23 | 1.18E-5 | 0.07 | POL5 | DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA |
YLR140W_d | 4.16 | 1.59E-5 | 0.26 | YLR140W_d | Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I |
YLR336C | 3.90 | 4.89E-5 | 0.01 | SGD1 | Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia |
YGR179C | 3.89 | 5.06E-5 | 0.22 | OKP1 | Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7 |
YOR250C | 3.67 | 1.21E-4 | 0.01 | CLP1 | Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation |
YML092C | 3.66 | 1.24E-4 | 0.11 | PRE8 | Alpha 2 subunit of the 20S proteasome |
YKR038C | 3.55 | 1.92E-4 | 0.12 | KAE1 | Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription |
YLR424W | 3.43 | 2.98E-4 | 0.01 | SPP382 | Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation |
YLR355C | 3.42 | 3.13E-4 | 0.04 | ILV5 | Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids |
YHR036W | 3.38 | 3.57E-4 | 0.03 | BRL1 | Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export |