st050112

6,7-diethoxy-1-(4-fluoro-3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1802
Screen concentration 57.9 μM
Source TimTec (Natural product derivative library)
PubChem CID 4662563
SMILES CCOC1=C(C=C2C(NCCC2=C1)C3=CC(=C(C=C3)F)OC)OCC
Standardized SMILES CCOc1cc2CCNC(c3ccc(F)c(OC)c3)c2cc1OCC
Molecular weight 345.4079
ALogP 3.91
H-bond donor count 1
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 8.67
% growth inhibition (Hom. pool) 4.29


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 4662563
Download HIP data (tab-delimited text)  (excel)
Gene:ERG1(YGR175C)|FD-Score:3.63|P-value:1.42E-4|Clearance:0.32||SGD DESC:Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine Gene:IMP4(YNL075W)|FD-Score:-3.25|P-value:5.74E-4|Clearance:0||SGD DESC:Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs Gene:NFS1(YCL017C)|FD-Score:4|P-value:3.15E-5|Clearance:0.32||SGD DESC:Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria Gene:PKC1(YBL105C)|FD-Score:3.11|P-value:9.33E-4|Clearance:0.13||SGD DESC:Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) Gene:POP6(YGR030C)|FD-Score:-3.17|P-value:7.73E-4|Clearance:0||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:TOM40(YMR203W)|FD-Score:3.72|P-value:1.02E-4|Clearance:0.32||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:VTI1(YMR197C)|FD-Score:3.31|P-value:4.60E-4|Clearance:0.07||SGD DESC:Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways Gene:YJL009W(YJL009W_d)|FD-Score:3.74|P-value:9.15E-5|Clearance:0.32||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex Gene:YLR458W(YLR458W_d)|FD-Score:3.24|P-value:5.88E-4|Clearance:0.13||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis Gene:ERG1(YGR175C)|FD-Score:3.63|P-value:1.42E-4|Clearance:0.32||SGD DESC:Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine Gene:IMP4(YNL075W)|FD-Score:-3.25|P-value:5.74E-4|Clearance:0||SGD DESC:Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs Gene:NFS1(YCL017C)|FD-Score:4|P-value:3.15E-5|Clearance:0.32||SGD DESC:Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria Gene:PKC1(YBL105C)|FD-Score:3.11|P-value:9.33E-4|Clearance:0.13||SGD DESC:Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) Gene:POP6(YGR030C)|FD-Score:-3.17|P-value:7.73E-4|Clearance:0||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:TOM40(YMR203W)|FD-Score:3.72|P-value:1.02E-4|Clearance:0.32||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:VTI1(YMR197C)|FD-Score:3.31|P-value:4.60E-4|Clearance:0.07||SGD DESC:Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways Gene:YJL009W(YJL009W_d)|FD-Score:3.74|P-value:9.15E-5|Clearance:0.32||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex Gene:YLR458W(YLR458W_d)|FD-Score:3.24|P-value:5.88E-4|Clearance:0.13||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 4662563
Download HOP data (tab-delimited text)  (excel)
Gene:ACE2(YLR131C)|FD-Score:4.28|P-value:9.21E-6||SGD DESC:Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Gene:AIM10(YER087W)|FD-Score:3.71|P-value:1.03E-4||SGD DESC:Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:ALD5(YER073W)|FD-Score:3.3|P-value:4.86E-4||SGD DESC:Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed Gene:APL3(YBL037W)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport Gene:BMH1(YER177W)|FD-Score:3.57|P-value:1.75E-4||SGD DESC:14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:BUD26(YDR241W_d)|FD-Score:3.26|P-value:5.59E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:CAN1(YEL063C)|FD-Score:4.66|P-value:1.58E-6||SGD DESC:Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication Gene:COQ4(YDR204W)|FD-Score:3.45|P-value:2.76E-4||SGD DESC:Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex Gene:COX10(YPL172C)|FD-Score:4.33|P-value:7.32E-6||SGD DESC:Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders Gene:CTF18(YMR078C)|FD-Score:3.12|P-value:9.05E-4||SGD DESC:Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint Gene:CTR1(YPR124W)|FD-Score:3.26|P-value:5.52E-4||SGD DESC:High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress Gene:DOG1(YHR044C)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified Gene:DYN2(YDR424C)|FD-Score:3.29|P-value:5.07E-4||SGD DESC:Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex Gene:ECM38(YLR299W)|FD-Score:6.37|P-value:9.37E-11||SGD DESC:Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation Gene:GIM5(YML094W)|FD-Score:3.82|P-value:6.60E-5||SGD DESC:Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Gene:GPX1(YKL026C)|FD-Score:3.77|P-value:8.22E-5||SGD DESC:Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress Gene:GUP1(YGL084C)|FD-Score:3.47|P-value:2.63E-4||SGD DESC:Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport Gene:IKS1(YJL057C)|FD-Score:4.83|P-value:6.83E-7||SGD DESC:Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p Gene:LYS4(YDR234W)|FD-Score:-3.19|P-value:7.13E-4||SGD DESC:Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway Gene:MEK1(YOR351C)|FD-Score:4.39|P-value:5.59E-6||SGD DESC:Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids Gene:MRPL16(YBL038W)|FD-Score:3.2|P-value:6.84E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NPR3(YHL023C)|FD-Score:3.39|P-value:3.46E-4||SGD DESC:Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair Gene:PCL8(YPL219W)|FD-Score:4.07|P-value:2.31E-5||SGD DESC:Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation Gene:PEX34(YCL056C)|FD-Score:3.83|P-value:6.45E-5||SGD DESC:Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation Gene:PRO2(YOR323C)|FD-Score:4.44|P-value:4.54E-6||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:PUS6(YGR169C)|FD-Score:-3.13|P-value:8.84E-4||SGD DESC:tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability Gene:RTC5(YOR118W)|FD-Score:3.15|P-value:8.27E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity Gene:SFB3(YHR098C)|FD-Score:3.42|P-value:3.19E-4||SGD DESC:Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p Gene:SLM5(YCR024C)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:SLX5(YDL013W)|FD-Score:3.14|P-value:8.31E-4||SGD DESC:Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers Gene:SPT2(YER161C)|FD-Score:3.38|P-value:3.62E-4||SGD DESC:Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins Gene:STL1(YDR536W)|FD-Score:3.35|P-value:4.03E-4||SGD DESC:Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock Gene:TAT1(YBR069C)|FD-Score:3.14|P-value:8.57E-4||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TIP41(YPR040W)|FD-Score:4.14|P-value:1.77E-5||SGD DESC:Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress Gene:TSC3(YBR058C-A)|FD-Score:-3.53|P-value:2.10E-4||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:TUB3(YML124C)|FD-Score:4.53|P-value:2.90E-6||SGD DESC:Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication Gene:YAP6(YDR259C)|FD-Score:-3.58|P-value:1.70E-4||SGD DESC:Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication Gene:YDR338C(YDR338C_p)|FD-Score:-3.11|P-value:9.38E-4||SGD DESC:Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily Gene:YGR018C(YGR018C_p)|FD-Score:-3.16|P-value:7.79E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W Gene:YHL005C(YHL005C_d)|FD-Score:3.78|P-value:7.69E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W Gene:YLR255C(YLR255C_d)|FD-Score:-3.22|P-value:6.41E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR066C(YNR066C_p)|FD-Score:3.31|P-value:4.70E-4||SGD DESC:Putative membrane-localized protein of unknown function Gene:ACE2(YLR131C)|FD-Score:4.28|P-value:9.21E-6||SGD DESC:Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Gene:AIM10(YER087W)|FD-Score:3.71|P-value:1.03E-4||SGD DESC:Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:ALD5(YER073W)|FD-Score:3.3|P-value:4.86E-4||SGD DESC:Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed Gene:APL3(YBL037W)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport Gene:BMH1(YER177W)|FD-Score:3.57|P-value:1.75E-4||SGD DESC:14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:BUD26(YDR241W_d)|FD-Score:3.26|P-value:5.59E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:CAN1(YEL063C)|FD-Score:4.66|P-value:1.58E-6||SGD DESC:Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication Gene:COQ4(YDR204W)|FD-Score:3.45|P-value:2.76E-4||SGD DESC:Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex Gene:COX10(YPL172C)|FD-Score:4.33|P-value:7.32E-6||SGD DESC:Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders Gene:CTF18(YMR078C)|FD-Score:3.12|P-value:9.05E-4||SGD DESC:Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint Gene:CTR1(YPR124W)|FD-Score:3.26|P-value:5.52E-4||SGD DESC:High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress Gene:DOG1(YHR044C)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified Gene:DYN2(YDR424C)|FD-Score:3.29|P-value:5.07E-4||SGD DESC:Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex Gene:ECM38(YLR299W)|FD-Score:6.37|P-value:9.37E-11||SGD DESC:Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation Gene:GIM5(YML094W)|FD-Score:3.82|P-value:6.60E-5||SGD DESC:Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Gene:GPX1(YKL026C)|FD-Score:3.77|P-value:8.22E-5||SGD DESC:Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress Gene:GUP1(YGL084C)|FD-Score:3.47|P-value:2.63E-4||SGD DESC:Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport Gene:IKS1(YJL057C)|FD-Score:4.83|P-value:6.83E-7||SGD DESC:Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p Gene:LYS4(YDR234W)|FD-Score:-3.19|P-value:7.13E-4||SGD DESC:Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway Gene:MEK1(YOR351C)|FD-Score:4.39|P-value:5.59E-6||SGD DESC:Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids Gene:MRPL16(YBL038W)|FD-Score:3.2|P-value:6.84E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NPR3(YHL023C)|FD-Score:3.39|P-value:3.46E-4||SGD DESC:Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair Gene:PCL8(YPL219W)|FD-Score:4.07|P-value:2.31E-5||SGD DESC:Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation Gene:PEX34(YCL056C)|FD-Score:3.83|P-value:6.45E-5||SGD DESC:Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation Gene:PRO2(YOR323C)|FD-Score:4.44|P-value:4.54E-6||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:PUS6(YGR169C)|FD-Score:-3.13|P-value:8.84E-4||SGD DESC:tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability Gene:RTC5(YOR118W)|FD-Score:3.15|P-value:8.27E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity Gene:SFB3(YHR098C)|FD-Score:3.42|P-value:3.19E-4||SGD DESC:Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p Gene:SLM5(YCR024C)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:SLX5(YDL013W)|FD-Score:3.14|P-value:8.31E-4||SGD DESC:Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers Gene:SPT2(YER161C)|FD-Score:3.38|P-value:3.62E-4||SGD DESC:Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins Gene:STL1(YDR536W)|FD-Score:3.35|P-value:4.03E-4||SGD DESC:Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock Gene:TAT1(YBR069C)|FD-Score:3.14|P-value:8.57E-4||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TIP41(YPR040W)|FD-Score:4.14|P-value:1.77E-5||SGD DESC:Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress Gene:TSC3(YBR058C-A)|FD-Score:-3.53|P-value:2.10E-4||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:TUB3(YML124C)|FD-Score:4.53|P-value:2.90E-6||SGD DESC:Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication Gene:YAP6(YDR259C)|FD-Score:-3.58|P-value:1.70E-4||SGD DESC:Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication Gene:YDR338C(YDR338C_p)|FD-Score:-3.11|P-value:9.38E-4||SGD DESC:Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily Gene:YGR018C(YGR018C_p)|FD-Score:-3.16|P-value:7.79E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W Gene:YHL005C(YHL005C_d)|FD-Score:3.78|P-value:7.69E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W Gene:YLR255C(YLR255C_d)|FD-Score:-3.22|P-value:6.41E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR066C(YNR066C_p)|FD-Score:3.31|P-value:4.70E-4||SGD DESC:Putative membrane-localized protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YCL017C4.003.15E-50.32NFS1Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria
YJL009W_d3.749.15E-50.32YJL009W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
YMR203W3.721.02E-40.32TOM40Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
YGR175C3.631.42E-40.32ERG1Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
YMR197C3.314.60E-40.07VTI1Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways
YLR458W_d3.245.88E-40.13YLR458W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis
YBL105C3.119.33E-40.14PKC1Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
YOL144W2.980.001460.06NOP8Nucleolar protein required for 60S ribosomal subunit biogenesis
YOL040C2.920.001750.06RPS15Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
YOR340C2.860.002120.09RPA43RNA polymerase I subunit A43
YGL075C2.770.002820.13MPS2Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
YJR042W2.630.004210.13NUP85Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75
YKR004C2.500.006140.03ECM9Non-essential protein of unknown function
YGR119C2.470.006690.01NUP57FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)
YPR162C2.460.006880.00ORC4Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YLR299W6.379.37E-11ECM38Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
YJL057C4.836.83E-7IKS1Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p
YEL063C4.661.58E-6CAN1Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
YML124C4.532.90E-6TUB3Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
YOR323C4.444.54E-6PRO2Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis
YOR351C4.395.59E-6MEK1Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids
YPL172C4.337.32E-6COX10Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders
YLR131C4.289.21E-6ACE2Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication
YPR040W4.141.77E-5TIP41Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress
YPL219W4.072.31E-5PCL8Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation
YCL056C3.836.45E-5PEX34Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation
YML094W3.826.60E-5GIM5Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YHL005C_d3.787.69E-5YHL005C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W
YKL026C3.778.22E-5GPX1Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YER087W3.711.03E-4AIM10Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss

GO enrichment analysis for SGTC_1802
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1063.99E-16SGTC_9831491-0821 12.2 μMChemDiv (Drug-like library)464951130.0657895
0.1041.09E-15SGTC_31759106517 49.5 μMChembridge (Drug-like library)414680730.0641026iron homeostasis
0.1001.70E-14SGTC_1603453-0671 289.7 μMChemDiv (Drug-like library)53222680.0869565
0.0961.89E-13SGTC_2727riluzole 51.8 μMMiscellaneous50700.0869565mitochondrial processes
0.0881.26E-11SGTC_2510benzyl isothiocyanate 8.3 μMMicrosource (Natural product library)23460.0666667
0.0872.24E-11SGTC_13521496-0991 99.0 μMChemDiv (Drug-like library)30000390.0571429tubulin folding & SWR complex
0.0848.58E-11SGTC_3071501-1223 22.3 μMChemDiv (Drug-like library)28303290.0375
0.0822.64E-10SGTC_2508celastrol 40.5 μMMicrosource (Natural product library)1227240.0537634PDR1
0.0815.34E-10SGTC_2501sodium tetradecyl sulfate 13.4 μMMicrosource (Natural product library)236657720.0547945
0.0816.05E-10SGTC_2630antimycin a 100.0 μMMicrosource (Natural product library)57021990.0769231mitochondrial processes
0.0809.65E-10SGTC_14780453-0656 35.7 μMChemDiv (Drug-like library)52584960.0945946
0.0773.17E-9SGTC_31619100388 49.5 μMChembridge (Drug-like library)252363680.0481928iron homeostasis
0.0764.11E-9SGTC_368fentichlor 4.6 μMChemDiv (Drug-like library)73290.0666667
0.0766.07E-9SGTC_21715739187 198.1 μMChembridge (Fragment library)22627610.0847458copper-dependent oxidative stress
0.0766.38E-9SGTC_1935st074532 41.6 μMTimTec (Natural product derivative library)28297420.114286

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1804st05007649.1 μM0.7547173895976TimTec (Natural product derivative library)407.4772435.48515
SGTC_1806st05000560.3 μM0.665194765TimTec (Natural product derivative library)331.836484.38313
SGTC_1808st05006361.5 μM0.664011993TimTec (Natural product derivative library)325.444584.66113
SGTC_1809st05008157.6 μM0.6538465036894TimTec (Natural product derivative library)347.45014.62713
SGTC_1800st05007929.07 μM0.6346153645560TimTec (Natural product derivative library)373.487385.23713NEO1-PIK1
SGTC_1803st05006852.4 μM0.629633984059TimTec (Natural product derivative library)381.388795.83917NEO1-PIK1
SGTC_1805st05001360.3 μM0.6226424037144TimTec (Natural product derivative library)331.836484.38313
SGTC_1760st04545310.45 μM0.6071433323419TimTec (Natural product derivative library)385.498085.38213NEO1-PIK1
SGTC_1810st05013853 μM0.63444541TimTec (Natural product derivative library)377.476084.61114PDR1
SGTC_1801st05008928.44 μM0.5892865008493TimTec (Natural product derivative library)389.486785.27914NEO1-PIK1