Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
---|
YDR280W | 4.43 | 4.80E-6 | 0.82 | RRP45 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress |
YPR165W | 3.61 | 1.55E-4 | 0.17 | RHO1 | GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) |
YDR228C | 3.44 | 2.92E-4 | 0.02 | PCF11 | mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping |
YPR143W | 3.42 | 3.11E-4 | 0.22 | RRP15 | Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs |
YBR196C | 3.20 | 6.92E-4 | 0.03 | PGI1 | Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation |
YDR367W | 3.17 | 7.67E-4 | 0.06 | KEI1 | Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene |
YHR101C | 3.11 | 9.26E-4 | 0.05 | BIG1 | Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan |
YOR260W | 3.07 | 0.00108 | 0.00 | GCD1 | Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression |
YGR005C | 3.06 | 0.00110 | 0.10 | TFG2 | TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30 |
YJL174W | 2.96 | 0.00152 | 0.01 | KRE9 | Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects |
YOR250C | 2.96 | 0.00156 | 9.14E-4 | CLP1 | Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation |
YDR396W_d | 2.95 | 0.00156 | 0.09 | YDR396W_d | Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex |
YCL043C | 2.87 | 0.00206 | 0.01 | PDI1 | Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication |
YLR029C | 2.86 | 0.00212 | 0.01 | RPL15A | Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication |
YNL282W | 2.85 | 0.00219 | 0.10 | POP3 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |