st050013

1-(3-chlorophenyl)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1805
Screen concentration 60.3 μM
Source TimTec (Natural product derivative library)
PubChem CID 4037144
SMILES CCOC1=C(C=C2C(NCCC2=C1)C3=CC(=CC=C3)Cl)OCC
Standardized SMILES CCOc1cc2CCNC(c3cccc(Cl)c3)c2cc1OCC
Molecular weight 331.8365
ALogP 4.38
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 28.11
% growth inhibition (Hom. pool) 8.24


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 4037144
Download HIP data (tab-delimited text)  (excel)
Gene:CCT3(YJL014W)|FD-Score:3.6|P-value:1.60E-4|Clearance:0.1||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:ERG1(YGR175C)|FD-Score:3.24|P-value:5.94E-4|Clearance:0.08||SGD DESC:Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine Gene:ERG27(YLR100W)|FD-Score:3.1|P-value:9.77E-4|Clearance:0.11||SGD DESC:3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs Gene:IPP1(YBR011C)|FD-Score:-3.36|P-value:3.92E-4|Clearance:0||SGD DESC:Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase Gene:MPE1(YKL059C)|FD-Score:3.29|P-value:5.02E-4|Clearance:0.05||SGD DESC:Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif Gene:PUP1(YOR157C)|FD-Score:3.5|P-value:2.32E-4|Clearance:0.21||SGD DESC:Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z Gene:RFA1(YAR007C)|FD-Score:-3.69|P-value:1.10E-4|Clearance:0||SGD DESC:Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination Gene:RPC37(YKR025W)|FD-Score:4.72|P-value:1.18E-6|Clearance:1.12||SGD DESC:RNA polymerase III subunit C37 Gene:ULP1(YPL020C)|FD-Score:-3.38|P-value:3.59E-4|Clearance:0||SGD DESC:Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions Gene:VRG4(YGL225W)|FD-Score:-3.14|P-value:8.45E-4|Clearance:0||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi Gene:YJL009W(YJL009W_d)|FD-Score:3.16|P-value:7.82E-4|Clearance:0.07||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex Gene:CCT3(YJL014W)|FD-Score:3.6|P-value:1.60E-4|Clearance:0.1||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:ERG1(YGR175C)|FD-Score:3.24|P-value:5.94E-4|Clearance:0.08||SGD DESC:Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine Gene:ERG27(YLR100W)|FD-Score:3.1|P-value:9.77E-4|Clearance:0.11||SGD DESC:3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs Gene:IPP1(YBR011C)|FD-Score:-3.36|P-value:3.92E-4|Clearance:0||SGD DESC:Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase Gene:MPE1(YKL059C)|FD-Score:3.29|P-value:5.02E-4|Clearance:0.05||SGD DESC:Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif Gene:PUP1(YOR157C)|FD-Score:3.5|P-value:2.32E-4|Clearance:0.21||SGD DESC:Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z Gene:RFA1(YAR007C)|FD-Score:-3.69|P-value:1.10E-4|Clearance:0||SGD DESC:Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination Gene:RPC37(YKR025W)|FD-Score:4.72|P-value:1.18E-6|Clearance:1.12||SGD DESC:RNA polymerase III subunit C37 Gene:ULP1(YPL020C)|FD-Score:-3.38|P-value:3.59E-4|Clearance:0||SGD DESC:Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions Gene:VRG4(YGL225W)|FD-Score:-3.14|P-value:8.45E-4|Clearance:0||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi Gene:YJL009W(YJL009W_d)|FD-Score:3.16|P-value:7.82E-4|Clearance:0.07||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 4037144
Download HOP data (tab-delimited text)  (excel)
Gene:AMS1(YGL156W)|FD-Score:-3.09|P-value:9.87E-4||SGD DESC:Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway Gene:ARA2(YMR041C)|FD-Score:-3.7|P-value:1.07E-4||SGD DESC:NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase Gene:DRS2(YAL026C)|FD-Score:3.29|P-value:4.95E-4||SGD DESC:Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease Gene:EMC4(YGL231C)|FD-Score:-3.28|P-value:5.20E-4||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85 Gene:ERP3(YDL018C)|FD-Score:-3.45|P-value:2.76E-4||SGD DESC:Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport Gene:ERS1(YCR075C)|FD-Score:3.9|P-value:4.91E-5||SGD DESC:Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains Gene:GPB2(YAL056W)|FD-Score:-3.12|P-value:8.93E-4||SGD DESC:Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication Gene:HBS1(YKR084C)|FD-Score:4.25|P-value:1.08E-5||SGD DESC:GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay Gene:HMI1(YOL095C)|FD-Score:3.67|P-value:1.19E-4||SGD DESC:Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD Gene:HRB1(YNL004W)|FD-Score:3.25|P-value:5.72E-4||SGD DESC:Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication Gene:IRC23(YOR044W)|FD-Score:3.9|P-value:4.76E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication Gene:LOS1(YKL205W)|FD-Score:-5.7|P-value:5.93E-9||SGD DESC:Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm Gene:MAK32(YCR019W)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:Protein necessary for structural stability of L-A double-stranded RNA-containing particles Gene:MDV1(YJL112W)|FD-Score:3.28|P-value:5.14E-4||SGD DESC:Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication Gene:MVP1(YMR004W)|FD-Score:-3.98|P-value:3.44E-5||SGD DESC:Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress Gene:NMA1(YLR328W)|FD-Score:-4.42|P-value:4.91E-6||SGD DESC:Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication Gene:ORM1(YGR038W)|FD-Score:-3.16|P-value:7.98E-4||SGD DESC:Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control Gene:PYC1(YGL062W)|FD-Score:3.16|P-value:7.77E-4||SGD DESC:Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication Gene:RXT3(YDL076C)|FD-Score:-3.75|P-value:9.02E-5||SGD DESC:Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress Gene:SAK1(YER129W)|FD-Score:3.11|P-value:9.40E-4||SGD DESC:Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome Gene:SAM3(YPL274W)|FD-Score:-3.23|P-value:6.10E-4||SGD DESC:High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p Gene:SHE4(YOR035C)|FD-Score:3.98|P-value:3.51E-5||SGD DESC:Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization Gene:SLM5(YCR024C)|FD-Score:3.29|P-value:4.94E-4||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:SNA2(YDR525W-A)|FD-Score:4.24|P-value:1.12E-5||SGD DESC:Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:SNX4(YJL036W)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p Gene:SPE4(YLR146C)|FD-Score:5.21|P-value:9.59E-8||SGD DESC:Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid Gene:STF2(YGR008C)|FD-Score:-4.55|P-value:2.71E-6||SGD DESC:Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress Gene:TCA17(YEL048C)|FD-Score:3.98|P-value:3.50E-5||SGD DESC:Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder Gene:TRM3(YDL112W)|FD-Score:-3.55|P-value:1.90E-4||SGD DESC:2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs Gene:UBP15(YMR304W)|FD-Score:-3.49|P-value:2.44E-4||SGD DESC:Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p Gene:UBX7(YBR273C)|FD-Score:3.5|P-value:2.30E-4||SGD DESC:UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication Gene:VPS70(YJR126C)|FD-Score:-3.95|P-value:3.95E-5||SGD DESC:Protein of unknown function involved in vacuolar protein sorting Gene:YBL086C(YBL086C_p)|FD-Score:-3.49|P-value:2.42E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Gene:YDR455C(YDR455C_d)|FD-Score:3.36|P-value:3.96E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W Gene:YEL028W(YEL028W_d)|FD-Score:4.23|P-value:1.14E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YER156C(YER156C_p)|FD-Score:3.12|P-value:8.95E-4||SGD DESC:Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1 Gene:YGL118C(YGL118C_d)|FD-Score:-3.97|P-value:3.56E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGL152C(YGL152C_d)|FD-Score:-3.18|P-value:7.34E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W Gene:YGR201C(YGR201C_p)|FD-Score:-3.15|P-value:8.06E-4||SGD DESC:Putative protein of unknown function Gene:YHR080C(YHR080C)|FD-Score:-3.19|P-value:7.15E-4||SGD DESC:Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication Gene:YJL068C(YJL068C)|FD-Score:3.16|P-value:7.83E-4||SGD DESC:Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D Gene:YKR047W(YKR047W_d)|FD-Score:5.2|P-value:1.02E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 Gene:YMR122C(YMR122C_d)|FD-Score:-5.58|P-value:1.20E-8||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL109W(YNL109W_d)|FD-Score:3.24|P-value:5.90E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C Gene:YOL013W-A(YOL013W-A_p)|FD-Score:-3.18|P-value:7.27E-4||SGD DESC:Putative protein of unknown function; identified by SAGE Gene:YPR015C(YPR015C_p)|FD-Score:-3.09|P-value:9.85E-4||SGD DESC:Putative protein of unknown function; overexpression causes a cell cycle delay or arrest Gene:AMS1(YGL156W)|FD-Score:-3.09|P-value:9.87E-4||SGD DESC:Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway Gene:ARA2(YMR041C)|FD-Score:-3.7|P-value:1.07E-4||SGD DESC:NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase Gene:DRS2(YAL026C)|FD-Score:3.29|P-value:4.95E-4||SGD DESC:Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease Gene:EMC4(YGL231C)|FD-Score:-3.28|P-value:5.20E-4||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85 Gene:ERP3(YDL018C)|FD-Score:-3.45|P-value:2.76E-4||SGD DESC:Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport Gene:ERS1(YCR075C)|FD-Score:3.9|P-value:4.91E-5||SGD DESC:Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains Gene:GPB2(YAL056W)|FD-Score:-3.12|P-value:8.93E-4||SGD DESC:Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication Gene:HBS1(YKR084C)|FD-Score:4.25|P-value:1.08E-5||SGD DESC:GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay Gene:HMI1(YOL095C)|FD-Score:3.67|P-value:1.19E-4||SGD DESC:Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD Gene:HRB1(YNL004W)|FD-Score:3.25|P-value:5.72E-4||SGD DESC:Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication Gene:IRC23(YOR044W)|FD-Score:3.9|P-value:4.76E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication Gene:LOS1(YKL205W)|FD-Score:-5.7|P-value:5.93E-9||SGD DESC:Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm Gene:MAK32(YCR019W)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:Protein necessary for structural stability of L-A double-stranded RNA-containing particles Gene:MDV1(YJL112W)|FD-Score:3.28|P-value:5.14E-4||SGD DESC:Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication Gene:MVP1(YMR004W)|FD-Score:-3.98|P-value:3.44E-5||SGD DESC:Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress Gene:NMA1(YLR328W)|FD-Score:-4.42|P-value:4.91E-6||SGD DESC:Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication Gene:ORM1(YGR038W)|FD-Score:-3.16|P-value:7.98E-4||SGD DESC:Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control Gene:PYC1(YGL062W)|FD-Score:3.16|P-value:7.77E-4||SGD DESC:Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication Gene:RXT3(YDL076C)|FD-Score:-3.75|P-value:9.02E-5||SGD DESC:Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress Gene:SAK1(YER129W)|FD-Score:3.11|P-value:9.40E-4||SGD DESC:Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome Gene:SAM3(YPL274W)|FD-Score:-3.23|P-value:6.10E-4||SGD DESC:High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p Gene:SHE4(YOR035C)|FD-Score:3.98|P-value:3.51E-5||SGD DESC:Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization Gene:SLM5(YCR024C)|FD-Score:3.29|P-value:4.94E-4||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:SNA2(YDR525W-A)|FD-Score:4.24|P-value:1.12E-5||SGD DESC:Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:SNX4(YJL036W)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p Gene:SPE4(YLR146C)|FD-Score:5.21|P-value:9.59E-8||SGD DESC:Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid Gene:STF2(YGR008C)|FD-Score:-4.55|P-value:2.71E-6||SGD DESC:Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress Gene:TCA17(YEL048C)|FD-Score:3.98|P-value:3.50E-5||SGD DESC:Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder Gene:TRM3(YDL112W)|FD-Score:-3.55|P-value:1.90E-4||SGD DESC:2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs Gene:UBP15(YMR304W)|FD-Score:-3.49|P-value:2.44E-4||SGD DESC:Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p Gene:UBX7(YBR273C)|FD-Score:3.5|P-value:2.30E-4||SGD DESC:UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication Gene:VPS70(YJR126C)|FD-Score:-3.95|P-value:3.95E-5||SGD DESC:Protein of unknown function involved in vacuolar protein sorting Gene:YBL086C(YBL086C_p)|FD-Score:-3.49|P-value:2.42E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Gene:YDR455C(YDR455C_d)|FD-Score:3.36|P-value:3.96E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W Gene:YEL028W(YEL028W_d)|FD-Score:4.23|P-value:1.14E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YER156C(YER156C_p)|FD-Score:3.12|P-value:8.95E-4||SGD DESC:Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1 Gene:YGL118C(YGL118C_d)|FD-Score:-3.97|P-value:3.56E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGL152C(YGL152C_d)|FD-Score:-3.18|P-value:7.34E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W Gene:YGR201C(YGR201C_p)|FD-Score:-3.15|P-value:8.06E-4||SGD DESC:Putative protein of unknown function Gene:YHR080C(YHR080C)|FD-Score:-3.19|P-value:7.15E-4||SGD DESC:Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication Gene:YJL068C(YJL068C)|FD-Score:3.16|P-value:7.83E-4||SGD DESC:Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D Gene:YKR047W(YKR047W_d)|FD-Score:5.2|P-value:1.02E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 Gene:YMR122C(YMR122C_d)|FD-Score:-5.58|P-value:1.20E-8||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL109W(YNL109W_d)|FD-Score:3.24|P-value:5.90E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C Gene:YOL013W-A(YOL013W-A_p)|FD-Score:-3.18|P-value:7.27E-4||SGD DESC:Putative protein of unknown function; identified by SAGE Gene:YPR015C(YPR015C_p)|FD-Score:-3.09|P-value:9.85E-4||SGD DESC:Putative protein of unknown function; overexpression causes a cell cycle delay or arrest

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YKR025W4.721.18E-61.12RPC37RNA polymerase III subunit C37
YJL014W3.601.60E-40.10CCT3Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YOR157C3.502.32E-40.21PUP1Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
YKL059C3.295.02E-40.05MPE1Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif
YGR175C3.245.94E-40.08ERG1Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
YJL009W_d3.167.82E-40.07YJL009W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
YLR100W3.109.77E-40.11ERG273-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs
YIL048W2.990.001390.15NEO1Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
YIL075C2.840.002280.04RPN2Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress
YNL126W2.800.002560.07SPC98Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
YKL180W2.730.003200.01RPL17ARibosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
YJL031C2.720.003310.02BET4Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
YJL109C2.700.003490.02UTP10Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance
YPR033C2.680.003680.09HTS1Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
YDR327W_d2.590.004740.01YDR327W_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YLR146C5.219.59E-8SPE4Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
YKR047W_d5.201.02E-7YKR047W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1
YKR084C4.251.08E-5HBS1GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay
YDR525W-A4.241.12E-5SNA2Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YEL028W_d4.231.14E-5YEL028W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YEL048C3.983.50E-5TCA17Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder
YOR035C3.983.51E-5SHE4Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
YOR044W3.904.76E-5IRC23Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication
YCR075C3.904.91E-5ERS1Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains
YOL095C3.671.19E-4HMI1Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
YCR019W3.641.37E-4MAK32Protein necessary for structural stability of L-A double-stranded RNA-containing particles
YJL036W3.581.69E-4SNX4Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p
YBR273C3.502.30E-4UBX7UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication
YDR455C_d3.363.96E-4YDR455C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
YCR024C3.294.94E-4SLM5Mitochondrial asparaginyl-tRNA synthetase

GO enrichment analysis for SGTC_1805
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0864.79E-11SGTC_28519015922 71.4 μMChembridge (Drug-like library)29968930.123288
0.0822.82E-10SGTC_32309131665 49.5 μMChembridge (Drug-like library)159437200.153846
0.0815.18E-10SGTC_8034488-1585 147.0 μMChemDiv (Drug-like library)7472040.116883
0.0713.97E-8SGTC_29359038016 30.0 μMChembridge (Drug-like library)64631950.0759494
0.0672.19E-7SGTC_28599028643 45.5 μMChembridge (Drug-like library)171515800.118421
0.0631.56E-6SGTC_21765809774 34.0 μMChembridge (Fragment library)28705390.0769231mitochondrial processes
0.0588.56E-6SGTC_30969117468 49.5 μMChembridge (Drug-like library)413163110.0675676
0.0561.94E-5SGTC_28479005661 71.4 μMChembridge (Drug-like library)29914490.19403
0.0552.09E-5SGTC_21515563267 85.4 μMChembridge (Fragment library)53108240.0746269
0.0552.44E-5SGTC_29609079389 6.0 μMChembridge (Drug-like library)164573550.139241
0.0542.91E-5SGTC_23809035439 200.0 μMChembridge (Fragment library)64625750.155172endomembrane recycling
0.0543.58E-5SGTC_1521st012942 49.4 μMTimTec (Pure natural product library)242072590.0666667
0.0534.45E-5SGTC_2745rifampicin 24.3 μMMiscellaneous251414280.0538462
0.0535.10E-5SGTC_2555cholic acid 100.0 μMMicrosource (Natural product library)67086570.0549451
0.0535.19E-5SGTC_2576guaiol 23.1 μMMicrosource (Natural product library)2278290.0793651

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1806st05000560.3 μM0.760875194765TimTec (Natural product derivative library)331.836484.38313
SGTC_1801st05008928.44 μM0.7058825008493TimTec (Natural product derivative library)389.486785.27914NEO1-PIK1
SGTC_1809st05008157.6 μM0.685036894TimTec (Natural product derivative library)347.45014.62713
SGTC_1800st05007929.07 μM0.663645560TimTec (Natural product derivative library)373.487385.23713NEO1-PIK1
SGTC_1808st05006361.5 μM0.6530614011993TimTec (Natural product derivative library)325.444584.66113
SGTC_1760st04545310.45 μM0.629633323419TimTec (Natural product derivative library)385.498085.38213NEO1-PIK1
SGTC_1802st05011257.9 μM0.6226424662563TimTec (Natural product derivative library)345.4078633.90815
SGTC_1804st05007649.1 μM0.5964913895976TimTec (Natural product derivative library)407.4772435.48515
SGTC_1803st05006852.4 μM0.5925933984059TimTec (Natural product derivative library)381.388795.83917NEO1-PIK1
SGTC_1807st05009258.9 μM0.585008496TimTec (Natural product derivative library)339.471165.1781360S ribosome export