st050092

6,7-diethoxy-1-(2,4,5-trimethylphenyl)-1,2,3,4-tetrahydroisoquinoline

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1807
Screen concentration 58.9 μM
Source TimTec (Natural product derivative library)
PubChem CID 5008496
SMILES CCOC1=C(C=C2C(NCCC2=C1)C3=CC(=C(C=C3C)C)C)OCC
Standardized SMILES CCOc1cc2CCNC(c3cc(C)c(C)cc3C)c2cc1OCC
Molecular weight 339.4712
ALogP 5.18
H-bond donor count 1
H-bond acceptor count 3
Response signature 60S ribosome export

Pool Growth Kinetics
% growth inhibition (Het. pool) 11.54
% growth inhibition (Hom. pool) 7.13


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5008496
Download HIP data (tab-delimited text)  (excel)
Gene:KAR1(YNL188W)|FD-Score:3.44|P-value:2.89E-4|Clearance:0.01||SGD DESC:Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p Gene:LSG1(YGL099W)|FD-Score:4.44|P-value:4.47E-6|Clearance:0.47||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:NMD3(YHR170W)|FD-Score:3.55|P-value:1.89E-4|Clearance:0.02||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:NOG2(YNR053C)|FD-Score:3.98|P-value:3.51E-5|Clearance:0.16||SGD DESC:Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation Gene:NUF2(YOL069W)|FD-Score:4.5|P-value:3.45E-6|Clearance:0.06||SGD DESC:Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering Gene:PHS1(YJL097W)|FD-Score:3.25|P-value:5.87E-4|Clearance:0.28||SGD DESC:Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking Gene:POL12(YBL035C)|FD-Score:3.54|P-value:2.03E-4|Clearance:0.03||SGD DESC:B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation Gene:SEC20(YDR498C)|FD-Score:3.43|P-value:2.98E-4|Clearance:0.19||SGD DESC:Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p Gene:SEC63(YOR254C)|FD-Score:-3.16|P-value:7.99E-4|Clearance:0||SGD DESC:Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SPC97(YHR172W)|FD-Score:5.08|P-value:1.86E-7|Clearance:0.59||SGD DESC:Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque Gene:SPT6(YGR116W)|FD-Score:3.51|P-value:2.25E-4|Clearance:0.07||SGD DESC:Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region Gene:TIF6(YPR016C)|FD-Score:3.81|P-value:6.82E-5|Clearance:0.26||SGD DESC:Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits Gene:KAR1(YNL188W)|FD-Score:3.44|P-value:2.89E-4|Clearance:0.01||SGD DESC:Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p Gene:LSG1(YGL099W)|FD-Score:4.44|P-value:4.47E-6|Clearance:0.47||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:NMD3(YHR170W)|FD-Score:3.55|P-value:1.89E-4|Clearance:0.02||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:NOG2(YNR053C)|FD-Score:3.98|P-value:3.51E-5|Clearance:0.16||SGD DESC:Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation Gene:NUF2(YOL069W)|FD-Score:4.5|P-value:3.45E-6|Clearance:0.06||SGD DESC:Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering Gene:PHS1(YJL097W)|FD-Score:3.25|P-value:5.87E-4|Clearance:0.28||SGD DESC:Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking Gene:POL12(YBL035C)|FD-Score:3.54|P-value:2.03E-4|Clearance:0.03||SGD DESC:B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation Gene:SEC20(YDR498C)|FD-Score:3.43|P-value:2.98E-4|Clearance:0.19||SGD DESC:Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p Gene:SEC63(YOR254C)|FD-Score:-3.16|P-value:7.99E-4|Clearance:0||SGD DESC:Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SPC97(YHR172W)|FD-Score:5.08|P-value:1.86E-7|Clearance:0.59||SGD DESC:Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque Gene:SPT6(YGR116W)|FD-Score:3.51|P-value:2.25E-4|Clearance:0.07||SGD DESC:Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region Gene:TIF6(YPR016C)|FD-Score:3.81|P-value:6.82E-5|Clearance:0.26||SGD DESC:Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5008496
Download HOP data (tab-delimited text)  (excel)
Gene:APL1(YJR005W)|FD-Score:-3.09|P-value:9.98E-4||SGD DESC:Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex Gene:ATP17(YDR377W)|FD-Score:4.11|P-value:2.02E-5||SGD DESC:Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Gene:ATP3(YBR039W)|FD-Score:3.33|P-value:4.32E-4||SGD DESC:Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Gene:BOR1(YNL275W)|FD-Score:3.36|P-value:3.91E-4||SGD DESC:Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1 Gene:BUD25(YER014C-A)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern Gene:ECM25(YJL201W)|FD-Score:3.74|P-value:9.03E-5||SGD DESC:Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p Gene:GDS1(YOR355W)|FD-Score:3.34|P-value:4.26E-4||SGD DESC:Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:HOP1(YIL072W)|FD-Score:-3.45|P-value:2.82E-4||SGD DESC:Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments Gene:HRD1(YOL013C)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon Gene:HXT1(YHR094C)|FD-Score:3.1|P-value:9.80E-4||SGD DESC:Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication Gene:ICL2(YPR006C)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol Gene:KHA1(YJL094C)|FD-Score:3.74|P-value:9.13E-5||SGD DESC:Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies Gene:MCM16(YPR046W)|FD-Score:4.01|P-value:3.07E-5||SGD DESC:Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 Gene:MMM1(YLL006W)|FD-Score:3.23|P-value:6.24E-4||SGD DESC:ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Gene:MRP8(YKL142W)|FD-Score:-3.4|P-value:3.39E-4||SGD DESC:Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis Gene:MSH2(YOL090W)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP Gene:NUP60(YAR002W)|FD-Score:5.4|P-value:3.39E-8||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153 Gene:NVJ1(YHR195W)|FD-Score:-3.1|P-value:9.83E-4||SGD DESC:Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) Gene:PAP2(YOL115W)|FD-Score:4.15|P-value:1.70E-5||SGD DESC:Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p Gene:PFA3(YNL326C)|FD-Score:4.29|P-value:8.97E-6||SGD DESC:Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions Gene:POL32(YJR043C)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p Gene:PSR1(YLL010C)|FD-Score:4.14|P-value:1.77E-5||SGD DESC:Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p Gene:REC8(YPR007C)|FD-Score:3.77|P-value:8.32E-5||SGD DESC:Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p Gene:RFM1(YOR279C)|FD-Score:6.41|P-value:7.13E-11||SGD DESC:DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance Gene:RIF2(YLR453C)|FD-Score:3.24|P-value:6.05E-4||SGD DESC:Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation Gene:RIM21(YNL294C)|FD-Score:-3.17|P-value:7.70E-4||SGD DESC:pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH Gene:RNH70(YGR276C)|FD-Score:-3.57|P-value:1.80E-4||SGD DESC:3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts Gene:RPS1A(YLR441C)|FD-Score:4.68|P-value:1.43E-6||SGD DESC:Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication Gene:RPS9A(YPL081W)|FD-Score:3.68|P-value:1.18E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication Gene:RSM23(YGL129C)|FD-Score:3.2|P-value:6.80E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p Gene:RTC3(YHR087W)|FD-Score:3.46|P-value:2.74E-4||SGD DESC:Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress Gene:SCO2(YBR024W)|FD-Score:3.71|P-value:1.03E-4||SGD DESC:Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication Gene:SWI4(YER111C)|FD-Score:3.67|P-value:1.19E-4||SGD DESC:DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p Gene:TGL3(YMR313C)|FD-Score:3.17|P-value:7.61E-4||SGD DESC:Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation Gene:TGS1(YPL157W)|FD-Score:3.34|P-value:4.26E-4||SGD DESC:Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs Gene:TNA1(YGR260W)|FD-Score:3.32|P-value:4.46E-4||SGD DESC:High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) Gene:UBC4(YBR082C)|FD-Score:3.83|P-value:6.46E-5||SGD DESC:Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication Gene:XDJ1(YLR090W)|FD-Score:3.83|P-value:6.52E-5||SGD DESC:Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YBL100W-C(YBL100W-C_p)|FD-Score:3.18|P-value:7.32E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YER077C(YER077C_p)|FD-Score:4.15|P-value:1.67E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport Gene:YER087C-A(YER087C-A_d)|FD-Score:-3.16|P-value:7.86E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase Gene:YFL032W(YFL032W_d)|FD-Score:3.63|P-value:1.41E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene Gene:YGR291C(YGR291C_d)|FD-Score:-4|P-value:3.12E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YJR107W(YJR107W_p)|FD-Score:4.09|P-value:2.18E-5||SGD DESC:Putative lipase Gene:YKL091C(YKL091C)|FD-Score:-3.19|P-value:7.21E-4||SGD DESC:Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study Gene:YMR001C-A(YMR001C-A_p)|FD-Score:4.87|P-value:5.68E-7||SGD DESC:Putative protein of unknown function Gene:YMR155W(YMR155W_p)|FD-Score:-3.44|P-value:2.87E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen Gene:YOR314W(YOR314W_d)|FD-Score:4.26|P-value:1.01E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YPR039W(YPR039W_d)|FD-Score:3.25|P-value:5.75E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W Gene:APL1(YJR005W)|FD-Score:-3.09|P-value:9.98E-4||SGD DESC:Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex Gene:ATP17(YDR377W)|FD-Score:4.11|P-value:2.02E-5||SGD DESC:Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Gene:ATP3(YBR039W)|FD-Score:3.33|P-value:4.32E-4||SGD DESC:Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Gene:BOR1(YNL275W)|FD-Score:3.36|P-value:3.91E-4||SGD DESC:Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1 Gene:BUD25(YER014C-A)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern Gene:ECM25(YJL201W)|FD-Score:3.74|P-value:9.03E-5||SGD DESC:Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p Gene:GDS1(YOR355W)|FD-Score:3.34|P-value:4.26E-4||SGD DESC:Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:HOP1(YIL072W)|FD-Score:-3.45|P-value:2.82E-4||SGD DESC:Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments Gene:HRD1(YOL013C)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon Gene:HXT1(YHR094C)|FD-Score:3.1|P-value:9.80E-4||SGD DESC:Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication Gene:ICL2(YPR006C)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol Gene:KHA1(YJL094C)|FD-Score:3.74|P-value:9.13E-5||SGD DESC:Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies Gene:MCM16(YPR046W)|FD-Score:4.01|P-value:3.07E-5||SGD DESC:Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 Gene:MMM1(YLL006W)|FD-Score:3.23|P-value:6.24E-4||SGD DESC:ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Gene:MRP8(YKL142W)|FD-Score:-3.4|P-value:3.39E-4||SGD DESC:Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis Gene:MSH2(YOL090W)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP Gene:NUP60(YAR002W)|FD-Score:5.4|P-value:3.39E-8||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153 Gene:NVJ1(YHR195W)|FD-Score:-3.1|P-value:9.83E-4||SGD DESC:Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) Gene:PAP2(YOL115W)|FD-Score:4.15|P-value:1.70E-5||SGD DESC:Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p Gene:PFA3(YNL326C)|FD-Score:4.29|P-value:8.97E-6||SGD DESC:Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions Gene:POL32(YJR043C)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p Gene:PSR1(YLL010C)|FD-Score:4.14|P-value:1.77E-5||SGD DESC:Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p Gene:REC8(YPR007C)|FD-Score:3.77|P-value:8.32E-5||SGD DESC:Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p Gene:RFM1(YOR279C)|FD-Score:6.41|P-value:7.13E-11||SGD DESC:DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance Gene:RIF2(YLR453C)|FD-Score:3.24|P-value:6.05E-4||SGD DESC:Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation Gene:RIM21(YNL294C)|FD-Score:-3.17|P-value:7.70E-4||SGD DESC:pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH Gene:RNH70(YGR276C)|FD-Score:-3.57|P-value:1.80E-4||SGD DESC:3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts Gene:RPS1A(YLR441C)|FD-Score:4.68|P-value:1.43E-6||SGD DESC:Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication Gene:RPS9A(YPL081W)|FD-Score:3.68|P-value:1.18E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication Gene:RSM23(YGL129C)|FD-Score:3.2|P-value:6.80E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p Gene:RTC3(YHR087W)|FD-Score:3.46|P-value:2.74E-4||SGD DESC:Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress Gene:SCO2(YBR024W)|FD-Score:3.71|P-value:1.03E-4||SGD DESC:Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication Gene:SWI4(YER111C)|FD-Score:3.67|P-value:1.19E-4||SGD DESC:DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p Gene:TGL3(YMR313C)|FD-Score:3.17|P-value:7.61E-4||SGD DESC:Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation Gene:TGS1(YPL157W)|FD-Score:3.34|P-value:4.26E-4||SGD DESC:Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs Gene:TNA1(YGR260W)|FD-Score:3.32|P-value:4.46E-4||SGD DESC:High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) Gene:UBC4(YBR082C)|FD-Score:3.83|P-value:6.46E-5||SGD DESC:Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication Gene:XDJ1(YLR090W)|FD-Score:3.83|P-value:6.52E-5||SGD DESC:Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YBL100W-C(YBL100W-C_p)|FD-Score:3.18|P-value:7.32E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YER077C(YER077C_p)|FD-Score:4.15|P-value:1.67E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport Gene:YER087C-A(YER087C-A_d)|FD-Score:-3.16|P-value:7.86E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase Gene:YFL032W(YFL032W_d)|FD-Score:3.63|P-value:1.41E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene Gene:YGR291C(YGR291C_d)|FD-Score:-4|P-value:3.12E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YJR107W(YJR107W_p)|FD-Score:4.09|P-value:2.18E-5||SGD DESC:Putative lipase Gene:YKL091C(YKL091C)|FD-Score:-3.19|P-value:7.21E-4||SGD DESC:Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study Gene:YMR001C-A(YMR001C-A_p)|FD-Score:4.87|P-value:5.68E-7||SGD DESC:Putative protein of unknown function Gene:YMR155W(YMR155W_p)|FD-Score:-3.44|P-value:2.87E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen Gene:YOR314W(YOR314W_d)|FD-Score:4.26|P-value:1.01E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YPR039W(YPR039W_d)|FD-Score:3.25|P-value:5.75E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR172W5.081.86E-70.59SPC97Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
YOL069W4.503.45E-60.06NUF2Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
YGL099W4.444.47E-60.47LSG1Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YNR053C3.983.51E-50.16NOG2Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
YPR016C3.816.82E-50.26TIF6Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits
YHR170W3.551.89E-40.02NMD3Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YBL035C3.542.03E-40.03POL12B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation
YGR116W3.512.25E-40.07SPT6Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region
YNL188W3.442.89E-40.01KAR1Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
YDR498C3.432.98E-40.19SEC20Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p
YJL097W3.255.87E-40.28PHS1Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking
YDR047W2.960.001520.05HEM12Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
YIL091C2.920.001770.02UTP25Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis
YKR004C2.890.001910.01ECM9Non-essential protein of unknown function
YGR145W2.880.001970.14ENP2Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOR279C6.417.13E-11RFM1DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance
YAR002W5.403.39E-8NUP60FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153
YMR001C-A_p4.875.68E-7YMR001C-A_pPutative protein of unknown function
YLR441C4.681.43E-6RPS1ARibosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication
YNL326C4.298.97E-6PFA3Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions
YOR314W_d4.261.01E-5YOR314W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER077C_p4.151.67E-5YER077C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
YOL115W4.151.70E-5PAP2Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p
YLL010C4.141.77E-5PSR1Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
YDR377W4.112.02E-5ATP17Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YJR107W_p4.092.18E-5YJR107W_pPutative lipase
YPR046W4.013.07E-5MCM16Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3
YBR082C3.836.46E-5UBC4Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
YLR090W3.836.52E-5XDJ1Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR007C3.778.32E-5REC8Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p

GO enrichment analysis for SGTC_1807
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1352.38E-25SGTC_1913914-0123 66.5 μMChemDiv (Drug-like library)31444120.054054160S ribosome export
0.1254.74E-22SGTC_32809140961 49.5 μMChembridge (Drug-like library)49012260.078947460S ribosome export
0.1211.19E-20SGTC_8103825-7150 143.0 μMChemDiv (Drug-like library)223304110.10666760S ribosome export
0.1093.83E-17SGTC_618k072-0232 33.2 μMChemDiv (Drug-like library)58727560.041666760S ribosome export
0.1071.40E-16SGTC_1663st014140 55.4 μMTimTec (Natural product derivative library)42071200.036144660S ribosome export
0.1071.88E-16SGTC_1070indatraline 8.8 μMNIH Clinical Collection103144720.11111160S ribosome export
0.1063.16E-16SGTC_32229128301 49.5 μMChembridge (Drug-like library)49113580.077922160S ribosome export
0.1025.11E-15SGTC_7651319-0117 244.0 μMChemDiv (Drug-like library)34877460.055555660S ribosome export
0.1016.96E-15SGTC_1958st076513 41.9 μMTimTec (Natural product derivative library)7321220.02816960S ribosome export
0.0931.06E-12SGTC_29839022671 13.0 μMChembridge (Drug-like library)64051610.095238160S ribosome export
0.0912.18E-12SGTC_5700987-0065 62.6 μMChemDiv (Drug-like library)31044280.042253560S ribosome export
0.0903.47E-12SGTC_32769139060 49.5 μMChembridge (Drug-like library)48706190.160S ribosome export
0.0904.57E-12SGTC_20785212016 200.0 μMChembridge (Fragment library)18997080.048387160S ribosome export
0.0904.65E-12SGTC_22047233102 200.0 μMChembridge (Fragment library)21724800.042253560S ribosome export
0.0904.80E-12SGTC_850868-0259 160.1 μMChemDiv (Drug-like library)831730.045454560S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1811st05006961.5 μM0.753877702TimTec (Natural product derivative library)325.444584.69113
SGTC_1806st05000560.3 μM0.6170215194765TimTec (Natural product derivative library)331.836484.38313
SGTC_1808st05006361.5 μM0.6170214011993TimTec (Natural product derivative library)325.444584.66113
SGTC_1800st05007929.07 μM0.5918373645560TimTec (Natural product derivative library)373.487385.23713NEO1-PIK1
SGTC_1810st05013853 μM0.5882353444541TimTec (Natural product derivative library)377.476084.61114PDR1
SGTC_1805st05001360.3 μM0.584037144TimTec (Natural product derivative library)331.836484.38313
SGTC_1809st05008157.6 μM0.585036894TimTec (Natural product derivative library)347.45014.62713
SGTC_1802st05011257.9 μM0.5576924662563TimTec (Natural product derivative library)345.4078633.90815
SGTC_1803st05006852.4 μM0.5576923984059TimTec (Natural product derivative library)381.388795.83917NEO1-PIK1
SGTC_1801st05008928.44 μM0.547175008493TimTec (Natural product derivative library)389.486785.27914NEO1-PIK1