Deletion Strain | FD score | P-value | Gene | Gene Description |
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YGR166W | 14.50 | 9.07E-48 | TRS65 | Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response |
YML037C_p | 9.81 | 5.36E-23 | YML037C_p | Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene |
YOR115C | 8.00 | 6.19E-16 | TRS33 | One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic |
YMR044W | 7.42 | 5.95E-14 | IOC4 | Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing |
YDR392W | 7.36 | 9.42E-14 | SPT3 | Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters |
YLR020C | 7.28 | 1.68E-13 | YEH2 | Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism |
YNL294C | 6.97 | 1.58E-12 | RIM21 | pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH |
YDL001W | 6.94 | 2.02E-12 | RMD1 | Cytoplasmic protein required for sporulation |
YOR357C | 6.77 | 6.49E-12 | SNX3 | Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p |
YER177W | 6.24 | 2.22E-10 | BMH1 | 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress |
YGR163W | 6.13 | 4.47E-10 | GTR2 | Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD |
YHR187W | 6.12 | 4.61E-10 | IKI1 | Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin |
YGL083W | 6.05 | 7.17E-10 | SCY1 | Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase |
YPL202C | 5.82 | 2.99E-9 | AFT2 | Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication |
YDL076C | 5.58 | 1.23E-8 | RXT3 | Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress |