st053448

6-[2-(3,4-dimethylphenoxy)ethylsulfanyl]-7H-purine

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1819
Screen concentration 58.6 μM
Source TimTec (Natural product derivative library)
PubChem CID 2857616
SMILES CC1=C(C=C(C=C1)OCCSC2=NC=NC3=C2NC=N3)C
Standardized SMILES Cc1ccc(OCCSc2[nH]cnc3ncnc23)cc1C
Molecular weight 300.3787
ALogP 3.45
H-bond donor count 1
H-bond acceptor count 5
Response signature amide catabolism

Pool Growth Kinetics
% growth inhibition (Het. pool) 11.64
% growth inhibition (Hom. pool) 11.47


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2857616
Download HIP data (tab-delimited text)  (excel)
Gene:CFD1(YIL003W)|FD-Score:-4|P-value:3.19E-5|Clearance:0||SGD DESC:Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol Gene:DRE2(YKR071C)|FD-Score:3.89|P-value:4.95E-5|Clearance:0.23||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:ECM9(YKR004C)|FD-Score:3.6|P-value:1.62E-4|Clearance:0.23||SGD DESC:Non-essential protein of unknown function Gene:RFC1(YOR217W)|FD-Score:3.17|P-value:7.62E-4|Clearance:0.08||SGD DESC:Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon Gene:TRR1(YDR353W)|FD-Score:3.79|P-value:7.63E-5|Clearance:0.23||SGD DESC:Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication Gene:YDR396W(YDR396W_d)|FD-Score:3.41|P-value:3.23E-4|Clearance:0.23||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex Gene:YML6(YML025C)|FD-Score:3.18|P-value:7.28E-4|Clearance:0.01||SGD DESC:Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins Gene:CFD1(YIL003W)|FD-Score:-4|P-value:3.19E-5|Clearance:0||SGD DESC:Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol Gene:DRE2(YKR071C)|FD-Score:3.89|P-value:4.95E-5|Clearance:0.23||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:ECM9(YKR004C)|FD-Score:3.6|P-value:1.62E-4|Clearance:0.23||SGD DESC:Non-essential protein of unknown function Gene:RFC1(YOR217W)|FD-Score:3.17|P-value:7.62E-4|Clearance:0.08||SGD DESC:Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon Gene:TRR1(YDR353W)|FD-Score:3.79|P-value:7.63E-5|Clearance:0.23||SGD DESC:Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication Gene:YDR396W(YDR396W_d)|FD-Score:3.41|P-value:3.23E-4|Clearance:0.23||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex Gene:YML6(YML025C)|FD-Score:3.18|P-value:7.28E-4|Clearance:0.01||SGD DESC:Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2857616
Download HOP data (tab-delimited text)  (excel)
Gene:AIM9(YER080W)|FD-Score:-3.46|P-value:2.68E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:CAF20(YOR276W)|FD-Score:-3.88|P-value:5.16E-5||SGD DESC:Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E Gene:CAR1(YPL111W)|FD-Score:5.48|P-value:2.13E-8||SGD DESC:Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance Gene:COG8(YML071C)|FD-Score:-3.22|P-value:6.45E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CPR2(YHR057C)|FD-Score:-4.44|P-value:4.47E-6||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway Gene:DAL81(YIR023W)|FD-Score:6.21|P-value:2.72E-10||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:DNF3(YMR162C)|FD-Score:-3.63|P-value:1.44E-4||SGD DESC:Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase Gene:ECM31(YBR176W)|FD-Score:3.72|P-value:9.80E-5||SGD DESC:Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate Gene:ECM4(YKR076W)|FD-Score:-3.49|P-value:2.45E-4||SGD DESC:Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:EIS1(YMR031C)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:ERV46(YAL042W)|FD-Score:-3.83|P-value:6.33E-5||SGD DESC:Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport Gene:FAR7(YFR008W)|FD-Score:3.76|P-value:8.64E-5||SGD DESC:Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress Gene:IRC18(YJL037W)|FD-Score:5.49|P-value:2.07E-8||SGD DESC:Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci Gene:KIN82(YCR091W)|FD-Score:3.56|P-value:1.86E-4||SGD DESC:Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p Gene:LAP3(YNL239W)|FD-Score:-3.43|P-value:3.07E-4||SGD DESC:Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH Gene:LOS1(YKL205W)|FD-Score:4.04|P-value:2.69E-5||SGD DESC:Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm Gene:LSB5(YCL034W)|FD-Score:3.36|P-value:3.91E-4||SGD DESC:Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat Gene:MET28(YIR017C)|FD-Score:3.22|P-value:6.38E-4||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism Gene:MRPS5(YBR251W)|FD-Score:4.45|P-value:4.29E-6||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSB1(YOR188W)|FD-Score:3.91|P-value:4.60E-5||SGD DESC:Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:MSS11(YMR164C)|FD-Score:-4.65|P-value:1.65E-6||SGD DESC:Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals Gene:NAM7(YMR080C)|FD-Score:3.14|P-value:8.45E-4||SGD DESC:ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress Gene:NMA1(YLR328W)|FD-Score:4.67|P-value:1.48E-6||SGD DESC:Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication Gene:NPR2(YEL062W)|FD-Score:6.05|P-value:7.45E-10||SGD DESC:Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline Gene:NTC20(YBR188C)|FD-Score:-3.52|P-value:2.17E-4||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs Gene:OXP1(YKL215C)|FD-Score:5.43|P-value:2.81E-8||SGD DESC:5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:PAD1(YDR538W)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX Gene:PCI8(YIL071C)|FD-Score:4.54|P-value:2.85E-6||SGD DESC:Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain Gene:PEX12(YMR026C)|FD-Score:3.6|P-value:1.56E-4||SGD DESC:C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder Gene:PPN1(YDR452W)|FD-Score:3.38|P-value:3.61E-4||SGD DESC:Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:PRO2(YOR323C)|FD-Score:3.57|P-value:1.75E-4||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:RIM15(YFL033C)|FD-Score:-3.26|P-value:5.61E-4||SGD DESC:Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase Gene:RMD9(YGL107C)|FD-Score:3.34|P-value:4.25E-4||SGD DESC:Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes Gene:ROM2(YLR371W)|FD-Score:4.11|P-value:1.96E-5||SGD DESC:GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p Gene:RPL37A(YLR185W)|FD-Score:3.46|P-value:2.74E-4||SGD DESC:Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication Gene:RTS3(YGR161C_p)|FD-Score:3.88|P-value:5.18E-5||SGD DESC:Putative component of the protein phosphatase type 2A complex Gene:SEC72(YLR292C)|FD-Score:3.22|P-value:6.41E-4||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SIP4(YJL089W)|FD-Score:-3.74|P-value:9.35E-5||SGD DESC:C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus Gene:SNF4(YGL115W)|FD-Score:3.66|P-value:1.25E-4||SGD DESC:Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress Gene:SPT4(YGR063C)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions Gene:TAT1(YBR069C)|FD-Score:3.31|P-value:4.61E-4||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TDH1(YJL052W)|FD-Score:3.21|P-value:6.58E-4||SGD DESC:Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress Gene:THI7(YLR237W)|FD-Score:3.12|P-value:9.02E-4||SGD DESC:Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia Gene:TPC1(YGR096W)|FD-Score:4.14|P-value:1.73E-5||SGD DESC:Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family Gene:TRP1(YDR007W)|FD-Score:4.1|P-value:2.08E-5||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP3(YKL211C)|FD-Score:3.33|P-value:4.40E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:YBL028C(YBL028C)|FD-Score:3.94|P-value:4.03E-5||SGD DESC:Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis Gene:YCR025C(YCR025C_d)|FD-Score:4.41|P-value:5.12E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene Gene:YCR100C(YCR100C_p)|FD-Score:3.49|P-value:2.46E-4||SGD DESC:Putative protein of unknown function Gene:YCR101C(YCR101C_p)|FD-Score:4.49|P-value:3.63E-6||SGD DESC:Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene Gene:YDR445C(YDR445C_d)|FD-Score:3.33|P-value:4.36E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YFR045W(YFR045W_p)|FD-Score:5.02|P-value:2.55E-7||SGD DESC:Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white Gene:YHR125W(YHR125W_d)|FD-Score:3.09|P-value:9.85E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHR202W(YHR202W_p)|FD-Score:3.75|P-value:9.02E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization Gene:YIL166C(YIL166C_p)|FD-Score:3.15|P-value:8.07E-4||SGD DESC:Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene Gene:YJL175W(YJL175W_d)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor Gene:YJL218W(YJL218W_p)|FD-Score:4.63|P-value:1.86E-6||SGD DESC:Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene Gene:YLR280C(YLR280C_d)|FD-Score:4.06|P-value:2.45E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR402W(YLR402W_d)|FD-Score:3.25|P-value:5.83E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR456W(YLR456W_p)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication Gene:YMR155W(YMR155W_p)|FD-Score:-3.97|P-value:3.65E-5||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen Gene:YMR265C(YMR265C_p)|FD-Score:4.48|P-value:3.71E-6||SGD DESC:Putative protein of unknown function Gene:YNL140C(YNL140C_p)|FD-Score:-3.1|P-value:9.66E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C Gene:YPR015C(YPR015C_p)|FD-Score:4.09|P-value:2.16E-5||SGD DESC:Putative protein of unknown function; overexpression causes a cell cycle delay or arrest Gene:AIM9(YER080W)|FD-Score:-3.46|P-value:2.68E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:CAF20(YOR276W)|FD-Score:-3.88|P-value:5.16E-5||SGD DESC:Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E Gene:CAR1(YPL111W)|FD-Score:5.48|P-value:2.13E-8||SGD DESC:Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance Gene:COG8(YML071C)|FD-Score:-3.22|P-value:6.45E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CPR2(YHR057C)|FD-Score:-4.44|P-value:4.47E-6||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway Gene:DAL81(YIR023W)|FD-Score:6.21|P-value:2.72E-10||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:DNF3(YMR162C)|FD-Score:-3.63|P-value:1.44E-4||SGD DESC:Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase Gene:ECM31(YBR176W)|FD-Score:3.72|P-value:9.80E-5||SGD DESC:Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate Gene:ECM4(YKR076W)|FD-Score:-3.49|P-value:2.45E-4||SGD DESC:Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:EIS1(YMR031C)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:ERV46(YAL042W)|FD-Score:-3.83|P-value:6.33E-5||SGD DESC:Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport Gene:FAR7(YFR008W)|FD-Score:3.76|P-value:8.64E-5||SGD DESC:Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress Gene:IRC18(YJL037W)|FD-Score:5.49|P-value:2.07E-8||SGD DESC:Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci Gene:KIN82(YCR091W)|FD-Score:3.56|P-value:1.86E-4||SGD DESC:Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p Gene:LAP3(YNL239W)|FD-Score:-3.43|P-value:3.07E-4||SGD DESC:Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH Gene:LOS1(YKL205W)|FD-Score:4.04|P-value:2.69E-5||SGD DESC:Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm Gene:LSB5(YCL034W)|FD-Score:3.36|P-value:3.91E-4||SGD DESC:Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat Gene:MET28(YIR017C)|FD-Score:3.22|P-value:6.38E-4||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism Gene:MRPS5(YBR251W)|FD-Score:4.45|P-value:4.29E-6||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSB1(YOR188W)|FD-Score:3.91|P-value:4.60E-5||SGD DESC:Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:MSS11(YMR164C)|FD-Score:-4.65|P-value:1.65E-6||SGD DESC:Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals Gene:NAM7(YMR080C)|FD-Score:3.14|P-value:8.45E-4||SGD DESC:ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress Gene:NMA1(YLR328W)|FD-Score:4.67|P-value:1.48E-6||SGD DESC:Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication Gene:NPR2(YEL062W)|FD-Score:6.05|P-value:7.45E-10||SGD DESC:Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline Gene:NTC20(YBR188C)|FD-Score:-3.52|P-value:2.17E-4||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs Gene:OXP1(YKL215C)|FD-Score:5.43|P-value:2.81E-8||SGD DESC:5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:PAD1(YDR538W)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX Gene:PCI8(YIL071C)|FD-Score:4.54|P-value:2.85E-6||SGD DESC:Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain Gene:PEX12(YMR026C)|FD-Score:3.6|P-value:1.56E-4||SGD DESC:C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder Gene:PPN1(YDR452W)|FD-Score:3.38|P-value:3.61E-4||SGD DESC:Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:PRO2(YOR323C)|FD-Score:3.57|P-value:1.75E-4||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:RIM15(YFL033C)|FD-Score:-3.26|P-value:5.61E-4||SGD DESC:Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase Gene:RMD9(YGL107C)|FD-Score:3.34|P-value:4.25E-4||SGD DESC:Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes Gene:ROM2(YLR371W)|FD-Score:4.11|P-value:1.96E-5||SGD DESC:GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p Gene:RPL37A(YLR185W)|FD-Score:3.46|P-value:2.74E-4||SGD DESC:Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication Gene:RTS3(YGR161C_p)|FD-Score:3.88|P-value:5.18E-5||SGD DESC:Putative component of the protein phosphatase type 2A complex Gene:SEC72(YLR292C)|FD-Score:3.22|P-value:6.41E-4||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SIP4(YJL089W)|FD-Score:-3.74|P-value:9.35E-5||SGD DESC:C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus Gene:SNF4(YGL115W)|FD-Score:3.66|P-value:1.25E-4||SGD DESC:Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress Gene:SPT4(YGR063C)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions Gene:TAT1(YBR069C)|FD-Score:3.31|P-value:4.61E-4||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TDH1(YJL052W)|FD-Score:3.21|P-value:6.58E-4||SGD DESC:Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress Gene:THI7(YLR237W)|FD-Score:3.12|P-value:9.02E-4||SGD DESC:Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia Gene:TPC1(YGR096W)|FD-Score:4.14|P-value:1.73E-5||SGD DESC:Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family Gene:TRP1(YDR007W)|FD-Score:4.1|P-value:2.08E-5||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP3(YKL211C)|FD-Score:3.33|P-value:4.40E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:YBL028C(YBL028C)|FD-Score:3.94|P-value:4.03E-5||SGD DESC:Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis Gene:YCR025C(YCR025C_d)|FD-Score:4.41|P-value:5.12E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene Gene:YCR100C(YCR100C_p)|FD-Score:3.49|P-value:2.46E-4||SGD DESC:Putative protein of unknown function Gene:YCR101C(YCR101C_p)|FD-Score:4.49|P-value:3.63E-6||SGD DESC:Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene Gene:YDR445C(YDR445C_d)|FD-Score:3.33|P-value:4.36E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YFR045W(YFR045W_p)|FD-Score:5.02|P-value:2.55E-7||SGD DESC:Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white Gene:YHR125W(YHR125W_d)|FD-Score:3.09|P-value:9.85E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHR202W(YHR202W_p)|FD-Score:3.75|P-value:9.02E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization Gene:YIL166C(YIL166C_p)|FD-Score:3.15|P-value:8.07E-4||SGD DESC:Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene Gene:YJL175W(YJL175W_d)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor Gene:YJL218W(YJL218W_p)|FD-Score:4.63|P-value:1.86E-6||SGD DESC:Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene Gene:YLR280C(YLR280C_d)|FD-Score:4.06|P-value:2.45E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR402W(YLR402W_d)|FD-Score:3.25|P-value:5.83E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR456W(YLR456W_p)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication Gene:YMR155W(YMR155W_p)|FD-Score:-3.97|P-value:3.65E-5||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen Gene:YMR265C(YMR265C_p)|FD-Score:4.48|P-value:3.71E-6||SGD DESC:Putative protein of unknown function Gene:YNL140C(YNL140C_p)|FD-Score:-3.1|P-value:9.66E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C Gene:YPR015C(YPR015C_p)|FD-Score:4.09|P-value:2.16E-5||SGD DESC:Putative protein of unknown function; overexpression causes a cell cycle delay or arrest

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YKR071C3.894.95E-50.23DRE2Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress
YDR353W3.797.63E-50.23TRR1Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication
YKR004C3.601.62E-40.23ECM9Non-essential protein of unknown function
YDR396W_d3.413.23E-40.23YDR396W_dDubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex
YML025C3.187.28E-40.01YML6Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
YOR217W3.177.62E-40.08RFC1Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YOR373W3.090.001000.01NUD1Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance
YAR007C3.080.001030.00RFA1Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YDL043C3.080.001050.05PRP11Subunit of the SF3a splicing factor complex, required for spliceosome assembly
YPR082C3.030.001220.00DIB117-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein
YOR103C3.030.001240.09OST2Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YKL172W2.940.001653.91E-4EBP2Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
YPR088C2.940.001650.03SRP54Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
YOR119C2.910.001800.01RIO1Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
YER082C2.900.001860.01UTP7Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YIR023W6.212.72E-10DAL81Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
YEL062W6.057.45E-10NPR2Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline
YJL037W5.492.07E-8IRC18Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
YPL111W5.482.13E-8CAR1Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
YKL215C5.432.81E-8OXP15-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
YFR045W_p5.022.55E-7YFR045W_pPutative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
YLR328W4.671.48E-6NMA1Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication
YJL218W_p4.631.86E-6YJL218W_pPutative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
YIL071C4.542.85E-6PCI8Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain
YCR101C_p4.493.63E-6YCR101C_pPutative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene
YMR265C_p4.483.71E-6YMR265C_pPutative protein of unknown function
YBR251W4.454.29E-6MRPS5Mitochondrial ribosomal protein of the small subunit
YCR025C_d4.415.12E-6YCR025C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
YGR096W4.141.73E-5TPC1Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
YLR371W4.111.96E-5ROM2GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p

GO enrichment analysis for SGTC_1819
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1441.07E-28SGTC_486niguldipine 82.0 μMMiscellaneous12360.09amide catabolism
0.1427.60E-28SGTC_20935331342 194.4 μMChembridge (Fragment library)338390.0555556
0.1397.79E-27SGTC_28459003024 43.0 μMChembridge (Drug-like library)29901730.0933333amide catabolism
0.1352.06E-25SGTC_24605552655 174.2 μMMiscellaneous54019890.0675676amide catabolism
0.1346.08E-25SGTC_3371315-0038 354.0 μMChemDiv (Drug-like library)16264370.0813954amide catabolism
0.1331.49E-24SGTC_21375261020 140.0 μMChembridge (Fragment library)7636550.0675676
0.1283.94E-23SGTC_30889117578 49.5 μMChembridge (Drug-like library)6783410.104478amide catabolism
0.1224.46E-21SGTC_2683piperine 63.0 μMTimTec (Pure natural product library)6380240.0512821
0.1189.85E-20SGTC_8230417-1665 178.0 μMChemDiv (Drug-like library)34298560.144578
0.1181.17E-19SGTC_2618avocadyne 43.4 μMMicrosource (Natural product library)30151890.0149254
0.1163.92E-19SGTC_10563448-1962 115.0 μMChemDiv (Drug-like library)7155070.149254amide catabolism
0.1141.32E-18SGTC_10583448-5425 97.3 μMChemDiv (Drug-like library)72797050.0869565
0.1133.45E-18SGTC_11811222-0449 220.0 μMChemDiv (Drug-like library)6583180.084507
0.1054.49E-16SGTC_2642cholecalciferol 100.0 μMMicrosource (Natural product library)98214650.0322581
0.1057.16E-16SGTC_9903985-0011 41.3 μMChemDiv (Drug-like library)53995650.109589amide catabolism

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1755st04196045.19 μM0.5964912257073TimTec (Natural product derivative library)328.43194.15515
SGTC_1769st04440664.4 μM0.4670903TimTec (Natural product derivative library)310.3487433.5415
SGTC_1641st00929947.1 μM0.3666674046054TimTec (Natural product derivative library)290.771243.46814mitochondrial processes
SGTC_2981901395238.96 μM0.2968752996344Chembridge (Drug-like library)348.234324.39112
SGTC_3125912753449.47 μM0.2741941639235Chembridge (Drug-like library)283.364844.12812
SGTC_2940906063845.86 μM0.2622954027022Chembridge (Drug-like library)297.37484.2114amide catabolism
SGTC_12011889-337245.9 μM0.2575765392199ChemDiv (Drug-like library)282.337023.49113Golgi
SGTC_21075363541170.16 μM0.237288244052Chembridge (Fragment library)199.63421.81812
SGTC_11770983-020423.6 μM0.230769766818ChemDiv (Drug-like library)318.369123.99613
SGTC_3273913785949.47 μM0.2258062377234Chembridge (Drug-like library)266.360764.53803